Predictive Factors of Gleason Score Upgrading in Localized and Locally Advanced Prostate Cancer Diagnosed by Prostate Biopsy

문성진,박성열,이춘용 대한비뇨의학회 2010 Investigative and Clinical Urology Vol.51 No.10

Purpose: The Gleason score (GS) is an important factor that is considered when making decisions about prostate cancer and its prognosis. However, upgrading of the GS can occur between transrectal ultrasonography (TRUS) biopsy and radical prostatectomy. This study analyzed the clinical factors predictive of upgrading of the GS after radical prostatectomy compared with that at the time of TRUS biopsy. Materials and Methods: We analyzed the medical records of 107 patients who had undergone radical prostatectomy. Patients were divided into two groups. Group 1 consisted of patients in whom the GS was not upgraded, and group 2 consisted of patients in whom the GS was upgraded. Associations between preoperative clinical factors and upgrading of the GS were analyzed. Preoperative clinical factors included age, prostate-specific antigen (PSA), prostate volume, PSA density, GS of TRUS biopsy, maximum core percentage of cancer, percentage of positive cores, number of biopsies, location of positive core with maximum GS, high-grade prostatic intraepithelial neplasia (HGPIN), inflammation on biopsy, and clinical stage. Results: Among 85 patients, 42 (49%) patients had an upgraded GS after operation. TRUS biopsy core number of 12 or fewer (p=0.029) and prostate volume of 36.5 ml or less (p<0.001) were associated with upgrading of the GS. Preoperative clinical factors associated with nonupgrading of the GS were the detection of positive cores with a maximum GS at the apex (p=0.002) or in a hypoechoic lesion (p=0.002) in TRUS. Conclusions: If the positive cores with maximum GS are located at the apex or in a hypoechoic lesion in TRUS, we can expect that the GS will not be upgraded. In patients with the clinical predictive factors of a prostate volume of 36.5 ml or less and TRUS biopsy core number of less than 12, we can expect upgrading of the GS after radical prostatectomy, and more aggressive treatment may be needed. Purpose: The Gleason score (GS) is an important factor that is considered when making decisions about prostate cancer and its prognosis. However, upgrading of the GS can occur between transrectal ultrasonography (TRUS) biopsy and radical prostatectomy. This study analyzed the clinical factors predictive of upgrading of the GS after radical prostatectomy compared with that at the time of TRUS biopsy. Materials and Methods: We analyzed the medical records of 107 patients who had undergone radical prostatectomy. Patients were divided into two groups. Group 1 consisted of patients in whom the GS was not upgraded, and group 2 consisted of patients in whom the GS was upgraded. Associations between preoperative clinical factors and upgrading of the GS were analyzed. Preoperative clinical factors included age, prostate-specific antigen (PSA), prostate volume, PSA density, GS of TRUS biopsy, maximum core percentage of cancer, percentage of positive cores, number of biopsies, location of positive core with maximum GS, high-grade prostatic intraepithelial neplasia (HGPIN), inflammation on biopsy, and clinical stage. Results: Among 85 patients, 42 (49%) patients had an upgraded GS after operation. TRUS biopsy core number of 12 or fewer (p=0.029) and prostate volume of 36.5 ml or less (p<0.001) were associated with upgrading of the GS. Preoperative clinical factors associated with nonupgrading of the GS were the detection of positive cores with a maximum GS at the apex (p=0.002) or in a hypoechoic lesion (p=0.002) in TRUS. Conclusions: If the positive cores with maximum GS are located at the apex or in a hypoechoic lesion in TRUS, we can expect that the GS will not be upgraded. In patients with the clinical predictive factors of a prostate volume of 36.5 ml or less and TRUS biopsy core number of less than 12, we can expect upgrading of the GS after radical prostatectomy, and more aggressive treatment may be needed.

