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중추신경의 방사선 조사와 회복효과: 항산화제와 NMDA-receptor 길항제의 작용
문연자,박승택,최민규,정동혁,문성록,정연태,Mun, Yeun-Ja,Park, Seung-Taeck,Choi, Min-Kyu,Jeong, Dong-Hyeok,Moon, Sun-Rock,Chung, Yeun-Tai 한국현미경학회 1998 Applied microscopy Vol.28 No.4
The neurotoxic effects of radiation have been studied in NSC-34 hybrid cells derived from embryonic mouse spinal cord cells. NSC-34 cells irradiated at 25Gy were decreased the cell viability in a time and dose dependent manner. The decrease in cell viability induced by the irradiation was blocked by catalase. Antagonists of the N-methyl-D-aspartate (NMDA) receptor, including D-2-amino-5-phosphonovaleric acid (APV) and chlorokynurenic acid (CKA), similarly blocked radiational induced in cell viability. We performed morphological analysis of light and electron microscope. NSC-34 cells irradiated at 25Gy were decreased the cell density and increased lysosomes and vacuoles in the cytoplasm. Especially chromatin modification was observed. These results indicated that radiation was involved in the oxidant-initiated neurotoxicity and the compounds catalase, APV and CKA were shown to be neuroprotective against radiation.
문연자,임난영,이성원,강대길,백순기,우원홍,Mun Yeun-Ja,Lim Nan-Young,Lee Sung-Won,Kang Dae-Gill,Baik Soon-Ki,Woo Won-Hong 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
This study was performed to investigate the effects of fermented extract of Pinus densiflora (FPD) on oxygen radicals and $H_2O_2$-induced damage. The results are as follows: 1. The 1.1-diphenyl-2-picrylhydrazyl (DPPH) free radicals were considerably reduced by FPD and $IC_{50}$ value was showed the concentration of 20 ㎍/㎖. 2. The cytotoxicity did not observe by FPD treatment in A548 cells. 3. The $H_2O_2$-induced cell damage was recovered by FPD pretreatment in A549 cells. These results suggest that FPD, as a natural antioxidant, has scavenging effect of free radicals and protection effect from $H_2O_2$-induced cytotoxicity.
홍삼과 어유(魚油) 복합식이에 의한 UV-유도 광노화 억제효과
문연자,전병국,김태현,이진호,최형욱,임규상,우원홍,Mun, Yeun-Ja,Jeon, Byoung-Kook,Kim, Tae-Hyun,Lee, Jin-Ho,Choi, Hyung-Wook,Lim, Kyu-Sang,Woo, Won-Hong 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3
Objective : UV irradiatiion causes skin-aging involving coarse wrinkles, thickning, dyspigmentation, and rough skin surface. This study was aimed to elucidate the anti-winkle activity of complex diet of Korean red ginseng (RG) and fish oil (FO) on UV-induced Photoaging. Methods : To investigated photo-protective effects of Korean red ginseng and fish oil on UV-induced damaged skins, SKH hairless female mice were randomly divided into six groups [control, UV, UV/RG, UV/FO, UV/RG/FO(low), UV/RG/FO(high)]and orally administered three times a week respectively. UV radiation was applied to the backs of the mice three times a week for 8 weeks. Expressions of matrix metalloproteinase (MMP)-3, MMP-13 and tissue inhibitor matrix metalloproteinase (TIMP)-1 in skin were measured by immunohistochemical staining. Results : In this study, UVB-induced epidermal hypertropy was diminished by RG group or FO group or complex group of RG and FO. Expression levels of MMP-3 and MMP-13 were reduced and expression level of TIMP-1 was increased by RG group or FO group or complex group of RG and FO. Especially MMP-3 and MMP-13 were markedly reduced by diet of FO and complex diet of RG and FO compared with untreated group. Conclusions : This results suggest that complex diet of RG and FO have a anti-wrinkle activity on UV-induced photo-aging and intrinsic aging.
납 , 수은 및 카드뮴이 백서 좌골신경에 미치는 영향에 관한 형태학적 연구
정종훈,문연자,문철성,유태전,최민규,정연태 ( Chong Hoon Chung,Yeun Ja Mun,Chul Sung Moon,Tae Jeon Yoo,Min Kyu Choi,Yeun Tai Chung ) 한국환경생물학회 1991 환경생물 : 환경생물학회지 Vol.9 No.2
In order to evaluate the effect of some heavy metals on the sciatic nerve of the rat, light and electron microscopic studies were performed to examine the fine structural changes of sciatic nerve of the rat after administration of lead nitrate, mercuric chloride and cadmium chloride, respectively. Rats were received 200㎎/ℓ of each heavy metal(Pb, Hg and Cd) solution ad libitum for 3 months and then, they were sacrificed. The results were summarized as follows; 1. Lead nitrate-treated group showed the decreased diameter of nerve fibers and axons, and mercuric chloride-treated group showed the decrement of number of nerve fibers per unit area, remarkably. 2. g ratio (d/D) measured in the heavy metal-treated groups were 0.75 in Pb, 0.82 in Hg and 0.85 in Cd respectively, compared to the 0.78 in control group. 3. Electron microscopy of lead nitrate-treated group showed the degeneration of myelin sheath, and the destructive change of membrane of Schwann cell. 4. The severe degeneration of myelin sheath and vacuoles in axon were observed in mercuric chloride-treated group. 5. In cadmium chloride-treated group, the degeneration of myelin sheath and axon, and Schwann cell were observed. 6. Degenerative changes of axon were highest in cadmium chloride-treated group(7.4%) and also those of myelin sheath were highest in mercuric chloride-treated group(23.7%) among the experimental groups. These findings indicate that lead, mercury and cadmium produce the morphological changes in the diameters of nerve fiber and axon, and thickness of myelin sheath of sciatic nerve.
