Design, Syntheses, and Conformational Study of Angiogenesis Inhibitors

박경수,백동하,임동열,박상돈,김민영,박영선,김양미,Park, Gyeong Su,Baek, Dong Ha,Im, Dong Yeol,Park, Sang Don,Kim, Min Yeong,Park, Yeong Seon,Kim, Yang Mi Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.9

Since anti-angiogenesis could lead to the suppression of tumor growth, angiogenesis inhibitors have received particular attention for their therapeutic potential. In this study, two angiogenic inhibitors using the bioactive sequence from the kring le 5, AK1(KLYDY), AK2(KLWDF) were designed and synthesized. We have investigated their solution structures using NMR spectroscopy and their activities as angiogenesis inhibitors. AK2 has an intramolecular hydrogen bon d between the side chain amino proton of Lys1 and the carboxyl oxygen of Asp4 with a N ${\cdot}{\cdot}{\cdot}$O distance of $3.27\AA$, while AK1 shows more flexible structures than AK2. Indole ring in Trp is much bigger than the phenyl ring in Tyr and may have good face-to-edge interaction enforcing more rigid and constrained conformational features of AK2. Because of this relatively stable structure, Trp3 in AK2 may have better hydrophobic interaction with Phe5 than Tyr3 in AK1 if two adjacent aromatic groups are located in hydrophobic pocket of receptor. Since AK2 shows the similar anti-angiogenic activities to AK1, we are also able to confirm that the activity of AK1 is irrelevant to the Tyr phosphorylation. More rigid drug with higher activities can be provided by the mimetic approaches. For the further development of the angiogenesis inhibitors, these conformational studies on our lead peptides will be helpful in design of peptidomimetics.

ZnO 나노선의 합성에서의 미량산소의 영향

박경수,최영진,박재관,강교성,임동건,박재환,Park, Kyung-Su,Choi, Young-Jin,Park, Jae-Gwan,Kang, Gyo-Sung,Lim, Dong-Gun,Park, Jae-Hwan 한국재료학회 2007 한국재료학회지 Vol.17 No.9

The effect of oxygen in the synthesis of oxide nanowires by using carbothermal reduction process have been studied thermodynamically and kinetically. By using laboratory air, ZnO nanowires could be fabricated in the carbothermal reduction process and a metal oxidation process. As the processing pressure decreases, the diameter of the nanowires decreases and the oxygen vacancy increases. As the processing pressure increases, the oxygen vacancy decreases and the shape of the ZnO becomes plate-like.

C-D gain의 변화를 고려한 Fitts 이동시간 추정 모델에 관한 연구

박경수,고봉기,김운회,Park, Kyung-soo,Koh, Bong-kee,Kim, Un-hoi 대한인간공학회 2000 大韓人間工學會誌 Vol.19 No.3

During human-computer interaction(HCI), people typically send inputs to computers through electromechanical pointing devices. Many applied studies have therefore evaluated cursor-positioning movements made with various pointing devices. Though there were so many studies about performance of various pointing devices, it was nearly impossible to compare device performance each other until the Fitts' law was applied. It does appear that Fitts' law may predict performance reasonably well for the one C-D gain level. But in varying C-D gain levels, Fitts' law could not predict movement time. This study investigated the effects of C-D gain in mouse movement time and suggested a revised Fitts' model including C-D gain as an independent variable. The revised Fitts' model may use to measure the performance of various devices in varying C-D gain levels.

운전자의 불안전한 행위와 성격유형과의 상호관계에 관한 연구

박경수,황상혁,이재인,Park, Kyung-Soo,Hwang, Sang-Hyuck,Lee, Jane 대한인간공학회 2006 大韓人間工學會誌 Vol.25 No.4

The goal of this study is to find out correlation between Driver's Unsafe acts(errors and violations) and Personality types. The experiment was performed on 180 subjects, men and women between 20's and 60's having experience in driving for 6 months at least. Personality types of the subjects were classified by MBTI(Myers-Briggs Type Indicator) GS type and Driver's unsafe acts were measured by KDBQ(Korean Driver Behavior Questionnaire) based on Reason's DBQ(Driver Behavior Questionnaire). The result of experiment showed several facts about the relation. The first is that the drivers of P (Perceiving) type commit more violations and slips than drivers of J(Judging) type. The second is that in the comparison among attitude indexes(EP, EJ, IP, IJ) the drivers of EP(Extroversions - Perceiving) commit more violations than other type drivers. Finally, only men of P(Perceiving) type commits more violations than men of J(Judging). Based on these facts, it is possible to use Personality types as a device to prevent unsafe acts in various fields for driver selection and accident prevention training classified by Personality types etc.

