한국 소비자생활협동조합의 조직변화 : 아이쿱 소비자생활협동조합 사례

오보영(Bo Young Oh),장승권(Seungkwon Jang) 한국인적자원개발학회 2019 인적자원개발연구 Vol.22 No.3

신기능을 고려한 $H_2$-receptor antagonist의 용량, 용법 및 투여경로의 적절성 및 약사자문의 수용성

황보영,오정미,Hwang, Bo Young,Oh, Jung Mi 한국의료질향상학회 2002 한국의료질향상학회지 Vol.9 No.2

Background : The purpose of this study was to develop, implement and evaluate the pharmacist intervention program designed to identify and correctly adjust the dosage of $H_2$-receptor antagonists ($H_2RA$) in renally impaired patients and promote timely conversion of $H_2RA$ from IV to PO therapy. Methods : The study population consisted of renally impaired patients who received $H_2RA$ therapy from April 9 to May 8, 2001 at Hallym Medical Center. Each morning a specifically developed software program identified patients with serum creatinine (Scr) greater than 1.2 mg/dl or age greater than 65 years. The pharmacist, then screened the pharmacy profiles of the identified patients to determine if the patient was on $H_2RA$. For these patients on $H_2RA$ with renal impairement the creatinine clearance (CrCl) was calculated using Cockroft & Gault equation. The pharmacist determined the proper dosage for each identified patients based on the calculated CrCl and the oral dosage that would be appropriate for whom IV therapy was no longer indicated. Result : A total of 149 cases (101 patients) were monitored during the study period. The dosage was inappropriately prescribed for renal function in 61 of 149 cases (41%), and of those, pharmacist made recommendations for 58 cases of which 33 cases (57%) were accepted by the physicians. The administration route of H2RA was inappropriately used as IV in 22 of 53 cases (42%), and pharmacist made recommendations for those 22 cases of which 15 cases (68%) were accepted. Conclusion : Monitoring of patients with renal dysfunction by a pharmacist improved the dosing of $H_2RA$ and a dosing program of patients with renal impairment would be of benefit to other clinicians and institutions seeking to optimize patient care.

인천지역에서 분리된 황색포도상구균의 분자생물학적 특성 분석

오보영,김정희,공용우,이제만,고종명,김용희,Oh, Bo-Young,Kim, Jung-Hee,Gong, Young-Woo,Lee, Jae-Mann,Go, Jong-Myoung,Kim, Yong-Hee 한국미생물학회 2008 미생물학회지 Vol.44 No.4

황색포도상구균은 주요한 기회 감염균으로, 최근 여러 가지 항생제에 내성을 지닌 메치실린 내성 황색포도상구균 Methicillin-resistant Staphylococcus aureus: MRSA)이 늘어나 문제가 되고 있다. 이에 본 연구에서는 인천지역관내 설사환자에서 분리한 장독소 양성인 S. aureus를 대상으로 항생제 감수성시험 및 PCR을 이용한 tsst, eta, etb mecA 유전자 검사를 실시하여 생물학적인 특성을 조사하였고, tsst 양성인 MRSA를 대상으로 Pulse Field Gel Electrophoresis (PFGE)에 의한 유전자형을 분석함으로서 경시적인 분자역학적 특성을 파악하고자 하였다. 그 결과 2,281건의 대변에서 173주의 장독소 양성인 S. aureus를 분리하였으며 A독소와 C독소가 각각 39%, 58%를 차지하는 것으로 나타났다. 항생제 감수성 결과 장독소 양성주는 모두 MRSA였으며, 이중 51%가 tsst 양성인 것으로 나타났고 eta, etb 유전자는 검출되지 않았다. mecA 내성유전자는 MRSA 균주의 97%가 양성으로 나타났다. tsst 양성인 MRSA 88주를 대상으로 PFGE한 결과, 10개의 유형으로 나뉘었으며 그중 A형, H형 및 F형 이 각각 58%, 10%, 9%로 주요한 형으로 나타났다. Staphylococcus aureus is one of the most significant pathogens and a causative agents of nosocomial infections. The emergence of methicillin resistant S. aureus (MRSA), in particular, has become a major clinical and epidemiological problems worldwide. In this study, we analyzed the toxin genes and investigated molecular epidemiological characteristics of S. aureus isolated from stools of diarrheal patients at the hospitals in Incheon. Of the 609 strains from 2,281 specimens, 173 strains retained enterotoxin; 68 isolates (39.30%), 100 isolates (57.80%) were classified to A and C type, respectively. In the antibiotic susceptibility, all of enterotoxin positive isolates were resistant to oxacillin. Eighty eight strains (50.86%) of 173 MRSA isolate possessed tsst gene, but eta and eth genes were not detected at all. In the detection of MRSA associated genes by PCR method, mecA genes were detected in 167 strains (96.53%). From the result of PFGE analysis, we classified tsst-positive MRSA to 10 types and 24 subtypes. Type A, H and F were the major strains comprised of 57.95% (51 strains), 10.22% (9 strains) and 9.09% (8 strains) respectively.

