Single-dose Intravenous Toxicology Testing of Daebohwalryeok Pharmacopuncture in Sprague-Dawley Rats

선승호,박선주,정종진,이광호,유준상,서형식,권기록 대한약침학회 2015 Journal of pharmacopuncture Vol.18 No.2

Objectives: The aims of the study were to test the single- dose intravenous toxicity of Daebohwalryeok pharmacopuncture (DHRP) in Sprague-Dawley (SD) rats and to estimate the crude lethal dose. Methods: The experiments were conducted at Biotoxtech Co., a Good Laboratory Practice (GLP) laboratory, according to the GLP regulation and were approved by the Institutional Animal Care and Use Committee of Biotoxtech Co. (Approval no: 110156). The rats were divided into three groups: DHRP was injected into the rats in the two test groups at doses of 10 mL/kg and 20 mL/kg, respectively, and normal saline solution was injected into the rats in the control group. Single doses of DHRP were injected intravenously into 6 week old SD rats (5 male and 5 female rats per group). General symptoms were observed and weights were measured during the 14 day observation period after the injection. After the observation period, necropsies were done. Then, histopathological tests were performed. Weight data were analyzed with a one-way analysis of variance (ANOVA) by using statistical analysis system (SAS, version 9.2). Results: No deaths and no statistical significant weight changes were observed for either male or female SD rats in either the control or the test groups during the observation period. In addition, no treatment related general symptoms or necropsy abnormalities were observed. Histopathological results showed no DHRP related effects in the 20 mL/kg DHRP group for either male or female rats. Conclusion: Under the conditions of this study, the results from single-dose intravenous injections of DHRP showed that estimated lethal doses for both male and female rats were above 20 mL/kg.

조직기업가정신이 예비창업자에게 주는 시사점

선승원,장아성,한정희,Seon, Seung Won,Jang, Ae Sung,Han, Jung Hee 한국벤처창업학회 2014 벤처창업연구 Vol.9 No.2

새롭게 창업을 준비하는 이들과 창업을 실행 단계에 옮기고 있는 이들에게는 많은 어려움들이 존재한다. 그리고 이를 극복하는데 무엇보다 중요한 요소로서 기업가정신이 요구된다. 하지만 기업가정신에 대한 이론과 연구들은 이들 창업자들과 예비창업자들에게는 접근하고 이해하기 어려운 것이 현 실정이다. 본 연구는 이러한 기업가정신이 실제 사례에서 어떻게 적용되고 있는지, 또한, 개인적인 기업가정신 조직 기업가정신이 창업초기서부터 어떠한 영향을 미치는지에 대해 중점을 두었다. 연구의 진행은 이론적인 어려움을 실제 사례로서 해석하기 위하여 국내의 2개의 중견 중소기업을 선정하였고, 이들 기업이 각각 30년, 20년을 성장할 수 있었던 원인에 대하여 기업가정신적인 요인을 파악하였고 쉽게 간과될 수 있는 조직기업가정신적인 특성을 함께 연구하였다. 2개 기업의 사례분석 결과는 크게 3가지로 요약할 수 있다. 첫 째, 창업초기부터 내부 네트워크 시스템을 잘 정비하였다. 이러한 숙달된 내부 네트워크는 장기적으로 외부 네트워크를 통해 직접적, 간접적인 네트워크 효과를 시장에서 빠르게 얻을 수 있었다. 두 번째, 최근 확산되고 있는 기업의 조직문화에 대한 창업자 개인과 조직적 차원의 수용이 시기적으로 매우 빨랐다. 이는 중소기업이 겪을 수 있는 인적자원문제를 해결하는 기초적인 원동력이 되었다. 마지막으로 기술혁신역량이다. 창업초기 사업을 진행하면서 나타나는 재무적인 어려움에도 불구하고 기술역량의 개발에 대한 집중적인 투자를 지속하였고, 이는 수익적인 성과 이외에도 최근 강조되는 지식재산 관리까지 빠르게 수용할 수 있는 결과를 가져왔다. 이 세 가지 특성은 창업자 개인들의 기업가적인 특성이면서도 동시에 조직이 보유한 초기부터의 특성이기도 하였다. 그리고 이러한 조직기업가적인 특성이 예비 창업자들에게 창업초기부터 꾸준하게 기업을 성장시킬 수 있는 핵심 요소로 본 연구에서는 판단하였다. Many preliminary entrepreneurs are ready to start a business in every year. However, starting and preparing business have a lot of difficulties. Entrepreneurship is the most important factor for overcoming these difficulties. But, it is not easy to understand entrepreneurship to founders despite many research scholars. In this paper, we are focused on easy understanding of entrepreneurs. Instead of vague theories, we analyzed selected two companies in Korea. From the beginning until now, these companies have founders entrepreneurship and organization entrepreneurship. we studied these entrepreneurship factors with other Various causes. Analysis of two cases is summarized into three type. First, both companies had well-founded internal network system. Trained employees in internal network were flexible to meet the market conditions. Also, network effect made that employees can offer their idea and make discussions. Second, The company quickly recognized for organizational culture despite of most other companies recent awareness. This factor was the basic driving force for solving human resource management problem of small size companies. final factor is innovation capacity of these companies. Financial difficulties experienced of establishment is common to every company. However, two companies has continued to invest research and development despite of this financial problem. As a result, intellectual property management was accepted, as well as technology development. Clearly, these three factors are consistently applied since established and led to the company's continued growth and success.

