Tetracycline 처리된 조직유도재생술용 차폐막의 약제유리양상 및 구조적 변화

이성미,정현주,Lee, Sung-Mi,Chung, Hyun-Ju 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.1

Tetracycline is known to be effective in eliminating periodontopathogens and have collagenolytic activity. This study was performed to observe the desorption kinetics and structural changes of tetracycline-treated barrier membranes for guided tissue regeneration. Four kinds of barrier membranes were tested : $Tefgen^{(R)}$(American Custom Medical, USA) and $Gore-Tex^{(R)}$(W.L. Gore & Associates Inc., USA) as nonresorbable membranes ; Resolut(polyglycolide & polylactide copolymer, W.L. Gore & Associates Inc., USA) and $Biomend^{(R)}$(collagen, Collatec Co., USA) as resorbable membranes. The membranes were cut into discs(diameter : 4mm) and were immersed in 5% tridodecylmethylammonium chloride(TIMAC) ethanol and air-dried. The membrane discs were absorbed with $100{\mu}g/ml tetracycline solution(pH8) for one minute and dried. For desorption kinetics, TC treated discs were immersed in phosphate buffered saline solution (PBS, pH 7.4). PBS was exchanged daily and TC concentration was measured by absorbance at 276nm on UV spectrophotometer. To measure remaining antibacterial activity, discs of 1 day to 4 weeks after desorption were placed on Mueller Hinton agar containing Bacillus cereus and incubated aerobically in $37^{\circ}C$ for twelve hours and the inhibition diameters were measured. To observe the structural change of membranes after TIMAC treatment or immersion in PBS, the membrane discs were examined under SEM. The results were as follows : 1. Total amounts of TC absorbed into membrane discs($0.7536mm^2$) were $2000{\mu}g$, $1800{\mu}g$, $2625{\mu}g$ and $2499{\mu}g$ for $Tefgen^{(R)}$, $Gore-Tex^{(R)}$, $Biomend^{(R)}$ and $Resolut^{(R)}$. 2. The concentration of TC released from barrier membrane discs was maintained over $4{\mu}g/ml$ until the fifth day in nonresorbable membranes and $Resolut^{(R)}$, but until the fourth day in $Biomend^{(R)}$, Until the ninth day in nonresorbable membranes and until the seventh day in resorbable membranes, the TC concentration was maintained over $1{mu}g/ml$. 3. The four membrane discs in the first day showed similar size of inhibition zone. One to four weeks later, the inhibition zone was much smaller in resorbable membrane discs than nonresorbable membrane discs. 4. Any structural change due to treatment of TIMAC was not observed on the nonresorbable membranes. $Resolut^{(R)}$ did not show any structural change except fibrillar loosening during immersion period, but Biomend showed destruction of membrane structure from the first week of immersion. This study indicates that tetracycline treated barrier membranes lead to the sustained release of tetracycline for over 7 days. This slow release pattern of tetracycline may contribute to the favorable clinical outcome of guided tissue regeneration.

여성결혼이민자 가족의 사회통합 지원대책

이성미,Lee, Seong-Mi 충남발전연구원 2006 열린충남 Vol.35 No.-

청고추, 쇠비름, 표고버섯의 물 추출물 및 당침액의 항산화 활성 및 ${\alpha}$-Glucosidase Inhibition 활성 비교

이성미,강윤환,김대중,김경곤,임준구,김태우,최면,Lee, Sung Mee,Kang, Yun Hwan,Kim, Dae Jung,Kim, Kyoung Kon,Lim, Jun Gu,Kim, Tae Woo,Choe, Myeon 동아시아식생활학회 2014 동아시아식생활학회지 Vol.24 No.1

