Colon Study(Teleflator)의 Bowel Preparation Fail로 인한 재검사 감소방안에 관한 연구

윤석환,조승영,조남수,Yoon Surk Hwan,Cho Seung Yung,Cho Nam Soo 대한방사선사협회 2004 대한방사선사협회지 Vol.30 No.1

Colon study(Teleflator) is the simplest and most effective method for diagnosing colon disease. However, if bowel preparation is insufficiently done, diseases such as polyps, cancer and inflammatory bowel disease could be mistaken for lesions. As a result

PET/CT 장비와 영상 재구성 차이에 따른 EQ PET을 이용한 표준섭취계수의 평가

윤석환,김병진,문일상,이홍재,Yoon, Seok Hwan,Kim, Byung Jin,Moon, Il Sang,Lee, Hong Jae 대한핵의학기술학회 2018 핵의학 기술 Vol.22 No.1

양전자 방출 단층촬영에서 정량적 평가에 통상적으로 쓰이는 표준섭취계수(SUV : Standardized Uptake Value)는 종양의 병소와 병기의 진단 그리고 치료 성적 평가에 있어서 사용되고 있는 유용한 지표이다. 하지만 SUV는 환자의 체격, 검사까지의 시간, 부분용적 효과, 관심영역의 설정, 검사장비, 영상재구성 차이 등에 따라 변화 되므로 다양한 인자의 영향을 고려하여야만 한다. 그 중에서도 PET/CT 장비와 영상의 재구성 방법의 차이에 의한 SUV의 차이를 SIEMENS 사의 EQ PET을 이용하여 방사능의 차이를 보정 할 수 있게 되었다. 그러므로 본 연구에서는 phantom 실험과 FDG PET 임상영상의 SUVmax를 비교 하여 EQ PET을 적용함으로써, SUV의 변화를 평가 하고 EQ PET의 유용성에 대해서 검증해보고자 하였다. 본원의 3대의 PET/CT 장비인 Biograph true point 40, Biograph mCT 40, Biograph mCT 64 장비를 이용하여 $^{18}F-FDG$를 주입 한 NEMA IEC body phantom 영상을 획득 한 후 OSEM3D+PSF, OSEM3D+TOF, OSEM3D+PSF+TOF의 알고리즘을 이용하여 영상을 재구성 하였다. 각각 재구성된 영상에서 관심영역의 방사능 농도를 측정한 후, EARL에서 권고하는 NEMA IEC body phantom의 방사능 농도의 회복계수 값을 비교하여 서로 다른 PET system 간에 방사능 농도의 차이를 줄일 수 있는 EQ filter 값을 산출 하였다. 산출한 EQ Filter 값을 장비와 영상 재구성에 따라 적용하여 팬텀의 회복계수와 61명의 폐암환자의 FDG PET 영상에서 종양의 SUVmax를 비교 분석 하였다. 3대의 PET/CT 장비에서 영상의 재구성 알고리즘을 달리하여 획득한 phantom의 영상의 6개구의 평균 변동계수는 EQ PET 적용 전 후의 값은 OSEM3D 재구성 영상에서 각각 0.05, 0.04 OSEM3D+TOF 재구성 영상에서는 각각 0.04, 0.03, OSEM3D+PSF 재구성 영상에서는 각각 0.04, 0.03, OSEM3D+PSF+TOF 재구성 영상에서는 각각 0.03, 0.02 값을 보여 EQ PET 적용 후 팬텀의 6개 구의 평균 변동계수는 감소하였다. 임상 영상 비교 에서는 폐암환자 종양의 SUVmax는 OSEM3D, OSEM3D+TOF, OSEM3D+PSF, OSEM3D+PSF+TOF 순으로 증가하였으며, EQ PET 적용 후 재구성 영상에 대한 SUVmax는 통계적으로 유의한 차이가 없었다(p=1.000). PET/CT 영상에서 서로 다른 PET/CT 장비와 영상의 재구성 방법의 차이에 의해 발생하는 방사능 농도의 차이를 EQ PET을 이용하여 측정함으로서 장비와 영상 재구성별 방사능 농도의 편차가 감소되었다. PET 영상에서 정량적 평가에 이용되는 SUV의 편차를 줄일 수 있어 종양의 병소와 병기의 진단, 그리고 치료 성적평가의 정량적 평가 신뢰도가 향상 될 것으로 사료된다. Purpose Standardized uptake value(SUV) has been widely used as a quantitative metric of uptake in PET/CT for diagnosis of malignant tumors and evaluation of tumor therapy response. However, the SUV depends on various factor including PET/CT scanner specifications and reconstruction parameter. The purpose of this study is to validate a EQ PET to evaluate SUV across different PET/CT systems. Materials and Methods First, NEMA IEC body phantom data were used to calculate the EQ filter for OSEM3D with PSF and TOF reconstruction from three different PET/CT systems in order to obtain EARL compliant recovery coefficients of each spheres. The Biograph true point 40 PET/CT images were reconstructed with a OSEM3D+PSF reconstruction, images of the Biograph mCT 40 and Biograph mCT 64 PET/CT scanners were reconstructed with a OSEM3D+PSF, OSEM3D+TOF, OSEM3D+PSF+TOF. Post reconstructions, the proprietary EQ filter was applied to the reconstruction data. Recovery coefficient can be estimated by ratio of measured to true activity concentration for spheres of different volume and coefficient variability(CV) value of RC for each sphere was compared. For clinical study, we compared SUVmax applying different reconstruction algorithms in FDG PET images of 61 patients with lung cancer using Biograph mCT 40 PET/CT scanner. Results For the phantom studied, the mean values of CV for OSEM3D, OSEM3D+PSF, OSEM3D+TOF and OSEM3D+PSF+TOF reconstructions were 0.05, 0.04, 0.04 and 0.03 respectively for RC. Application of the proprietary EQ filter, the mean values of CV for OSEM3D, OSEM3D+PSF, OSEM3D+TOF and OSEM3D+PSF+TOF reconstructions were 0.04, 0.03, 0.03 and 0.02 respectively for RC. Clinical study, there were no statistical significance of the difference applying EQ PET on SUVmax of 61 patients FDG PET image. (p=1.000) Conclusion This study indicates that CV values of RC in phantom were decreased after applying EQ PET for different PET/CT system and The EQ PET reduced reconstruction dependent variation in SUVs for 61 lung cancer patients, Therefore, EQ PET will be expected to provide accurate quantification when the patient is scanned on different PET/CT system.

