토끼 음경해면체의 비-아드레날린 비-콜린성 이완반응에서 산화질소의 역할

박미선,김진보,홍은주,홍승철,Park, Mi-Sun,Kim, Jin-Bo,Hong, Eun-Ju,Hong, Sung-Cheul 대한약학회 1997 약학회지 Vol.41 No.3

The role of nitric oxide (NO) on the non-adrenergic non-cholinergic (NANC) relaxations induced by the short and prolonged electrical field stimulation (EFS) has been studied in the rabbit corpus cavernosum. In the presence of atropine and guanethidine the prolonged EFS (2-16 Hz) of corpus cavernosal strips precontracted with phenylephrine produced frequency-dependent relaxations, which were abolished by tetrodotoxin as shown in the relaxations induced gy the short EFS, indicating that their orgin is NANC nerve stimulation. $N^G$-nitro-L-arginine (L-NNA), inhibitor of nitirc oxide synthase, caused a concentration-dependent inhibition to the NANC relaxation, and at 100 M L-NNA the relaxation were virtually abolished. The inhibitory effect of L-NNA was reversed by L-arginine. Hemoglobin abolished the relaxations to NO and also caused a concentration-dependent inhibition of the NANC relaxation. The hemoglobin-resistant relaxation induced by EFS was eliminated by L-NNA. Methylene blue significantly reduced the NANC relaxation in a conentration-dependent manner. The NANC relaxation was not affected by a VIP-inactivating pepridase, alpha0chymotrypsin, whereas VIP-induced relaxation was completely abolished. NO- and VIP-induced relaxation were not affected by L-NNA. These results indicate that the NANC relaxation induced by prolonged EFS of the rabbit corpus cavernosum is mediated by NO-guanosine 3',5'-cyclic monophosphate pathway as shown in the relaxation induced by the short EFS, and that VIP release is not essential for the NANC relaxation of the rabbit corpus cavernosum and VIP is not involved the generation fo NO.

『온병조변(溫病條辨)』 처방의 기원과 처방 변화의 병리학적 고찰

박미선,김영목,Park, Mi Sun,Kim, Yeong Mok 대한한의학방제학회 2017 대한한의학 방제학회지 Vol.25 No.2

Ojectives : To indicate source of prescriptions in "Wenbingtiaobian" and draw pathologic consideration for differences between prescription and source. Methods : Analysed cause and mechanism of disease, pattern identification, treatment, prescriptions and medicinal herbs based on "Translation of Wenbingtiaobian", "Modern Shanhanlun", "Jinkuiyaolueyishi", "Medical collection of Yetianshi" and "Herbal Formula Science". Results : 64.5% of prescriptions in "Wenbingtiaobian" are derived from "Linzhengzhinanyian", "shanghanlun" or "Jinkuiyaolue". Prescriptions from "shanghanlun" or "Jinkuiyaolue" have been modified to fit for heat pattern differentiations, to expand or reduce their medicinal scope, to build up efficacy by adding cold herbs, herbs of nourishing yin, engendering fluid or outthrusting through the exterior, to diffuse water-dampness or warm yang by adding warm herbs. Prescriptions from "Linzhengzhinanyian" have been modified to eliminate cold-dampness, disperse and outthrust with lightness, tonify yin. Conclusions : Wenbingtiaobian" inherited "Linzhengzhinanyian", "shanghanlun" nd "Jinkuiyaolue" andchanged and developed them to cure the febrile disease in the aspect of prescription, mechanism of disease, pattern differentiation and treatment.

어혈증(瘀血證)의 임상 질환 범위에 대한 고찰

박미선,김영목,Park, Mi Sun,Kim, Yeong Mok 대한한의학방제학회 2013 대한한의학 방제학회지 Vol.21 No.1

Objectives : This article is a study on to which categories of modern diseases blood stasis patterns are assigned and the meaning of blood stasis interpreted with perspectives of Korean Medicine and modern medicine. Methods : We reviewed "Neijing", "Shanghanlun", "Yilingaicuo", "Xuezhenglun" and other books and modern clinical papers related with blood stasis. Results : 1. Blood stasis patterns are related with disorders of hemorrheology, hemodynamics, platelet function, microcirculation, microelements and endothelial damage. 2. From the types of syndrome differentiation, diverse diseases classified in type of qi deficiency with blood stasis and type of blood stasis due to qi stagnation are reported, which reflects qi and blood are closely connected. And many diseases are classified in type of kidney deficiency with blood stasis, which has something in common with chronic diseases can achieve effect from treatment considering blood stasis. 3. Diseases related with kidney involve menopausal disorder, mazoplasia, prostatitis, erectile dysfunction, chronic nephritis, renal calculus, osteoporosis and bursitis. Diseases related with heart involve coronary artery disease, arrhythmia and cerebral thrombosis. Diseases related with spleen involve gastritis, colonitis and digestive organ ulcer. Diseases related with liver involve hepatitis, hyperthyroidism and stroke. Diseases related with lung involve neurodermatitis, bronchitis and paranasal sinusitis. Conclusions : Blood stasis pattern which is one of the areas to draw medicine's attention has broad clinical application.