본 연구에서는 최근 건강 관리를 위해 다양하게 상용되고 있는 당침액의 오 남용을 막기 위해 과학적으로 물 추출물과 당침액의 특성을 규명하고자 하였다. 그 결과, 일반 물 추출물과 비교하였을 때 당침액의 총 폴리페놀 및 플라보노이드 함량이 크게 감소하는 것을 확인하였으며, 그에 따라 항산화 활성 또한 감소한 것을 확인할 수 있었다. 이는 물 추출물과 비교하여 당침액의 건조 분말에는 설탕 또는 그 분해물들이 많은 부분을 차지하기 때문이라 판단된다. 그러나 혈당강하 효능의 target 효소로 연구되고 있는 ${\alpha}$-amylase 및 ${\alpha}$-glucosidase의 활성을 측정한 결과, 청고추, 쇠비름, 표고버섯의 물 추출물과 당침액은 ${\alpha}$-amylase 억제 활성을 나타내지 않았지만, ${\alpha}$-glucosidase 억제 활성은 의약품인 acarbose에는 미치지 못하였으나, 물 추출물에 비해 당침액이 농도 의존적으로 높은 억제 활성을 나타내었다. 또한 세포 독성을 HepG2 cell에서 확인한 결과, 물 추출물과 비교하여 당침액의 독성이 약 1/10 감소한 것을 확인할 수 있었다. 이와 같은 결과는 민간에서의 믿음처럼 당침액이 물 추출물과 비교하였을 때 모든 부분에서 우수한 기능을 가진다고 할 수 없으며, 활용할 용도에 따라 소재를 물 추출하거나 당침액을 제조하는 등의 가공 과정을 거치는 것이 목표한 기능을 효과적으로 확보하는 방법임을 의미한다. 따라서 민간에서 맹목적으로 믿는 당침액의 효능에 대한 과학적인 연구 접근법은 당침액의 적절한 사용 목적과 방법을 설정하는 기초 자료로 활용이 가능할 것이다. This study was conducted in order to compare the biological activities of water extracts and sugar immersion extracts of green pepper (Capsicum annuum L.), purslane (Portulaca oleracea L.) and shiitake (Lentinula edodes (Berk.) Pegler) by measuring total polyphenol and flavonoid contents, antioxidant activities and inhibitory effects on ${\alpha}$-amylase and ${\alpha}$-glucosidase. The contents of total polyphenols and flavonoids were higher in water extracts than in sugar immersion extracts. The anti-oxidative activities of water and sugar immersion extracts were measured using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenging activity assay and reducing power assay. All extracts scavenged radicals in a concentration-dependent manner, and water extracts showed stronger radical scavenging activity and reducing power than sugar immersion extract. However, they all exhibited lower activities than ascorbic acid. Compared to the anti-diabetic drug acarbose, which was used as a positive control, the two types of extracts exhibited low ${\alpha}$-glucosidase inhibitory activities, although the activity of sugar immersion extracts were 2-fold higher than that of water extracts. ${\alpha}$-Amylase inhibitory action was not observed for any of the extracts. Finally, by cytotoxicity test, we confirmed that sugar immersion extracts were safer than water extracts. These results indicate that water extracts and sugar immersion extracts of green pepper, purslane and shiitake have different advantages in terms of their antioxidant and anti-diabetic effects, respectively.

보건관리대행사례47 - 제조업의 뇌심혈관질환 예방 사례

이성미,Lee, Seong-Mi 대한산업보건협회 2009 산업보건 Vol.250 No.-

주요 신문매체를 통해 본 아파트 주거문화 분석

이성미,이연숙,Lee Sung-Mi,Lee Yeon-Sook 한국주거학회 2005 한국주거학회 논문집 Vol.16 No.3

Daily newspapers are one of the most influential mass media and the news coverage can be used an indicator of social issues and needs. The purpose of this study was to investigate characteristics of physical environment in apartments, and to examine the underlying social ideas. In doing so, the contents of national daily newspapers in the past ten years were analyzed by using frequencies. The study found that sophistication, diversity, and differentiation were drawn as social values that lie in the physical environment of apartments, and the characteristics were related to housing types, space planning and complex layout. The finding shows that the coverage of the physical environment in apartments has been growing, and the increasing attention to the residential environment remains strong and significant.

노인주택의 개념과 유형화 연구

이연숙(Lee, Yeunsook),이성미(Lee, Sungmi),김민수(Kim, Minsoo),이유진(Lee, Yoojin),이선민(Lee, Sunmin) 한국생태환경건축학회 2007 한국생태환경건축학회 논문집 Vol.7 No.1