동적 영상 획득 방식을 이용한 정적 영상의 움직임 보정

윤석환,승종민,김계환,김재일,이형진,김진의,김현주,Yoon, Seok-Hwan,Seung, Jong-Min,Kim, Kye-Hwan,Kim, Jae-Il,Lee, Hyung-Jin,Kim, Jin-Eui,Kim, Hyun-Joo 대한핵의학기술학회 2010 핵의학 기술 Vol.14 No.1

정적 영상 획득 시 기존의 정적 영상 획득 방식 대신 동적 영상 획득 방식을 이용하여 움직임에 의한 motion correction을 적용함으로써 정적 영상 획득 시 발생되는 움직임에 의한 문제점을 해결하고자 하였다. 실험은 capillary tube와 IEC body phantom을 이용하여 움직임이 없을 때 정적 영상 획득 방식으로 얻은 영상과 동적 영상 획득 방식으로 얻은 각각의 frame을 더한 영상에 대해 resolution, frequency, total counts, blind test를 비교 분석하였으며 임의로 최소한의 움직임과 과도한 움직임을 주어 motion correction 전후의 영상에 대해서도 resolution, frequency, total counts, blind test를 비교 분석 하였다. 기존의 정적 영상 획득 방식으로 얻은 영상과 동적 영상 획득 방식으로 얻은 각각의 frame을 더한 영상의 resolution, frequency, total counts, blind test의 결과 값의 차이가 없었다. 또한 최소한의 움직임과 과도한 움직임을 준 영상에 대해 motion correction 적용 전후의 비교 결과 값은 motion correction 후 resolution, frequency, blind test의 결과 값이 움직임이 없을 때의 정적 영상과 거의 차이가 없었다. 하지만 과도한 움직임에 대한 보정 시 frame당 흐림 현상이 많이 발생 하였으므로 좌표 보정이 어려워 frame을 제외하는 방법을 적용하였기 때문에 과도한 motion correction 후 삭제한 frame 수만큼 total counts에서 차이를 보였다. 정적 영상 획득 시 움직임이 예상되는 환자에게 기존의 정적 영상 획득방식이 아닌 동적 영상 획득 방식을 이용하여 움직임 발생시 좌표 보정과 흐림 현상이 심한 frame 제외 방법을 이용하여 정적 영상에서 움직임에 의해 발생되었던 영상의 질 저하와 정량적 분석의 신뢰도 감소, 재검사에 대한 문제점을 해결할 수 있을 것이라고 생각되며 motion correction에 제공되는 다양한 프로그램 개발과 임상 적용에 대한 광범위한 연구가 현실적으로 필요하며 향후 지속적인 연구가 기대되는 바이다. Purpose: The static image of nuclear medicine study should be acquired without a motion, however, it is difficult to acquire static image without movement for the serious patients, advanced aged patients. These movements cause decreases in reliability for quantitative and qualitative analysis, therefore re-examination was inevitable in the some cases. Consequently, in order to improve the problem of motion artifacts, the authors substituted the dynamic acquisition technique for the static acquisition, using motion correction. Materials and Methods: A capillary tube and IEC body phantom were used. First, the static image was acquired for 60 seconds while the dynamic images were acquired with a protocol, 2 sec/frame${\times}$30 frames, under the same parameter and the frames were summed up into one image afterwards. Also, minimal motion and excessive motion were applied during the another dynamic acquisition and the coordinate correction was applied towards X and Y axis on the frames where the motion artifact occurred. But the severe blurred images were deleted. Finally, the resolution and counts were compared between the static image and the summed dynamic images which before and after applying motion correction, and the signal of frequency was analysed after frequency spatial domain was transformed into 2D FFT. Supplementary examination, the blind test was performed by the nuclear medicine department staff. Results: First, the resolution in the static image and summed dynamic image without motion were 8.32 mm, 8.37 mm on X-axis and 8.30 mm, 8.42 mm on Y-axis, respectively. The counts were 484 kcounts, 485 kcounts each, so there was nearly no difference. Secondly, the resolution in the image with minimal motion