소형 전기자동차의 무인주행시스템 개발

오동규,이희무,이민철 제어로봇시스템학회 2014 제어로봇시스템학회 국내학술대회 논문집 Vol.2014 No.5

F-165 Outcomes of T790M+ lung cancer patients treated with Osimertinib in real world practice after acquiring resistance to the previous EGFR-TKI in Korea

오동규,최창민,김우성,이재철 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.0

Purpose: Osimertinib is a 3rd generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) active for both sensitizing mutations and T790M of EGFR. Although it has proven its efficacy and safety in clinical trials, there are limited data in real world practice, especially in Korea. Methods: We reviewed medical records of T790M+ lung cancer patients treated with Osimertinib after acquiring resistance to 1st or 2nd generation EGFR-TKI between February 2016 and June 2017. In addition to the efficacy and safety, the moleculo- pathologic data of rebiopsy samples after the development of resistance to Osimertinib were analyzed. Results: Of 22 patients, median age was 59.5 and 10 (45.5%) were male. The median duration of follow-up was 11.9 months (IQR 4.7-15.8). Fourteen (63.6%; 95% CI 43.0-80.3) achieved an objective response and the disease was controlled in 21 (95.5%; 95% CI 78.2-99.2). Median progression-free survival was 7.3 months (95% CI 3.6-11.0). The adverse effects were minimal except a case of pneumonitis. Among 14 patients who experienced disease progression during Osimertinib, rebiopsy was performed in 8. T790M disappeared in 4 (50%) and one of them showed a wild-type conversion. Transformation to small cell carcinoma was observed in 2 (25.0%) and the C797S mutation was detected in 1 (12.5%). Conclusion: Osimertinib showed favorable efficacy and safety profiles comparable to those of clinical trials in real world practice in Korea. The rebiopsy samples after the acquisition of Osimertinib-resistance is needed to guide the following treatment strategy.

특발성폐섬유증 환자에서 폐기종 동반 여부가 노력성폐활량(FVC)감소 및 생존에 미치는 영향 - 임상연구와 관련된 관점에서의 분석

오동규,도경현,이상민,한승봉,김동순 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.0

목적: 폐기종을 동반한 특발성폐섬유증(CPFE)환자는 노력성폐활량(FVC)의 감소는 적지만 폐확산능(DLco)의 감소가 심하고 폐고혈압의 유병률이 높아 FVC 변화를 주지표로 하는 임상연구에서 이들을 제외해야 한다는 주장이 있다. 하지만 아직까지 이에 대한 근거가 없어 본 연구를 시행하였다. 방법: 서울아산병원에서 IPF로 진단된 환자 중 고해상도흉부전산화단층촬영(HRCT)의 분석이 가능하고 진단 후 12개월의 폐기능검사 결과가 있는 212명을 대상으로 진단시 HRCT 상 폐섬유증및 폐기종의 정도, 진단 후 12개월의 FVC 감소와 생존율의 관계를 조사하였다. 결과: CPFE군은 77명(36.3%)으로 순수 IPF군에 비해 남성과 흡연자가 많았고, 진단 시 두군 사이에 폐섬유화 지수는 차이가 없었으나(7.8 vs. 8.4,p=0.168), FVC 86.3% vs. 74.5% (p<0.001), DLco 65.0% vs. 69.3% (p=0.136)였고, 폐고혈압의 빈도는 23.4% vs 6.1% (p=0.004)였다. 두 군간에 생존률의 차이는 없었고 폐섬유화지수는 중요한 생존예측인자였다. 양군에서 진단 후 12개월의 FVC 감소 정도는 사망의 유의한 예측인자였으나(CPFE군: HR 1.038, p=0.030; 순수IPF군: HR 1.061, p<0.001), FVC 감소 정도는 CPFE군에서 순수 IPF군보다 작았다(120 ml: 4.65% vs 20ml: 0.27%, p=0.008). 결론: CPFE군에서는 진단 후 12개월의 FVC 감소가 적고 사망예측에 미치는 영향도 감소하므로 임상연구에서는 이들을 제외하는 것이 타당할 것으로 사료된다.

