제 7 차 춘계학술대회 초록집 : 포스터 발표 ; 만성 간질환에서 간섬유화의 비침습적 표지자로써 혈청 히아루론산치의 유용성

윤보라,김배영,이미화,윤상정,이승민,조윤주,최덕례,박성규,윤경식,김문희,문해란 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.2(S)

Intratumoral Heterogeneity of Breast Cancer Xenograft Models: Texture Analysis of Diffusion-Weighted MR Imaging

윤보라,조나리야,Mulan Li,장민혜,박소연,강호철,김보형,송인찬,문우경 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.5

Objective: To investigate whether there is a relationship between texture analysis parameters of apparent diffusion coefficient (ADC) maps and histopathologic features of MCF-7 and MDA-MB-231 xenograft models. Materials and Methods: MCF-7 estradiol (+), MCF-7 estradiol (-), and MDA-MB-231 xenograft models were made with approval of the animal care committee. Twelve tumors of MCF-7 estradiol (+), 9 tumors of MCF-7 estradiol (-), and 6 tumors in MDA-MB-231 were included. Diffusion-weighted MR images were obtained on a 9.4-T system. An analysis of the first and second order texture analysis of ADC maps was performed. The texture analysis parameters and histopathologic features were compared among these groups by the analysis of variance test. Correlations between texture parameters and histopathologic features were analyzed. We also evaluated the intraobserver agreement in assessing the texture parameters. Results: MCF-7 estradiol (+) showed a higher standard deviation, maximum, skewness, and kurtosis of ADC values than MCF-7 estradiol (-) and MDA-MB-231 (p < 0.01 for all). The contrast of the MCF-7 groups was higher than that of the MDA-MB-231 (p = 0.004). The correlation (COR) of the texture analysis of MCF-7 groups was lower than that of MDA-MB-231 (p < 0.001). The histopathologic analysis showed that Ki-67mean and Ki-67diff of MCF-7 estradiol (+) were higher than that of MCF-7 estradiol (-) or MDA-MB-231 (p < 0.05). The microvessel density (MVD)mean and MVDdiff of MDA-MB-231 were higher than those of MCF-7 groups (p < 0.001). A diffuse-multifocal necrosis was more frequently found in MDA-MB-231 (p < 0.001). The proportion of necrosis moderately correlated with the contrast (r = -0.438, p = 0.022) and strongly with COR (r = 0.540, p = 0.004). Standard deviation (r = 0.622, r = 0.437), skewness (r = 0.404, r = 0.484), and kurtosis (r = 0.408, r = 0.452) correlated with Ki-67mean and Ki-67diff (p < 0.05 for all). COR moderately correlated with Ki-67diff (r = -0.388, p = 0.045). Skewness (r = -0.643, r = -0.464), kurtosis (r = -0.581, r = -0.389), contrast (r = -0.473, r = -0.549) and COR (r = 0.588, r = 0.580) correlated with MVDmean and MVDdiff (p < 0.05 for all). Conclusion: The texture analysis of ADC maps may help to determine the intratumoral spatial heterogeneity of necrosis patterns, amount of cellular proliferation and the vascularity in MCF-7 and MDA-MB-231 xenograft breast cancer models.

치매 환자는 누가 돌보는가: 독거 치매 노인 현황과 주부양자 조사 연구

윤보라,심용수,김용덕,이기욱,나상준,홍윤정,양동원 대한치매학회 2012 Dementia and Neurocognitive Disorders Vol.11 No.1

Background: Cultural characteristics of taking care of patients with dementia in Korea are based on the influence of Confucianism on the lifestyle of Koreans. In addition, as the family size has been getting smaller, the number of old persons who live alone has been increasing. The purpose of this study is to examine the proportion of the elderly with dementia who live alone and demographics of caregivers when such patients live with their family. Methods: From the multiple hospital-based cohort, 973 elderly patients with very mild dementia (Clinical Dementia Rating [CDR]=0.5), 1,056 patients with mild dementia (CDR=1) and 359 patients with moderate dementia (CDR=2) were recruited. We analyzed the proportion of the patients with dementia who live alone and the demographics of the caregivers if such patients live with and are taken care of by such caregivers depending upon the severity of dementia. Results: The proportion of the patients with dementia who live alone accounts for about 40% of all elderly patients with dementia. Major age groups of caregivers are of 40s and 50s. Sons, daughters, and spouses were ranked in the said order in the proportion of caregivers according to their relationship to patients. Conclusions: Up to now, family members care for about 60% of elderly patients with dementia, which may suggest that from the objective viewpoint, direct burden borne by caregivers for old patients with dementia would be considerably high. On the other hand, about 40% of dementia patients live alone, implying that the social care system is needed for them.

