소아 급성 세균성 신엽염의 임상상 및 신장 예후

이동기,권덕근,임윤주,신윤혜,윤석남,배기수,Lee Dong-Ki,Kwon Duck-Geun,Lim Yun-Ju,Shin Yun-Hye,Yun Suk-Nam,Pai Ki-Soo 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.2

목적: 소아에서 드문 질병인 급성 세균성 신엽염의 질병 성격을 살피기 위하여, 9명의 환아를 대상으로 발현 증상, 임상 경과, 치료 반응, 동반 요로 기형, 신장 손상 정도 등을 조사하였다. 방법: 1994년 9월부터 2004년 8월까지 복부 초음파 또는 복부 컴퓨터 단층 촬영을 통하여 신엽염으로 확진된 9명의 환아를 대상으로 진료 기록을 후향적으로 분석하였다. 결과: 대상 환자들의 연령분포는 1개월에서 6세까지 평균 $2.8{\pm}2.2$세였으며, 성별로는 남자 6명 여자 3명이었다. 발열 및 오한은 모든 환자에서 있었고, 그 외 복통, 배뇨곤란 및 빈뇨가 있었다. 내원 당시 시행한 검사실 검사상, 백혈구수 $21,000{\pm}5,600/uL$, ESR $60{\pm}23mm/hr$, CRP $17{\pm}10\;mg/dl$이었으며. 혈액 배양 검사는 모두 음성이었다. 소변 검사상, 농뇨 및 현미경적 혈뇨는 모든 환자에게 있었고, 치료후 농뇨가 소실되기까지 $10.5{\pm}7.8$일이 소요되었다. 복부 초음파 검사상, 신장에 국소적으로 경계가 불명확하면서 에코가 떨어져 있는 신엽염 소견이 5명(55.5%)에서 관찰되었다. 복부 컴퓨터 단층 촬영에서는 불명확한 경계를 띠고 조영제에 증강이 잘 되지 않는 쐐기 모양의 신엽염의 소견이 모든 환자에서 관찰되었다. 방광요관역류는 3명(33.3%)에서 있었으며, 모두 3단계 이상이었다. $^{99m}Tc-DMSA$ 스캔에서는 일측 또는 양측 신장의 피질 손상이 확인되었다. 4개월 후 추적한 스캔상, 6명중 2명(33%)은 이전에 비해 병변의 크기가 감소되었으나, 나머지 4명(67%)은 병변의 크기가 불변 또는 약간 악화된 소견이었다 환아의 총 발열기간은 $11.8{\pm}6.3$일로, 이중 입원전 기간은 $4.0{\pm}3.0$일, 입원후 기간은 $7.8{\pm}5.5$일이었다. 입원 기간은 7일에서 31일까지 평균 $17.2{\pm}8.1$일이었다. 결론: 요로감염 환아에서 치료 후에도 1주이상 발열, 농뇨, 높은 혈액 염증 수치가 지속될 경우 '급성 세균성 신엽염'을 적극 의심하여야 하며, 질환의 정확한 진단을 위하여 신장 초음파검사 보다는 컴퓨터 단층 촬영을 우선 실시할 것을 제안하는 바이다. Purpose: This study was perfonned to elucidate the clinical pictures of acute focal bacterial nephritis(nephronia) in children. Methods: We reviewed 9 children with nephronia diagnosed by ultrasonography or computed tomography of kidneys from September 1994 to August 2004. Results: The overall male to female ratio was 2:1, and the age distribution ranged from 0.1 to 6 years(mean $2.8{\pm}2.2$). The cardinal symptoms were fever, chills, abdominal pain and dysuria/frequency. The initial leukocyte count was $21,000{\pm}5,600/uL$, ESR $60{\pm}23mm/hr$, CRP $17{\pm}10\;mg/dl$. Pyuria was noted in every patient and persisted for $10.5{\pm}7.8$ days after antimicrobial treatment. Abdominal sonography demonstrated focal lesion of ill-defined margin and low echogenicity in 5 of 9 patients(55.6%), while computed tomography revealed nonenhancing low density area in all patients(100%). Three of 9 patients(33.3%) had vesicoureteral reflux, greater than grade III. The initial $^{99m}Tc-DMSA$ scan showed one or multiple cortical defects in every patient, and improvements were noted in 2(33.3%) of 6 patients who received follow up scan after 4 months. Intravenous antibiotics was given in every patient under admission. Total febrile period was $11.8{\pm}6.3$ days(pre-admission, $4.0{\pm}3.0;$ post-admission, $7.8{\pm}5.5$ days) and the patients needed hospitalization for $17.2{\pm}8.1$ days. Conclusion: For the early diagnosis of 'acute focal bacterial nephritis' we should perform renal computed tomography first rather than ultrasonography, when the child has toxic symptoms and severe inflammatory responses in blood and urine.

