합곡(合谷), 삼음교(三陰交) 자침(刺鍼)이 백서(白鼠) 자궁(子宮) 운동(運動) 및 Cyclooxygenase-2 발현(發現)에 미치는 영향(影響)

이병철,이호섭,김경식,이건목,나창수,김정상,황우준,Lee, Byung-Chul,Lee, Ho-Sub,Kim, Kyung-Sik,Lee, Geon-Mok,Na, Chang-Soo,Kim, Jung-Sang,Hwang, Woo-Jun 대한침구의학회 2000 대한침구의학회지 Vol.17 No.2

By the activation of ovary hormone, many morphological changes occur in the epithelial cell lines and muscle cells in rat uterus. These two cells in uterus are important to the implantation of embryo, maintaining pregnancy and starting parturition. One important change associated with the morphological change of these two cells in uterus is the change on prostaglandin(PG) metabolism. Its presence and synthesis in endometriurn and myometrium in uterus affects estrous cycle and the start of embryo implantation in uterus. It also performs as an important modulator in parturition. So the abnormally weak expression of PG causes difficulty during labor and over-expression causes pre-term labor. PG biosynthesis starts from either free or liberated arachidonic acids from membrane phospholipid by phospholipase. Such arachidonic acids are converted into PG catalyzed by Cyclooxygenase. Under normal physiological condition, Cyclooxygenase-1(COX-1) having 602 units of amino acids controls the synthesis of PG. It acts as a local hormone regulating vasomodulation of blood flow, flexible muscle movement, increasing the blood permeability and contributing the protective role in preserving integrity of the stomach lining and Cyclooxygenase-2 (COX-2) is induced by the inflammation, pregnancy and increased its expression until parturition. Lipid metabolite like PG is located in uterine and expression of COX-2 increased with pregnancy. Increased expression of COX proteins in epithelial cells and myometrial cells are told to increase the muscle contractility in uterus but decreased right after the labor in rat. It is a good sign indicating that COX proteins are deeply related to the start of labor. Currently, Several studies report the use of PG and COX-2 inhibitor as medication for controlled abortion or to prevent pre-term labor but they entail various side-effects. Our study proposed to suggest use of acupuncture as an another mediator to control abortion or pre-term labor without causing unnecessary side-effects by those medicines. Two acupuncture sites, LI-4 & SP-6 were selected due to their known efficacy. From the immunohistochemical staining of COX-2, normal expression of COX-2 protein in nonpregnant SD rat's uterus revealed that COX-2 protein was primarily detected in the lumina epithelial lining and in the epithelial cell lining contacting the stromal cells. High resolution optical microscopic scanning revealed distinguishable staining in the myometrial mucosa. LI-4 acupuncture administered nonpregnant rat's uterus showed strong expression for COX-2 in endometrium contacted with lumina epithelial lining of rat uterus and in myometrial mucosa. Stromal cells showed more staining than untreated nonpregnant rat's uterus and stronger staining in stromal cells contacting myometrial layer compared to untreated nonpregnant rat's uterus. SP-6 acupuncture administered nonpregnant rat's uterus showed weak expression for COX-2 in myometrial layers and stromal cells but no staining was visible in lumina epitheliai and glandular epithelial cells. Few stromal cells and myometrial mucosa were positively stained for COX-2. Pregnant SD rat's uterus was also immunostained for COX-2 expression after 18 days of pregnancy. Unlike to untreated nonpregnant rat's uterus, luminal epithelial cells were not positively stained for COX-2 but stronger staining for COX-2 was revealed in stromal cells. LI-4 acupunctured SD rat's uterus had very strong expression of COX-2 in luminal epithelial lining. Few stromal cells showed stronger positive COX-2 staining and myometrial layers also showed more expression than untreated pregnant rat. SP-6 acupuncture administered pregnant SD rat's uterus showed positive expression of COX-2 in epithelial cells of luminal mucosa layer but weaker than that of LI-4 acupuncture treatment's case. However, strong positive staining was revealed in stromal mucosa and myometrial layers. Virgin SD rat's uterus motility index during LI-4 acupunctur

라만과 적외선 분광기를 이용한 P₂O₅-Na₂O-MgO 유리의 이상성에 관한 연구

이병철,권용준,류봉기,Lee, Byung-Chul,Kwon, Young-Jun,Ryu, Bong-Ki 한국세라믹학회 2002 한국세라믹학회지 Vol.39 No.3