Colorimetric Detection of Fatty Amines Based on Conjugated Polydiacetylenes

윤보라,김광환,김종만 한국고분자학회 2011 한국고분자학회 학술대회 연구논문 초록집 Vol.2011 No.1

Inkjet Printing of Polydiacetylene Microemulsions on Paper Substrates

윤보라,신효라,김종만 한국고분자학회 2012 한국고분자학회 학술대회 연구논문 초록집 Vol.2012 No.4

류마티스 관절염에서 Glutathione S-transferase 유전자 다형성에 관한 연구

윤보라,AhmedEl-Sohemy,MarilynC.Cornelis,곽은주,강태영,정청일,이혜순,엄완식,김태환,전재범,유대현,배상철 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.3

Association of Polymorphism in Glutathione S-transferase Gene with Susceptibility and Severity of Rheumatoid ArthritisBo-Ra Yun, M.D., Ahmed El-Sohemy, Ph.D.*, Marilyn C. Cornelis, M.S.*,Eun-Joo Kwak, M.S., Tae-Young Kang, M.D., Chung-Il Joung, M.D.,Hye-Soon Lee, M.D., Wan-Sik Uhm, M.D., Tae-Hwan Kim, M.D.,Jae-Bum Jun, M.D., Dae-Hyun Yoo, M.D., Sang-Cheol Bae, M.D.Center, Seoul, Korea,

Radiofrequency Ablation for Treating Liver Metastases from a Non-Colorectal Origin

윤보라,이정민,백지현,김세형,이재영,한준구,최병인 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.5

Objective: We wanted to assess the safety and efficacy of performing radiofrequency ablation (RFA) in patients with noncolorectal liver metastases. Materials and Methods: In this retrospective study, 25 patients with 40 hepatic metastases (M:F = 17:8; mean age, 57years; tumor size, 0.5-5.0 cm) from a non-colorectal origin (stomach, biliary, breast, pancreas, kidney and skin) were treated with RFA. The RFA procedures were performed using either an internally cooled electrode or a clustered electrode under ultrasound or CT guidance. Contrast-enhanced CT scans were obtained immediately after RFA and follow-up CT scans were performed within three months after ablation and subsequently at least every six months. The intrahepatic diseasefree interval was estimated and the overall survival from the time of the initial RFA was analyzed using the Kaplan-Meier method. Results: No intraprocedural deaths occurred, but four major complications developed, including abscesses (n = 3) and pneumothorax (n = 1). Technical effectiveness was determined on the initial follow-up images. During the follow-up period (range, 5.9-68.6 months; median time, 18.8 months) for 37 tumors in 22 patients where technical effectiveness was achieved, 12 lesions (32%, 12 of 37) showed local tumor progression and new intrahepatic metastases occurred in 13patients (59%, 13 of 22). The median intrahepatic disease-free interval was 10.1 months. The 1-year, 3-year and 5-year overall survival rates after RFA were 86%, 39% and 19%, respectively. Conclusion: RFA showed intermediate therapeutic effectiveness for the treatment of non-colorectal origin liver metastases.

Incidentally Found Absence of the Left Brachiocephalic Vein with Venous Return Through the Left Superior Intercostal Vein in an Adult Patient: Venography and CT Findings

윤보라,권세환,오지영,윤효철,오주형 대한영상의학회 2018 대한영상의학회지 Vol.79 No.3

A 63-year-old male patient was referred for venography of the thoracic venous system and multidetector computed tomography (CT) due to the unusual location of the left subclavian catheter tip. His venogram and CT images showed an absence of the left brachiocephalic vein (LBCV). Instead of through the LBCV, the usual venous circulation of neck and left upper limb was carried out by the engorged left superior intercostal vein (LSIV); this subsequently drained into the accessory hemiazygos vein and then the azygos vein that drains into the superior vena cava. Here, we report a rare case of an incidentally found absence of the LBCV with venous return through the LSIV in an adult patient, and we present a brief review of the relevant literature.

