비 카세트 방식과 카세트 방식을 이용한 [⁶⁸Ga]PSMA-11의 자동 합성 방법 비교

박현식,조병민,안현호,이홍진,이진형,이경재,이병철,이원우,Hyun-Sik, Park,Byeong-Min, Jo,Hyun-Ho, An,Hong-Jin, Lee,Jin-Hyeong, Lee,Gyeong-Jae, Lee,Byung-Chul, Lee,Won-Woo, Lee 대한핵의학기술학회 2022 핵의학 기술 Vol.26 No.2

Purpose [⁶⁸Ga]PSMA-11 is needed the high reproducibility, excellent radiochemical yield and purity. In term of radiation safety, the radiation exposure of operator for its production also should be considered. In this work, we performed a comparative study for the fully automated synthesis of [⁶⁸Ga]PSMA-11 between non-cassette type and cassette type. Materials and Methods Two different type of modules (TRACERlab FX N pro for non-cassette type and BIKBox for cassette type) were used for the automated production of [⁶⁸Ga]PSMA-11. According to the previously identified elution profile, Only 2.5 ml with high radioactivity was used for the reaction. After adjusting the pH of the reaction solution with HEPES buffer solution, the precursor was added and reacted with at 95 ℃ for 15 minutes. The reaction mixture was separated and purified using a C18 light cartridge. The product was eluted with 50% EtOH/saline solution and diluted with saline. It was completed by sterilizing filter. In the non-cassette type, the aforementioned process must be prepared directly. However, in the cassette method, synthesis was possible simply by installing a kit that was already completed. Results Both total [⁶⁸Ga]PSMA-11 production time were 25±3(non-cassette type) and 23±3 minutes(cassette type). The radiochemical yield of the non-cassette type(65.5±5.7%) was higher than that of the cassette type(61.6±4.8%) after sterilization filter. The non-cassette type took about 120 minutes of preparation time before synthesis due to washing of synthesizer and reagent preparation. However, since the cassette type does not require washing and reagent preparation, it took about 20 minutes to prepare before synthesis. Both type of synthesizer had a radiochemical high purity(>99%). Conclusion The non-cassette type production of [⁶⁸Ga]PSMA-11 showed higher radiochemical yield and lower cost than the cassette type. However, The cassette type has an advantage in terms of preparation time, convenience, and equipment maintenance.

고력황동의 Hard Spots 형성에 미치는 첨가원소의 영향

박현식,나형용 ( Hyun Sik Park,Hyung Yong Ra ) 한국주조공학회 1986 한국주조공학회지 Vol.6 No.1

This study was undertaken to understand the formation mechanism of the hard spots in high strength brass. To investigate the behavior of the hard spots in the isothermal liquid state with varying silicon content, the rapidly quenched specimens were obtained by suctioning the melt into the silica tube and water quenching. To examine the growth process of the hard spots with holding time, the unidirectional solidification technique was used. The results of this study are summarized as follows: 1) With the addition of Fe in order to get the effects of grain refinement in high strength brass, the two different type of Fe-rich phases are occurred, which are defined as dendritic and globular phase. The chemical composition of the globular phase was different from that of the dendritic phase in that the globular phase contained Si. 2) With increasing Si content, the Fe-rich phase had a tendency to form globular phase. 3) As the holding time increased in the liquid state, globular was also prone to coalesce. The further growth of globular phase to large size was due to reducing the interfacial energy. 4) The primary phase of copper alloy was nucleated preferentially on the dendritic phase. It was noticeable that the dendritic phase acted as a grain refiner. However, the agglomerate (hard spots) which was composed of the globular phase decreased the mechanical properties of high strength brass. 5) Once the hard spots formed in the high strength brass casting, it was very difficult to remove them. This is due to the fact that their meting temperature is higher than the pouring temperature of high strength brass.

