만성 부비동염 환자 비즙의 진균 배양

신승헌,이영호,이성준,김창균,예미경 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.5

Background and Objectives:Fungi have been increasingly recognized as important pathogens in sinusitis. Different types of fungi colonize in the nasal secretion of different individuals and the geographic distribution of fungi is different all across spectrum of fungal elements in the Korea population, and to clarify the association between fungal sinusitis with type I hypersensitivity. Materials and Methods:This prospective study evaluated 40 patients with chronic rhinosinusitis (CRS), 20 allergic rhinitis (AR), and 20 normal volunteers. Fungi were cultured with nasal irrigation and swab method, and skin prick test was done to determine the specific IgE against fungi. Results:Fungal cultures of nasal secretions were positive in Penicillium, Aspergillus were comonly cultured, but the fungal culture results were not so significantly different among three groups. Type I hypersensitivity to fungal allergens was not important in the majority of CRS patients. Conclusion:Fungi was present in every nasal secretion, and type I hypersensitivity seemed not important in the pathogenesis of CRS. (Korean J Otolaryngol 2002;45:479-82)

비강점막 건조증 치료를 위한 Lanolin 크림의 이용

신승헌,예미경 대한비과학회 2007 Journal of rhinology Vol.14 No.2

Background and Objectives:Many people experience problems with a dry nasal mucous membrane, often without wondering why. The cause of problem is known as rhinitis sicca, senile rhinitis, and atrophic rhinitis, etc. A common form of treatment for patients who have such symptoms has been to begin by rinsing the inside of the nose with saline solution, to drop peanut oil, to apply antibiotic-ointment and moisturizing agents. Lanolin has been know as a safe skin moisturizing agent and used to treat dry nose. The purpose of this study was to evaluate the effect of lanolin on a group of patients seeking treatment for dryness of the nose. Material and Methods:Ninety-three patients experiencing problems with dry nasal mucosa were selected from the out-patient clinic. Fifty-seven patients, average age 36.3 years old, were treated with 1:2 mixture of lanolin and vaseline ointment. Thirty-six patients, average age 32.0 years, were treated with vaseline ointment. Both ointments were applied three times a day for two weeks. The efficacy of treatment was determined with pre and post-treatment six symptoms on a visual analogue scale:nasal obstruction, crust formation, mucosal dryness, respiratory discomfort, sleep disturbance, and general discomfort. Results:For subjects treated with lanolin, the average VAS value for nasal obstruction was 5.84±2.28 and it decreased to 2.89±1.29, while the corresponding values for subjects treated with vaseline were 4.39±1.77 decreasing to 3.11± 1.24 (p<0.05). Crust formation of lanolin treated subjects were 5.67±2.39 and it decreased to 2.09±1.46, while the vaseline treated subjects were 4.83±1.99 decreasing to 2.33±1.31 (p<0.05). Average total symptom improvement was 65.7% (from 27.95±9.30 to 9.86±4.58) in lanolin treated group, while it was 44.8% (from 20.9±76.59 to 11.64±4.18) in vaseline treated group. Conclusion:We found that the efficacy of lanolin was statistically signigicantly better than that of vaseline. During the study period, there was no local reactions have been reported, nor have any allergic reactions. The present study underlines the fact that the way to treat nasal mucosal dryness is to use lanolin ointment.

옴나리스Ⓡ에 의한 비용상피세포 염증반응 및 점액유전자 발현 억제

신승헌,강승현,진효승,김이혁,예미경 대한이비인후과학회 2014 대한이비인후과학회지 두경부외과학 Vol.57 No.9

Background and Objectives Glucocorticoids are a potent anti-inflammatory agent. The au-thors conducted this study to investigate the effect of Omnaris® on suppression of inflammation induction and mucin gene expression in nasal polyp epithelial cells. Subjects and Method Primary nasal polyp epithelial cells were stimulated by 5 ug/mL of streptococcal enterotoxin B (SEB) and lipopolysaccharide (LPS). To determine the effects of Omnaris®, cells were pretreated with 200, 100, 10, 1 ng/mL of Omnaris®. The anti-inflammatory effect of epithelial cells were confirmed by measuring interleukin (IL)-6, IL-8, and granulocyte-macrophage colony stimulating factor (GM-CSF), and mucin gene expressions were determined by real time PCR for MUC4, MUC5AC, MUC5B, MUC8. Results SEB and LPS enhanced the production of IL-6, IL-8, and GM-CSF from nasal polyp epithelial cells. The increased cytokine levels were significantly suppressed by Omnaris® at 100 and 10 ng/mL. The expressions of MUC4, MUC5AC, MUC5B, MUC8 mRNA, and MUC4 mRNA were increased by SEB and LPS, respectively. The increased expression of these mucin genes were significantly suppressed by 100, 10, and 1 ng/mL of Omnaris®. Conclusion Omnaris® significantly suppressed the production of chemical mediators and mucin gene expression, which indicated that Omnaris® is effective in improving and treating inflammatory diseases in the nasal cavity. Korean J Otorhinolaryngol-Head Neck Surg 2014;57(9):603-9