applying motion correction was 8.66 mm on X-axis, 8.85 mm on Y-axis and had 469 kcounts while the image without motion correction was 21.81 mm, 24.02 mm and 469 kcounts in order. So, this shows the image with minimal motion applying motion correction has similar resolution with the static image. Lastly, the resolution in the images with excessive motion applying motion correction were 9.09 mm on X-axis, 8.83 mm on Y-axis and had 469 kcounts while the image without motion correction was 47.35 mm, 40.46 mm and 255 kcounts in order. Although there was difference in counts because of deletion of blurred frames, we could get similar resolution. And when the image was transformed into frequency, the high frequency was decreased by the movement. However, the frequency was improved again after motion correction. In the blind test, there was no difference between the image applying motion correction and the static image without motion. Conclusion: There was no significant difference between the static image and the summed dynamic image. This technique can be applied to patients who may have difficulty remaining still during the imaging process, so that the quality of image can be improved as well as the reliance for analysis of quantity. Moreover, the re-examination rate will be considerably decreased. However, there is a limit of motion correction, more time will be required to successfully image the patients applying motion correction. Also, the decrease of total counts due to deletion of the severe blurred images should be calculated and the proper number of frames should be acquired.

지리정보 데이터 압축률 향상을 위한 Run-Length/Byte-Packing 압축 알고리즘 설계 및 구현

윤석환,양승수,박석천,Yoon, Seok-Hwan,Yang, Seung-Su,Park, Seok-Cheon 한국정보통신학회 2017 한국정보통신학회논문지 Vol.21 No.10

최근 압축 알고리즘이 지리정보 데이터를 압축하기 위한 방법으로 가장 많이 사용되고 있다. 그러나 이와 같은 압축 알고리즘은 지리정보 데이터 압축에 실제 적용하기에는 지도 데이터의 연속성이 미흡하고, 단일 데이터로 압축할 수 없기 때문에 압축률이 저하된다는 문제점이 있다. 따라서 본 논문에서는 이러한 문제점을 개선하기 위해 압축 알고리즘들의 장점을 취합해 지리정보 데이터 압축을 가능하게 하고, 압축 및 복원 속도를 향상시킨 Run-Length/Byte-Packing 압축 알고리즘을 설계 및 구현하였다. 구현한 알고리즘을 평가한 결과 기존 압축 알고리즘에 비해 제안 알고리즘이 평균 약 5% 향상된 것을 확인하였으며, 압축률과 복원 속도가 향상되었다는 것을 확인하였다. Recently, a compression algorithm is widely used as a method for compressing geographic information data. However, such a compression algorithm has a problem that the continuity of the map data is insufficient to actually apply it to the geographic information data compression, and the compression rate is lowered because it can not be compressed into a single data. Therefore, in this paper, we have designed and implemented a Run-Length / Byte-Packing compression algorithm that enables compression of geographic information by combining the advantages of compression algorithms and improves compression and restoration speed. As a result of evaluating the implemented algorithm, it was confirmed that the proposed algorithm improved about 5% on average compared with the existing compression algorithm, and it was confirmed that the compression rate and the restoration speed were improved.