Preoperative Nutritional Status as a Predictor of Survival in Colorectal Cancer

Bo-Young Oh(오보영),Kyung Sook Hong,Soon Sup Chung,Ryung-Ah Lee,Kwang Ho Kim 대한종양외과학회 2013 대한임상종양학회 학술대회지 Vol.2013 No.3

HPLC 및 GC에 의한 농약분석에서 전처리에 대한 연구

오보영,배준현,강준길,김연두,Oh, Bo Young,Bae, Jun Hyun,Kang, Jun Gil,Kim, Youn Doo 대한화학회 1999 대한화학회지 Vol.43 No.6

HPLC/UV 및 GC/FPD 법을 사용하여 환경수에 존재하는 Diazinon, EPN, Fenitrothion, Phosalon 및 Phosmet 등 5종의 유기인계 잔류농약을 분석하였다. 전처리 과정으로 고체상추출법(SPE)과 용매추출법(LLE)을 각각 적용한 결과, 회수율과 재현성에 있어, HPLC/UV에서는 용매추출법(LLE)보다 고체상추출법(SPE)이 더 우수하였고, GC/FPD에서는 고체상추출법(SPE)보다 용매추출법(LLE)이 더 우수하였다. 또 수돗물 및 하천수(와룡천)에 일정량의 유기인계 농약을 가하여 만든 합성시료중 각 성분을 분석한 결과, SPE-HPLC/UV 법에서는 회수율이 101%, % RSD는 4.3∼8.7이었고, LLE-GC/FPD 법에서는 회수율이 100%, % RSD는 3.2∼9.5이었다. 이 결과는 두 방법 모두 유기인계 잔류농약 분석에 이용할 수 있는 우수한 방법임을 제시하고 있다. For determination of separated pesticides by using GC and HPLC, liquid-liquid extraction(LLE) and solid phase extraction(SPE) have been carried out to separate and concentrate the organophophorous pesticides such as Diazinon, Fenitrothion, Phosmet, Phosalon and EPN in environmental water samples. ln determination of pesticides by HPLC/UV, SPE has resulted in higher recovery and more precision than LLE, while in determination of pesticides by GC/FPD, vice versa. HPLC/UV after the pretreatment process of sample by solid phase extraction (SPE-HPLC/UV) has suggested the possibility of determination of pesticides ppb level. ln comparison of detection limit, both SPE-HPLC/UV and LLE-GC/FPD are reasonably suitable for analysis of residue pesticides. ln the respect of the rapidity and the solvent required, SPE-HPLC/UV method has proven to be superior to LLE-GC/FPD.

