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Analysis of the Clinicopathological Characteristics of Gastric Cancer in Extremely Old Patients
손일웅,정다현,김지현,정현수,박준철,신성관,이상길,이용찬 대한암학회 2017 Cancer Research and Treatment Vol.49 No.1
Purpose Gastric cancer is the third-leading cause of cancer-related death in Korea. As the Korean population is ageing, the number of extremely old patients with this disease is increasing. This study examined the clinicopathological characteristics of gastric cancer in extremely old (over 85 years) patients who received treatment or conservative observations and compared the treatment outcomes according to the treatment modality. Materials and Methods A total of 170 patients over 85 years of age were diagnosed with gastric cancer. Of these, 81 underwent treatment for gastric cancer and 89 received conservative observations. The clinicopathological characteristics of the treatment and conservative groups were compared. Results The mean age of the patients was 86.5 years. The conservative group included significantly more patients with older ages, macroscopically advanced cancer and upper-middle located cancer. The overall survival rate of the treatment group was significantly higher than that of the conservative group. The disease-specific mortality rate was significantly lower in the treatment group than in the conservative group. Multivariate analysis revealed the clinical course, alarm sign, and macroscopic classification to be independent prognosis factors. Conclusion By itself, the chronological age should not be used as a strategy to determine whether treatment will be administered for gastric cancer. Patients who have early gastric cancer or lowerrisk preexisting comorbidities should not be discouraged from treatment, even if they are older than 85 years.
손일웅 ( Il Woong Sohn ),방소영 ( So Young Bang ),김담 ( Dam Kim ),김태환 ( Tae Hwan Kim ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.1
Back pain is the most common symptom of ankylosing spondylitis (AS). The aggravation of back pain in AS patients is usually thought to be a flare-up of the disease activity. We report here on the case of a 31-year-old AS patient with low back pain. The lesions of this patient were unexpectedly diagnosed as metastatic spinal tumor due to cholangiocarcinoma. In a patient with AS, an acute aggravation of low back pain may be due to other pathologic conditions such as osteoporotic vertebral fracture, vertebral discitis and metastatic bone disease. Therefore, when a patient with AS presents with nonspecific low back pain, a physician should consider the above mentioned conditions.
Infliximab으로 치료한 건선 관절염 환자의 지염 1예
김담,손일웅,김진주,최윤영,정경희,김태환,성윤경 대한내과학회 2011 대한내과학회지 Vol.80 No.-
Dactylitis is a hallmark feature of psoriatic arthritis. It is usually managed with non-steroidal anti-inflammatory drugs and oral corticosteroids. Some cases have been treated successfully with intravenous corticosteroids or some disease-modifying antirheumatic drugs. Recently, inflximab has been reported as an effective treatment for dactylitis that is resistant to conventional treatment. This report describes a 37-year-old man with psoriatic arthritis who had multiple dactylitis on both thumbs and great toes. He was resistant to conventional treatment but was effectively treated with infliximab. This report highlights the effectiveness of infliximab for dactylitis, and the usefulness of blood pool imaging from bone scans as a method for determining treatment response. (Korean J Med 2011;80:S310-S313) 저자들은 건선 관절염으로 NSAIDs를 사용하던 환자에서 양측 엄지손가락의 지간 관절 및 말단과 양측 발의 지간 관절을 대칭적으로 침범한 건선 관절염에 의한 지염을 관찰하였고, infliximab을 투여하여 치료한 예를 경험하여 이런 예가 국내에서 보고가 없었으므로 이를 보고한다. 또한 본 환자에서는 단순 방사선 사진에서의 변화가 뚜렷하지 않아 bone scan 중 blood pool image로의 추적관찰이 유용했다.
Emerging Pathogens and Vehicles of Food- and Water-borne Disease Outbreaks in Korea, 2007–2012
문신제,손일웅,홍영선,이형민,박지혁,권근용,이상원,윤승기 질병관리본부 2014 Osong Public Health and Research Persptectives Vol.5 No.1
Objectives: Food- and water-borne disease outbreaks (FBDOs) are an important public health problem worldwide. This study investigated the trends in FBDOs in Korea and established emerging causal pathogens and causal vehicles. Methods: We analyzed FBDOs in Korea by year, location, causal pathogens, and causal vehicles from 2007 to 2012. Information was collected from the FBDOs database in the Korean Centers for Disease Control and Prevention. Results: During 2007e2012, a total of 1794 FBDOs and 48,897 patients were reported. After 2007, FBDOs and patient numbers steadily decreased over the next 2 years and then plateaued until 2011. However, in 2012, FBDOs increased slightly accompanied by a large increase in the number of affected patients. Our results highlight the emergence of norovirus and pathogenic Escherichia coli other than enterohemorrhagic E. coli (EHEC) in schools in 2012. We found that pickled vegetables is an emerging causal vehicle responsible for this problem. Conclusion: On the basis of this study we recommend intensified inspections of pickled vegetable manufacturers and the strengthening of laboratory surveillance of relevant pathogens.