호산구성 만성비부비동염

신승헌 대한이비인후과학회 2013 대한이비인후과학회지 두경부외과학 Vol.56 No.9

Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the nasal and paranasal sinus mucosa. Generally CRS can classify depend on the presence of polyps or eosinophilic infiltration. Eosinophils have immune-modulatory effects on the inflammatory response of CRS and eosinophilia has been noted to be a marker for more extensive disease. Eosinophilic CRS (ECRS) is a clinical entity of chronic inflammation accompanied by numerous infiltrations of eosinophils in sinonasal tissues. The purpose of this review is to define and characterize the potential subcategories of ECRS and to discuss pathophysiology for targeted treatment modalities. Although it is difficult to differentiate one form of ECRS from another, genetic and molecular study will lead to unreveal the immunologic mechanism and pathogenesis of ECRS.

SESSION Ⅰ : 인간공학 ; 가속도 외란 자극에 의한 balance 능력의 평가 ( 고령자를 중심으로 )

신승헌 대한산업공학회 1989 89년도 PKIIE Vol.- No.-

정보전달에 있어서 System error

신승헌 대한인간공학회 1982 大韓人間工學會誌 Vol.1 No.2

과거의 많은 사고를 분석해 보면 정보전달에 어떤 결함이나 불비가 원인이 되어 사고가 발생한 예가 많다. 그 예로서 정비작업이 끝나기도 전에 전원을 넣어서 기계가 작동하여 정비원이 기계에 휘말려 사망했다던가, 공항에서 이륙태세를 취하고 있던 항공기가 소음때문에 관리관의 목 소리를 전부 듣지 못하고 이륙 OK 라고 생각하여 이륙동작을 하다가 다른 항공기와 충돌한 사고 등이 있다. 인적원인으로 되는 사고에서는 system error와 human error로 구분할 수 있다. system error는 인원의 부족, 순서의 불비, 통신의 불비와 같은 system의 구성요소가 적절하지 못하거나 충분하지 못한 때에 발생하는 error이다. 이에 반하여 human error는 system의 순서나 설계에서 미리 정해진 권동에 반대가 되는 인간의 행동 때문에 발생한다. 지금까지 human error에 의한 사고로서 결말을 지웠던 것도 그 원인을 깊이 추구해가면 생각 밖의 system error였던 예가 적지 않다. 그러므로 여기에서는 주로 정보전달과정에서 system의 불비로 인하여 발생하는 error에 대하여 고찰한다.

중고령 동노자의 노동적응능력의 평가

신승헌 대한인간공학회 1986 大韓人間工學會誌 Vol.5 No.2

In recent years, the average life span of people in advanced countries has increased. Conwequently, the number of middle-aged and old workers who have the will to work has increased. On the other hand, the declining birth rate has decreased the number of young workers. However, because many enterprises in advanced countries have extended their mandatory retirement age from 55 to 60 years, labor accidents involving aged workers are on the increase. As a result, the need for a method to evaluate the work skills of middle-age and old workers has become urgent. To explore one such method, this study investigated the relationship between aging and manual dexterity. Dexterity was found to deteriorate with age, but with large variability from individual to individual. The parameters of dexterity used in this experiment were found to be reliable.

진균의 단백질분해효소에 의한 비강 상피세포의 활성화

신승헌,박규옥,전창호 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.2

Background and Objectives:The nasal epithelium is the first barrier encountered by airborne allergens and an active participant in airway inflamation. Fungi have ben increasingly recognized as important pathogens in sinusitis and consists of several sm of epithelial cell activation. Subjects and Method:The epithelial cels of nasal polyp were obtained from patients and stimulated with Alternaria, Aspergillus, and Cladosporium. Interleukin-8 (IL-8), granulocyte-macrophage colony stimulating factor (GM-CSF), regulated on activation and normal T expressed and secreted (RANTES) were measured to determine the activation of tase-polymerase chain reaction (RT-PCR) test for protease-activated receptors (PARs) mRNA expresion in nasal epithelial cells were performed. Results:Fungi enhanced the production of chemical mediators from nasal epithelial cels. Serine protease inhibitors inhibited the activation of nasal epithelial cells. When nasal epithelial cells were activated, PAR2 and PAR3 mRNAs were more strongly expresed than non-activated cells. Conclusion:enhance the production of inflamatory cytokines. PARs might play a role in the proces of epithelial cell activation.

만성 부비동염과 진균의 역할

신승헌 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.4

딥러닝 기반 초단기 강수 예측 모델의 설명 가능성과 멀티 모달리티를 활용한 입력 변수 중요도 분석

신승헌,김소연,최준호,정성엽,최예지,최재식 한국기상학회 2023 한국기상학회 학술대회 논문집 Vol.2023 No.4