급성 충수돌기염 진단 시 연령에 따른 Alvarado Score의 진단적 가치

오보영(Bo-Young Oh),김광호(Kwang-Ho Kim),이령아(Ryung-Ah Lee),정순섭(Soon Sup Chung) 대한외과학회 2010 Annals of Surgical Treatment and Research(ASRT) Vol.78 No.2

Purpose: This study aims to assess the diagnostic efficacy of the Alvarado score and to determine cut-off values of Alvarado score according to age for deciding on the options for patients with suspected appendicitis. Methods: From October 2008 to January 2009, we prospectively reviewed 152 patients with suspected appendicitis. The patients were classified into adults and children groups. We then determined cut-off values of the Alvarado score by analyzing each score’s sensitivity and specificity. Results: Of the 147 patients, 96 patients were adults and 51 were children. The mean Alvarado score for adults and children were 6.08±1.85, and 6.69±1.43 in appendicitis and 4.32±2.02, and 4.60±1.81 in non-appendicitis, respectively. In adults, the sensitivity of the Alvarado scores 7 or higher for appendicitis was 66.2%, and the specificity was 67.7%. And the sensitivity of the Alvarado scores 4 or lower for non-appendicitis was 58.1%, and the specificity was 81.5%. In children, the sensitivity of the Alvarado scores 7 or higher for appendicitis was 80.8%, and the specificity was 68.0%. And the sensitivity of the Alvarado scores 4 or lower for non-appendicitis was 52.0%, and the specificity was 92.3%. Conclusion: The cut-off values for Alvarado score were not different according to age of the patient. If the Alvarado score is 7 or higher, surgical management is recommended, and if the Alvarado score is 4 or lower, observation without CT or US is recommended. In equivocal appendicitis as defined by the Alvarado scores 5 to 6, adjunctive CT or US are recommended to confirm appendicitis.

인천지역에서 분리된 비브리오 패혈증균의 특성

오보영,김정희,공용우,제갈승,김혜영,이미연,황경화,고연자,이제만,고종명,김용희,Oh, Bo-Young,Kim, Jung-Hee,Gong, Young-Woo,JeGal, Seung,Kim, Hye-Yeung,Lee, Mi-Yeon,Hwang, Kyoung-Wha,Koh, Yeon-Ja,Lee, Jae-Mann,Go, Jong-Myoung,Kim, Yong-H 한국미생물학회 2007 미생물학회지 Vol.43 No.4