증례 : 류마티스 ; Infliximab으로 치료한 건선 관절염 환자의 지염 1예
김담 ( Dam Kim ),손일웅 ( Il Woong Sohn ),김진주 ( Jin Ju Kim ),최윤영 ( Yun Young Choi ),정경희 ( Kyong Hee Jung ),김태환 ( Tae Hwan Kim ),성윤경 ( Yoon Kyoung Sung ) 대한내과학회 2011 대한내과학회지 Vol.80 No.2S
저자들은 건선 관절염으로 NSAIDs를 사용하던 환자에서 양측 엄지손가락의 지간 관절 및 말단과 양측 발의 지간 관절을 대칭적으로 침범한 건선 관절염에 의한 지염을 관찰하였고, infliximab을 투여하여 치료한 예를 경험하여 이런 예가 국내에서 보고가 없었으므로 이를 보고한다. 또한 본 환자에서는 단순 방사선 사진에서의 변화가 뚜렷하지 않아 bone scan 중 blood pool image로의 추적관찰이 유용했다. Dactylitis is a hallmark feature of psoriatic arthritis. It is usually managed with non-steroidal anti-inflammatory drugs and oral corticosteroids. Some cases have been treated successfully with intravenous corticosteroids or some disease-modifying antirheumatic drugs. Recently, inflximab has been reported as an effective treatment for dactylitis that is resistant to conventional treatment. This report describes a 37-year-old man with psoriatic arthritis who had multiple dactylitis on both thumbs and great toes. He was resistant to conventional treatment but was effectively treated with infliximab. This report highlights the effectiveness of infliximab for dactylitis, and the usefulness of blood pool imaging from bone scans as a method for determining treatment response. (Korean J Med 2011;80:S310-S313)
리네졸리드와 수술로 치료에 성공한 하지 동정맥 기형 감염과 동반 된 반복된 메티실린 내성 황색포도알균 패혈증 및 심내막염 1례
이강원,김혁,김지은,이길우,이형탁,김형태,김동찬,손일웅,배현주 대한감염학회 2010 Infection and Chemotherapy Vol.42 No.6
Vancomycin treatment failure in methicillin-resistant Staphylococcus aureus (MRSA) bacteremia patients has increased over the past decade. We experienced a case of repeated MRSA bacteremia resulting in left-side endocarditis in 38-yearold male with a huge complicated arteriovenous malformation in the left thigh. After vancomycin treatment failure, the patient was successfully treated with the administration of linezolid, leg amputation, and mitral valve replacement.
원저 : 피부근육염/다발근육염에서 발생한 자발 종격동기종의 임상적 의미
김진주 ( Jin Ju Kim ),김담 ( Dam KIm ),김은경 ( Eun Kyoung Kim ),손일웅 ( Il Woong Sohn ),정경희 ( Kyong Hee Jung ),최찬범 ( Chan Bum Choi ),성윤경 ( Yoon Kyoung Sung ),전재범 ( Jae Bum Jun ),엄완식 ( Wan Sik Uhm ),김태환 ( Tae H 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.2
Objective: Pneumomediastinum (PnM), a rare complication of dermatomyositis and polymyositis (DM/PM), is sporadic and has an unclear pathogenesis. PnM is almost always associated with interstitial lung disease (ILD), and is a poor prognostic factor in inflammatory myositis patients. We studied the prevalence of PnM in Korean DM/PM and its clinical significance. Methods: We retrospectively studied the medical records of 161 patients diagnosed with DM/PM meeting Bohan-Peter`s criteria at Hanyang University Hospital for Rheumatic Diseases from 1995 to 2010. We collected following findings; demographic data, diagnosis, lung involvement, cause of death, and duration from diagnosis to death. Results: One hundred nineteen patients (73.9%) were DM and 42 patients (26.1%) were PM. Eighty three patients (51.6%) developed ILD at diagnosis or during follow up. Eighteen patients (11.2%) died because of ILD aggravation, infection, or malignancy. The mean duration from diagnosis to death was 11.5 months, with 10 patients (6.2%) dying from from ILD aggravation but none with spontaneous PnM. 6 patients (3.7%) presented with PnM, and it was associated with ILD worsening in all cases. PnM resolved with O2 inhalation, corticosteroids, and/or immunosuppressive agents after 11 weeks (mean) of therapy Conclusion: PnM is rare but associates with DM and aggravation of ILD. PnM does not usually cause fatalities and can be cured by appropriate therapy.