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당부분에서 4'-플루오린 또는 4'-아자이드로 치환된 3'-히드록시다우노루비신과 3'-히드록시독소루비신 유도체의 합성과 항암활성
옥광대,박정배,김문성,정동윤,양중익,Ok, Kwang-Dae,Park, Jeong-Bae,Kim, Moon-Sung,Jung, Dong-Yoon,Yang, Junn-Ick 대한약학회 1996 약학회지 Vol.40 No.2
3'-Deamino-3-hydroxy-4'-fluoro- or 3'-deamino-3'-hydroxy-4'-azido-daunorubicin(6,8) and -doxorubicin(7,9) have been synthesized, respectively. Compounds 7,8 and 9 were mo re cytotoxic than daunorubicin(1) and doxorubicin(2) against L1210 murine leukemic cell in vitro. When administered intraperitoneally for 9 days starting 1 day after tumor inoculation, compounds 7(T/C 605%) and 9(T/C 488%) showed significant antitumor activity for ip-inoculuated L1210 murine leukemia at wide range of doses.
7-O-(alpha-L-람노피라노실) 또는 7-O-(4''-아미노-alpha-L-람노피라노실)-다우노마이시논과 -아드리아마이시논 유도체의 합성과 항암활성
옥광대(Kwang Dae Ok),박정배(Jeong Bae Park),김문성(Moon Sung Kim),정동윤(Dong Yoon Jung),안상용(Sang Yong An),배중석(Chung Seok Bae),양중익(Junn Ick Yang) 대한약학회 1996 약학회지 Vol.40 No.1
Daunirubicin and doxorubicin analogues (5,7,8,9,) in which the natural amino sugar, daunosamine, is replaced by rhamnopyranosyl or 4''-amino rhamnopyranosyl residues have been prepared. The in vitro cytotoxicity of compound 5 or 7 was similar to that of doxorubicin for P388 murine leukemic cell line. But compound 8 or 9 was less cytotoxic than doxorubicin. When administered intravenously on day 1, compound 9 showed antitumor activity comparable to that of doxorubicin against ip-inoculated L1210 murine leukemia and found to be less toxic than doxorubicin. But the in vivo antitumor activity of compound 7 or 8 was inferior to that of doxorubicin.
유영법,이종호,최명락,옥광대,박종철,Yu, Young-Beob,Lee, Jong-Ho,Choi, Myeong-Rak,Ok, Kwang-Dae,Park, Jong-Cheol 한국생약학회 1996 생약학회지 Vol.27 No.1
Nucleoside, flavonol glycoside and disaccharide have been isolated from the aerial part of Angelica keiskei Koidz and identified by means of spectral analysis as adenosine, hyperoside and sucrose, respectively.
박종철(Jong Cheol Park),옥광대(Kwang Dae Ok) 대한약학회 1993 약학회지 Vol.37 No.4
Five phenolic compounds have been isolated from the stems and leaves of Rosa rugosa Thunb. (Rosaceae) in Korea. They were methyl gallate and catechin from the stems, and quercetin, methyl gallate and hyperin from the leaves respectively. The structures were established by spectroscopic and chemical methods.
Angelica keiskei의 고지혈증 개선효과 및 2종의 플라본 7-O-배당체의 분리
박종철,조영숙,박석규,박정로,전순실,옥광대,최종원,Park, Jong-Cheol,Cho, Young-Sook,Park, Seok-Kyu,Park, Jeong-Ro,Chun, Soon-Sil,Ok, Kwang-Dae,Choi, Jong-Won 한국생약학회 1995 생약학회지 Vol.26 No.4
Two flavone glycosides were isolated from the aerial part of Angelica keiskei Koidz and identified by means of spectral analysis as luteolin-$7-O-{\beta}-{_D}-glucoside$ and Iuteolin-7-O-rutinoside. Intraperitoneal administration of methanolic extract(100mg/kg) and $luteolin-7-O-{\beta}-{_D}-glucoside(5mg/kg)$ isolated from this plant produced a significant hypolipemic activity.
