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Glycated Serum Albumin Induces Interleukin-6 Expression in Vascular Smooth Muscle Cells
Seung-Il Baek(백승일),Byung-Yong Rhim(임병용),Koanhoi Kim(김관회) 한국생명과학회 2011 생명과학회지 Vol.21 No.1
Glycate화된 단백질이 혈관질환의 발생에 관여하는지 알아보기 위하여 glycated albumin (GA)이 혈관평활근세포에서 인터루킨-6 발현에 영향을 주는지 조사하고 또한 그 기전을 구명하였다. GA에 노출된 혈관평활근세포에서 인터루킨-6 transcript가 증가하고, 인터루킨-6 단백질의 분비가 증가하고, 또한 인터루킨-6 유전자의 promoter가 활성화되었다. GA에 의한 인터루킨-6 유전자의 promoter 활성화는 dominant negative 형태의 Toll-like receptor (TLR)-4와 myeloid differentiation factor 88 (Myd88)에 의하여 크게 감소되었지만, dominant negative 형태의 TLR-2와 TIR-domain-containing adapter-inducing interferon-β (TRIF)의 영향을 받지 않았다. 그리고 Extrcellular signal-related kinase (ERK) 억제 물질들은 GA에 의한 인터루킨-6의 분비 및 인터루킨-6 유전자 promoter 활성화를 억제하였다. 그리고 인터루킨-6 유전자의 promoter의 NF-κB-binding sequence에 변이는 GA에 의한 인터루킨-6 유전자의 promoter 활성화 억제하였다. 이러한 결과는 혈관평활근세포에서 GA에 의한 인터루킨-6 유전자 활성화에 TLR-4와 ERK 및 NF-κB가 관여함을 의미한다. Diabetes mellitus is associated with vascular complications. Diabetic patients exhibit high levels of glycated adducts in serum compared to non-diabetic individuals. The aim of this study was to investigate whether extracellular glycated albumin (GA) predisposes vascular smooth muscle cells (VSMCs) to pro-inflammatory phenotype. Exposure of rat aortic smooth muscle cells (AoSMCs) to GA not only enhanced interleukin-6 (IL-6) release but also activated promoter activity of the IL-6 gene. GA-induced IL-6 promoter activation was suppressed by dominant-negative forms of Toll-like receptor (TLR)-4 and myeloid differentiation factor 88 (MyD88), but not by dominant-negative-forms of TLR-2 and TIR-domain-containing adapter-inducing interferon-β (TRIF). Extracellular signal-regulated kinase (ERK) inhibition and diphenyleneiodium (DPI) also attenuated IL-6 induction by GA. Mutation at the nuclear factor-κB (NF- κB)-binding site in the IL-6 promoter region suppressed promoter activation in response to GA. The present study proposes that GA would contribute to inflammatory reaction in the stressed vasculature by inducing IL-6 in VSMCs, and that TLR-4, EKR, and NF-κB play active roles in the process.
폐유(肺兪)·격유(膈兪)의 호도약침(胡桃藥鍼) 자극이 알레르기 반응에 미치는 영향
백승일,이용태,장경전,Baek, Seung-il,Lee, Yong-tae,Jang, Kyung-jeon 대한침구의학회 2003 대한침구의학회지 Vol.19 No.3
Objective & Methods : Experimental studies were done to research the clinical effects of Juglandis Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) on the anti-allergic response. anaphylaxis provoked by the compound48/80, delayed type hypersensitivity response to picryl chloride and SRBC and inflammation response to egg albumin. Results : The following results have been obtained; 1. Juglandis Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) group were increased the survival rate in compound 48/80 induced systemic anaphylactic reaction. 2. Picryl chloride induced contact dermatitis and delayed type hypersensitivity in SRBC challenged mouse were significantly decreased in Juglandis Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) group. 3. Inflammation response-WBC, CRP and Nitric Oxide in egg albumin induced allergic rat were significantly decreased in Juglandis Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) group. Conclusions : According to the above results, Semen aqua-acupuncture and acupuncture($BL_{13}{\cdot}BL_{17}$) both depress the allergy reaction.
