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송우정,김주영,조은정,이승은,김민혜,양민석,강혜련,박흥우,장윤석,민경업,조상헌 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.5
Purpose: The present study aimed to examine the age and gender distributions among chronic cough patients referred to a tertiary cough clinic inKorea, and to investigate clinical factors related to the demographic findings. Methods: Study participants were unselectively recruited from adultchronic cough patients who attended the cough clinic for the first time during one year. To validate their representativeness, their age and genderdistributions were compared to the entire chronic cough population, or with those presenting with other chronic disease. Data from the baseline investigationswere analyzed to identify clinical factors related to the demographic findings. Results: A total of 272 chronic cough patients were included. They had a middle-aged female predominant feature (mean age: 52.8±15.7 years and female 69.1%). Their age and gender distributionswere almost identical to the entire chronic cough population, but were distinct from patients with hypertension. Among clinical factors, the older femalepredominance was associated with enhanced capsaicin cough sensitivity, and also with the presence of ‘cough by cold air’ symptom. Allotussiaand laryngeal paresthesia were highly common in chronic cough patients, affecting 94.8% and 86.8% of them, respectively. Conclusions: Thepresent study demonstrated older female predominance among adult chronic cough patients attending a referral cough clinic in Korea. The demographicfeatures were significantly associated with the capsaicin cough responses and also potentially with allotussia (particularly cold air as thetrigger). These findings suggest a role of cough reflex sensitization in the pathophysiology of chronic cough in adults.
Cough Hypersensitivity Syndrome: A Few More Steps Forward
송우정,Alyn H Morice 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.5
Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high degree of morbidity. Recently, a unifying paradigm of cough hypersensitivity syndrome has been proposed. It represents a clinical entity in which chronic cough is a major presenting problem, regardless of the underlying condition. Although it remains a theoretical construct, emerging evidence suggests that aberrant neurophysiology is the common etiology of this syndrome. Recent success in randomized clinical trials using a P2X3 receptor antagonist is the first major advance in the therapeutics of cough in the past 30 years; it at last provides a strategy for treating intractable cough as well as an invaluable tool for dissecting the mechanism underpinning cough hypersensitivity. Additionally, several cough measurement tools have been validated for use and will help assess the clinical relevance of cough in various underlying conditions. Along with this paradigm shift, our understanding of cough mechanisms has improved during the past decades, allowing us to continue to take more steps forward in the future.
Two Cases of H2-Receptor Antagonist Hypersensitivity and Cross-Reactivity
송우정,김민혜,이상민,권용은,김새훈,조상헌,민경업,김유영,장윤석 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.2
H2-receptor antagonists, such as cimetidine, ranitidine and famotidine, are some of the most commonly prescribed medications for gastric acid-related disorders. These compounds are generally well-tolerated and anaphylactic reactions to them are rare. Here, we report two cases of H2-receptor antagonist-induced anaphylactic reactions: the first presented with sudden dyspnea, sneezing, urticaria, and swelling of the eyelids after ranitidine intake. The second presented with sudden severe urticaria, facial swelling, chest discomfort, dizziness, and hypotension. Possible cross-reactivity with other H2-receptor antagonists was assessed by oral challenge and skin tests. To date, only a few reports addressing cross-reactivity among H2-receptor antagonists have been published. We review the literature and summarize the data available on drug cross-reactivity in H2-receptor antagonist hypersensitivity.
Clinical Application of Exhaled Nitric Oxide Measurements in a Korean Population
송우정,조상헌,홍수종,권지원,김은진,이상민,김새훈,김상헌,박흥우,장윤석,이소연,김우경,심정연,서주희,김병주,김효빈,송대진,장광천,장안수,박정원,윤호주,이주실 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.1
Nitric oxide (NO) is a biologic mediator of various physiologic functions. Recent evidence suggests the clinical utility of fractional exhaled NO (FeNO) as a biomarker for assessing asthma and other respiratory diseases. FeNO methodologies have been recently standardized by international research groups and subsequently validated in several Korean population studies. Normal ranges for FeNO have been reported for various ethnic groups, and the clinical utility has been widely evaluated in asthma and various respiratory diseases. Based on current evidence including most of Korean population data, this position paper aims to introduce the methodological considerations, and provide the guidance for the proper clinical application of FeNO measurements in Korean populations.