새로운 Capsaicin 유도체 DA - 5018 의 구조 및 물리화학적 성질 연구
김흥재,이종진,이응두,심현주,이상득,옥광대,김원배,박노상 ( Heung Jae Kim,Jong Jin Lee,Eung Doo Lee,Hyun Joo Shim,Sang Deuk Lee,Kwang Dae Ok,Won Bae Kim ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.2
N/A The physicochemical and structural properties of new capsaicin derivative. DA-5018, were examined. The reference standard of this compound was obtained by the recrystallization. A method for the determination of the dissociation constant of the compound is described. pH-solubility and distribution coefficient were determined by chromatographic method. Fundamental properties on thermal behaviors were investigated by TG, DTA and DSC. Structural analysis based on spectroscopic method coincided with the chemical structure of DA-5018. Approximate dissociation constant of the compound determined by UV spectral method was 9.35. Solubilities and partition coefficients in various pH buffer solution appeared pH-dependency. No crystal transition or further transition was found in the thermal analysis. This compound showed good stability, but pH 13 buffer and acetone made some degradative products.
Methyl-6-deoxy-beta-L-idopyranoside의 합성
민신홍(Shin Hong Min),박복구(Bok Ku Park),옥광대(Kwang Dae Ok) 大韓藥學會 1986 약학회지 Vol.30 No.6
Methyl-6-deoxy-beta-L-idopyranoside was prepared in good yield by treatment of methyl 2,3,4-tri-O-benzyl-6-deoxy-alpha-D-xylo-hex-5-enopyranoside with H2 on pd, followed by reaction of Na/NH3 at -50oC. The ratio of L-idopyranoside and D-glucopyranoside was 7 to 1 in 80.7%. It was confirmed that L-idopyranoside was 1C conformation as being expected.
Catalytic NiO Filter Supported on Carbon Fiber for Oxidation of Volatile Organic Compounds
심종기,서현옥,정명근,김광대,김영독,임동찬 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.7
Carbon-fiber-supported NiO catalytic filters for oxidation of volatile organic compounds were prepared by electroless Ni-P plating and subsequent annealing processes. Surface structure and crystallinity of NiO film on carbon fiber could be modified by post-annealing at different temperatures (500 and 650 oC). Catalytic thermal decompositions of toluene over these catalytic filters were investigated. 500 oC-annealed sample showed a higher catalytic reactivity toward toluene decomposition than 650 oC-annealed one under same conditions, despite of its lower surface area and toluene adsorption capacity. X-ray diffraction and X-ray photoelectron spectroscopy studies suggest that amorphous structures of NiO on 500 oC-annealed catalyst caused the higher reactivity for oxidation of toluene than that of 650 oC-annealed sample with a higher crystallinity.
CO oxidation of bare and TiO2-coated NiO–Ni(OH)2 nanoparticles
남종원,김광대,김동운,서현옥,김영덕,임동찬 한국물리학회 2012 Current Applied Physics Vol.12 No.2
CO oxidation reactivity of bare and TiO2-coated nanoparticles consisting of both NiO and Ni(OH)2surfaces was studied. For the deposition of TiO2, atomic layer deposition was used, and formation of three-dimensional domains of TiO2 on NiOeNi(OH)2 could be identified. Based on the data of X-ray Photoelectron Spectroscopy, we suggest that upon TiO2 deposition only Ni(OH)2 was remained on the surface, whereas NiO surface disappeared. Both CO adsorption and CO oxidation took place on NiOeNi(OH)2 surfaces under our experimental conditions. CO adsorption was almost completely suppressed after TiO2 deposition, whereas CO oxidation activity was maintained to large extent. It is proposed that bare NiO cannot be active for CO oxidation, and can only uptake CO under our experimental condition, whereas hydroxylated surface of NiO can be active for CO oxidation.