한약을 사용하는 아시아권 국가의 유해사례 보고 양식에 관한 비교 연구

선승호,이은경,장보형,박선주,고호연,전찬용,고성규,Sun, Seung-Ho,Lee, Eun-Kyoung,Jang, Bo-Hyoung,Park, Sunju,Go, Ho-Yeon,Jeon, Chan-Yong,Ko, Seong-Gyu 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objective : The purpose of this study is to find out the possibility of application to herbal medicine's report form for adverse drug reaction (ADR) by reviewing and analyzing Asian countries's ADR report forms. Method : We investigated, compared, and analyzed ADR report forms (ADR-RF) of Asian countries's ADR institutions (ACAI), such as, Korea institute of drug safety & risk management and Dongguk university Ilsan oriental hospital (DUIOH) in Korea, national center for ADR monintoring (NCAM) in China, pharmaceuticals and medical devices agency (PMDA) in Japan, Ministry of Health and Welfare (MOHW) in Taiwan, and drug office, department of health, the government of the Hong Kong special administrative region (GHKSAR) in Hong Kong. Results : ADR-RF for ACAI included common contents, such as, patients information (name(initial), gender, age, weight), adverse event (AE)'s report information (Recognition and report for AE occurrence, first or follow up report, Severe AE), the detailed information of AE (the title of AE, onset & closing date of AE symptoms, the progress & results detailed test of AE), the information of AE's medicine (the types of medicine, product name, ingredient name, suspected or combination drug, single dose & frequency, dosage form, administration route, dealing for AE-suspected medicine), and AE reporter's information (reporter's information, institution's information). Taiwan had ADR-RF and the department exclusively for herbal medicine (HM), but others (except DUIOH) had not only no ADR report form but also contents for HM. Conclusion : ADR-RF for HM have to include the common contents of ACAI at least, as well as HM information related to ADR, such as the title, composition and types of HM, history related to HM's ADR, and the contents of drug-induced liver injury and so on. In addition, the main department of government for HM's ADR will be needed.

2009년 유행 신종인플루엔자 A(H1N1)의 한약 및 기타 비전형적 치료에 대한 고찰

선승호,장인수,백유상,배선재,한창호,Sun, Seung-Ho,Jang, In-Soo,Baik, You-Sang,Bae, Sun-Jae,Han, Chang-Ho 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.3

Background : Since March 2009, when the first patient of novel influenza A (H1N1) was reported, many deaths have occurred in North and Central America. The start of the 2009 influenza pandemic was declared by WHO Director-General Dr. Margaret Chan on 11 June 2009, and the level of influenza pandemic alert raised from phase 5 to phase 6. There was no vaccine yet developed, and many experts worried that the novel H1N1 virus could kill as many or more as did the influenza pandemic in 1918-1919. Objective : To evaluate the possibility of treatment for 2009 novel influenza A (H1N1) using herbal remedies and other non-conventional therapies. Methods : We researched the clinical studies for novel H1N1 influenza virus-related herbal medicine or non-conventional medicine treatment using internet search engines including PubMed and CNKI. In addition, we reviewed many reports and clinical practice guidelines (CPG) for influenza A (H1N1). Results : Two case series were selected after reviewing 701 papers, and two CPG published by the Chinese government and Jilin province identified. They reported that the clinical symptoms were no more significant than seasonal influenza, and the condition of patients more than 45 years old was milder than those less than 45 years old. There are no patients with gastric problems, and oseltamivir has been used at the same time in all patients. Conclusion : The efficacy and effectiveness of herbal medicine and other non-conventional treatments for the novel influenza A (H1N1) is questionable, and more studies are needed to draw a firm conclusion. However, in the severe acute respiratory syndrome (SARS) experience in 2002/2003, it was demonstrated that herbal medicine can relieve all symptoms of SARS patients, promote absorption of lung inflammation, improve the degree of blood oxygen saturation, regulate immunological functions, reduce the required dosage of glucocorticoid and other medicines, and reduce case fatality rate. In light of the current situation that there is no vaccine or conventional treatment yet available, the study of herbal medicine and other non-conventional therapies are also necessary for appropriate evaluation.