용융법으로 제작된 인산염 유리시편의 조성변화에 따른 밀도와 물에 대한 안정성 및 각각의 구조변화를 조사하기 위해 Raman과 적외선 흡수 스펙트럼이 측정되었다. 그 결과 $P_2O_5$가 60mol% 부근에서 밀도와 물에 대한 안정성이 급격히 증가하는 구조적인 이상성을 나타내었다. 이러한 변화는 $Mg^{2+}$ 이온을 중심으로 DBO(Double-Bonded Oxygen)이 배위하면서 유리구조의 강한 수축을 유발시켜 나타난 구조변화에 기인하는 것으로, $Mg^{2+}$ 이온을 배위하고 있는 DBO은 이중결합의 성격을 잃어버리고, 다른 하나의 NBO(Non-Bonding Oxygen)과 함께 공명구조를 이룬다고 생각된다. Density, water resistance, Raman and infrared spectroscopy were used to investigate the change of structural characteristics with the composition of phosphate galss samples made by melting method. The structural abnormality of the density and water resistance were rapidly increased and shown near the 60mol% of $P_2O_5$. This result could be explained by the structural changes owing to the strong shrinkage of glass network by the coordination of DBO(Double-Bonded Oxygen) around $Mg^{2+}$ cations. In addition, it seems that the DBOs coordinating $Mg^{2+}$ cations lose its characteristics of double bonding and resonate with other NBOs(Non-Bonding Oxygen).

The Clinical Effect of Bosingunyang-tang on Chronic Non-bacterial Prostatitis/Chronic Pelvic Pain Syndrome : Randomized Double-blind, Placebo-controlled Clinical Trial

이병철,Song, Moon-Koo,Kang, Ji-Suck,Kang, Cheol-Ho,Ahn, Young-Min,Ahn, Se-Young,Doo, Ho-Kyung,Lee, Byung-Cheol 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3

Objective : Although chronic prostatitis/chronic pelvic pain syndrcme(CP/CPPS) is a common disease, there is no consensus on the etiology or pathology and treatment. This was a double-blinded, placebo-controlled, randomized clinical trial, investigating the therapeutic effects of the traditional Korean medicine, Bosingunyang-tang(BSGYT). Method : Participants who met US National Institutes of Health (NIH) consensus criteria for CP/CPPS were entered after applying inclusion/exclusion criteria. They were randomized to the BSGYT or placebo group. and treated three times a day for 6 weeks. NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) was used to estimate the clinical symptoms of CP/CPPS. Prostaglandin E2 and ${\beta}$-endorphin in prostatic fluid, collected by 2-glass pre-massage and post-massage test, were analyzed as factors associated with pain and inflammation. Result : The mean decrease in NIH-CPSI total score of the BSGYT group was 11.0 points, which is 5.7 points more than the placebo group. (Mann Whitney test P=0.038) Also the BSGYT group showed three times higher response rate than the placebo group in NIH-CPSI pain subscale score. (Fisher's exact test P=0.027) In those responders, prostaglandin E2 decreased significantly. (Wilcoxon's signed-ranks test P=0.037). No specific side effects were observed. Conclusion : After a 6-week treatment period, BSGYT improved clinical symptoms of CP/CPPS patients by decreasing PGE2 level in prostatic fluid.

봉독약침이 장기환자의 LFT와 RFT에 미치는 영향

이병철,천미나,양명복,Lee, Byung-Chol,Cheon, Mi-Na,Yang, Myung-Bok 대한침구의학회 2000 대한침구의학회지 Vol.17 No.2

Bee-venom Acupucture has good effect on pain control but We may be anxious about the problem of Liver and Kidneys on many times treated patients. Therefore, In order to analysis the clinical form, We have observed the LFT, RFT of 37 patients who visited Won-Kwang University Kunpo Oriental Medical Hospital and treated Bee Venom therapy over 20 times from March 1999 to February 2000. The results were summarized as follows 1. The distribution of sex was 25 females, 12 males, and the average of patients age was 42.3 years 2. The distribution of disease was degenerative arthritis, HIVD of L-spine, HIVD of C-spine, spinal stenosis, RA, etc. 3. The total treated times is 1464 and the average of treated times is 39.6 times 4. The results of the LFT(AST, ALT) of 37 patients showed that normal impression is occupied 91.9% and abnormal impression is occupied 8.1%. 5. The results of the RFT(BLTN, Creatinine) of 37 patients showed that normal impression is occupied 100%. 6. The results of treatment using BV-acupunture showed that 81.1% achieved above excelent recovery 13.5% achieved above good recovery, 5.4% achieved fair recovery.