차례 : 사회생물학적 관점에서 본 부모의 욕구

이성미 ( Seong Mi Lee ) 한국교육철학회 2012 교육철학 Vol.46 No.-

Many modern parent-theories tacitly premise norms that parent-child relationship should be full of love, understanding, encouraging, and comforting. Even though they regard the conflicts between parent and child as their subject of the study, it is very difficult to find their basic questions such as why and from where the conflicts begins, Besides, even though they present how to be good parents, they do not show radical skepticism about ``what is the real parent-child relationship``. In fact, parental love for child, on which parental authority and responsibility are based, has been accepted as indemonstrable theme so far. But we need to ascertain the realities or facts before discussing about parental sacrifice, love, authority, and responsibility. This article focuses on the parent`s desires among many facts which explain parent-child relationship. Because parent`s desires based on his/her power cannot avoid the conflict with child`s independent freedom, it becomes the key reason that causes complications between parent and child. As the first step of philosophical thinking about parent-child relationship, with priority given to parent`ffs desires, I tried to infer parent`ffs biological desires from some sociobiological researches which analyze the cause of altruistic instinct. The most of relationships that we can find purely altruistic instinct are the ones between parent and child. Sociobiology finds the reason from gene, which has the nature of self-reproduction as the only survival principle. Through the child who inherits his/her gene, parent feels the life which survives transcending the limits of generations. On the other hand, parent has the desire to recreate him/herself through his/her child because of the self-centered and out-intentional consciousness. But child is not an extension of parent him/herself but an extension of the immortal life in parent. Child is another independent existence and the fate of parent is to help child become wholly independent from parent.

영유아 대상 TV 캐릭터 놀잇감에 대한 부모의 인식

이성미(Lee, Sung-Mi),고준희(Koh, Joon-Hee) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.19

목적 본 연구는 TV 캐릭터 놀잇감에 대한 전반적인 부모의 인식을 확인하는데 목적이 있다. 방법 편의표집 및 눈덩이 표집방식으로 서울시, 경기도, 강원도 지역에 거주하는 만 1 - 5세 미만의 영유아기 자녀를 양육하고 있는 부모 17명을 대상으로 심층면담을 진행하고, 전사자료를 분석하였다. 결과 TV 캐릭터 놀잇감은 영유아의 요구에 의해 구매하거나 부모가 자발적으로 구매하는 것으로 확인되었다. 부모들은 영유아들이 TV와 유튜브, 유아교육기관 및 놀이터와 같은 또래들과 만나는 장소, 크리에이터를 통해 TV 캐릭터 놀잇감을 알게 되고 소유하고 싶은 마음이 생겨 부모에게 놀잇감 구매를 요청한다고 밝혔다. 그리고 부모들은 어린 시절의 향수와 학습적인 부분에 대한 기대, 맞벌이로 인한 미안한 마음으로 인해 자발적으로 TV 캐릭터 놀잇감을 구매하는 것으로 확인되었다. 한편, 부모는 TV 캐릭터 놀잇감이 자녀의 기본생활습관을 형성하고 언어능력 및 사회성을 향상하는데 도움이 된다는 점에서 긍정적인 인식을 가지고 있었다. 반면, TV 캐릭터 놀잇감의 약한 내구성과 연속적인 시리즈 상품 출시, 선정성, 과대광고 등의 부분에서 부정적인 인식을 가지고 있는 것으로 확인되었다. 또한 부모들은 영유아들이 TV 캐릭터 놀잇감을 수집만 할 뿐 자주 놀이하지 않고 단순한 놀이를 반복한다고 인식하고 있음을 확인할 수 있었다. 결론 본 연구는 질적 연구를 통해 다양한 측면에서 TV 캐릭터 놀잇감에 대한 부모의 인식을 전반적으로 확인하였다는 점에서 의의를 가진다. 그리고 본 연구의 결과는 영유아의 발달에 적합한 TV 캐릭터 놀잇감 개발의 필요성을 시사하고, 부모와 자녀가 TV 캐릭터 놀잇감을 구매하고 놀이를 할 때 필요한 안내 지침 및 교육이 제공되어야 함을 제안하고 있다. 또한 본 연구는 TV 캐릭터 놀잇감에 대한 부모 및 교사 교육의 기초자료를 마련하였다는 점에서 의미가 있다. Objectives The purpose of this study is to confirm the overall parents perception of TV character play materials. Methods In-depth interviews were conducted with 17 parents raising young children at the age of 1-5 who live in Seoul, Gyeonggi-do, and Gangwon-do using convenience sampling and snowball sampling, and then the transcribed data were analyzed. Results It was confirmed that TV character play materials were purchased at the request of young children or voluntarily by parents. Parents said that their young children asked them to purchase play materials after they knew such materials through TV, YouTube, early childhood education institutions, places where young children meet their peers such as playgrounds, or creators, and wanted to own them. In addition, it was confirmed that parents voluntarily purchased TV character play materials due to their childhood nostalgia, expectations for their children’s voluntary learning through such materials, or feeling sorry about their insufficient inattention to their children because of dual income. Parents have positive perceptions of the materials in that TV character play materials help their children form basic lifestyles and improve their language skills and social skills. On the other hand, it was confirmed that they have negative perceptions of the materials in that TV character play materials had poor durability, continuous series product launches, and sensationalism. Meanwhile, it was confirmed that when young children play with TV character play materials, they just collect without often playing with them, but they repeat simple plays. Conclusions This study is meaningful in that it confirmed the overall perception of parents about TV character play materials from various aspects through a qualitative study. And the results of this study suggest the need to develop TV character play materials suitable for the development of young children, and suggest that guidance and education necessary for parents and children to purchase and play TV character play materials be provided. In addition, this study is meaningful in that it prepared basic data for parent and teacher education on TV character play materials.