중추성 현훈과 소뇌성 보행실조를 주소로 한 태음인 환자 치험2례

선승호,이재은,한동윤,이성우,이선란,고성규,Sun, Seung-Ho,Lee, Jae-Eun,Han, Dong-Youn,Lee, Seong-Woo,Lee, Seon-Lan,Ko, Seong-Gyu 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.2

The two case reports here presented are based on an inpatient with lateral medullary infarction, known as Wallenberg's syndrome with chief complains of central dizziness and cerebellar ataxia, and an inpatient with infarctions of cerebellar, pontine, and lacunar thalamic region. QSCCII was performed while the patient was hospitalized and, by consultation with the Dept. of Sasang Constitutional Medicine, the patient was diagnosed with Taeumin. Thus, an oriental medical therapy of Cheongsimyeonjatang, acupuncture, and moxibustion was carried out. As a result the degree of dizziness decreased noticeably while other symptoms improved as well. Before leaving the hospital, the degree of cerebellar ataxia also improved and the patient was able to go on foot by himself. In conclusion, significant improvements were observed in cerebellar and a pontine infarction patients who suffered central dizziness and cerebellar ataxia through Sasang medical therapy.

편두통 변증과 처방에 관한 문헌적 고찰 - 중국 논문 중심으로 -

선승호,고호연,Sun, Seung-Ho,Ko, Ho-yoen 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1

Objective : To investigate the syndrome differentiation's types and herbal medicine of migraine through Chinese journals review Methods : Journal search was performed using the searching engine of China Academic Journal(CAJ) in China National Knowledge Infrastructure(CNKI) from January 2000 to November 2010. Searching key words were "migraine", "chinese traditional medicine" and "syndrome differentiation". We included all kinds type of journals that explained or referred definite syndrome differentiations. The methods of treatment and Herbal medications by syndrome differentiation in contents of finally selected journals were extracted and summarized. Results : Eighteen chinese journals were selected finally. Fifteen kinds of syndrome differentiations about migraine were investigated, which included blood stasis due to qi stagnation (氣滯血瘀) quoted 15 times, middle obstruction of phlegm-dampness (痰濕中阻) 11 times, liver yang transforming into wind (肝陽化風) 10 times, deficiency of qi and blood (氣血虧虛) 6 times, wind-cold invading 風寒侵襲 淸陽鬱遏 4 times, cold invading reverting yin (寒犯厥阴) 4 times, liver-kidney deficiency (肝腎虧虛) 3 times, liver qi depression and qi stagnation (肝鬱氣滯) 2 times, liver depression transforming into fires (肝鬱化火) 2 times, wind-fire of liver-gallbladder (肝膽風火) 3 times, intense stomach fire and heat (胃火熱盛) 2 times, insufficiency of blood deficiency (血虛不榮) 2 times, insufficiency of qi deficiency (氣虛不充) 2 times, insufficiency of kidney qi and sea of marrow deficiency (腎氣不足, 髓海空虛) 2 times, and qi depression due to wind invading (風邪侵襲, 氣鬱不宣) 2 times. Conclusion : We suggests the first choice of oriental treatment for migraine can be considered among syndrome differentiation's types of blood stasis due to qi stagnation, middle obstruction of phlegm-dampness, liver yang transforming into wind, deficiency of qi and blood, and cold invading reverting yin. further systematic study will be needed.

대한민국 모병제 전환의 필요성과 도입 방안

선승배,박상혁 국제문화기술진흥원 2024 The Journal of the Convergence on Culture Technolo Vol.10 No.4

본 연구는 대한민국의 저출산 문제와 사회적 변화로 인한 징병제도의 지속 가능성에 대한 의문을 제기하며, 모병제 전환의 필요성과 도입 방안을 모색하는 데 목적이 있다. 대한민국은 오랫동안 징병제를 기반으로 국가 안보를 유지해왔지만, 병역자원 감소와 첨단 군사 기술 발전 등의 변화에 직면해 있다. 이를 해결하기 위해 국내외 모병제 사례를 분석하고, 대한민국 병역제도의 현황과 문제점을 진단하였다. 연구 결과, 모병제는 군의 전문성과 효율성을 제고하고, 개인의 선택권을 보장하며, 성별 불균형 해소와 사회적 형평성 증진에 기여할 수 있다는 장점이 있는 것으로 나타났다. 또한 모병제 도입을 위해 단계적 로드맵을 제안하였으며, 이를 뒷받침하기 위한 법적 및 제도적 기반 마련의 필요성과 국민적 공감대 형성을 위한 방안을 제시하였다. 특히, 모병제 전환이 국가 경제에 미칠 긍정적 영향과 장기적 관점에서의 국방비 절감 가능성도 논의되었다. 본 연구는 한국형 모병제 도입을 위한 구체적인 전략과 정책 제언을 통해, 미래 안보환경 변화에 선제적으로 대응하고 지속 가능한 국방태세를 확립하는 데 기여하고자 한다. This study aims to address the sustainability of South Korea's conscription system, which is being questioned due to issues like low birth rates and societal changes, and to explore the necessity and implementation strategies for transitioning to an all-volunteer force (AVF). South Korea has long maintained national security through conscription, but it now faces challenges such as a decrease in military resources and the advancement of high-tech military technologies. To address these challenges, the study analyzes domestic and international cases of AVF and assesses the current state and issues of South Korea's military service system. The findings indicate that an AVF can enhance military professionalism and efficiency, respect individual choice, and contribute to reducing gender imbalance and promoting social equity. A phased roadmap for the implementation of the AVF is proposed, along with the need for legal and institutional frameworks and measures to foster public consensus. The study also discusses the potential positive economic impacts and long-term cost savings of the AVF. This research aims to provide concrete strategies and policy recommendations for adopting a Korean-style AVF, thereby proactively responding to changes in the future security environment and establishing a sustainable national defense posture.

