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Design, Syntheses, and Conformational Study of Angiogenesis Inhibitors
박경수,백동하,임동열,박상돈,김민영,박영선,김양미,Park, Gyeong Su,Baek, Dong Ha,Im, Dong Yeol,Park, Sang Don,Kim, Min Yeong,Park, Yeong Seon,Kim, Yang Mi Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.9
Since anti-angiogenesis could lead to the suppression of tumor growth, angiogenesis inhibitors have received particular attention for their therapeutic potential. In this study, two angiogenic inhibitors using the bioactive sequence from the kring le 5, AK1(KLYDY), AK2(KLWDF) were designed and synthesized. We have investigated their solution structures using NMR spectroscopy and their activities as angiogenesis inhibitors. AK2 has an intramolecular hydrogen bon d between the side chain amino proton of Lys1 and the carboxyl oxygen of Asp4 with a N ${\cdot}{\cdot}{\cdot}$O distance of $3.27\AA$, while AK1 shows more flexible structures than AK2. Indole ring in Trp is much bigger than the phenyl ring in Tyr and may have good face-to-edge interaction enforcing more rigid and constrained conformational features of AK2. Because of this relatively stable structure, Trp3 in AK2 may have better hydrophobic interaction with Phe5 than Tyr3 in AK1 if two adjacent aromatic groups are located in hydrophobic pocket of receptor. Since AK2 shows the similar anti-angiogenic activities to AK1, we are also able to confirm that the activity of AK1 is irrelevant to the Tyr phosphorylation. More rigid drug with higher activities can be provided by the mimetic approaches. For the further development of the angiogenesis inhibitors, these conformational studies on our lead peptides will be helpful in design of peptidomimetics.
박경수,최영진,박재관,강교성,임동건,박재환,Park, Kyung-Su,Choi, Young-Jin,Park, Jae-Gwan,Kang, Gyo-Sung,Lim, Dong-Gun,Park, Jae-Hwan 한국재료학회 2007 한국재료학회지 Vol.17 No.9
The effect of oxygen in the synthesis of oxide nanowires by using carbothermal reduction process have been studied thermodynamically and kinetically. By using laboratory air, ZnO nanowires could be fabricated in the carbothermal reduction process and a metal oxidation process. As the processing pressure decreases, the diameter of the nanowires decreases and the oxygen vacancy increases. As the processing pressure increases, the oxygen vacancy decreases and the shape of the ZnO becomes plate-like.
Structure of Seed Storage Protein and Starch Grains in the Endosperm of Rice Seeds
박경수,노영복,Park, Kyoung-Soo,Rho, Young-Bok,Kaufman, Peter B. Korean Society of Electron Microscopy 1988 Applied microscopy Vol.18 No.2
두가지 쌀 품종(品種) 종자(種子)(S-201, IR-8)의 호분층을 주사(走査) 및 투과(透過) 전자현미경(電子顯微鏡)으로 관찰(觀察)하면 구형(球形)과 결정형(結晶形)의 단백질체(蛋白質體)가 있는 것으로 밝혀졌으며, 구형(球形) 단백질체(蛋白質體)는 세포질내(細胞質內)에 존재(存在)하고 결정형(結晶形) 단백질체(蛋白質體)는 액포내(液胞內)에서 관찰(觀察)되었다. 가상적(假想的)인 한발 스트레스로서 열자극 처리(處理)($40^{\circ}C$ 에서 4시간)는 호분층(糊粉層)내에 단백질체(蛋白質體) 수에서 정상적(正常的)인 대조구보다 $40{\sim}50%$ 감소(減少)되었다. 또한 호분층(糊粉層)에서 단백질체(蛋白質體) 수의 감소(減少)는 IR-8품종(品種)보다 S-201품종(品種)에서 더욱 현저(顯著)하게 관찰(觀察)되었다. 열자극 처리(處理)로서 단백질체(蛋白質體) 수의 감소(減少)는 S-201품종(品種)에서 결정형(結晶形) 단백질체(蛋白質體)를 둘러싸고 있는 tonoplast membrane의 손상(損傷)으로 밝혀졌으며, 이런 손상(損傷)은 IR-8품종(品種)에는 좀 덜하다는 것으로 나타났다. 즉 이것은 S-201품종(品種)이 IR-8품종(品種)보다 열 자극(刺戟)(한발 스트레스)에 더욱 민감(敏感)하다는 것으로 사료된다. 두 품종(品種)의 종자(種子) 내배유(內胚乳)에 녹말(綠末)이 가득찬 주사(走査) 전자현미경(電子顯微鏡) 사진(寫眞)은 녹말(綠末)이 내배유(內胚乳)의 중앙(中央)으로부터 사출(査出)되는 hexagonal rods로 구성(構成)되어 있다는 것을 나타낸다. 이러한 hexagonal rods는 rods부터 쉽게 분쇄될 수 있는 triangular sectors로 구성(構成)되어 있으며, 이 sectors들의 각 내부(內部)는 $2{\sim}8$개의 단위(單位)로 구성(構成)되어 있는 커다란 compound starch grains들이 들어 있다. 이것은 쌀 내배유세포(內胚乳細胞)에서 compound starch drains들의 매우 다양한 크기를 설명(說明)하고 있다.
