Factors Associated with Glycemic Variability in Patients with Type 2 Diabetes: Focus on Oral Hypoglycemic Agents and Cardiovascular Risk Factors

유소연,진상욱,이상아,고관표 대한내분비학회 2015 Endocrinology and metabolism Vol.30 No.3

Background: The role of glycemic variability (GV) in development of cardiovascular diseases remains controversial, and factors that determine glucose fluctuation in patients with diabetes are unknown. We investigated relationships between GV indices, kinds of oral hypoglycemic agents (OHAs), and cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). Methods: We analyzed 209 patients with T2DM. The GV index (standard deviation [SD] and mean absolute glucose change [MAG]) were calculated from 7-point self-monitoring of blood glucose profiles. The patients were classified into four groups according to whether they take OHAs known as GV-lowering (A) and GV-increasing (B): 1 (A only), 2 (neither), 3 (both A and B), and 4 (B only). The 10-year risk for atherosclerotic cardiovascular disease (ASCVD) was calculated using the Pooled Cohort Equations. Results: GV indices were significantly higher in patients taking sulfonylureas (SUs), but lower in those taking dipeptidyl peptidase-4 inhibitors. In hierarchical regression analysis, the use of SUs remained independent correlates of the SD (β=0.209, P=0.009) and MAG (β=0.214, P=0.011). In four OHA groups, GV indices increased progressively from group 1 to group 4. However, these did not differ according to quartiles of 10-year ASCVD risk. Conclusion: GV indices correlated significantly with the use of OHAs, particularly SU, and differed significantly according to combination of OHAs. However, cardiovascular risk factors and 10-year ASCVD risk were not related to GV indices. These findings suggest that GV is largely determined by properties of OHAs and not to cardiovascular complications in patients with T2DM.

중세국어 사이시옷의 기능

유소연 국어사학회 2017 국어사연구 Vol.0 No.24

본고는 기존의 연구들에서 사이시옷으로 불리던 중세국어의 예들 중 관형격표지로 설명할 수 있는 경우를 살펴보았다. ‘관형격’의 개념을 넓게 본다면, 중세국어의 사이시옷 중 관형격표지로 설명이 가능한 경우가 존재한다. 관형격표지가 실현되는 환경은 관형격표지에 의해 결합되는 선행요소와 후행요소가 매우 긴밀한 관계를 지녀, 하나의 발화단위로 인식되는 언어단위이다. 이들은 하나의 발화단위로 인식되지만 그 사이에 음운론적 단어 내부경계를 지니는 두 요소 간의 결합이므로 경계를 인식해 발화하게 되며, 이를 통해 나타나는 음운현상이 기존에 사잇소리 현상이라고 불리는 음운현상이다. 따라서 중세국어 시기의 사이시옷 중 관형격표지가 실현되는 환경에서 나타나는 자연스러운 음운현상을 반영한 ‘ㅅ’이 존재할 것이며, 이때의 ‘ㅅ’의 쓰임을 근대국어와 현대국어의 ‘ㅅ’과 관련지어 설명할 수 있을 것이다. ‘ㅅ’ in Middle Korean has been dealt with two perspectives. One is “Is ‘ㅅ’ considered as the grammatical marker or the phonological marker?” and the other is “Are the Saisiot marking Saitsori phenomenon and the grammatical morpheme ‘ㅅ’ considered as one or separate thing”. After considering recent arguments, the fact that ‘ㅅ’ in Middle Korean functions as the adnominal case marker can be verified. Usages of ‘ㅅ’ which have been defined as Saisiot marking Saitsori phenomenon can be considered as the adnominal case marker. To define ‘ㅅ’ as the adnominal case marker, this paper solves issues of how to define the concept of ‘Case’ in Korean and how to define the usages of ‘the Adnominal Case’. Also, through expanding the concept of ‘the Adnominal Case’ broadly, this paper confirms that examples considered as exceptional usages of Saisiot in Middle Korean in current studies can be explained as the adnominal case marker and checks what functions the adnominal case has and what characteristics the adnominal case has. In addition, this paper studies two issues that can occur if ‘ㅅ’ in Middle Korean is only considered as the adnominal case marker. The various letters called as allomorph of Saisiot can be considered as orthography influenced by the phoneme phenomenon that appears in the condition where the adnominal case marker is actualized. This orthography only appears on several literature and is a unique phenomenon. Furthermore, this paper checks that because the condition where the adnominal case marker is actualized is quite similar to the condition where Saitsori is actualized, the error that the adnominal case marker is defined as a sign marking Saitsori phenomenon can appear.