주관적기억장애 환자의 미래계획기억: 예비 연구

윤보라,정성우,심용수 대한치매학회 2008 Dementia and Neurocognitive Disorders Vol.7 No.1

Background: Subjective memory impairment (SMI), defined by memory complaints with normal age-, gender- and education-adjusted cognitive performance, is a frequent phenomenon in elderly people. According to longitudinal studies, SMI is probably a predictor for future mild cognitive impairment (MCI) and dementia. However, there has been no objective neuropsychological test for evaluating SMI, and previous studies relied solely on patients’ subjective complaints. Thus, our goal was to make an objective standard that is useful in distinguishing SMI from normal aging as well as MCI by considering prospective memory (PM) as a higher level of memory. Methods: The study participants included seven healthy controls, 25 individuals with SMI and eight patients with amnestic MCI (aMCI). The inclusion criteria for SMI were 1) over 55 yr, 2) sustained subjective memory complaints, 3) normal general cognition, 4) no abnormality (within-1SD) in neuropsychological battery and 5) no depression. aMCI was followed by Pitersen’s criteria. To assess prospective memory, the Cambridge Behaviour Prospective Memory Test, which consisted of four time-based and four event-based tasks, was performed. Subsequently, scores from Korean Mini-mental Status Examination (K-MMSE), the 20 min delayed recall Seoul verbal learning test (SVLT), and individual task scores of PM and total PM scores were compared among each group. Results: There were no significant group differences in age, education, sex, K-MMSE score and time-based PM among the three groups. However, SVLT scores and total PM scores showed a significant decline in the aMCI group, unlike that for the SMI and control groups. Moreover, eventbased PM score was significantly decreased stepwise in both SMI and aMCI groups. Conclusions: These findings suggest that PM, especially for event-based tasks, is sensitive for detecting the earliest cognitive changes associated with SMI, and PM tasks seem to be more susceptible to the early cognitive decline than retrospective memory tasks. As PM is a sensitive predictor for future cognitive decline, SMI may be a first manifestation of future dementia in the elderly regardless of depression. Future research will help determine the clinical usefulness of PM tasks. Background: Subjective memory impairment (SMI), defined by memory complaints with normal age-, gender- and education-adjusted cognitive performance, is a frequent phenomenon in elderly people. According to longitudinal studies, SMI is probably a predictor for future mild cognitive impairment (MCI) and dementia. However, there has been no objective neuropsychological test for evaluating SMI, and previous studies relied solely on patients’ subjective complaints. Thus, our goal was to make an objective standard that is useful in distinguishing SMI from normal aging as well as MCI by considering prospective memory (PM) as a higher level of memory. Methods: The study participants included seven healthy controls, 25 individuals with SMI and eight patients with amnestic MCI (aMCI). The inclusion criteria for SMI were 1) over 55 yr, 2) sustained subjective memory complaints, 3) normal general cognition, 4) no abnormality (within-1SD) in neuropsychological battery and 5) no depression. aMCI was followed by Pitersen’s criteria. To assess prospective memory, the Cambridge Behaviour Prospective Memory Test, which consisted of four time-based and four event-based tasks, was performed. Subsequently, scores from Korean Mini-mental Status Examination (K-MMSE), the 20 min delayed recall Seoul verbal learning test (SVLT), and individual task scores of PM and total PM scores were compared among each group. Results: There were no significant group differences in age, education, sex, K-MMSE score and time-based PM among the three groups. However, SVLT scores and total PM scores showed a significant decline in the aMCI group, unlike that for the SMI and control groups. Moreover, eventbased PM score was significantly decreased stepwise in both SMI and aMCI groups. Conclusions: These findings suggest that PM, especially for event-based tasks, is sensitive for detecting the earliest cognitive changes associated with SMI, and PM tasks seem to be more susceptible to the early cognitive decline than retrospective memory tasks. As PM is a sensitive predictor for future cognitive decline, SMI may be a first manifestation of future dementia in the elderly regardless of depression. Future research will help determine the clinical usefulness of PM tasks.

Immobilization of Conjugated Polydiacetylens Supramolecules for Microarray Sensors

윤보라,김종만 한국고분자학회 2007 한국고분자학회 학술대회 연구논문 초록집 Vol.2007 No.10