암 환자를 돌보는 간호사의 부담감, 직무 만족도 및 삶의 질

박미선,유양숙,Park, Mi-Sun,Yoo, Yang-Sook 한국호스피스완화의료학회 2005 한국호스피스.완화의료학회지 Vol.8 No.1

Purpose: This study was performed to investigate burden, job satisfaction and quality of life of nurses who take care of cancer patients. Methods: The subjects were 237 nurses working at the oncology unit of hospitals with over 500 beds in Seoul and Gyeonggi-do. Data were collected using questionnaire from the February to March, 2005. Data were analyzed through t-test, ANOVA, Pearson's correlation coefficient and stepwise multiple regression using SAS. Results: 1. The item that showed the highest level of burden was 'I feel limited even if I make efforts to reduce patients' pain. 'Burden was high in those group both who were younger than 35 years old and who had clinical experiences caring cancer patients for $3{\sim}4$ years. 2. The item that showed the lowest level of job satisfaction was 'the possibility of promotion'. Job satisfaction was high in those group both who had a spouse and were head nurses or incharge nurses. 3. The item that showed the lowest level of quality of life was 'I am physically exhausted'. Over 35 years old who had a spouse, and over 2,000,000 won monthly income made a high score in the quality of life. 4. There were negative correlations among burden, iob satisfaction and the quality of life. 5. The major factor affecting the quality of life was burden. Conclusion: The results of this study are expected to be utilized as basic data for developing support system to improve nurses' work conditions and quality of life.

LC/ESI-MS/MS를 이용한 식육(소, 돼지)중 잔류 phoxim 분석

박미선,이진주,명승운,Park, Mi-Sun,Lee, Jin-Joo,Myung, Seung-Woon 대한화학회 2011 대한화학회지 Vol.55 No.4

Phoxim, which is one of veterinary drugs, is a well-known antiparasitic agent in wide use. In this paper, phoxim was extracted from cattle and pig tissue using solid-phase extraction (SPE) employing a silica cartridge with acetonitrile. Liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS) for the analysis of phoxim from animal tissue was presented. Phoxim was detected on a $C_{18}$ column ($2.1{\times}100\;mm$, $3.5\;{\mu}m$) using a mobile phase of 0.1% formic acid in water and acetonitrile. A linear correlation observed in the calibration curves for cattle (0.0048~2.0 mg/kg) and pig (0.0055~2.0 mg/kg) showed above $r^2$=0.995. Accuracy measured at concentrations ranging from 0.0048 to 0.2 mg/kg was the range of 68.2~106.9%. Limit of detection (LOD) and limit of quantitation (LOQ) were the range of 0.0014~0.0017 mg/kg and 0.0048~0.0055 mg/kg, respectively. The precision (RSD%) was below 11.2%.

陰虛證의 임상적 질환 범위에 대한 고찰

박미선(Mi Sun Park),김영목(Yeong Mok Kim) 한의병리학회 2013 동의생리병리학회지 Vol.27 No.3

The purposes of this article are understanding the meaning of yin deficiency interpreted with a perspective of Traditional Korean Medicine and a modern perspective a study and assigning modern diseases to yin deficiency pattern types. Clinical papers were searched in China National Knowledge Infrastructure(CNKI) from 1995 to 2013. Results are as follows. First, yin deficiency written in the 『Neijing』has been understood in many ways. It is translated such as deficiency of yin qi, inner qi, essence, cubit pulse, yin meridians qi, viscera yin and kidney. Second, yin deficiency pattern are related with disorders of the endocrine system, immunity, energy metabolism, blood circulation, cytokine, microelements, lipid metabolism and capability of getting rid of oxygen free radicals. Third, from pattern types, diverse diseases classified in types involving the heat from yin deficiency, which reflects pathologic conditions of deficiency heat which is distinct characteristics of yin deficiency pattern. Various diseases classified in types related with liver or kidney are reported, which reflects two viscera are more related with yin deficiency than other viscera. Fourth, levels of pattern types surveyed are more specific than Korean Standard Classification of Diseases(KCD) and specific enough to be applied clinically. This article surveyed the categories of modern diseases yin deficiency pattern types is assigned to but the detailed relation between them will be necessary to be studied in the future.