양수배양검사시 Trisomy 20 Mosaicism 1예

오동규,최남수,윤인선,주갑순 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.12

Anti-inflammatory Effects of Aroma Oil Complex on DNCB-Induced Allergic Contact Dermatitis in Dogs

오동규,오태호 한국임상수의학회 2014 한국임상수의학회지 Vol.31 No.3

Allergic contact dermatitis (ACD) is an inflammatory skin disease and regarded as a prototype of T-cellmediated delayed-type hypersensitivity reactions. Aroma Oil Complex (AOC) is composed of lavender true oil,chamomile roman oil and tea tree oil. This study was performed to assess the effects of AOC in a canine modelof ACD. ACD was induced on the back of dogs induced by sensitization and repeated application by 2,4-dinitro-1-chlorobenzene (DNCB). Topical treatment of AOC was applied once a day for 8 days and skin biophysical parametersincluding transepidermal water loss (TEWL), skin hydration, skin thickness and erythema index, were measured everytwo days during experimental periods. Histopathology and immunohistochemistry were performed to evaluate the antiinflammatoryeffect. In skin biophysical parameters, TEWL, skin hydration, skin thickness and erythema index weresignificantly increased, with a maximum increase appeared on day 2 (p < 0.05). After the completion of AOC treatment,skin biophysical parameters were significantly reached those of baseline in a time-dependent manner (p < 0.05). Inhistopathology, marked increases of epidermal thicknesses were induced after DNCB challenge with numerousinflammatory cell infiltrations and edematous changes, decreases of connective tissue occupied regions in dermis. Inaddition, marked increases of cytokine - tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ)-immunoreactivitiesin the dermis and of apoptotic markers - caspase-3 and PARP-immunoreactivities in the epidermis were observed inDNCB control as compared with intact control, respectively (p < 0.01). The decrease of infiltrated inflammatory cellsand related decreases of pro-inflammatory cytokine immunoreactivities were observed in AOC treated skin (p < 0.01). Based on these findings, AOC may have anti-inflammatory and alleviatory effects in the allergic contact dermatitis.

Lung Regeneration Therapy for Chronic Obstructive Pulmonary Disease

오동규,김유선,오연목 대한결핵및호흡기학회 2017 Tuberculosis and Respiratory Diseases Vol.80 No.1

Chronic obstructive pulmonary disease (COPD) is a critical condition with high morbidity and mortality. Although several medications are available, there are no definite treatments. However, recent advances in the understanding of stem and progenitor cells in the lung, and molecular changes during re-alveolization after pneumonectomy, have made it possible to envisage the regeneration of damaged lungs. With this background, numerous studies of stem cells and various stimulatory molecules have been undertaken, to try and regenerate destroyed lungs in animal models of COPD. Both the cell and drug therapies show promising results. However, in contrast to the successes in laboratories, no clinical trials have exhibited satisfactory efficacy, although they were generally safe and tolerable. In this article, we review the previous experimental and clinical trials, and summarize the recent advances in lung regeneration therapy for COPD. Furthermore, we discuss the current limitations and future perspectives of this emerging field.

대전트램 추진현황과 향후 과제

오동규 대한교통학회 2018 대한교통학회 학술대회지 Vol.79 No.-

P-18 Age-specific trends in the utilization of medical intensive care unit in a tertiary hospital in Korea

오동규,나원준,박유랑,허진원 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-

Purpose: Age is an important prognostic factor of the patients treated in the medical intensive care unit (MICU). We performed the study to assess the age-specific trends in the MICU utilization. Methods: Data were obtained from the patients admitted to an MICU of a tertiary hospital between July 2006 and June 2015. Patients were grouped by age and the age-specific trends were analyzed in demographics, comorbidities, disease severities, and MICU admission and mortality rates. Results: Of 8,018 patients, the mean age was 61.1 years and male were 5,094 (63.5%). The most common comorbidity was cancer (42.0%). Interestingly, in the age group < 50 years, the proportion of hematologic malignancy was more common than in the other age group (18.6% vs. 11.0%, p < 0.001). The disease severity assessed by sequential organ failure assessment (SOFA) score was higher in the age group < 50 years than in ≥ 70 years (8.1 [95% CI 7.8 - 8.3] vs. 7.2 [95% CI 7.0 - 7.3], p < 0.001). The MICU admission rates were consistently increased with age, but the MICU mortality rates showed bimodal distribution peaked in the age group < 50 and ≥ 80 years. Contrary to the decreasing temporal trend in the MICU mortality rates in the age group ≥ 80 years (R² = 0.35, p = 0.09), those in < 40 years showed increasing temporal trend (R² = 0.66, p = 0.005). Conclusion: Although the MICU admission rate was much lower in younger age group, the MICU mortality rate in this group was comparable to that in older age group. These might be related to the comorbidities and disease severities.

