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레버 증폭 구조의 플렉서를 이용한 공초점 현미경의 개발
이상원,김위한,정영대,박민규,김지현,이상인,이호,Lee, Sang-Won,Kim, Wi-Han,Jung, Young-Dae,Park, Min-Kyu,Kim, Jee-Hyun,Lee, Sang-In,Lee, Ho 한국광학회 2011 한국광학회지 Vol.22 No.1
본 연구에서는 레버 증폭 구조를 이용한 플렉서 기반의 나노 스테이지를 설계, 제작하였다. 제작된 나노 스테이지를 샘플 스테이지로 채용한 공초점현미경을 개발하였다. 2차원 이미징의 구현을 위해서, 기존의 공초점현미경은 레이저를 이미징 평면상에 스캐닝하는 방식으로 구현된다. 본 연구에서는 백 나노미터의 구동정밀도를 가지는 나노 스테이지 위에 놓인 샘플을 2차원으로 스캐닝하면서 2차원 이미지를 구현할 수 있는 공초점현미경을 개발하였다. 플렉서 기반의 나노 스테이지는 이중 판스프링, 변위증폭 레버, PZT 엑추에이터 그리고 변위 센서로 구성 되어 있다. 스테이지의 구동 성능 해석을 위해 상용 유한요소 해석 프로그램을 이용하였다. 현미경에 사용되는 광원은 적색광 레이저이며, 레이저는 여러 광학요소를 거쳐 샘플스테이지의 샘플에 입사되고, 반사된 빛은 광센서인 PMT(Photo Multiplying Tube)로 계측되게 된다. 계측된 빛의 크기를 이용하여서 2차원 이미징을 구현하였다. 개발된 공초점 현미경으로 생쥐 귀의 피부조직을 관찰하여 현미경의 이미징 성능을 검증하였다. 설계된 샘플 스테이지는 기존의 공초점 현미경의 기계적인 Beam 스캐너를 대신함으로써 현미경의 광경로 및 전체시스템을 간소화 하였다. A confocal microscope was developed utilizing a scanning sample stage based on a home-built double-compound flexure guide. A scanning sample stage with nano-scale resolution consisted of a double leaf spring based flexure, a displacement amplifying lever, a Piezo-electric Transducer(PZT) actuator and capacitance sensors. The performance of the two-axis stage was analyzed using a commercial finite element method program prior to the implementation. A single line laser was employed as the light source along with the Photo Multiplier Tube(PMT) that served as the detector. The performance of the developed confocal microscope was evaluated with a mouse ear skin imaging test. The designed scanning stage enabled us to build the confocal microscope without the two optical scanning mirror modules that are essential in the conventional laser scanning confocal microscope. The elimination of the scanning mirror modules makes the optical design of the confocal microscope simpler and more compact than the conventional system.
$H_{2}O_2$와 A$\beta$로 유도된 pc12 cell에서 생산조인(生酸棗仁) 수추출물의 항산화 및 항치매 효과
이상원,김대현,윤종현,김진우,정은영,이성근,이기상,김태헌,류영수,강형원,Lee, Sang-Won,Kim, Dae-Hyun,Yun, Jong-Hyun,Kim, Jin-Woo,Jung, Ejun-Young,Lee, Seoung-Geun,Lee, Key-Sang,Kim, Tae-Heon,Lyu, Yeoung-Su,Kang, Hyung-Won 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.3
Objective: The antioxidant and anti-Alzheimer effects of Semen Ziziphi Spinosae (SZS) water extract against the amyloid beta peptide (1-42) or H202-induced oxidative damage and cell death were investigated in rat pheochromocytoma line PC 12. Methods: The cells were incubated with SZS water extract and oxidative damage-inducing materials, amyloid beta peptide (1-42) or H2O2 for 24 h. The cellular viability was assessed by WST-1 assay, cytotoxic damage by LDH activity assay, oxidative damages of cells by fluorescence spectrophotometric method, and apoptosis by TUNEL staining assay. Results and Conclusions: 1. Preincubation of the cells with SZS water extract prior to amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) exposure elevated the cell survival close to the control and decreased the level of LDH activity and the fluorescence from the cell homogenates and TUNEL staining of the cells, compared to only amyloid beta peptide (1-42) (2 uM) or H2O2 (30 uM) treated conditions. 2. Our study suggests that Semen Ziziphi Spinosae (SZS) water extract has protective effects against amyloid beta peptide (1-42) or H2O2-induced cell toxicity through the antioxidation mechanism, which might be beneficial for the treatment of Alzheimer's disease.