송우정,김정원 한국품질경영학회 2019 한국품질경영학회 학술대회 Vol.2019 No.-
선정기업 YK네셔널은 사은품/ 사무용품 등 여러가지 제품을 직접 제작부터 유통까지 담당하는 유통업체이다. 우리는 기업 전반 프로세스를 파악한뒤 거기서 발생하는 문제점과 개선점을 데이터베이스(SSMS)프로그램 기반 통합과 공용을 통하여 해결하였다. 또 실질적인 프로그램 (비주얼베이직)을 통하여 실용 가능성도 보여주었다. 선정 기업을 대상으로 대상 업체의 소개, 현 상황 업무 분석, 문제점 및 개선안과 개선 후의 장단점 그리고 비용에 대하여 설명하였으며, 이를 통하여 개체 / 관계성 집합의 분석과 속성 및 영역의 정의 그리고 관계형 데이터베이스 및 정규화를 통하여 데이터 베이스에 대한 선 작업을 마무리하였고 이어서 데이터 베이스를 비주얼 베이직과 Sql을 사용하여 직접 구동시켰습니다.
Recent progress in the management of chronic cough
송우정,Jin An,Lorcan McGarvey 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4
Chronic cough is a common clinical condition with significant impact on quality of life and for which effective therapy remains an unmet clinical need. Over the past decade, there has been a major shift in how we approach this problem, driven by better appreciation of the clinical manifestation of chronic cough and an improved understanding of the associated neurobiology. “Cough hypersensitivity syndrome” has been proposed as a new diagnostic term for chronic cough, encompassing different phenotypes of the condition. Accumulating evidence suggests that this new concept is clinically relevant. However, while it is gaining widespread endorsement within the allergy and respiratory community, raising its profile in routine clinical practice is a priority. Thus, the present paper reviews recent progress in our understanding and management of chronic cough, with focus on mechanistic and clinical studies. It also provides detail on knowledge gaps and future research directions.
Defining Chronic Cough: A Systematic Review of the Epidemiological Literature
송우정,장윤석,Shoaib Faruqi,강민구,김주영,강민규,김수정,조은정,이승은,김민혜,Jana Plevkova,박흥우,조상헌,Alyn H. Morice 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.2
Purpose: Recent evidence suggests a global burden of chronic cough in general populations. However, the definitions vary greatly among epidemiological studies, and none have been validated for clinical relevance. We aimed to examine previous epidemiological definitions in detail and explore the operational characteristics. Methods: A systematic review was conducted for epidemiological surveys that reported the prevalence of chronic cough in general adult populations during the years 1980 to 2013. A literature search was performed on Pubmed and Embase without language restriction. Epidemiological definitions for chronic cough were classified according to their components, such as cutoff duration. Meta-analyses were performed for the male-to-female ratio of chronic cough prevalence to explore operational characteristics of epidemiological definitions. Results: A total of 70 studies were included in the systematic review. The most common epidemiological definition was identified as ‘cough ≥3 months’ duration without specification of phlegm (n=50); however, it conflicted with the cutoff duration in current clinical guidelines (cough ≥8 weeks). Meta-analyses were performed for the male-to-female ratio of chronic cough among 28 studies that reported sex-specific prevalence using the most common definition. The pooled male-to-female odds ratio was 1.26 (95% confidence interval 0.92-1.73) with significant heterogeneity (I2=96%, P<0.001), which was in contrast to clinical observations of female predominance from specialist clinics. Subgroup analyses did not reverse the ratio or reduce the heterogeneity. Conclusions: This study identified major issues in defining chronic cough in future epidemiological studies. The conflict between epidemiological and clinical diagnostic criteria needs to be resolved. The unexpected difference in the gender predominance between the community and clinics warrants further studies. Clinical validation of the existing definition is required.