2006년도 인천지역 해양환경에서 분리된 Vibrio vulnificus에 대한 생화학적, 분자생물학적 특성 및 항생제 감수성 결과를 알아보았다. 본 실험에 사용된 균주는 총 233주로 해수, 갯벌, 어패류, 수족관수에서 분리되었다. API 20E kit 실험 결과 15개 profile로 분류되었으며, 모든 균주가 ONPG와 Amygdalin 양성이었다. 209주를 대상으로 vvhA와 viuB 유전자 부위에 대해 PCR 실험결과 vvhA는 206주(98.6%) 양성, viuB는 110주(52.6%)가 양성이었으며, 특히 viuB 유전자부위에 대한 PCR 결과는 해수, 어패류, 갯벌에서 분리한 균주의 48%, 48.5%, 61.1%가 양성인 것으로 나타났다. 시험균주 175주에 대해 항생제 감수성 실험 결과 Imipenem (100.0%), Sulfamethoxazole/trimethoprim (98.9%), Tetracycline, Ciprofloxacin (98.3%), Ampicillin/sulbactam (97.1%), Chloramphenicol (96.6%), Cefepime (94.9%), Ceftriaxone (94.8%)이 감수성을 나타내었고, 항생제 하나 또는 그 이상의 약제에 대해 내성을 나타낸 것은 56주(32%)로 해수 28주(31.5%), 갯벌 21주(34.4%), 어패류 7주(29.2%)였다. V. vulnificus 233주에 대해 PFGE를 실시하여 dendrogram으로 분석한 결과 90%이상의 상동성 기준으로 126개의 유형으로 분리되었고, 58%이상의 상동성을 기준으로 13개의 cluster로 분류되었다. Cluster I는 104주(44.6%)로 가장 많은 균주들이 분포하였고 채취시기 대부분 I에 가장 많은 균주들이 분포하였으나 10월과 6월에 채취한 검체는 J에 16주(69.6%)와 13주(36.1%)로 가장 많은 균주들이 분포하였다. 7월에 채취한 검체에서 분리된 균주는 9개의 cluster에 속하였고 8월은 8개, 6월은 7개, 9월은 6개, 10월은 5개, 5월은 3개, 3월은 1개를 나타냈다. We performed the biochemical characteristics, molecular epidemiologocal analysis, and drug susceptibility test on V. vulnificus isolated from environmental sources in Incheon. For this study, 233 strains were isolated from seawater, sediment, shellfish. V. vulnificus isolates were divided into 15 biochemical groups, which were positive for ONPG and Amygdalin test. Among the 209 strains, 206 (98.6%) strains and 110 (52.6%) strains revealed positive for vvhA and viuB gene, and the viuB gene detection rates of V. vulnificus from seawater, shellfish and sediment were 48%, 48.5% and 61.6%, respectively. From disc diffusion test on 175 isolates, most of strains were sensitive to Imipenem (100.0%), Sulfamethoxazole/trimethoprim (98.9%), Tetracycline, Ciprofloxacin (98.3%), Ampicillin/sulbactam (97.1%), Ohloramphenicol (96.6%), Cefepime (94.9%) and Ceftriaxone (94.8%), multi-drug resistance rates was 31.5% of seawater, 34.4% of sediment and 29.2% of shellfish. PFGE was performed on 233 V. vulnificus isolates with the objective of investigating the extent of genetic diversity of these isolates in our region. We could find that at least 126 different PFGE patterns were generated according by 90% of similarity and 13 clusters by 58% of similarity. The major cluster was type I (44.6%) during the most of the year, and type J was frequent pattern in June and October. There were 9 distinct PFGE types in July, 8 types in August, 7 types in June, 6 types in September, 5 types in October 3 types in May and 1 type in March.

신생아 기복증의 수술 후 생존 예후 인자

오보영(Bo-young Oh),최금자(Kum-ja Choi) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.2

Purpose: This study aims to determine the prognostic factors of pneumoperitoneum in neonates. Methods: We reviewed 35 neonates who underwent operations for pneumoperitoneum between 1999 and 2007. The prognostic factors on survival were evaluated. Results: Twenty-eight patients were male and 7 were female. Mean gestational age was 35.9±4.6 weeks and birth weight was 2,703.1±999.2 gr. Mean apgar-score were 6.0±2.9 at 1 min, and 6.7±2.6 at 5 min. The most common clinical finding was abdominal distension. Most patients were diagnosed with a simple abdominal X-ray. Perforation sites were stomach (n=8), small bowel (n=20), colon (n=5), and small bowel and colon (n=2). Operative methods were bowel resection with enterostomy (n=15), resection with anastomosis (n=9), wedge resection (n=4), primary closure (n=3), primary closure with enterostomy (n=3), and penrose-drain insertion (n=1). Postoperative complications occurred in 16 patients, and 26 patients survived and 9 expired. Mortality rate was significantly higher in lesser gestational age, lower birth weight and apgar-score, need of preoperative ventilator, and abnormalities in ABGA or platelet count. Conclusion: The significant prognostic factors were gestational age, birth weight, Apgar-score, need of preoperative ventilator, and abnormal laboratory findings in ABGA and platelet count. The other variables including sex, symptom duration, underlying diseases, perforation sites, and operation methods were not correlated with survival.

