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박정열,신수정,김재관,Kyoung Chan Park,박정호 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.9
To improve Alzheimer's disease (AD) therapeutics, we have designed and synthesized new benzoisoxazole derivatives that are potent inhibitors of cholinesterase (acetylcholinesterase [AChE] and butyrylcholinesterase [BuChE]). Since inhibition of cholinesterase (ChE) is still considered to be one of the most effective ways of treating AD patients, many new classes of ChE inhibitors have been synthesized. To identify a new type of cholinergic drug, the benzoisoxazole moiety which is the pharmacophore moiety of Risperidone was coupled with natural antioxidants. Some benzoisoxazole derivatives (26–28 and 30) were found to effectively inhibit BuChE (IC50 < 20 μM), and some (20 and 26–28) to moderately inhibit AChE (IC50 < 100 μM). Furthermore, compound 28 showed better inhibitory activity against BuChE (IC50 = 0.72 ± 0.11 μM) than galantamine (IC50 = 8.4 ± 0.1 μM). The new benzoisoxazole derivatives showing BuChE inhibitory activity represent a new class of ChE inhibitor and can be used to create novel compound derivative drugs for treating AD patients.
자궁내막증이 동반된 Mayer-Rokitansky-$K{\ddot{u}}ster$-Hauser 증후군의 수술적 치료경험 1례
박정열,김정훈,강천식,이지영,박소연,김성훈,채희동,강병문,Park, Jeong-Yeol,Kim, Chung-Hoon,Kang, Cheon-Sik,Lee, Ji-Young,Park, So-Youn,Kim, Sung-Hoon,Chae, Hee-Dong,Kang, Byung-Moon 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.2
The Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome refers to a condition which presents as normal female secondary sex characteristics, normal external genitalia, congenital absence of the internal vagina, usually a rudimentary uterus in the form of bilateral noncanaliculated muscular buds, and normal tubes and ovaries with normal cytogenetic and endocrine evaluation, frequent association of renal, skeletal and other congenital anomalies. However, rarely, whole uterus or a segment of uterus may be present, but lacking a conduit to the introitus. If a partial endometial cavity is present in a segment of uterus, cyclic abdominal pain may be a complaint and furthermore endometiosis can be developed. Recently, we experienced a case of MRKH syndrome with the segments of uterus accompanying endometriosis in young woman. We present this case with a brief review of literatures.
한영 병렬 코퍼스 구축을 위한 하이브리드 기반 문장 자동 정렬 방법
박정열,차정원,Park, Jung-Yeul,Cha, Jeong-Won 대한음성학회 2008 말소리 Vol.68 No.-
The recent growing popularity of statistical methods in machine translation requires much more large parallel corpora. A Korean-English parallel corpus, however, is not yet enoughly available, little research on this subject is being conducted. In this paper we present a hybrid method of aligning sentences for Korean-English parallel corpora. We use bilingual news wire web pages, reading comprehension materials for English learners, computer-related technical documents and help files of localized software for building a Korean-English parallel corpus. Our hybrid method combines sentence-length based and word-correspondence based methods. We show the results of experimentation and evaluate them. Alignment results from using a full translation model are very encouraging, especially when we apply alignment results to an SMT system: 0.66% for BLEU score and 9.94% for NIST score improvement compared to the previous method.
박정열 ( Jung Ryul Park ),방경식 ( Kyung Sik Bang ) 한국감정평가학회 2007 감정평가학논집 Vol.6 No.1
Appraisers have been stably done their jobs for 35 years according to the needs of the country. The number of appraiser and the size of appraisal market have been increased by 2,500 persons and 500 billion won, respectively. Developing new areas of the appraisal business is essence to appraisers business because of social and economic environmental change. However appraisers hesitate to expand their business into the other market in spite of they have high competition each other in their business. Appraisers have to cooperate with the specialists of the other business, such as lawyers and certified public accountants. In the research, we interviewed specialists and asked them about the cooperation with appraisers. Most of the specialists are in favour of business affiliations with an appraiser. Therefore appraisers have to expand a new business area with a positive attitude. Otherwise, other specialists try slowly and easily to invade the appraisers business. Appraisers have to make an effort to protect the existing business area. In order to protect their interest, appraisers have to increase R&D investment and strengthen their professionalism. Also, it is important that appraisers realize the threat of their survivals.
Analysis and control of adhesion for efficient transfer printing
박정열(Jungyul Park),김민석(Min Sock Kim),이탁건(Tahk Guhn Lee),최범규(Bumkyoo Choi) 한국생산제조학회 2011 한국생산제조시스템학회 학술발표대회 논문집 Vol.2011 No.4
The adhesion-based transfer printing process allows the devices to be fabricated through low temperature process, which is important for realizing flexible electronics with high mobility. Therefore, comprehensive understanding about adhesion between the solid object and the surface of elastomeric stamp (generally, polydimethylsiloxane (PDMS) is used) and the optimal strategy to control adhesion can support the effective and high yield transfer. In this paper, a novel adhesive force measurement system is developed to measure dynamic adhesive forces from the surface on the flexible stamp. The thermodynamic work of adhesion at the moment of debonding of a tip of sensor from the flexible stamp is modeled and used for developing the adhesion control strategy. The measurement results show that the work of adhesion is strongly dependent on the peel-off velocity of tip, while the indentation force has only minor effects on it. The effect of Young’s modulus of elastomeric stamp is also investigated using the model of work of adhesion based on the relation between the adhesive force and peel-off velocity. The elastomeric stamp with low Young’s modulus is preferred for efficient transfer printing.