현대주거의 기하조작에 의한 보이드 공간의 생성과 친환경적 특성에 관한 연구

이동기,Lee, Dong-Ki 한국주거학회 2010 한국주거학회 논문집 Vol.21 No.6

This study is aimed to grasp the spatial characteristics exhibited in the modern housing architecture from the aspect of a geometrical manipulation, which transforms basic geometrical shapes and persue the formative diversity, to identify and verify the various characteristics of spatial structure in modern housing architecture. In this regard, this paper analyze and identify the influences of the void spaces that are created by geometrical manipulations on housing architecture, in terms of morphological and environmental aspects. Theoretical approaches define the concept of geometrical manipulation according to the characteristics of residence and examine the spatial features of void spaces. Additionally, case studies result in the classification of void spaces that are created by geometrical manipulation. Furthermore, to understand environment-friendly characteristics of the void space, the researcher elicited the factors that can affect environment friendly housing from previous studies, and analyzed their correlation between those factors and the void spaces that are classified.

벤처기업의 R&D 투자와 성과에 관한 실증연구

이동기,이철규,김정환,Lee, Dong-Ki,Lee, Cheol-Kyu,Kim, Jung-Hwan 한국벤처창업학회 2008 벤처창업연구 Vol.3 No.1

In this research, an empirical analysis was performed to determine the correlation between management performance and Empirical Research on the R&D investment for domestic venture businesses in each industry. Specifically, an empirical analysis for each industry was attempted not only to clarify the general hypothesis on the relationship between management performance and R&D investment for venture businesses but also to demonstrate that differences exist for each industry. Empirical analysis was conducted for eight industries with respect to the $2002{\sim}2006$ panel data extracted as investigative results from the "Investigation Report on Science and Technology R&D Activities" published by the Ministry of Science and Technology. Industrial classification was limited to the middle-level classification (2-digit) in the Korea Standard Industry Code (KSIC) owing to the limited number of panels. Although this research only verified the overall positive effect of R&D activities and funds for existing research on corporate value or productivity and management performance, it was able to document the difference for each individual industry and each business size unlike existing research. Furthermore, the reliability of the research results was enhanced by targeting companies that have been continuously conducting R&D and management activities using consistent 5-year panel data in the analysis. Again, this was something that existing research did not have. Finally, through the use of recent data from 2002 after the IMF economic crisis up to 2006 in the empirical analysis, this research proposed the problems due to the prevailing circumstances at the time of entering the advanced nation stage based on an empirical analysis; the prevailing problems during the pursuit of advanced nation status before the IMF crisis broke out were not tackled. The key empirical analysis yielded several results. First, capital and size of the labor force have a positive correlation with the management performance for the entire company or the venture business. This applies to all eight industries as the subjects of the analysis. Second, although the number of years since a company has been established can have positive or negative correlation with management performance for the entire company or venture business in specific industries, a definite overall trend cannot be identified. Third, R&D investment can be said to have an overall positive effect on corporate management performance. Fourth, the size of the research staff cannot be said to be a factor unilaterally affecting the management performance of the entire company or the venture business. Fifth, the number of years a research institute has been in operation, which was assumed to have a positive effect on the management performance of a company because of the accumulated R&D know-how -- definitely acts as a positive factor contributing to the management performance of a company.

형제선별검사로 유아기에 조기 진단된 심한 방광요관역류 1례

이동기,신윤혜,유재은,배기수,Lee Dong-Ki,Shin Yun-Hye,Yu Jey-Un,Pai Ki-Soo 대한소아신장학회 2004 Childhood kidney diseases Vol.8 No.2

저자들은 역류성 신질환 남아의 생후 6개월된 남동생을 대상으로 시행한 조기 형제선별검사에서 신손상을 보이지 않는 5단계의 좌측 방광요관역류를 발견할 수 있었다. 이후 요로감염의 발생을 방지하고자 하였으며, 이를 통하여 신손상발생의 위험을 줄일 수 있었기에 문헌고찰과 함께 보고하는 바이다. 또한 역류성 신질환 환아의 형제자매에서 방광요관역류 여부에 대한 형제선별검사를 적극적으로 시행할 것을 제안하는 바이다. We report a case of severe(gradeV) unilateral vesicoureteral reflux(VUR) without any renal damage in a 6-month-old boy through the early sil)ling screening test for VUR, whose old brother had reflux nephropathy. The early detection of VUR aroused us to take special precautions to prevent urinary tract infection in this patient. We believe that this approach was helpful to reduce the risk of renal damage in this patient and are reporting the case with a brief review of related literatures. It is our firm suggestion that screening for vesicoureteral reflux should be carried out in every child who has siblings with refluf nephrouathy.