해금사가 만성 비세균성 전립선엽 모델에서 혈액학적 및 세포조직학적 변화에 미치는 영향

이병철,김상우,안영민,두호경,안세영,Lee, Byung-Cheol,Kim, Sang-Woo,Ahn, Young-Min,Doo, Ho-Kyung,Ahn, Se-Young 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3

Objective : Although chronic non-bacterial prostatitis is a common disease, it is very difficult to treat effectively. Lygodium japonicum has been traditionally used in treatment of urinary tract inflammation and voiding disturbance. In this study, we investigated the therapeutic effects and action mechanism of Lygodium japonicum in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Methods : Five-month-old rats were treated with 17$\beta$-estradiol after castration for induction of experimental non-bacterial prostatitis, which is similar to human chronic prostatitis in histopathological profiles. Lygodium japonicum and testosterone were administered as an experimental specimen and a positive control. respectively. The prostates were evaluated by histopathological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. PCNA labeling index for cyto-proliferation and a TUNEL(deoxyuridine triphosphate biotin nick end-labeling) assay for cell apoptosis. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with Lygodium japonicum showed a diminished range of tissue damage. Epithelial score was improved in the Lygodium japonicum group over that of the control (P<0.05). The epithelio-stromal ratio was lower in the Lygodiutn japonicum group when compared to that of the control (P<0.05). Although there was no difference in PCNA and TUNEL positive cells of the glandular epithelia. we found an decreased number of PCNA positive cell and concurrent increase of TUNEL positive cells in the stroma of Lygodium japonicum treated rats (P<0.01). Conclusions : These findings suggest that Lygodium japonicum may protect the glandular epithelial cells and also inhibit stromal proliferation in association with suppression of cyto-proliferation and stimulation of apoptosis. We concluded that Lygodium japonicum could be a useful remedy agents for treating chronic non-bacterial prostatitis.

계획작품 - 여가 스포츠 문화센터

이병철,Lee, Byeong-Cheol 대한건축사협회 2005 建築士 Vol.2005 No.11

회원작품 - 소양강댐 물 문화관

이병철,Lee, Byung-chul 대한건축사협회 2008 建築士 Vol.2008 No.7

나의 주장 - "기술지향적 의사결정보다 경영지향적 의사결정을"

이병철,Lee, Byeong-Cheol 한국과학기술단체총연합회 1999 과학과 기술 Vol.32 No.8

최고의 기술이라고 해서 모든 사람들이 이를 수용하고 미래 기술계를 주도하는 것이 아니다. 기술혁신을 실현하려면 일정한 수용기간이 필요하고 기존기술을 바탕으로 해야하며 기술지향적 차원이 아닌 경영전략적 차원에서 이뤄져야 한다. 90년대 초반에 선정된 네트워크기간망 ATM도 지금와서 보면 값만 비싸고 표준화 작업이 부진한 실정이다. 실수요자들이 이를 외면한다면 수천억원의 투자손실을 누가 책임질것인가.

멀티미디어 통신용 병렬 아키텍쳐 고속 비터비 복호기 설계

이병철,선우명훈,Lee, Byeong-Cheol 대한전자공학회 2000 電子工學會論文誌-SD (Semiconductor and devices) Vol.37 No.2

