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영양막 질환 환장에서의 혈청 β - HCG 치 및 24 시간 소변의 HCG 양과 갑상선 기능과의 관계
김용태(Yong Tae Kim),조진아(Jin A Cho),박찬문(Chan Mun Park),이선화(Sun Hwa Lee),정호연(Ho Yeon Chung),한인권(In Kwon Han),민현기(Hun Ki Min) 대한내과학회 1996 대한내과학회지 Vol.51 No.2
N/A Objectives: It has been recognized that hyperthyroidism occur in patients with trophoblastic disease, either hydatidiform moles or choriocarcinoma. Recently, several lines of evidence have shown that human chorionic gonadotropin, secreted by the trophoblastic disease, is a thyroid stimulator and cause hyperthyroidism. The study was undertaken to evaluate the incidence of hyperthyoidism in patients with trophoblastic disease and relationship between level of thyroid hormone and human chorionic gonadotropin. Methods: In 51 patients with hydatidiform mole and 13 patients with choriocarcinoma, we measured level of thyroid hormone, serum β -HCG and amount of urinary excretion of HCG. Results: 1) Hyperthyroidism was observed in 19.6% of the patients with hydatidiform mole and in 7,6% of the patients with choriocarcinoma. 2) The level of serum β -HCG and the amount of 24 hour urinary excretion of HCG in patients with hyperthyroidism were more than that in euthyroid patients, 3) The amount of 24 hour urinary excretion of HCG in patients with hydatidiform mole was more than that in choriocarcinoma patients. 4) The level of serum β -HCG and the amount of 24 hour urinary excretion of HCG had significant correlation with serum T3 and T4 levels, but, the level of serum β -HCG had beteer correlation. Conclusion: The occurrence of hyperthyroidism is more frequent in patients with trophoblastic disease, and the degree of thyroid function is related with the level of serum B -HCG and urinary excretion of HCG, but, more closely related with serum β -HCG level.
본태성 고혈압 환자의 적혈구 Na+-Li+ Countertransport 와 적혈구막 지방산 구성에 대한 연구
이영우,고경수,고재준,박경수,김원배,한은경,김성연,조보연,이홍규,고창순,민현기 한국지질학회 1991 韓國脂質學會誌 Vol.1 No.1
Since the changes of Na^+-Li^+ countertransport (SLC) Vmax in essential hypertension have been reported. it has been known that hyperlipidemia could affect SLC independently of blood pressure. To reveal the relation between SLC Vmax and RBC membrane fatty acid conposition in the hypertensive patients, we divided patients into two groups according to their levels of SLC Vmax of erythrocytes(elevated SLC Vmax: n=4, normal SLC Vamx: n=6). The results were as follows: 1) There was no difference in body mate index, waist-hip ratio, blood pressure, serum cholesterol level between two groups. Triglyceride were higher in elevated group (278.0±180.0 ㎎/㎗) than normal group (124.3±60.7 ㎎/㎗) but there was no statistical significance. HDL-cholesterol levels were significantly lower in elevated group (32.0±3.6 vs. 44.8±8.9 ㎎/㎗) and free fatty acid concentrations, intracellular (RBC) Na^+ concentrations were similar between two groups. 2) The results of oral glucose tolerance test showed no differences in the glucose and insulin area, however the incremental insulin areas of elevated group (108.8±31.3, μU. min/㎖×10²) were significantly higher compared with those of normal group (56.3±20.7 μU. min/㎖×10²). 3) In the elevated group, palmitic acid proportions of erythrocytes (22.1±0.7%) were higher than those of normal group (20.1±0.7%) and SLC Vmax showed significant correlation (r=0.81, p$lt;0.01) with palmitic acid proportion. These results suggest that the abnormal lipid metabolism may change the RBC Na^+ transport system through the alterations of RBC membrane fatty acid composition.
