경련과 자연발생 엽상뇌출혈의 임상적연구

유성동,손은희,권도형,김태우,김재문,정기영 대한임상신경생리학회 2002 Annals of Clinical Neurophysiology Vol.4 No.1

Background and Objective : Epileptic seizures are frequent complication of lobar hemorrhage. We investigated the factors affecting development of epilepsy following spontaneous lobar ICH. Methods : From January 1986 to July 1999, 114 patients were admitted to Chungnam National University Hospital with spontaneous lobar ICH. We analyzed 75 patients. Excluded were no follow-up(8 patients) and patients died within few days(31 patients). All the patient was followed up at least two years aside from two patients who underwent epileptic seizure and died five and eight months later each. Medical history was obtained through medical record and by telephone interview. Statistical analyses were performed using Chi-square test, Student’s t - test, Fisher’s exact test. Results : Seizure occurred in 19 patients. As three patients had previous history of seizures, 16 patients(22.2%) showed first onset early- and late- seizures. Early seizure occurred in 14 patients(19.4%). Three out of 14 were heavy alcoholics. Five patients developed late recurrent seizure 61 days to 800 days after the early seizure. Late seizure with no acute seizure occurred in two patients. The types of seizure were diverse as generalized tonic clonic seizure(10), partial seizure with secondary generalization(5), and complex partial seizure(1). The common risk factors for lobar ICH were hypertension(HT), arteriovenous malformation(AVM), and excessive use of alcohol. We could not find any causes in 23 patients. Although size of hematoma, age of onset, sex, incidence of HT or AVM were not different between patients with seizure and without seizure, the history of excessive alcohol drinking was more frequent in patients with seizure. Five patients with late recurrent seizure had ICH involving temporal area. Conclusions : This study suggests that the risk of seizure in patients with lobar ICH was increase in chronic alcoholics and patient with late recurrent seizure had ICH frequently involving temporal area.

국내산 대마로부터 추출한 칸나비디올 함유 크림의 역가 및 안정성 평가

유성동,김혜림,성기준,전정태,송애리,강종수,박일범 사단법인 대한화장품학회 2022 대한화장품학회지 Vol.48 No.4

In this study, the stability of cream containing 1% of cannabidiol (CBD) with more than 99% extracted from domestic Cannabis sativa was evaluated. The pH, hardness, content, and chromaticity were measured at intervals of 2 weeks under storage conditions for each temperature for 12 weeks (4 ℃, 25 ℃, 37 ℃, and 45 ℃). The pH of the experimental group containing 1% of CBD tended to decrease more than that of the control group. As a result of measuring the change in the content of CBD in the cream under each temperature for 12 weeks using HPLC, the difference in the amount of decrement according to temperature was confirmed. It was confirmed that as a result of measuring the chromaticity using color difference meter, the yellowness of the cream containing CBD increased according to the increase by the storage period and temperature compared to the control group. From the above results, it was confirmed that the content decrease and color change according to the temperature of the pH 5 ~ 6 cream formulation containing CBD. When CBD is applied to medicine and cosmetic formulations in the future, it is considered that research and development should be conducted in consideration of the change in the quantity and physicochemical quality of CBD under the temperature. 본 연구에서는 국내산 대마로부터 추출된 순도 99% 이상 칸나비디올(cannabidiol, CBD)을 1% 함유한크림의 안정성을 평가하였다. 12 주간 온도별 저장조건(4 ℃, 25 ℃, 37 ℃, 45 ℃)에서 2 주 간격으로 pH, 경도, 함량, 색도를 측정하였다. CBD를 1% 함유한 실험군 의 pH는 대조군보다 더 감소하는 경향을 나타내었다. HPLC를 이용하여 온도별로 12 주 동안 실험군 내 CBD의 함량 변화를 확인한 결과, 온도에 따른 감소량의 차이를확인하였다. 분광측색계를 이용하여 색차를 확인한 결과, 저장 기간 및 온도 증가에 따라 대조군에 비해 실험군황색도가 증가함을 확인하였다. 이상의 결과로부터 pH 5 ~ 6의 실험군 제형의 온도에 따른 함량 감소 및 색상변화를 확인하였다. CBD를 향후 의약품 및 화장품에 적용 시 온도에 따른 CBD의 역가 및 이화학적 품질변화를고려한 연구개발이 수행되어야 할 것으로 판단된다.