"동의보감"과 "제중신편"에 기재된 처방중 수치대황의 종류와 효능에 대한 고찰
이상원,김현정,김진숙,Lee, Sang-Won,Kim, Hyeun-Jeong,Kim, Jin-Sook 한국한의학연구원 2003 한국한의학연구원논문집 Vol.9 No.1
The Effects and processing methods of Rhei Rhizoma from Donguibogam and Chejungsinpyeon were studied, Through the study, we found 21 kinds of processing method of Rhei Rhizoma in Donguibogam and Chejungsinpyeon, Processing methods used in Donguibogam and Chejungsinpyeon were effective from reducing side effects of Rhei Rhizoma, and were safe in clinical application, the aims of processing methods of Rhie Rhizoma were safer application by reducing poisonous character, and increase the range of clinical application by useing 21 kinds of processing methods.
재발성 뇌실내출혈을 일으킨 경연수접합부 동정맥기형 - 증례보고 -
이상원,최창화,차승헌,박동준,송근성,이영우,Lee, Sang Weon,Choi, Chang Hwa,Cha, Seung Heon,Park, Dong June,Song, Geun Sung,Lee, Young Woo 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.6
Cervicomedullary junction arteriovenous malformation(AVM) is extremely rare. The authors present a case of a cervicomedullary junction AVM in a 31-year-old woman presenting with recurrent intraventricular hemorrhage (IVH). Magnetic resonance imaging revealed the AVM(of a size of approximately $2{\times}2.5{\times}4cm$) extending from a lower medulla to C2-3 level. Vertebral angiography demonstrated a tightly coiled vascular mass with multiple feeders (radiculomedullary arteries) and irregular-shaped aneurysm at distal part of feeder originating at right C-1 level. The patient underwent superselective embolization of upper nidus and the aneurysm. The pertinent literature is reviewed, and diagnostic and therapeutic implications are discussed.
고등학교(高等學校) 학생(學生)의 대수(代數) 문제(問題) 해결(解決) : 전략(戰略)과 오류(誤謬) 분석(分析)
이상원,전평국,Lee, Sang-Won,Jeon, Pyung-Kook 한국수학교육학회 1997 수학교육논문집 Vol.2 No.-
The purpose of this study is to provide the primary sources to improve the problem solving performance by analyzing the errors and the strategies selection of the high school students when solving given algebraic problems. To attain the purpose of this study, the questions for investigation in this study are : 1. What are the differences / similarities in the patterns of errors committed by successful and unsuccessful problem-solvers when solving particular algebraic problems ? 2. What are the error types chosen by unsuccessful problem-solvers when solving particular algebraic problems? 3. Do students utilize checking, either locally or globally, when solving particular algebraic problems? Twenty students were drawn out of 10th grade students in J girls' high school in Yengi -gun, Chung-Nam, for this study. The problem-solving test was used as a test instrument. From the data, the verbal protocols and the written protocols were analyzed by the patterns. The conclusions drawn from the results obtained in the present study are as follows: First, in solving particular algebraic problems, when the problems were solved with one strategy, most students didn't give any consideration to other strategies. So mathematics teachers should teach them to use the various strategies, and should develop the problems to be used the various strategies. Second, in solving particular algebraic problems, errors on notions or transformations of equations were found. Thus, the basic knowledges related to equation should be taught. In addition, most unsuccessful students seleted the strategies inadequately to solve the problems because of misunderstanding the problems. So, to improve the problem solving performance the processes of 'understanding problem' should be emphasized to students. Third, although the unsuccesful students used the 'checking' processes when solving the problems, most of them did not find the errors because of misconceptions related to the problems, carelessness, and unskillfulness of checking. Thus, students must be taught more carefully and encouraged to use the checking.
미국도시경찰(美國都市警察)의 법죄예방활동(犯罪預防活動)에 관한 연구(硏究) - NYPD를 중심(中心)으로 -
이상원,Lee, Sang-Won 한국경호경비학회 1999 시큐리티연구 Vol.- No.2
The Police is the provider of the Police Service that is the most evident and active. This paper centers on the crime prevention activity of New york City Police Department that is most large and representable in America on account of the enormity of the scale and the material selection. I examine the duty and organization of the City Police Department the Crime Prevention activity of the city police and I research a conclusion.
서울 경찰(警察)의 방범체제(防犯體制) 개선(改善)에 관한 연구(硏究)
이상원,Lee, Sang-Won 한국경호경비학회 1997 시큐리티연구 Vol.- No.1
I study the actual condition and the problem of the crime prevention system of two seoul police station. that is operated on the unit of police box, and present the new improvement. Stragic and active is the new crime prevention system that introduces a concept of community oriented policing, the tendency of a developed country police. I present a medium - sized police station where 250${\sim}$300 policemen work. It consist of a patrol division, a community division and a administration support division. The chief of police bears the responsibility only for crime prevention service by concentrating on pure Patrol - centered crime prevention activity and community relation activity. Next I present a police inspector system. The most important on this paper is the community policing officer system that a policeman bears responsibility on district apart from a patrol division and support a police service related community. To be operated these systems effectively, these need to be regulated according to a police distinct, a police purpose and it's demand. Also a scale, function, authority of a existing. Police station must be regulated and the police training must be carried out.