박경수,최성열,신필수,고영호,Park Kyoung-Su,Choi Sung-Youl,Shin Phil-Soo,Ko Young-Ho 대한전자공학회 2004 電子工學會論文誌-TC (Telecommunications) Vol.41 No.6
무선랜에 대한 수요의 급격한 증가로 HyperLAN(5.1-533GHz, 5.725-5.825GHz)이 전세계 적으로 무선랜을 위하여 새롭게 할당되고 있다. 또한 대부분의 이동통신기기는 크기가 작으므로 안테나의 크기는 효과적인 설계를 위해 매우 중요하다. 본 논문에서는 5GHz 무선랜을 위해 소형 광대역 안테나를 설계하였다. U슬롯 안테나는 간단한 구조이지만 $10-40\%$의 광대역을 가지고 있으며, 또한 좋은 방사특성을 가지고 있다. 그러나, 일반적으로 U슬롯 안테나의 크기는 크므로 PDA나 노트북과 같은 무선통신기기에 적용하기에 어려움이 있다. 제안된 안테나는 사각패치에 U형 슬롯을 이용하여 광대역 특성을 얻었고, 두 개의 유전체 기판과 스티로폼을 이용함으로써 소형화하였다. U슬롯 안테나의 설계를 위해 유한차분시간영역(FDTD) 법이 적용되었고 MPI 병렬화기법을 이용하여 FDTD법의 분석속도를 향상하였다. According to rapid increment of demand for wireless Local Area Network (LAN), the HyperLAN of 5.1-533GHz and 5.725-5.825GHz is newly allocated for wireless LAM in many regions over the world. Also, because most of mobile communication equipments are small, the size of antenna is important factor of effective design. In this paper, the compacted and wide bandwidth antenna is designed for wireless LAN at 5GHz band. Although the structure of U-shaped slot antenna is simple, It has large bandwidth of $10-40\%$. Also, the U-slot antenna has good radiation pattern. However, in general, the size of U-slot antenna is large. Therefore, it is difficult to apply to wireless equipment such as PDA and Notebook. This proposed antenna has a wide bandwidth by U-shaped slot in rectangular patch and is compacted by using two layered dielectric substrates and foam. For the design of U-slot antenna, the Finite Difference Time Domain method is applied. Also, the method of MPI parallel program is used for the enhancement of the analyzing speed of the FDTD method.
마이크로 컴퓨터를 이용한 기본표준자료(基本標準資料) 개발
박경수,Park, Gyeong-Su 대한인간공학회 1985 大韓人間工學會誌 Vol.4 No.1
This research developes a microcomputer program for MSD which is one of the most widely llsed predetermined time standards. The program is written in BASIC and designed mainly for desk-top or portable microcomputer to facilitate the development of standard times for time study analysis. A simple case is illustrated to show the program running procedure.
머리의 자세를 추적하기 위한 효율적인 카메라 보정 방법에 관한 연구
박경수,임창주,이경태,Park, Gyeong-Su,Im, Chang-Ju,Lee, Gyeong-Tae 대한인간공학회 2000 大韓人間工學會誌 Vol.19 No.1
The aim of this study is to develop and evaluate an efficient camera calibration method for vision-based head tracking. Tracking head movements is important in the design of an eye-controlled human/computer interface. A vision-based head tracking system was proposed to allow the user's head movements in the design of the eye-controlled human/computer interface. We proposed an efficient camera calibration method to track the 3D position and orientation of the user's head accurately. We also evaluated the performance of the proposed method. The experimental error analysis results showed that the proposed method can provide more accurate and stable pose (i.e. position and orientation) of the camera than the conventional direct linear transformation method which has been used in camera calibration. The results of this study can be applied to the tracking head movements related to the eye-controlled human/computer interface and the virtual reality technology.