유아 교육용 어플리케이션에서 표현 모티브에 따른 캐릭터 선호도 분석 : 스마트폰을 사용하여 학습하는 만3-6세의 유아를 대상으로

유소연,김회광,신재욱 한국디지털디자인학회 2012 디지털디자인학연구 Vol.12 No.3

현재 스마트폰 기기의 확산으로 다양한 어플리케이션이 개발되고 있다. 또한 더욱 많은 콘텐츠와 기획으로 유아교육용 어플리케이션은 소비자들에게 제공되어 지고 있다. 하지만 아직 유아 교육에 관한 어플리케이션의 사용현황은 미흡한 상태이며 더 나은 콘텐츠를 개발하기 위해서는 다양한 연구가 요구되는 상태이다. 유아 교육에 있어 가장 중요한 전달자 역할인 '캐릭터'는 어플리케이션을 통한 교육에서도 밀접한 관련이 있다고 할 수 있다. 이에 본 연구는 유아 교육용 스마트폰의 어플리케이션 사용 현황에 대한 분석과 스마트폰의 한정적인 공간 안에서 유아들은 어떠한 표현 모티브를 가진 캐릭터에 반응하고 선호하는가에 대한 분석을 하였다. 조사를 통해 유아들의 어플리케이션 선택 기준은 캐릭터에 큰 영향을 받고 있음을 알 수 있었고, 학습 내용보다는 캐릭터에 더욱 취중 되어 학습하고 있음을 알 수 있었다. 캐릭터의 형태성에 관한 자료를 참고하여 분석한 결과 동물을 모티브로 삼은 캐릭터를 가장 선호하는 것으로 나타났다. 다양한 설문조사와 분석을 통한 결과들은 유아 교육용 어플리케이션 개발 시 연구 자료가 될 수 있으며, 유아교육에도 기여할 수 있음을 시사한다. 또한 유아 교육용 어플리케이션의 발전 방향과 다양한 캐릭터 개발의 미래를 위하여 그 활용 가능성이 기대된다. With dissemination of smart devices, various educational applications for children have been developed and have been provided to consumers through more sufficient contents and planning. However, the current use of educational applications for children is not sufficient, and various studies are needed for development of better contents. In early childhood education, the most important role of a 'character' is closely related to the study through the application. In this regard, this study analyzed the current state of using smart phone applications for children education and also conducted an analysis on the types of expression motive with which children respond to and prefer characters in the limited space of a smart phone. Children's standard choice of application is greatly affected by the characters. Instead of learning from the content, the study was more focused onto the characters. The result of an analysis which was reference to the character's forms, animal motif characters are preferred the most. The results derived from various surveys and analysis will be materials for study in case of development of educational applications for children, and also will contribute to children education. In addition, it is expected that this study can be utilized for suggesting a developmental direction of educational applications for children and a future of development of various characters.

메디컬 시험기관에서 측정 불확도의 중요성과 의의

유소연,김년옥,임수연,윤태석,신용환,Yoo, Soh Yeon,Kim, Nyun Ok,Lim, Soo Yeon,Youn, Tae Seok,Shin, Yong Hwan 대한핵의학기술학회 2015 핵의학 기술 Vol.19 No.2

Purpose Medical laboratories carrying out all types of measurement are increasingly being asked to evaluate the uncertainties associated with their measurement results. For medical laboratories, measurement uncertainty is now an accreditation requirement as specified by standard such as ISO/IEC 17025 and ISO 15189. In order to satisfy the level of 'accredited medical laboratory', we need to evaluate the measurement uncertainties and have to provide them to certification authority such as KOLAS. For this reason, we carried out processes of measurement uncertainties by using the real test examples. Materials and Methods We searched and arranged the terms associated with ISO 15189. The CA19-9 test results of three (A, B, C) hospitals accredited by KOLAS, was the object of the measurement uncertainty estimation. We evaluated type A and, B both uncertainty estimation methods. Type A evaluation is using the repeated measurement values, (bottom-up approach). Type B evaluation is not using statistical analysis, but doing another method such as variation coefficient of internal quality control materials (Top-down approach). Results Hospital A of the expanded uncertainty on CA19-9 control 1 was $27.0{\pm}5.11U/mL$, control 2 was $181{\pm}30.97U/mL$, that of hospital C was $41.22{\pm}7.56U/mL$(type A evaluation). By using the variation coefficient of intra quality control materials we could estimate the standard uncertainty, combined standard uncertainty, expanded standard uncertainty(k=2). The expanded uncertainty of A hospital was 10.7~15.8%, B hospital was 8.0~22.7%(type A evaluation). Conclusion Medical laboratories should require the estimation results of measurement uncertainties in compliance with ISO 15189. Then, we studied the concept and estimation process with real examples in measurement uncertainty and made an appropriate form to report. Medical laboratories accredited by KOLAS could evaluate measurement uncertainty by using type A and B. We need to make an effort to standardize our laboratories, which could be a chance to reduce the rate of misdiagnosis and improve the reliability in medical laboratories.

