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전자간증과 총혈장 Fibronectin과의 관련성의 조사
박정돈,황순구,이기원,한만식,박순우 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.5
Of 119 full-term pregnant subjects studied from October, 1995 to March, 1996, 79 had preeclampsia(severe; 43, mild; 36) and 40 were normotensive controls. The plasma fibronectin levels of each subject were assayed by turbidometric immunoassy(Boehringer Mannheim). The objective of this study was to evaluate the relationship of plasma fibronectin with preeclampsia as a marker for vascular injury. The results were as follows: 1. There were significant differences of plasma fibronectin values among the normotensive pregnancy, mild preeclampsia and severe preeclampsia. Within each group of patients, plasm a fibronectin values were 101.7+-59.4 ㎍/ml and 249.7+-96.3 ㎍/ml and 329.2+-169.5 ㎍/ ml, respectively (p$lt;0.001). 2. Plasma fibronectin values had positive correlations with severity of preeclampsia, proteinuria, diastlic blood pressure and systolic blood pressure, but negative correlations with birth weight and platelet count(p$lt;0.001). 3. When the severity of proteinuria on preeclampsia were +1, +2, and +3 or more, plasma fibr onectin values revealed 246.0+-93.3 ㎍/ml, 342.3+-185.1 ㎍/ml and 345.0+-168.1 ㎍/ml, respectively and there were significant differences among three groups. 4. To verify the variables correlated with plasma fibronectin by using mutiple regression analysis, the only variable which was selected significantly was the severity of preeclampsia (r2: 0.529). 5. With receiver operating characteristic(ROC) curve analysis of the relationship between plasma fibronectin values and preeclampsia, if cut off value was selected at the level of 175㎍/ml or more, the sensitivity for diagnosis of preeclampsia was 87.3%, specificity 90.0%, positive predictive value 94.5%, and negative predictive value 78.3%, respectively.
초기 정상임신과 계류유산의 혈청내 Estradiol, Testosterone , Free Testosterone 및 Percent Free Testosterone 치
허창규,황순구,이기원 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.5
초기 정상임신군과 계류유산군을 대상으로 혈청내 estradiol, testosterone, free testosterone, % free testosterone을 측정하여 비교, 관찰한 결과 다음과 같은 결과를 얻었다. 1. 정상임신군과 게류유산군간 estradiol 측정결과 정상임신군에서 유의한 증가를 관찰하였다(p$lt;0.001). 2. total testosterone, free testosterone, % free Testosterone 측정결과 계류 유산군에서 유의한 증가를 관찰하였다(p$lt;0.01). 3. 유산율과 estradiol, total testosterone, free testosterone, % free testosterone의 관계에서 estradiol과 % free testosterone이 가장 유용한 지표로 관찰되었고, estradiol이 높을 수록, % free testosterone이 감소할수록 유산율이 감소하였다. To determine value of clinical application of endocrine study for early detection of spontaneous abortion, a retrospective study was made in 50 cases of missed abortion and 61 cases of normla pregnancy as control group by measuring serum Estradiol, Testosterone, free Testosterone and percent free Testosterone in maternal serum. The results were as follows: 1. There were significant differences in serum Estradiol between normla pregnancies and missed abortions according to the gestational age(p$lt;0.001), and serum Testosterone, free Testosterone and percent free Testosterone were also significantly different between normal pregnancies and missed abortions(p$lt;0.001). 2. The lower the Estradiol level, the higher the rate of subsequent abortion and the higher the free Testosterone and % free Testosterone levels, the higher the rate of subsequent abortion. 3. Among Estradiol, total Testosterone, free Testostrone and % free Testosterone, estradiol was the most distinctly correlated marker in predicting abortion rate.
허창규,박정돈,김미숙,김상원,이기원,한만식,한재수 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.1
unctional epidermolysis bullosa(JEB) is a rare hereditary and mechanobullous disease characterized by blistering and erosions of the skin in response to even minor trauma. We report here in a case of JEB in a 1-day-old female newborn. She was delivered by cesarean section, with normal Apgar scores and body status. Bullous and erosive lesions had distributed on the extremities, hands and feet localized at the sites of pressure since birth, and, thereafter, tended to improve gradually, with no scars. The presented case seemed to be a recessive, benign type considering the absence of family history with dinstinctive histopathologic and electron microscopic findings.