감마방사선에 의한 암세포의 세포손상에 관한 연구

윤석환,Yoon Surk Hwan 대한방사선사협회 2004 대한방사선사협회지 Vol.30 No.1

To evaluate the process of radiation-induced cell damage in human promyelocytic leukemia cell HL-60 cell and chinese hamster cell CHO cell lines. I irradiated HL-60 cells, CHO cell line, using the V - radiation from Cs-137 cell irradiation(Gamma cell 3000

자동노출제어장치를 이용한 비정질 실리콘 평판형 검출기에서 격자의 조건에 따른 환자선량 변화와 촬영 거리의 변화가 검출기 획득선량에 미치는 영향

윤석환,최준구,한동균,Yoon, Seok-Hwan,Choi, Jun-Gu,Han, Dong-Kyoon 대한디지털의료영상학회 2007 대한디지털의료영상학회논문지 Vol.9 No.2

This study attempts to propose an appropriate method of using digital medical imaging equipments, by studying the effects of automatic exposure control(AEC), grid ratio and the change of radiography distance on the patient dose and detertor acquisition dose during the procedure of acquiring image through a digital medical imaging detector. The change of dose following the change of grid ratio's exposure and radiography distance was measured, by using an abdominal phantom organized with tissue equivalent materials in an amorphous silicon thin film transistor detecter installed with AWC. The case to use grid ratio 12 : 1, focal distance 180cm to radiography distance 110cm in AEC, the patient dose increased rather when we used grid ration 10 : 1, focal distance 110cm. When AEC was not used,the dose necessary for image acquisition decreased as the grid ratio became higher and the distance became further. but detector acquisition dose was not reduced when in applied AEC. When purchasing digiral medical imaging equipments, optional items such as AEC and grid shall be accurately selected to satisfy the use of the equipments. Radiography error made by radiation technologist and unnenessary patient dose can be reduced by selecting equipments with a radiography distance marker equipment when it did not apply AEC. These equipments can also be helpful in maintaining high imaging quality, one of the merits of digital detectors.

30톤 추력급 터보펌프 터빈의 구조 강도 및 진동 해석을 통한 안정성 예측

윤석환,전성민,이관호,김진한,Yoon, Suk-Hwan,Jeon, Seong-Min,Lee, Kwan-Ho,Kim, Jin-Han 한국유체기계학회 2004 한국유체기계학회 논문집 Vol.19 No.5

Static and dynamic structural analyses of a turbine bladed-disk for a liquid rocket turbopump are performed to investigate the safety level of strength and vibration at design point. During operation, turbopump is exposed to various external loads. Therefore, the effects of them should be carefully considered and properly modeled. First, due to the high rotational speed of the turbopump, effects of centrifugal forces are considered in the structural analysis. Thermal load caused by severe temperature differences is also considered. A three dimensional finite element method (FEM) is used for linear and nonlinear structural analyses with modified Newton-Raphson iteration method. After the nonlinear solution is obtained from the structural analysis, dynamic characteristics are obtained as a function of rotational speed from the linearized eigenvalue analysis at an equilibrium position. From the analysis results, characteristics of stress distribution and vibration were thoroughly examined and investigated.

응용논문 : 통신 품질 향상을 위한 최단 시간 경로 알고리즘

윤석환,김평중,김진수 ( Seok Hwan Yoon,Pyeong Jung Kim,Jin Soo Kim ) 한국품질경영학회 1998 품질경영학회지 Vol.26 No.1

HEC-HMS를 활용한 무심천 유역내 도시화에 의한 유출 특성

윤석환,이종형,Yoon, Seok-Hwan,Lee, Jong-Hyeong 한국농공학회 2004 한국농공학회논문집 Vol.46 No.3

For a given watershed that consists of urbanized areas, it was essential to predict how the runoff characteristics, such as runoff peak and volume, and travel time, change with time far planning and designing various kinds of hydraulic facilities with given recurrence interval. In this study, Mushim stream watershed was simulated using HEC-HMS model to get runoff characteristics of an urbanization basin. The results was showed that runoff was increased $1794.20{\sim}2104.65\;m^{3}/s$> and $1751.90{\sim}1961.30\;m^{3}/s$ according to the increased of rainfall and CN value recurrence interval in years. Observed storm was increased $497.91{\sim}581.71\;m^{3}/s$ and $506.57{\sim}537.01\;m^{3}/s$ for increased of CN value and impervious area. This paper is also possible to evaluate the effect of urbanization quantitatively.

응용논문 : 대규모 소프트웨어 개발 사업에서의 품질 보증을 위한 개발방법론

윤석환,박지은,신용백 ( Seok Hwan Yoon,Ji Eun Park,Yong Back Shin ) 한국품질경영학회 1997 품질경영학회지 Vol.25 No.1