http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Filter aid 류에 의한 약제의 흡수에 관한 연구
민신홍,김용배,현영우,이상희 한국약제학회 1973 Journal of Pharmaceutical Investigation Vol.3 No.4
緩衝液에서의 caffeine, niacinamide, pyridoxine hydrochloride, thiamine hydrochloride의 濾過助劑에 依한 吸着현상을 比較檢討하였다. 實驗에 使用한 vitamin類의 吸着은 Langmvir 吸着式의 pattern에 따랐으며 caffeine은 거의 吸着되지 않았다. 濾過助劑中 Dawsonite는 Celite 545 보다 큰 吸着현상을 나타냈으며 pH 變化에 따른 影響은 niacinamide가 가장 예민하였고 pH의 增加는 吸着量을 현저히 감소시켰다.
민신홍,권종원,양중익,차봉진,정비환 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.1
Physical properties of oral adhesive tablets prepared with four kinds of gums for topical or systemic drug delivery were investigated. Oral adhesive tablets containing 5㎎ of brilliant blue (BB) were prepared from direct compression. Viscosity of 2% gum solutions, water absorption, fracture resistance, stickiness of tablets, and dissolution of BB in pH 6.8 dissolution medium were tested. Acacia showed good stickiness and fracture resistance, and tragacanth showed good retarding effect on the release of BB from tablets. Therefore, tablets with varing ratios of acacia and tragacanth were prepared and their physical properties were examined. In conclusion, it was possible to obtain some adequate properties by compounding acacia and tragacanth.
민신홍 한국미생물학회 1990 微生物과 産業 Vol.16 No.2
이글은 (주)동아제약 연구소의 간단한 연혁과 조직, 연구활동, 현재 진행중인 연구 과제와 앞으로의 연구소 활동 방향에 대해 적고 있다.
Acrylic - methacrylic Ester 공중합체 필름의 약물 지속방출효과에 관한 연구
민신홍,김용배,이상희,김근혁,권종원 한국약제학회 1980 Journal of Pharmaceutical Investigation Vol.10 No.2
Spherical granules obtained by extrusion-spheronization processing were used to prepare sustained release spherical granules by pan coating method. Acrylic-methacrylic ester copolymer and mixtures of ethylcellulose, cellulose acetate phthalate and hydroxypropylmethylcellulose were utilized for prolongation of drug release from spherical granules containing acetaminophen as a model drug. In vitro release rate of sustained release spherical granules was investigated by varying the quantity of release retardants applied. Dissolution studies revealed that sustained release spherical granules coated with acrylic-methacrylic ester copolymer showed more protracted release than those granules coated with ethylcellulose mixtures.
민신홍,이상희,이강춘,김용배 한국약제학회 1975 Journal of Pharmaceutical Investigation Vol.5 No.1
Extrusion-Spheronization Processing (ESP) was applied to preparate sustained release spherical particles as a form of matrix spherical particle (MSP). dl-methylephedrine HCI (ME) was the drug chosen and several dissolution retardants and binders were selected to estimate a relatively good formulation on this purpose. The effect of physicochemical nature, concentration, and solvents of these dissolution retardants and binders on regularity in shape of MSP and in vitro release rate was investigated. The effect of particle size of matrix particles was also evaluated. It is, therefore, concluded that this ESP would be a relatively good preparation method of sustained release MSP of ME which has the sustained action of about 5 and 8 hours by formulating of ethylcellulose and ethylcellulose-paraffin as a dissolution retardant, respectively, and then ethylcellulose solution of 80% EtOH is recommended as a binder.