Identification of Fel ursi and Cattle and Pig Bile Juices by speciesspecific PCR and PCR-RFLP
권기록,백승일,최석호,Kwon, Ki-Rok,Baek, Seung-Il,Choi, Suk-Ho KOREAN PHARMACOPUNCTURE INSTITUTE 2009 Journal of pharmacopuncture Vol.12 No.1
Objective : This study developed species-specific PCR and PCR-RFLP to detect the adulteration of Fel ursi products with cattle and pig bile juices. Methods : All the primers for PCR and PCR-RFLP in this study were designed based on nucleotide sequences of cytochrome b genes in the mitochondria. Results : The species-specific PCR amplified a DNA fragment of 214, 214, 295, and 167 bp from Fel ursi product, bear fur, cattle bile juice, and pig bile juice, respectively. The survey using the speciesspecific PCR indicated that some of commercial Fel ursi products were adulterated with cattle and pig bile juices. PCR-RFLP using the restriction endonucleases, HaeIII and HinfI enabled differentiation among Fel ursi product, cattle bile juice, and pig bile juice. Bear furs from two animals showed variations in PCR-RFLP patterns with HaeIII. Discussion : The detection methods of the species-specific PCR and PCR-RFLP could be useful in eliminating adulterated Fel ursi products from the market.
관절경적 후내측 도달법을 이용한 슬와 낭종의 절삭 절제술
곽경덕,안상민,백승일,정찬종,노재수,Kwak, Kyoung-Duck,Ahn, Sang-Min,Baek, Seung-Il,Jung, Chan-Jong,Roh, Jae-Su 대한관절경학회 2006 대한관절경학회지 Vol.10 No.2
목적: 관절경적 후내측 도달법을 이용한 밸브기전의 교정을 통한 슬와 낭종의 절삭 절제술의 임상적 결과와 그 유용성을 보고 하고자 한다. 대상 및 방법: 2004년 4월부터 2005년 6월까지 변형된 관절경적 방법으로 슬와 낭종을 치료하였던 15례를 대상으로 하였다. 평균추시 기간은 15개월(범위: $12{\sim}28$) 이었다. Rauschning과 Lindgren의 평가 기준을 근거로 예후를 판정하였으며, 수술에 소요된 시간과, 슬관절의 통증이 없어지고 완전한 운동범위를 얻는데 걸린 기간을 측정하였다. 수술 후 12개월에 초음파를 시행하여 재발 여부를 관찰하였다. 결과: 기능평가는 Rauschning 과 Lindgren의 기준으로 최종 추시시 전례에서 Grade 0 또는 Grade 1 이었다. 수술 시간은 평균 45분(범위 $35{\sim}70$) 이었다. 전례에서 수술 후 5일 이내에 통증 없는 슬관절 운동범위의 완전한 회복을 얻을 수 있었으며, 1년 이상의 최종 추시에서도 운동범위는 모두 정상이었다. 재발한 예는 없었고, 통증과 보행 장애도 없었다. 결론: 후내측 도달법을 이용한 관절경술은 낭 주름의 밸브기전을 쉽게 교정할 수 있고, 슬와 낭종의 절삭술을 효과적으로 시행할 수 있는 대치방법으로 사료된다. Purpose: We evaluated the effectiveness of arthroscopic shaving cystectomy by using posteromedial portal for popliteal cyst with the correction of valvular mechanism. Materials and Methods: We had treated 15 cases of popliteal cyst with arthroscopic shaving cystectomy by using posteromedial portal from April 2004 to June 2005. The mean duration of follow up was 15 months (range: $12{\sim}28$). Functional results were based on the Rauschning and Lindgren criteria. We estimated operative time, time for regaining pain-free full range of motion and checked sonography for recurrence of the cyst at 12 months after the surgery. Results: The functional results by Rauschning and Lindgren criteria were rated Grade 0 or Grade 1 in all cases at last follow up. The average operation time was 45 minutes (range: $35{\sim}70$). All cases regained pain-free full range of motion within five days after surgery and range of motion was also normal at last follow up. There were no recurrence and no walking disturbance in all cases. Conclusion: Arthroscopic shaving cystectomy by using posteromedial portal is one of the effective alternative method of the treatment for popliteal cyst and it is also useful to correct the valvular mechanism.