Clinical outcomes of extracorporeal membrane oxygenation as a bridge to lung transplantation

오동규,심태선,조경욱,박승일,김동관,최세훈,이근동,정성호,최상호,이상오,홍상범 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-

Introduction: Extracorporeal membrane oxygenation (ECMO) may be considered as a bridge to lung transplantation (BTT) in patients with acutely decompensated end-stage lung disease. However, it has been discussed controversially because of the discouraging results. Herein, we present our experience with this challenging strategy. Methods: We retrospectively analyzed medical records of adult patients who underwent lung transplantation at a tertiary referral center between January 2008 and December 2017 (n=61). Data were compared between patients who required ECMO support as a BTT (BTT group, n=33) and those without such support (non-BTT group, n=28). Results: Of 61 patients, the mean age was 44.2 years and 43 (60.6%) were male. The median bridging time to transplantation was 14 days (IQR, 9-19 days) in BTT group. Despite of the higher baseline simplified acute physiology score II (SAPS II) in BTT group (34.4 vs. 17.5, p<0.001), the 1-year, 3-year, and 5-year survival rates were comparable between the groups (74%, 74%, and 60%, respectively in BTT group vs. 77%, 67%, and 67%, respectively in non-BTT group, p=0.611). In BTT group, the 1-year, 3-year, and 5-year survival rates were worse in patients with ECMO support ≥14 days (n=16) than those with ECMO support <14 days (n=17) (56%, 56%, and 46%, respectively vs. 94%, 94%, and 75%, respectively, p=0.046). Conclusions: Successful lung transplantation may be achieved with ECMO support, even in marginal recipients. Careful patient selection such as bridging time <14 days appears to be important for the successful transplantation.

초등학교 창의적 체험활동을 위한 녹색기술 교육프로그램의 개발

오동규 대한공업교육학회 2011 대한공업교육학회지 Vol.36 No.1

The purpose of this study was the development of green technology education program for elementary school creative activities. The result of this study were follow. Basically this program was developed through three steps of preparation, development and improvement. First, in the preparation step, Need analysis were analyzed by investigation the needs of the society. Then the themes of this program were determined by thestages based on the National and social issues. Second, in the development step, the following was included. 1) Begin with Setting up education goals of this program. 2) selecting of learning object and content. 3) structuring educational program. Third, in the improvement step, program was verified of validity by experts 이 연구는 저탄소녹색성장의 중요성을 밝히기 위하여 초등학생을 대상으로 창의적 체험활동을 위한 녹색기술교육 프로그램을 개발하는데 있다. 이 교육 프로그램은 준비-개발-개선 단계로 개발하였다. 이 교육프로그램의 개발 결과는 다음과 같다. 첫째, 준비 단계에서 녹색기술교육 프로그램에 대한 학생, 사회의 요구분석과 경상북도교육청의 녹색성장교육실천메뉴얼, 에너지관리공단의 에너지인정도서, 미국의 NEED프로젝트를 바탕으로 녹색 기술에 관한 예비 주제를 선정하였다. 예비 주제는 현실성, 관련성, 활동성의 요소로 최종 주제를 정하였다. 둘째, 개발 단계에서 교육프로그램에 대한 목표를 선정하고, 활동프로그램의 내용을 정하였다. 세부 학습목표와 교육내용, 학습방법, 평가방법을 정하였다. 녹색기술교육프로그램은 에너지, 전기에너지, 태양과 풍력에너지, 그린홈, 그린카, 재활용으로 구성하였다. 셋째, 개선 단계에서 개발된 교육프로그램을 초등학교 교사와 기술교육전문가를 대상으로 타당도를 평가하였다. 초등학생 12명을 대상으로 현장평가를 실시하였다. 개선 요구를 반영하여 프로그램을 재개발하였다.