독일 냉전사 연구의 관점과 주제들

이동기(Lee Dong-Ki) 역사비평사 2015 역사비평 Vol.- No.111

The new studies of Cold War history in Germany have continued to evolve over the last two decades. They have not confined itself to the narrow discussion on the German policy of Soviet Union in the early years of the Cold War. They have extended, to a greater degree, to the perspective of Cold War Studies which takes a look into the European context and global interdependence. The German exponents of the recent trends of historical research on the Cold War as Wilfried Loth, Bernd Stover, the Manheim project "Ostpolitik and CSCE in Europe" and the Cold War project of the Hamburg Institute for Social Research have freed themselves form both the ideological historiography and the nation-centered Cold War Studies. In particular the Hamburg Cold War project, leaded by Bernd Greiner, has attempted to overcome the Euro-centric narrative of the Cold War and to develop new topics, methods and paths for the Cold War history. Under its various study results, the perception into the fear which Loth has also paid great attention to, has attracted attention. For the innovative research of the Cold War one should more try to understand the function and effect of the hostile image of enemy in the social culture and every day life. The elucidation of the wider interdependence of the Cold War as global epoche and the insight into its social cultural depths could provide the foundation of the historical perspective and political consideration for a post-Cold War and post-division society in Korea.

제약사에서 바라보는 B형 간염 신약개발

이동기 ( Dong Ki Lee ) 대한간학회 2021 임상연구방법론워크숍 Vol.2021 No.1

흰쥐 이자에서 Secretin-CCK 상승작용 기전에 관한 연구

이동기(Dong Ki Lee),김준명(Jun Myeong Kim),권상옥(Sang Ok Kwon),박경선(Kyung Sun Park),정재복(Jae Bock Chung),강진경(Jin Kyung Kang),김경환(Kyung Hwan Kim) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3

N/A Background/Aims: The rnechanism of secretin and CCK potentiation effect was evaluated in the dispersed pancreatic acini of rat. Methods: To observe the presence of potentiating effect of secretin and insulin on CCK, the amount of amylase release according to secretagogues were measured. The mechanism of the potentiating effect of secretagogues were studied by measuring the change of the intracellular amount of cAMP and IP, and concentration of intracellular Ca. Results: In the dispersed pancreatic acini, secretin potentiates the amylase release stimulated by JO and 10'M CCK-8. Insulin slightly increased the secretory response to secretin plus CCK-8, but with no statistical significance. Secretin or forskolin did not increase the intracellular Ipy accumulation stimulated by CCK-8. Alo insulin had no influence on the intraeellular IP accumulation stimulated by CCK-8 plus secretin. CCK-8 and A23187 significantly decreased the intracellular cAMP accumulation stimulated by secretin. But the insulin did not influence the intracellular cAMP accumulation stimulated by secretin plus CCK-8. Secretin alone did not increase the intracellular concentration of Ca . Secretin and dibutyryl cAMP significantly increa- sed the intracellular concentration of Ca stimulated by CCK-8. Conclusions: These results verify the presence of the potentiating effect of secretin but not insulin on CCK. Also the poten- tiating effect of amylase secretion by the simultaneous activation of the secretin and CCK was shown to be associated with increased intracellular Ca concentration, without a further elevation of intracellular IP or cAMP accumulation. (Korean J Gastroenterol 1997;29:380 - 393)

드레스덴, 한반도 통일 역사의 에피소드?

이동기(Lee, Dong-Ki) 역사비평사 2014 역사비평 Vol.- No.107

3점 굴곡 실험에서 하중 속도 변화에 따른 단결정 실리콘 칩의 파괴강도 측정

이동기 ( Dong Ki Lee ),이성민 ( Seong Min Lee ) 대한금속재료학회 ( 구 대한금속학회 ) 2012 대한금속·재료학회지 Vol.50 No.2

The present article shows how the fracture strength of single crystal silicon chips, which are generally used as semiconductor devices, is influenced by loading rate variation during a 3-point bending test. It was found that the fracture strength of the silicon chips slightly increases up to 4% with increasing loading rate for loading rates lower than 20 mm/min. Meanwhile, the fracture strength of the chips hardly increases with increase of loading rate to levels higher than 40 mm/min. However, there was an abrupt transition in the fracture strength within a loading rate range of 20 mm/min to 40 mm/min. This work explains through microscopic examination of the fracture surface of all test chips that such a big transition is related to the deflection of crack propagation direction from the (011) [100] system to the (111) [211] system in a particular loading rate (i.e. from 20 mm/min to 40 mm/min).

SNS 중독 경향성에 미치는 영향 요인

김지현(Kim ji-hyun),유지인(Yu ji-in),정지원(Jung Ji-won),최훈(Choi Hoon) 한국콘텐츠학회 2022 한국콘텐츠학회 종합학술대회 논문집 Vol.2022 No.7