토양 오염에 따른 위해성 평가

박경수,Park, Gyeong-Su 한국식품연구원 2004 食品技術 Vol.17 No.2

VDT작업에서의 근골격계 질환 예방을 위한 새로운 팔 지지대 제안

박경수,김상수,조일행,홍기범,Park, Gyeong-Su,Kim, Sang-Su,Jo, Il-Haeng,Hong, Gi-Beom 대한인간공학회 2006 大韓人間工學會誌 Vol.25 No.2

In spite of the rapid increase of computer use in our everyday life, not much effort is undertaken to take measures to prevent Musculoskeletal Disorders(MSDs). In this paper, we suggest a movable armrest which would lower the exposure to the MSDs, especially on the vicinity of arm. The aim of this study is to determine whether there are differences in wrist angle variations, forearm muscular loads, comfort and normal performance between the invented movable armrest and a conventional armrest when using a computer mouse. Eight experienced VDU workers performed a standardized simple task set which consists of 15 detailed tasks with each armrest. The wrist angle variations in the right arm were registered by electrogoniometer and the muscle activities in the shoulder, deltoid and two extensors in the forearm were also registered by electromyograph. The subjects rated perceived comfort while performing the tasks with each armrest. Working with the invented armrest, compared to general, gave significantly decreased wrist angle variations at most of the detailed tasks of both biaxial movements. Moreover, as the distance of targets increased, the difference of muscle activities in two different situations trend to be increasing. At the same time, in work with invented armrest, the subjects rated more comfort and they showed decreased normal performances in 8 detailed tasks which were mainly caused by macro moving time.

폐유리 및 레드머드를 활용한 순환 상온 아스팔트 혼합물의 공학적 특성

박경수,강석표,Park, Koung-Soo,Kang, Suk-Pyo 한국건설순환자원학회 2021 한국건설순환자원학회지 Vol.9 No.1

In this study, the engineering charateristics of recycled cold asphalt mixtures using waste glass and red mud were examined as part of the development of low carbon road pavement materials using large amounts of waste. It also examined the satisfaction of the performance criteria specified in the standard. As a result of the study, it was found that RCA using waste glass were not met standard of GR since strain resistance reduced. Therefore, it has been shown that improvements in the composition of the mixture are needed. It has also been shown to significantly improve the performance of the mixture when adding red mud. In addition, it was found that the quality standards for stability, flow value, indirect tensile strength and tensile strength ratio as specified by GR are satisfied. 본 연구에서는 폐기물을 대량 활용한 저탄소 도로포장재 개발의 일환으로 폐유리 및 레드머드를 활용한 상온 아스팔트 혼합물의 물성 및 역학적 특성을 검토하고, 해당 표준에서 규정하고 있는 성능기준에 대한 충족여부를 검토하였다. 연구결과 폐유리 혼입 시 혼합물의 변형저항성을 저하시켜 GR의 품질기준치를 충족시키지 못하는 것으로 나타나 이에 대한 배합상 개선이 필요한 것으로 나타났다. 또한 레드머드 첨가로 폐유리 활용 혼합물의 성능을 크게 개선시키는 것으로 나타났으며, 폐유리 혼입에 따른 변형저항성 저하를 개선시켜 현재 GR에서 규정하고 있는 안정도, 흐름값, 간접인장강도 및 인장강도비 등에 대한 품질기준치를 모두 충족시키는 것으로 나타났다. 따라서 폐유리 및 레드머드의 순환 상온 아스팔트 혼합물용 적용 소재로의 가능성을 확인할 수 있었다.