Case Series Report on the Effect of Hand Acupuncture - Focusing on 29 Patients with Headache -

선승호 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.3

Objectives : The purpose of 29 case series is to report the possibility that a hand acupuncture is effective in relieving headache. Methods : After approval from the Institutional Review Board (IRB), I analyzed 29 cases medical records of outpatients with headache, who visited OO oriental medical hospital from December 2008to December 2010, who have taken a hand acupuncture's treatment without other intervention, and who were diagnosed with one disease of international classification of headache disease second version (ICHD-2). The data was analyzed with Wilcoxon signed rank test to determine whether a hand acupuncture's treatment differed between before and after treatment's Visual Analogue Scale(VAS) according to types of headache and syndrome differentiation. Statistics program was used SPSS 18.0. Differences were considered significant at P<0.05. Results : The VAS of patients with headache was reduced after treatment of hand acupuncture from 6.57±2.04 to 2.90±2.04 for overall headache, from 6.32±2.05 to 2.47±2.03 for tension-type headache(P<0.001), from 7.10±2.18 to 3.70±1.77 for migraine(P<0.001), and from 6.00±1.41 to 2.50±3.54 for headache unspecified. A hand acupuncture produced a decrease in VAS of both ascendant hyperactivity of liver yang(P<0.001) and phlegm turbidity according to syndrome differentiation(P=0.002). No adverse event were encountered in any of the patients. Conclusions : It is suggested that a hand acupuncture may be effective in relieving headache, and could be applicable to first choice of acupuncture treatment for headache.

Petri-Net을 이용한 효과적인 다중로봇 제어알고리즘의 구현

선승원(Seung-Won Sun),국태용(Tai-Young Kurk) 제어로봇시스템학회 2003 제어·로봇·시스템학회 논문지 Vol.9 No.11

수족냉증 치료 표준화를 위한 델파이 연구

선승호,고호연,고승우,조윤영,신지혜,김태훈,최동준,이진무,장준복,정기용,송윤경,고성규,최유경,임은미,박종형,전찬용,Sun, Seung-Ho,Go, Ho-Yeon,Ko, Seungwoo,Cho, Yoon-Young,Shin, Ji-Hye,Kim, Tae-Hoon,Choi, Dong-Jun,Lee, Jin-Moo,Jang, Jun-Bok,Jung, Ki-Yon 대한예방한의학회 2015 대한예방한의학회지 Vol.19 No.3

Objective : The purpose of this study is to figure out the treatment of coldness in hands and Feet by using Delphi survey. Method : This study was approved by institutional review boards at Kyung Hee University. Self recording type delphi survey were sent by e-mail to 55 Korean medicine specialists (19 gynecologist, 36 internal medical doctors) who treat coldness in hands and Feet. And replies were analyzed. As this study is cross sectional study, simple descriptive analysis was applied. Results & Conclusion : Herbal medicine, acupuncture and moxibustion were mainly applied and extract (granule), pharmacopuncture, bee venom pharmacopuncture and cupping therapy were also added case by case. Treatment was done twice a weak for 4 months. Cupping therapy was done at GB21 and SI11. Bee venom pharmacopuncture and Kidney yang deficiency pharmacopuncture were applied at ST36, GB21, CV4 and LR3. As extract (granule) Ijungtang, Dangguisayeokgaosuyusaenggangtang and Dangguisayeoktang were mainly used and as herbal medicine formula Palmijihwangwon, Bojungikgitang, Ijungtang, Danggwisayeok-gaosuyusaenggangtang and Danggwisayeoktang were mainly prescribed. Comprehensive treatment of acupuncture, moxibustion and herbal medicine was considered to have more effective and more rapid result than single treatment of herbal medicine have.