Silica에 담지된 Al 화합물을 이용한 L-Lactide 중합

유소연,유지연,김소희,김영조,고영수 한국고분자학회 2009 한국고분자학회 학술대회 연구논문 초록집 Vol.2009 No.10

다가오는 연말을 맞이하는 당뇨인의 마음가짐과 자세

유소연 사단법인 한국당뇨협회 2002 당뇨 Vol.157 No.-

만 2세 표준보육과정을 기반으로 보육계획안의 수학교육 내용분석

유소연,이순복 경인교육대학교 교육연구원 2019 교육논총 Vol.39 No.1

The purpose of this study is to analyze the mathematics contents that involve life themes and activity types, provided for young children, based on the daily child care plans drawn up by day care center teachers and identify how such are being actually applied at day care centers. For a frequency-based analysis, daily education plans used for classes in seven day care centers located in P City were collected., All the daily education plans were found to accord with the names and contents of daily activity by life theme in the standardized child care curriculum for young children aged two. The findings of this study are summarized as follows. First, the most frequent mathematics education content in the daily child care plans was ‘taking interest in space and figure and classifying the twos,’ whereas ‘taking interest in simple rules’ was the least frequent. By life theme, ‘playing animals’ and ‘enjoying colorful autumn’ were the most frequent, whereas in mathematics education contents, ‘taking interest in space and figure and classifying the twos’ was the most frequent and ‘taking interest in simple rules’ was the least frequent. Second, the indoor free play activity with the greatest number of mathematics contents was ‘sense/exploration area of interest’. In addition, in mathematics education contents, ‘taking interest in space and figure’ was the most frequent, with the most frequent sub-topic being ‘taking interest in shape of objects around us.’ 본 연구의 목적은 만 2세 표준보육과정을 기반으로 보육계획안에 나타난 수학교육 내용을 분석하는 데 있다. 분석대상은 P시에 위치한 7개의 어린이집 수업에 적용한 일일보육계획안이며, 표준보육과정에 기초한 보육계획안을 바탕으로 수학교육의 생활주제별 분포와 실내자유놀이 활동별 분포를 빈도와 백분율로 분석하였다. 본 연구의 결과를 요약하면 다음과 같다. 첫째, 만 2세 표준보육과정 일일보육계획안의 수학교육 내용은 공간과 도형에 관심가지기와 구분하기의 영역이 가장 많이 분포가 나타났고, 단순한 규칙성에 관심가지기는 가장 적게 나타났다. 생활주제별 수학적 탐구하기 내용으로 ‘동물놀이해요’와 ‘알록달록 가을이에요’의 생활주제에서 가장 많이 나타났다. 둘째, 만 2세 표준보육과정 일일보육계획안에 나타난 수학교육 내용 중 실내자유놀이영역에서는 감각·탐색 흥미 영역, 수학교육내용에서는 공간과 도형에 관심가지기의 내용이 가장 많이 나타났으며, 세부내용으로 ‘주변사물의 모양에 관심을 가진다’에 집중적인 분포가 나타났다.

텍스트마이닝과 의미네트워크분석을 활용한 뉴스 의제 분석: 코로나19 감정을 중심으로

유소연,임규건 한국지능정보시스템학회 2020 한국지능정보시스템학회 학술대회논문집 Vol.2020 No.11

일부 지체장애인의 미치료 경험에 영향을 주는 결정요인 분석

유소연,김예순,홍현숙,천미경,모진아 한국보건행정학회 2011 보건행정학회지 Vol.21 No.4

Objective: This study is examined the factors affecting forms of untreated experiences in persons with physical disability. Method: The data collected from 461 persons with physical disability in community. Based on the Behavioral Model of Andersen, predisposing, enabling, and need factors are hypothesized to affect persons with physical disability's untreated experiences. The data were analyzed by statistical methods such as frequency and multiple logistic regression analysis. Result: Participation rates of untreated experiences were 26.7%. The significant factors of persons with physical disability's untreated experiences are predisposing factors (gender, partner, and religion), enabling factors (income, private insurance, information of assistive device, disability discrimination, and subjective discrimination), and need factors(subjective health status health screening and chronic disease). Also untreated experiences related to gender, subjective health status, health screening, and chronic disease factors using multiple logistic regression analysis. Conclusion: Implications of the findings were discussed and the recommendations for the improvement of health care utilization, subjective health statue. Especially, development of health education and program should be needed persons with physical disability.

독감 예방접종군과 미접종군 간의 독감의사질병 발생 차이 비교

유소연,김옥선 기초간호학회 2016 Journal of korean biological nursing science Vol.18 No.2