MOCVD 더스트로부터 Ga과 In의 침출 거동

박경수,강이승,이찬기,홍현선,심종길,박정진,Park, Kyung-Soo,Swain, Basudev,Kang, Lee Seung,Lee, Chan Gi,Hong, Hyun Seon,Shim, Jong-Gil,Park, Jeung-Jin 한국분말야금학회 2014 한국분말재료학회지 (KPMI) Vol.21 No.3

Leaching of MOCVD dust in the LED industry is an essential stage for hydro-metallurgical recovery of pure Ga and In. To recover Ga and In, the leaching behavior of MOCVD scrap of an LED, which contains significant amounts of Ga, In, Al and Fe in various phases, has been investigated. The leaching process must be performed effectively to maximize recovery of Ga and In metals using the most efficient lixiviant. Crystalline structure and metallic composition of the raw MOCVD dust were analyzed prior to digestion. Subsequently, various mineral acids were tested to comprehensively study and optimize the leaching parameters such as acidity, pulp density, temperature and time. The most effective leaching of Ga and In was observed for a boiling 4 M HCl solution vigorously stirred at 400 rpm. Phase transformation of GaN into gallium oxide by heat treatment also improved the leaching efficiency of Ga. Subsequently high purity Ga and In can be recovered by series of hydro processes.

Studies on Some Physiological and Morphological Characteristics of Actinomycetes in Paddy Soil applied Organic Materials

박경수,박열,류진창,Park, Kyung-Soo,Park, Youl,Ryu, Jin-Chang 한국토양비료학회 1987 한국토양비료학회지 Vol.20 No.1

볏짚 퇴비(堆肥) 및 무기질비료(無機質肥料)를 시용(施用)한 논토양(土壤)의 포장조건(圃場條件)에서 방선균(放線菌)의 군락(群落)을 경시적(經時的)으로 계수(計數)하고, 이들 분리균주(分離菌株)들의 형태적(形態的) 및 생리적(生理的) 특성(特性)과 전자현미경(電子顯微鏡)상에서 균(菌)의 포자체(胞子體) 형태(形態)를 관찰(觀察)한 결과(結果)를 요약(要約)하면 다음과 같다. 1. 방선균(放線菌)의 균수(菌數)는 $2.1{\times}10^6$에서 $7.4{\times}10^7$ 의 범위(範圍)로 무기질비료(無機質肥料)보다 퇴비(堆肥) 시용시(施用時) 많았으며, 연중(年中) 방선균(放線菌)의 경시적(經時的) 군락(郡落)은 1월(月)과 9월(月)보다 6월중(月中)에 채취(採取)한 토양(土壤)에서 많았다. 2. 분리(分離)한 250개(個) 균주(菌株)의 방선균(放線菌)을 형태적(形態的) 특성(特性)으로 구분(區分)한 결과(結果) 21개군(個群)으로 분류(分類)되었으며, 이들 각군(各群)들중 Streptomyces 속(屬)은 15개군(個群)의 87.2%, 그리고 non-Streptomyces 속(屬)은 6개군(個群)의 12.8%로 확인(確認)되었다. 또한 전체(全體) 분리균주(分離菌株)중 포자체(胞子體)의 Spiral Chain 형태(形態)의 Streptomyces 속(屬)이 80%로서 우점하였다. 3. Streptomyces 속(屬)의 15개군(個群)을 전자현미경(電子顯微鏡)상에서 포자체(胞子體)의 표면형태(表面形態)를 관찰(觀察)한 결과(結果) 3개군(個群)은 spiny 형태(形態)를 보였고, 12개군(個群)은 smooth 형태(形態)를 갖는 것으로 동정(同定)되었다. The population of actinomycetes in paddy soils, with hay compost and inorganic fertilizer had been applied respectively was investigated. Actinomycetes were isolated by using selective medium and the population densities of actinomycetes in paddy soil was examined. The population of actinomycetes were reached at a range from $2.1{\times}10^6$ to $7.4{\times}10^7$ per gram of the soil. The composition of actinomycetes flora changed considerably after hay compost applied. The significant positive correlations between the organic matter content in paddy soil and the actinomycetes populations were given at 1.38 to 2.69 level. According to the result of several morphological observation, similar strains isolated were classified into 21 groups. More detailed taxonomic characterization were carried out on the isolated strains. Therefore, 15 groups of Streptomyces and 6 groups of non-Streptomyces were classified into actinomycetes isolates, percentage of streptomyces and non-Streptomyces strains were 87.2% and 12.8% in the isolated 250 actinomycetes strains respectively. Streptomyces with sporophore of the spiral chain form accounted for 80% of all the Streptomyces isolates. Surface morphology of spores were determined with the electron microscope, three species have a spiny surface, and 13 strains have a smooth spore surface.

협력은 기적을 낳는다

박경수,Park, Gyeong-Su 한국자연공원협회 1994 한국자연공원 Vol.63 No.-