폐경 후 여성에서 생화학적 지표의 비교 분석에 관한 연구
정호연,임창훈,김상우,한기옥,한인권,민현기 대한폐경학회 1996 대한폐경학회지 Vol.2 No.2
To evaluate the clinical utility of recently devdoped biochemical markers in postmenopausal women, we compared the results of six assay for markers of bone formation, such as bone specific alkaline phopohatase & serum osteocalcin measured by RIA, ELISA(Novocalcin & N-mid terminal) and resorption, such as urinary deoxypyridinoline(Pyrilinks-D) and urinary degradation product of type I collagen peptides(CrossLaps). The intraassay coefficients of variation were less than 8% except Novocalcin(13.3%) and N-mid terminal osteocalcin(15%). Highly significant correlations were observed between tumover markers(r=0.625-0.953, p$lt;0.001) except N-mid terminal osteocalcin. Before we analyze correlation between BMD and tumover markers, we have to standardize patient's BMD values among different dual X-ray aborptiometry(DEXA) scanners from three manufacturers. European spine phantom & patient for standardization for DEXA were evaluated on three system(DPX-L, XR36, QDR2000) and the linear regression equations calculated Overall correlation between instruments were highly significant using phantom(r2=0.995-0.998) and patients(r2=0.973-0.978). In simple regression analysis, corrected spinal BMD using regression equation was significantly correlated with Novocalcin(r=0.38, p=0.01) and osteocalcin by RIA(r=0.4, P=0.01). But stepwise regression showed that YSM(years since menopause), Pyrilinks-D and N-mid terminal osteocalcin use of currently available biochemical markers of bone tumover shows that they nearly all have a role to play in diagnostic procedure. Combination of two to three markers determined at baseline in postmenopause women might predict bone loss.
김상우,조진아,임창훈,정호연,한기욱,윤현구,한인권,민현기,홍성란 대한폐경학회 1997 대한폐경학회지 Vol.3 No.1
Menopause refers to the complete or permanent cessation of menstruation. One the other hand, climacteric refers to the phase of the aging process of women, which a transition is made from the reproductive stage of life to the nonreproductive stage. Due to decreasing the estrogen in the menopause, many postmenopausal discomforts are appeared. Estrogens for hormone replacement therapy is important for a variety of functions including recreation of the receptive endometrial environment and symptomatic relief of hot flushes, genitourinary symptoms, osteoporosis prophylaxis, psychological well-being, and reduction of coronary heart disease. Elevated serum estradiol level varies by composition of the prescribed estrogens, after hormone replacement therapy gonadotropin level decreases and ovulation induction is achieved. Recently we experienced a case of pregnancy with hormone replacement therpay in menopausal woman, so we report the case with a review of literature.
연천 지역사회를 대상으로 한 혈청 지질 농도의 분포 및 관련인자 연구
신영수,박영배,백희영,김현규,김용익,김성연,김진규,조보연,이홍규,고창순,민현기,박용수,박경수 한국지질학회 1993 韓國脂質學會誌 Vol.3 No.2
The chronic diseases represent a greater proportion of morbidity as well as mortality, because of rapid modernization and the lengthened average span of life. Data on chronic diseases especially in, case of hyperlipidemia are very limited in Korea. The present study was undertaken to determine the prevalence of hyperlipidemia and to find out possible cardiovascular risk factors associated with hyperlipidemia in Yonchon County, Kyunggi Province, Korea. A population-based cross-sectional study by random cluster sampling of registered residents over 30 yr of age was performed. Of the 3804 subjects scheduled for the survey, 2520 underwent the actual examination. The prevalence of hypercholesterolemia (serum cholesterol $gt; 220 ㎎/㎗) was only 4%, while that of hypertriglyceridemia (serum triglyceride $gt; 250 ㎎/㎗) was as high as 11.3%, About half of the inhabitants had serum HDL cholesterol levels less than 35 ㎎/㎗. The serum levels of cholesterol, triglyceride and HDL cholesterol correlated with anthropometric indices, such as body mass index and waist hip ratio. The prevalences of diabetes and hypertension increased as serum cholesterol and triglyceride level increased. Finally, We identify central obesity as a significant independent risk factor for diabetes and hypertension. From these results, we could realize that the prevalence of hypercholesterolemia in Yonchon County was substantially lower than that previously suggested, while that of hypertrigyceridemia was very high. But we could also find a varying transition in health in Yonchon County, from the rural to the urban area, with the rapid emergence of noncommunicable diseases as a result of modernization.