박막저항기 특성에 미치는 제조 공정 인자의 영향

박현식,유윤섭,Park Hyun-Sik,Yu Yun-Seop 한국마이크로전자및패키징학회 2005 마이크로전자 및 패키징학회지 Vol.12 No.1

저항 값을 맞추기 위한 트리밍 공정이 낮은 저항온도계수와 높은 정밀성을 요구하는 박막저항기 특성에 미치는 영향에 대한 연구가 수행되었다. 스퍼터링 방법으로 제조된 박막 저항기의 트리밍 속도에 따른 저항기의 특성 변화와 온도계수의 변화가 관찰되었다. 트리밍 속도의 증가에 따라서 박막 저항기 특성은 저하되었으며, 열처리로 저항 값의 평균 편차 $0.26\%$ 및 저항온도계수 52.77(ppm/K)의 개선효과가 있었다. 1k$\Omega$와 10k$\Omega$저항기가 100k$\Omega$ 박막저항기 보다는 특성이 양호하였으며, 트리밍 속도의 치적 조건으로는 20mm/sec와 특성 개선을 할 수 있는 최적 열처리 온도는 593K였으며 최적 조건에서 제작된 저항기의 저항 값의 평균 편차는 $0.31\%$ 및 저항온도계수 10(ppm/K)미만이었다. The effect of trimming process to adjust accurate resistance of a thin-film resistor was studied with respect to low temperature coefficient of resistance(TCR) and high precision. The characteristics of a thin-film resistor fabricated by sputtering were investigated depending on trimming condition and annealing temperature. Measured results showed that the characteristic of a thin-film resistor was degraded with increased trimming speed. However, an average resistance deviation and a TCR were improved to $0.26\%$ and 52.77[ppm/K], respectively, through annealing treatment. Also, thin-film resistors with 1 k$\Omega$ and 10k$\Omega$ showed better performance compared to a resistor with 100k$\Omega$. The Optimal trimming speed and annealing temperature were 20mm/sec and 539K, respectively, and under this optimal condition, a thin-film resistor with an average resistance deviation of $0.31\%$ and a TCR of below 10[ppm/K] was obtained.

가시광에서 하이브리드 렌즈를 사용한 반사굴절식 전방위 줌 광학계의 설계 및 성능평가

박현식,조재흥,Park, Hyun Sik,Jo, Jae Heung 한국광학회 2020 한국광학회지 Vol.31 No.2

주간 무인 감시를 위하여 가시광 파장 범위인 400~700 nm에서 렌즈와 거울의 기능을 동시에 갖는 구멍 없는 하이브리드 렌즈를 활용한 반사굴절식 전방위 줌 광학계를 설계하고 그 성능을 분석하였다. 하이브리드 렌즈는 렌즈에 구멍을 뚫는 작업이 없고 광학 부품의 수량을 줄일 수 있기 때문에 전방위 줌 광학계의 제작과 조립에서 많은 장점을 갖는다. 이 광학계에서 결상된 도넛 형태의 상에서 안쪽의 압축된 낮은 공간주파수의 상 영역을 확대하여 보기 위해서 줌 렌즈의 기능을 추가한 전방위 광학계의 최적화 설계를 진행하였다. 그 결과 최적화 설계된 광학계의 변조전달함수, 스폿 다이어그램 분석, 공차 분석을 통해 이 광학계의 성능을 분석한 결과로부터 설계 목표 사양을 만족함을 알 수 있었다. 줌 광학계를 주밍할 때 -30~50℃의 온도 변화에 따른 비열화 해석을 한 결과, 적절한 렌즈의 재질을 선정하여 온도 변화에도 상 거리 변화가 거의 없는 광학계임을 확인하였다. A catadioptric omnidirectional zoom optical system using a hybrid lens (COZOSH) that performs simultaneously two functions of a lens and a mirror was designed at the visible wavelength range for daytime unmanned surveillance, and its performance was analyzed. The hybrid lens has lots of advantages in terms of fabrication and assembly of a COZOSH, because of the obviation of a lens boring process and reduction of the number of optical components. Additionally, we designed the COZOSH to expand the compressed inner-image region of a donut image at low spatial frequencies. As a result, the optimized design performance of the optical system that satisfies all initial design specifications was obtained from calculation of the modulation transfer function, spot diagram, and tolerance analysis. We confirmed that the COZOSH is a passively athermalized optical system under conditions of temperature variation from -30℃ to 50℃, by using athermalization analysis during zooming.