조미경,안병상,문연자,우원홍,Jo, Mi-Gyeong,An, Byung-Sang,Mun, Yeun-Ja,Woo, Won-Hong 대한한방피부미용학회 2005 대한한방피부미용학회지 Vol.1 No.1
The aim of this study was to investigate the effect of Fructus Forsythiae on the melanogenesis. To determine whether Fructus Forsythiae methanol extract suppress melanin synthesis in cellular level, HM3KO human melanoma cells were cultured in the presence of various concentrations of Fructus Forsythiae methanol extract and the effects on cell proliferation, tyrosinase activity and melanin contents were examined. Treatment with Fructus Forsythiae methanol extract inhibited tyrosinase activity, regulate melanin biosynthesis as the key enzyme in melanogenesis, in a dose-dependent manner. And also suppressed melanin contents as a dose dependent manner without cytotoxicity morphological change. It was observed that the color of cell pellets was totally different from the control. These results suggest that the inhibitory effect of Fructus Forsythiae methanol extract on melanogenesis is due to the suppression of tyrosinase in HM3KO cells and Fructus Forsythiae is a candidate for an efficient whitening agent.
Inhibitory Effects of Herb and Seeds of Oenothera odorata on the Melanogenesis
최미은,우원홍,문연자,Choi, Mi-Eun,Woo, Won-Hong,Mun, Yeun-Ja The Society of Korean Medicine Ophthalmology 2010 한방안이비인후피부과학회지 Vol.23 No.1
목적 : 월견초는 다량의 불포화 지방산인 리놀렌산과 감마 리놀렌산을 함유하고 있으며, 천식성 기침이나 아토피피부염에 효능이 있는 것으로 알려져 있다. 본 연구는 월견초의 전초와 종자 추출물의 피부 멜라닌 합성에 대한 억제 효과를 조사하였다. 방법 : B16F10 멜라닌세포주를 이용하여 멜라닌, tyrosinase 활성 및 세포생존율을 측정하였다. 또한 멜라닌 합성- 관련효소인 tyrosinase, TRP-1, TRP-2의 단백질발현과 $\alpha$-MSH를 처리하여 색소침착을 유도 한 뒤 단백질 발현을 조사하였다. 결과 : 월견자는 B16F10 세포의 멜라닌 합성을 $5\;{\mu}g/ml$와 $10\;{\mu}g/ml$ 농도에서 각각 대조군의 81.3%, 68.3%로 억제하였고 tyrosinase의 활성도 이와 유사하게 억제하였다. 멜라닌 합성-관련효소들의 단백질발현을 관찰한 결과 월견초와 월견자는 tyrosinase 발현을 억제하였으며 TRP-1과 TRP-2의 발현에는 영향을 주지 않았다. 특히 $\alpha$-MSH에 의한 과색소 유도 시 tyrosinase 발현이 현저하게 감소되었으며, 월견자의 멜라닌 합성 억제 효과가 월견초 보다 높게 나타났다. 결론 : 이상의 연구 결과 월견자는 멜라닌세포의 tyrosinase 단백질 발현과 tyrosinase 활성을 억제하여 멜라닌 생성을 감소시키는 것으로 사료된다.
이성진,김대성,문연자,우원홍,이장천,임규상,Lee, Sung-Jin,Kim, Dae-Sung,Mun, Yeun-Ja,Woo, Won-Hong,Lee, Jang-Cheon,Lim, Kyu-Sang 대한한방안이비인후피부과학회 2009 한방안이비인후피부과학회지 Vol.22 No.1
Objective : The purpose of this study is to investigate the antibacterial activity of Saussurea lappa for the applications of herb-based extracts to both cosmetic and medicinal industries. Methods : Antibacterial activity of ethanol extract of Saussutes lappa (ESL) was assessed using agar diffusion and broth dilution methods, and determined by whether clear zone was formed around paper disc and in terms of the size (mm) of clear zone, Results : ESL provided activity against Staphylococcus aureus KCTC 1927 in concentration of 1 mg/ml with an clear zone of 16 mm, and showed an activity against Staphylococcus epidermids KCTC 1917 in concentration of 1 mg/ml with an clear zone of 18mm. Moreover, the minimum inhibitory concentration (MIC) of ESL against S. sureus and S. epidermidls were 1 mg/ml for both bacterial species. However, ESL showed no growth inhibition against Pseudomonas aeruginosa KCTC 12513, Enterobactet aerogenes KCTC 2190, Escherichia coli KCTC 2571, Salmonella typhimurium KCTC 1925 and Propionibacterium acnes KCCM 41747. Conclusions : Antibacterial activity of ESL against Staphylococcus sureus and Staphylococcus epidermids causing eye and skin diseases was proved. The result suggest that ESL may be useful as a natural preservative on behalf of synthetic preservatives.