다양한 환경조건하에서 5-Aminolevulinic Acid 처리에 의한 피와 자귀풀의 제초 효과

임보영(Bo-Young Lim),국용인(Yong In Kuk),천상욱(Sang-Uk Chon),정선요(Sunyo Jung),권오도(Oh Do Kwon),김경문(Kyung-Moon Kim),구자옥(Ja Ock Guh) 韓國雜草學會 2006 Weed&Turfgrass Science Vol.26 No.1

디자인사고(Design Thinking) 과정을 적용한 고등학교 디자인수업 모형 연구

오보영 ( Bo Young Oh ),문철 ( Chul Moon ) 한국기초조형학회 2015 기초조형학연구 Vol.16 No.6

디자인사고(Design Thinking)는 혁신적인 비즈니스를 위한 방법론을 일컫는 말로 현재 통용되며 디자인 실무에서 적용되고 있다. IDEO의 팀 브라운(2010)은 혁신을 이끌어내는 ‘방법론’이며, 교육과 경영의 ‘새로운 패러다임’이라고 하였다. 디자인사고는 확산적사고와 수렴적사고의 반복적인 프로세스를 통해 창의적인 문제해결이 가능하므로 교육에서의 적용이 유용하다. 현대는 지식이 빠르게 증가하고 있다. 단편적 지식의 암기와 표현 위주의 교육에 의지하는 교육은 미래를 대비할 수 없다. 수많은 정보 중에서 필요한 지식을 식별하고 적용할 수 있는 인재가 요구되어지므로 학습자 중심 교육이 되어야 할 것이다. 디자인사고는 발견하기, 해석하기, 아이디어내기, 실험하기, 발전시키기의 다섯 단계 프로세스를 중심으로 이루어져있다. 각 단계마다 고등학생의 인지 수준에 맞도록 학습목표와 학습과정을 재구성하여 수업지도안을 작성하였다. 고등학교 학생들에게 ‘디자인사고’는 낯선 용어이므로 어려워 할 것이라 예상했으나 많은 학생들이 적극적으로 반응했다. 자료를 통합하고 분석하여 스스로 문제점을 찾아내고 대안을 제시하였다. 교수자와 학습자는 단계별 과정중심의 교육을 통해 문제를 능동적으로 발견하고 해결할 수 있음을 확인하였다. 고학년의 프로젝트 중심 교과목과 연계되어있는 학업에서 성취도를 높일 수 있을 것이다. 본 연구는 ‘디자인사고’ 방법론을 활용하여 디자인 교육 모델의 가능성을 발견하고 교수학습과정을 제안하여 새로운 디자인 교육을 시도하는 것에 그 의의가 있다. Design education is an integrative activity that solves various problems in everyday life through practical operations. “Design Thinking” is a term commonly used today as an innovative business design methodology. It has already been applied in actual design operations. According to Tim Brown of IDEO (2010), it is a ‘methodology’ that leads to innovation, a ‘new paradigm’ towards education and management. Since it encourages creative problem solving through the repetitive process of diffusive thinking and convergent thinking, Design Thinking has many useful applications in the field of education. Today``s information is increasing at a rapid rate. Education which relies on the memorization of fragmentary information or which centers around expression cannot prepare for the future. Because this age requires the human resources who are able to select and apply necessary information out of overflowing information, there is a need for learner-oriented education. Design Thinking is composed of a five-step process that includes the following: finding, analyzing, giving ideas, experimenting, and developing. The curriculum was designed by restructuring educational goals and processes for each step of “Design Thinking” according to cognitive levels of high school students. Contrary to the expected difficulty that the term “Design Thinking” would be unfamiliar to the students, they responded positively to the curriculum. When it was applied in actual design classes, students integrated information, analyzed, discovered problems and offered suggestions for alternatives all on their own. It was confirmed that instructors and learners could actively find and solve problems through a step-by-step oriented education. It has the ability to enhance the academic achievement of the upper grades in regards to their studies particularly related to a project-centered curriculum. This study’s significance lies in its attempt to redesign education by discovering the possibilities of the Design Education model through the application of the methodology of “Design Thinking”, and by presenting it to the teaching-learning process.