비터비 복호기는 직렬 복호 방식과 병렬 복호 방식 2 가지로 분류할 수 있다. 병렬 비터비 복호기는 직렬비터비 복호기에 비해 보다 높은 데이타율을 얻을 수 있다. 본 논문에서는 고속 멀티미디어 통신을 위한 병렬 비티비 복호기 구조를 설계하고 구현한다. 설계한 비터비 복호기는 고속 동작을 위해 64개의PE(Processing Element)를 사용해 한 클럭에 처리가 가능하도록 하였다. 또한 파이프라인 스테이지를 갖는 시스톨릭 어레이 구조의 TB(Traceback) 블럭을 설계하였다. 본 논문에서 설계한 비터비 복호기는 puncturing을 통해 부호율 1/2, 2/3, 3/4, 5/6, 7/8을 지원한다. Verilog 모델을 구현하였고 0.6㎛ Samsung KG75000 SOG 셀 라이브러리를 이용하여 논리합성을 수행하였다. 구현된 비터비 복호기는 약100,400 게이트이며 동작 속도는 worst case에서 70㎒로 기존 상용 칩들보다 빠르다. The Viterbi decoders can be classified into serial Viterbi decoders and parallel Viterbi decoders. Parallel Viterbi decoders can handle higher data rates than serial Viterbl decoders. This paper designs and implements a fully parallel Viterbi decoder for high speed multimedia communications. For high speed operations, the ACS (Add-Compare-Select) module consisting of 64 PEs (Processing Elements) can compute one stage in a clock. In addition, the systolic away structure with 32 pipeline stages is developed for the TB (traceback) module. The implemented Viterbi decoder can support code rates 1/2, 2/3, 3/4, 5/6 and 7/8 using punctured codes. We have developed Verilog HDL models and performed logic synthesis. The 0.6 ${\mu}{\textrm}{m}$ SAMSUNG KG75000 SOG cell library has been used. The implemented Viterbi decoder has about 100,400 gates, and is running at 70 MHz in the worst case simulation.

The Association of the -675 4G/5G and A-844G Polymorphisms of the Plasminogen Activator Inhibitor-1 Gene with a Risk of Ischemic Stroke in Korean Population

이병철,변상혁,김순일,강기훈,안세영,두호경,서정철,임강현,조성호,안영민,Lee, Byung-Cheol,Byun, Sang-Hyuk,Kim, Soon-Il,Kang, Ki-Hoon,Ahn, Se-Young,Doo, Ho-Kyung,Seo, Jung-Chul,Leem, Kang-Hyun,Cho, Seong-Ho,Oh, Chad K.,Ahn, Young-Min The Society of Internal Korean Medicine 2004 大韓韓方內科學會誌 Vol.25 No.4

연구배경 : 플라스미노겐 활성 억제인자-1 (plasminogen activator inhibitor-1; PAI-1)은 허혈성 뇌경색의 발생의 원인이 되는 섬유소 용해작용의 저하를 매개하는 인자로서, PAI-1의 작용이 촉진되면 섬유소 용해기능이 저하되어 관상동맥 및 뇌혈관질환의 발생을 증가시키게 된다. PAI-1 유전자의 촉진자(promoter) 영역에는 -675 4G/5G (4G/5G)와A -844G (A/G)의 두 개의 유전자 다형성이 존재하며, 이는 PAI-1의 유전자 전사과정에 영향을 미쳐 혈청 PAI-1의 농도를 증가시키고 결과적으로 허혈성 뇌경색의 발생확률을 높이는 작용을 하게 된다. 연구방법 : 허혈성 뇌경색으로 진단 받은 167명의 환자와 173명의 건강인의 말초혈액에서 DNA를 분리한 후 PAI-1의 4G/5G와 A/G 유전자 다형성에 대한 연쇄중합반응 및 제한효소 절편길이 다형성 (polymerase chain reaction-restriction fragment length polymorphism; PCR-RFLP) 방법을 이용하여 허혈성 뇌경색 발생과 유전자 다형성과의 관계를 비교 분석하였다. 결과 : 허혈성 뇌경색 환자에서의 4G/4G의 유전자형의 빈도는 15.0%으로 정상 대조군의 33.5%에 비해 현저하게 낮게 나타났다 (P < 0.0001). 각각의 유전자형과 허혈성 뇌경색의 발생 위험도 (odd ratio ; OR)와의 관계를 분석했을 때 4G/4G 유전자형을 가질 경우 위험도는 0.35배로 현저하게 낮아졌으며, (P < 0.0001), 5G/5G 유전자형을 가질 경우 위험도는 4.49배 로 현저하게 높아졌다 (P < 0.0001). 그러나, A/G 유전자 다형성과 허혈성 뇌경색의 발생과는 유의한 연관성을 발견하지 못하였다. 결론 : 이상의 결과로 볼 때 PAI-1 유전자의 4G/4G 유전자형은 허혈성 뇌경색의 발생 비율을 감소시키는 작용을 하는 것으로 여겨진다.