http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
산전 세포유전학적 검사의 임상적 분석: 서울아산병원 4년 간의 경험
심재윤 ( Sim Jae Yun ),김성훈 ( Kim Seong Hun ),김정숙 ( Kim Jeong Sug ),안송미 ( An Song Mi ),서을주 ( Seo Eul Ju ),유한욱 ( Yu Han Ug ),김구환 ( Kim Gu Hwan ),이지영 ( Lee Ji Yeong ),최은영 ( Choe Eun Yeong ),원혜성 ( Won Hye Se 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.3
Objective : To review and evaluate a total of 2,372 cases of prenatal cytogenetic diagnoses at Asan Medical Center from 1999 to 2002. Methods : We reviewed to medical records of the patients in whom the procedure for prenatal cytogenetic diagnosis was performed. A total of 1780 cases of amniocentesis, 455 cases of cordocentesis, and 137 cases of chorionic villus sampling were analyzed. The cytogenetic results, indications for prenatal cytogenetic diagnoses, maternal ages, and the profiles of abnormal karyotypes were reviewed. We calculated the positive predictive value of each indication for abnormal fetal karyotypes and evaluated a factor that was the most sensitive marker for abnormal fetal karyotypes. Results : Among the 2,372 cases of prenatal cytogenetic diagnoses, abnormal karyotypes were identified in a total of 158 cases (6.7%). The most frequent indication for prenatal cytogenetic diagnosis was abnormal maternal serum screening (33.9%), followed by ultrasonographic abnomality (22.9%) and old age (20.0%). No significant difference was found between mean maternal age with and without abnormal fetal karyotypes after excluding balanced rearrangements and polymorphisms (31.9±5.3 vs. 32.1±4.5 years). Among the 92 cases of abnormal fetal karyotypes after excluding balanced rearrangements and polymorphisms, the most frequent indication for prenatal cytogenetic diagnosis was ultrasonographic abnormality (58.7%), followed by abnormal maternal serum screening (10.9%). The positive predictive value of ultrasonographic abnormality for abnormal fetal karyotype was 9.9%. Conclusion : Among the several indications for prenatal cytogenetic diagnosis, ultrasonographic abnormality could be the most predictive marker for abnormal fetal karyotypes.
이형송 ( Lee Hyeong Song ),최혜원 ( Choe Hye Won ),임천규 ( Im Cheon Gyu ),민동미 ( Min Dong Mi ),변혜경 ( Byeon Hye Gyeong ),김진영 ( Kim Jin Yeong ),궁미경 ( Gung Mi Gyeong ),유한욱 ( Yu Han Ug ),김수찬 ( Kim Su Chan ),전진현 ( 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.4
Objective: Preimplantation genetic diagnosis (PGD) is reserved for couples with a risk of transmitting a serious and incurable disease, and hence avoids the undesirable therapeutic abortion. Herein, we report the result of PGD to carriers at risk of trans