원자층 증착법(Atomic Layer Deposition)에 의해 성장된 단말장치용 ZnO 투명 전도 박막 특성

박현식(Hyun Sik Park) 대한전기학회 2012 정보 및 제어 심포지엄 논문집 Vol.2012 No.10

코딩 교육을 위한 그래픽 기반의 게임 제작 도구 개발

박현식(Hyun Sik Park),박민우(Min Woo Park),나정일(Jeong Il Na),한경현(Kyung-Hyun Han),황성운(Seong Oun Hwang) 대한전자공학회 2019 대한전자공학회 학술대회 Vol.2019 No.11

Research on changes in social perceptions of games, software education, and coding education is being actively conducted. One of the most important things in the education of young students is how to draw their attentions. Games are powerful tools to draw their interests, and we suggest a simple and easy way to create a game.

복지국가의 변화에 따른 노후소득보장제도 구축

박현식(Park, Hyun-Sik),김근홍(Kim, Keun-Hong) 한국지역사회복지학회 2009 한국지역사회복지학 Vol.0 No.29

지역자활사업의 임파워먼트 확립을 위한 개선방안

박현식(Park, Hyun-Sik),김세원(Kim, Se-Won) 한국지역사회복지학회 2006 한국지역사회복지학 Vol.18 No.-

혈액종양 ; 납 함유 한약환에 의한 철적모구빈혈(sideroblastic anemia) 1예

박현식 ( Hyun Sik Park ),김성용 ( Sung Young Kim ),조진희 ( Jin Hee Cho ),문희원 ( Hee Won Moon ),윤소영 ( So Young Yoon ),조요한 ( Yo Han Cho ),이홍기 ( Mark Hong Lee ) 대한내과학회 2010 대한내과학회지 Vol.79 No.4

Although lead intoxication is commonly mentioned as a cause of sideroblastic anemia, no well-documented case exists in the literature. We encountered a patient with sideroblastic anemia caused by lead-containing herbal medicine. A 34-year-old woman was admitted to our hospital with abdominal pain. She had taken herbal medicine for her general health. Anemia, hyperbilirubinemia, and elevated lactic dehydrogenase were found from the laboratory data. Bone marrow biopsy showed pathological ringed sideroblasts. Her serum level of lead was high and the lead content of the tablet was higher than permitted. We diagnosed her with sideroblastic anemia secondary to lead poisoning caused by herbal medicine. We stopped her from taking herbal medicine and she gradually recovered from anemia. (Korean J Med 79:448-452, 2010)

필리핀 베이비부머 교민의 성공적 노후준비

박현식(Hyun-Sik Park) 한국콘텐츠학회 2013 한국콘텐츠학회논문지 Vol.13 No.10

본 연구는 필리핀 교민 중 베이비부머의 노후준비가 성공적 노후에 미치는 영향을 알아보기 위해 필리핀 마닐라에 거주하는 베이비부머(1955-1963년생)을 대상으로 2011년 6월 1일부터 8월 15일까지 이루어졌으며, 배포된 총 150부 중 105부를 SPSS 18.0프로그램을 이용하여 분석하였다. 본 연구는 해외 교민들의 노후 준비 실태 파악을 통해 해외 교민의 노후 정책을 수립하는데 기초자료를 제공하는데 목적을 두고 연구하였다. 연구결과 연구 대상자들은 경제적 노후준비 수준이 상대적으로 가장 높았으며, 신체적 노후준비, 정서적 노후준비는 비슷한 수준으로 나타났다. 성공적 노후를 위해서 정서적 준비가 경제적, 신체적 준비에 비해 중요도 및 예측에 있어서 상대적인 영향력이 매우 큰 것으로 나타났으며 해외 교민의 노후에 대한 사회복지적 정책을 수립하기 위해 정서적 프로그램의 개발이 필요하다. This research was conducted to explore the influences and factors that are related to the preparation for successful aging life after retirement of Koreans living in Philippine. The subject of survey is the generation of baby-booming(born from 1955-1963) and it was done from June 1 to August 15 in 2011. 150 survey questionnaire sheets were distributed and 126 answered sheets returned. Among them 105 that are to be recognized were analyzed using SPSS 18.0 program. The purpose of this research and the survey is to provide basic sources and information for setting up policies and programs of aged life of the generation. The survey shows that the answers are in comparatively good financial level including average level of physical readiness and mental stability. Relative impacts are also strong in mental attitude and emotional preparation.