아파트 실내공간 의미분석방법에 관한 연구

이성미(Lee, Sung Mi) 한국디자인지식학회 2006 디자인지식저널 Vol.3 No.-

『장자』를 통해 본 마음과 교육

이성미 ( Seomg Mi Lee ) 한국교육철학학회 2014 교육철학연구 Vol.36 No.1

본 논문은 심학적 교육 전통의 발굴과 현대적 재해석이라는 마음교육 연구과제의 하나로서 장자의 마음과 교육을 논한 것이다. ‘성심’과 ‘허정한 마음’은 장자가 이해한 마음의 두 차원을 함축적으로 표현한 개념이다. 이 가운데 ‘성심’은 물아의 분리로 만들어진 허구적인 ‘나(我)’의 마음으로, 주변세계를 자신의 제한된 경험과 지식으로 분별하고 소유와 지배의 대상으로 파악하는 마음을 가리킨다. ‘허정한 마음’은 ‘나’라는 허구적인 관념이 해체된 후(喪我), 우주의 일부로 전체 생명과 연결된 ‘참된 나(眞我)’의 마음으로, 부분과 분별, 그리고 소유의 지평에 머물러 있던 의식이 전체와 수용, 그리고 존재의 지평으로 확장된 정신경계를 의미한다. 교육이 성심에 근거하여 행해질 때 그것은 하나의 ‘유위’이다. 유위의 교육은 교육대상에게 일정한 틀을 강제하고, 그 틀 바깥을 모험할 용기를 빼앗음으로써 교육대상의 자기창조적 본성을 마멸시킨다. 반면 교육자의 허정한 마음은 교육대상의 존재를 있는 그대로 품으며, 감화를 통해 자연스러운 배움을 일으킨다. 장자는 이러한 교육을 ‘불언지교(不言之敎)’라 했다. 장자의 마음과 교육의 이해는, 교육자의 마음에 교육대상의 주체적이고 창조적인 삶의 가능성을 결정하는 힘이 있음을 보여준다. This dissertation aims to clarify Zhuangzi`s understanding about heart-mind (xin, 心) and education (敎) as an assignment of ‘maum (마음) education’ that tries to reinterpret heart-mind centered traditions of eastern education and to apply it in today`s educational arena. Zhuangzi employs the metaphor of a huge fish and a huge bird which is transformed from the fish in order to explain that there are two different stages of human`s heart-mind. Cheng-xin (成心) and empty and unruffled (xu-jing, 虛靜) heart-mind represent impliedly two different stages of heart-mind in Zhuangzi`s philosophy. Cheng-xin is xin of ``I(我)``, a fabricated idea of a individual who separates himself from the whole (tiandi, 天地). Cheng-xin of ``I`` stays at a horizon of having (所有) to gain recognition from others and furthermore it trys to dominate other people`s sprit by reproducing itself through others. Xu-xin is the heart-mind of the true self who returns to be a part of the whole after deconstructing the fabricated idea of ``I`` (sang-wo, 喪我). Intentional act (有爲) is a kind of way to make a relationship with the outside world with cheng-xin and teaching is called as an intentional act when it is derived from cheng-xin. Educators with xu-xin perceive children partially with his discriminative knowledge while educators with empty and unruffled heart-mind understand children or students in relation to the whole cosmos and embrace(懷) their children as they are. Therefore parents and teachers with xu-xin can accept and wait for children`s growth and change as an inevitability in the large flow of the great nature. Zhuangzi called the teaching through one`s empty and unruffled heart-mind as "wordless teaching (不言之敎)." Zhuangzi`s understanding about human heart-mind and education shows that the possibility to encourage children to create their own lives depands on educators` heart-mind which dictates the features of education.