학교 밖 교사학습공동체를 통한 수업 개선 사례 연구: 충남초등영어교육연구회를 중심으로

유성동,김도기 한국교육행정학회 2023 敎育行政學硏究 Vol.41 No.3

본 연구는 학교 밖 교사학습공동체에서의 수업 개선 활동 경험이 학교 안으로 구현되고 공유되는 방식을 조명해 보고, 이를 바탕으로 학교 안팎의 교사학습공동체 활성화를 위한 시사점을 찾는 데 목적이 있다. 이러한 연구 목적의 달성을 위해 본 연구는 질적 사례 연구 방법을 사용하여 충남초등영어교육연구회에서 활동 중인 교사 4명과 면담을 진행하였다. 연구 결과는 다음과 같다. 첫째, 교사들은 지식 및 경험의 공유와 협력적 배움에 대한 기대로 연구회에 가입하였다. 둘째, 교사들은 지식과 수업 전문성 습득, 협력적 실천과 성찰, 상호 나눔과 공유를 통한 성장을 경험하였다. 셋째, 연구회 활동은 수업 관점과 도구의 변화, 새로운 교수전략의 활용, 지식과 수업기술의 공유를 통해 학교 안의 수업 개선으로 이어졌다. 본 연구 결과를 바탕으로 한 시사점 및 후속 연구의 방향을 제안하면 다음과 같다. 첫째, 학교 밖 교사학습공동체 활동이 일선 학교의 수업 개선에 어떠한 영향을 미치는지에 대한 객관적인 양적 연구가 필요하다. 둘째, 학교 밖 교사학습공동체에 대한 실질적인 지원체계 모색과 전문적 학습공동체의 질적 성장을 위한 맞춤형 정책이 필요하다. 셋째, 학교 밖 교사학습공동체를 둘러싼 현안에 대한 지속적인 성찰과 상상력이 요구된다.

예비교사 전문성 개발에 기여하며 학교현장 수용성이 제고되는 교육실습

유성동 한국교원교육학회 2022 한국교원교육학회 학술대회자료집 Vol.2022 No.5

대뇌 백질 변성을 보인 환자에서의 뇌파와 인지기능의 변화

권도형,유성동,이애영 대한임상신경생리학회 2002 Annals of Clinical Neurophysiology Vol.4 No.1

B a c k g r o u n d : Spatial analysis of EEG is a phenomenal assessment and not so informative for phase space and dynamic aspect of EEG data. In contrast, nonlinear EEG analysis attempts to characterize the dynamics of neural networks in the brain. We have analyzed the features of EEG nonlinearly in subjects with white matter change on brain MRI and compared the results with cognitive function in each. Methods : Digital EEG data were taken for 30 seconds in 9 subjects with white matter degeneration and in 5 healthy normal controls without white matter change on MRI. Then we analyzed them nonlinearly to calculate the correlation dimension(D2) using the MATLAB software. The cognitive function was assessed by 3MS(modified mini-mental state examination). The severity of white matter change was assessed by Scheltens scale. Results : The mean D2 value of normal control was greater than that of white matter degeneration group. The D2s of some channels were correlative with 3MS and degree of white matter degeneration significantly. Conclusions : nonlinear analysis of EEG can be used as one of adjuvant functional studies for prediction of cognitive impairment in subjects with white matter degeneration and subcortical white matter change can be influential on cognitive function and correlation dimension of EEG.

피질하혈관성 치매와 알쯔하이머병에서 뇌량 용적의 변화 비교

이애영,손은희,유성동 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.2

Background : The clinical significance of callosal atrophy in demented patients has not been elucidated. We performed this study to compare the total and regional difference of corpus callosum according to demenua subtypes and analyzed the relationship with the white matter changes. Methods : Twenty-eight patients with Alzheimer's disease (NINCDS-ADRDA criteria), 17 patients with vascular dementia (NINDS-AIREN criteria), and 14 healthy controls were included. The total area of corpus callosum and three distinct subdivision were measured by manual tracing with Paintshop Pro 6.02 software. The degree of white matter changes were graded by the Scheltens' scale. The MMSE and Modified Mini-Mental Stats (3MS) Examination were used for cognitive function test Results : Total callosal area was much smaller in vascular dementia compared with those of Alzheimer's disease and control. The degree of white matter change correlated siginficantiy with the callosal atrophy in vascular dementia Callosal atrophy was proportional to the cognitive decline. Conclusion : We suggest that callosal atrophy in patients with subcortical vascular dementia may be a neuroradiological clue for the coginitive decline and reflects the cerebral white matter injury.