조선 숙종 대 장희빈의 왕비 책례 거행과 그 함의

박미선(Park, Mi?sun) 한국학중앙연구원 2021 한국학 Vol.44 No.2

『溫病條辨』濕類溫病에 대한 고찰

박미선(Mi Sun Park),김영목(Yeong Mok Kim) 한의병리학회 2012 동의생리병리학회지 Vol.26 No.6

Oriental Medicine always attach great importance to the damp diseases. Dampness is related with many organs and many clinical diseases. The cause and the location of the damp disease, nature of the symptoms, combination with other pathogenic factors are very diverse. This article analyzed the concept, cause of disease, pathogenesis, characteristic of symptoms, treatment method and prescriptions of Epidemic Warm Diseases of dampness syndrome and cases of dampness-heat diseases based on the theories of Epidemic Warm Diseases and found that theories of Epidemic Warm Diseases have very wide area of application. Dampness is classified into cold-dampness and dampness-heat by combination of heat or cold. The dampness syndrome is related with organs such as lung, spleen, kidney, triple energizers and bladder, and affects liver and heart. The basic treatment methods are dispelling dampness turbidity and diffusing qi movement. The detail treatment methods are spreading lung qi with lightness and resolving dampness and excreting turbidity in upper energizer, opening and dipping down with pungent-bitter and diffusing qi movement and strengthening the spleen and stomach in the middle energizer, draining dampness with bland in the lower energizer. Warming Yang is the main method of treatment for cold-dampness and clearing heat is for dampness-heat with the assistant methods such as resolving dampness and promoting the flow of qi. 5. Acute fever, virus diseases, epidemic diseases among modern diseases are much related with the dampness-heat syndrome.

HPLC/ESI-MS/MS에 의한 먹는물(정수) 중 의약물질의 분석

박미선(Mi Sun Park),김병주(Byung-Joo Kim),명승운(Seung-Woon Myung) 한국분석과학회 2010 분석과학 Vol.23 No.5

청소년의 열등감, 지연행동과 진로미결정의 관계에 사회적 지지와 자기격려가 미치는 영향

박미선(Mi-sun Park),구본용(Bon-yong Koo) 영곡사회심리발달학회 2022 사회심리발달연구 Vol.3 No.2

본 연구는 청소년의 열등감, 지연행동과 진로미결정의 관계에서 사회적 지지와 자기격려가 어떠한 영향을 미치는지를 알아보는 데 있다. 이를 위해 우선 청소년의 열등감과 진로미결정의 관계에서 지연행동의 매개효과를 확인하고, 이 과정에서 사회적 지지와 자기격려의 조절효과를 검증하고자 하였다. 이를 위해 경기지역의 3개 고등학교에 재학 중인 고등학생 585명을 대상으로 열등감, 지연행동, 진로미결정, 사회적 지지와 자기격려를 측정하여 회귀분석을 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 열등감과 지연행동의 영향이 높을수록 진로미결정 수준이 높아졌지만, 사회적 지지와 자기격려의 영향이 많을수록 진로미결정 수준은 낮아졌다. 둘째, 열등감과 진로미결정의 관계에서 지연행동은 매개효과를 보였다. 셋째, 사회적 지지와 자기격려는 열등감과 진로미결정의 관계에 미치는 지연행동의 매개효과를 조절하였다. 이러한 결과에 기초하여 열등감과 지연행동으로 인해 진로선택의 어려움을 경험하는 청소년에게 사회적 지지와 자기격려의 필요성을 제기하고, 연구의 한계와 후속연구의 필요성을 제언하였다. The purpose of this study is to investigate the influence of social support and self-encouragement on adolescent inferiority complexes, procrastination, and career indecision. To that end, the mediating effect of procrastination and the moderating effect of social support and self-encouragementon on the relationship between feelings of inferiority and career indecision were examined. Regression analysis was performed on data collected from 585 students at three high schools in Gyeonggi Province on social support, self-encouragement, feelings of inferiority, procrastination, and career indecision. The results of this study are as follows. First, inferiority complexes and procrastination were positively correlated with career indecision, but social support and self-encouragement were negatively correlated with career indecision. Second, procrastination showed a mediating effect on the relationship between inferiority and career indecision. Third, social support and self-encouragement moderated the mediating effects of procrastination on inferiority and career indecision. Such results present the necessity of social support and self-encouragement for adolescents experiencing career indecision due to procrastination and feelings of inferiority. Subsequent research is recommended to expand upon current findings and their limitations.