인지 기능에 미치는 대뇌 백질 변성의 영향 및 원인분석

손은희,이애영,유성동,권도형,김태우,김재문 대한신경과학회 2001 대한신경과학회지 Vol.19 No.5

대마에서 초임계유체 추출방법으로 얻은 칸나비디올 및 칸나비디올 첨가 크림의 항염증 효능 평가

김세영,김혜림,유성동,안선미,송애리,성기준,박일범,강종수,박현제 한국피부과학연구원 2024 아시안뷰티화장품학술지 Vol.22 No.1

목적: 본 연구는 초임계유체 추출로부터 얻어진 칸나비디올(CBD) 및 CBD 첨가 크림의 항염증 효능 평가를 위해 수행되었다. 방법: CBD의 정량 분석은 액체크로마토그래피 분석을 통해 수행되었다. CBD의 항염증 평가는 LPS로 유도된 Raw 264.7 세포에서 NO 함량을 측정하였다. CBD 첨가 크림의 항염증 평가는 SDS로 유도된 keraskinTM 모델에서 IL-1α 함량을 측정하였다. CBD 및 CBD 첨가 크림의 세포독성은 각 세포 모델에서 MTT assay를 이용하여 수행하였다. 결과: 초임계유체추출로 얻어진 CBD의 함량은 99.40%로 확인되었다. CBD의 항염증 효능 평가 결과 농도 의존적인 NO 생성 감소를 보였으며, 특히 음성 대조군에 비해 4 μg/mL에서 64.98%로 유의적으로 감소하였다. 또한 CBD 첨가 크림은 농도 의존적인 IL-1α 의 감소 경향을 보였으며, 특히 CBD 0.4% 첨가 크림은 음성 대조군에 비해 54.17%, 양성 대조군에 비해 22.09% 감소하였다. 결론: 현재 국내에서 CBD는 의료용으로 연구되고 있으며, 본 연구에서는 CBD의 우수한 항염증 효능을 확인하였고 크림제형으로 활용할 수 있는 방안을 제시하였다. 향후 추가적인 연구를 통해 안전성과 효능에 대해 입증된다면, 기존 항염증 소재 대체제로써 활용 가능할 것으로 기대된다. Purpose: This study evaluated the anti-inflammatory properties of a cannabidiol (CBD) extract obtained by supercritical fluid extraction (SFE) from Cannabis sativa L. and a cream containing the extract. Methods: The CBD extract was quantitatively analyzed using high-performance liquid chromatography. We used a lipopolysaccharide (LPS)-induced RAW 264.7 cell model of inflammation to determine the anti-inflammatory effect of the CBD extract by measuring nitric oxide (NO) production. We evaluated the anti-inflammatory properties of a cream containing the CBD extract by measuring interleukin-1 alpha (IL-1α) levels induced by sodium dodecyl sulfate (SDS) in KeraSkinTM, a human skin model. The cytotoxicity of the CBD and CBD-containing cream was assessed by MTT assay in each model. Results: The average purity of the CBD extracted and refined by SFE was 99.40%. The CBD extract and CBD cream showed concentration-dependent inhibition of inflammation. At 4 μg/mL, NO production in the RAW 264.7 cell model was significantly decreased by 64.98% compared with the negative control. IL-1α production induced by SDS in the KeraSkinTM model decreased by 54.17% in the group treated with cream containing 0.4% CBD compared with the negative control and 22.09% compared with the positive control groups. Conclusion: The medicinal use of CBD is attracting interest in Korea. Our study confirmed its exceptional anti-inflammatory properties and effectiveness in a cream product. Should additional research confirm its safety and efficacy, CBD is expected to replace existing anti-inflammatory ingredients.

서울신경심리검사-단축형의 지역사회 치매 관리 사업 인지평가도구로써 효용성

이애영,이주연,오응석,윤수진,윤보라,유성동 대한신경과학회 2019 대한신경과학회지 Vol.37 No.3

Background: The increasing number of dementia patients is increasing the importance of identifying them and also those at a high risk of dementia. The early diagnosis and management of dementia can slow the progression of the disease and reduce the socioeconomic burden. For these purposes, the Local Dementia Centers established in all regions of Korea are working on the early detection of dementia using neuropsychological batteries. This study investigated the utility of the Seoul Neuropsychological Screening Battery-Core (SNSB-C) in a dementia management project performed in the local community. Methods: This study was conducted in two parts. The first part used data from the Local Dementia Centers to investigate the accuracy of detecting cognitive impairment in SNSB-C compared with the Seoul Neuropsychological Screening Battery-Second Edition (SNSB-II). The second part of this study which data from hospital examined the accuracy of diagnosing dementia using SNSB-C. Results: Data were collected from 508 participants at the Local Dementia Centers in Daejeon and 50 participants at a hospital. SNSB-C had a high sensitivity and specificity for detecting cognitive impairment, and also a high sensitivity, high specificity, and positive predictive value for diagnosing dementia. Conclusions: The sensitivity in diagnosing dementia was as high for SNSB-C as for SNSB-II while taking less time. SNSB-C could therefore be a good diagnostic evaluation tool for use in local dementia centers.