전파를 이용한 도체 Scale 분석에 Regression Progress 기법 이용 연구

문성진,박위상 한국인터넷방송통신학회 2010 한국인터넷방송통신학회 논문지 Vol.10 No.5

본 논문은 열연 공정을 거친 철강 강판에 형성된 산화철 층, 즉 scale 층의 두께를 유전체 렌즈 안테나를 이용하여 측정하는 방법을 소개하였다. 유전체 렌즈 안테나는 X 밴드 대역에서 주파수에 독립적인 특성을 가지며, 혼 안테나에서 방사되는 구면파를 초점이 형성되는 평면에 평면파를 형성하는 역할을 한다. 이러한 동작원리를 이용하여 철강 강판에 형성된 scale 층에 완전 도체와 유전체로 형성된 two-layer 구조에 직각 입사하는 평면파의 이론적 해석이 적용될 수 있다. Scale의 두께를 도출해 내는 과정에서 유전체 렌즈의 영향을 최소화하기 위한 calibration 과정이 삽입되었으며, 이로 인한 반사 계수 위상의 오차가 발생하였다. 이러한 위상 오차에 의한 scale 두께의 오차를 줄이기 위하여, 수치적으로 regression 방법을 사용하였으며, 기존의 iteration 방법과 비교하여, 주기적으로 얻어지는 두께의 값이 아닌 단일 두께 값을 얻어낼 수 있었다. This paper deals with a method to measure the thickness of scale-layer, iron oxide formed on the surface of the rolling steel, using a dielectric lens antenna. The dielectric lens antenna has an independent characteristic with the frequency in the X-band and changes the spherical wave radiated from a horn antenna into a plane wave at the focusing point. Using this concept, we regard a scale-layer on the rolling steel as a dielectric-PEC(Perfect Electric Conductor) layer and apply a theoretical analysis of the normal-incident plane wave. To reduce the phase error arising from the use of the dielectric lens antenna, this paper utilizes a regression process algorithm. In comparison with the conventional iteration algorithm, the present algorithm led to a unique solution for the thickness of the scale-layer.

S(pider)S(afety)Belt

문성진,강진헌,김경영,노형묵,우경빈,이동은,이경선 한국감성과학회 2018 춘계학술대회 Vol.2018 No.-

Determinants Of Particulate Matter (PM-10): Regression Analysis in U.S. Cities

문성진,김기환 한국국정관리학회 2014 현대사회와 행정 Vol.24 No.4

To enable government to design appropriate measures to reduce damage caused by high concentrations of fine dust (PM-10) in the air, it is necessary to define the major determinants of PM-10, quantify their effects on PM-10 concentration, and provide other information that can help handle the problem. The factors that influence the level of PM-10 include “per capita daily miles driven,” “per capita annual congestion cost,” “construction index,” and “per capita income.” The empirical result of this study shows that human and industrial variables are stronger predictors than natural and geographical factors, including precipitation, elevation, wind, proximity to the ocean, and temperature. This finding suggests the important role that government can play in reducing the level of PM-10 concentration through various regulatory instruments and programs. For example, government can design regulatory standards to effectively reduce particulate matter from vehicles, implement engine retrofit programs, and initiate engine idling-reduction programs.

The Effect of Trust on Giving: Evidence from Korean-Americans in California

문성진 서울대학교행정대학원 2017 The Korean Journal of Policy Studies Vol.32 No.1

Trust in a nonprofit organization is recognized by many scholars as a pivotal function of giving activity. However, there is limited empirical evidence, and it remains unclear how trust influences giving practices. This study empirically examines the effects of trust toward nonprofit organizations on giving among Korean-Americans in California. Based on the Korean-American Philanthropic Survey, regression models are constructed to estimate such effects. The empirical results indicated a strong and positive relationship between trust in nonprofits and giving. Basically, immigrants with a greater stock of trust in nonprofits are more likely to give than their counterparts. In addition, acculturation, age, female, and religiosity are significantly and positively related to giving.

ACT IN GOOD FAITH? THE EFFECTIVENESS OF U.S. VOLUNTARY ENVIRONMENTAL PROGRAMS

문성진,고길곤 한국행정학회 2013 International Review of Public Administration Vol.18 No.3

This study identifies the factors and their associated motivations that can influence corporate environmental performance in U.S. voluntary environmental programs (VEPs). The effectiveness of the programs is discussed. We construct an ordered logit regression model to estimate the voluntary environmental performance of 330 firms that participated in the Green Lights/Energy Star for Buildings (GL/ESBs) program between 1995 and 2000. Our analysis suggests that corporate participants with motives that are aligned with market interests are more likely to complete their environmental pledges to a higher level than those whose primary intent is to relieve institutional and regulatory pressures. It also provides strong evidence of corporate opportunism in the program.

DEVS 시뮬레이션을 이용한 자재 재고 관리의 발주 전략에 관한 연구

문성진 한국시뮬레이션학회 1995 한국시뮬레이션학회 논문지 Vol.4 No.2

One of many factors that influences the profit of an enterprise is the amount of the stock in an enterprise. When the stock amounts are optimal the economic burden of the enterprise decreases which in turn results in the optimum number of employment and spatial utilization of storages. The purpose of this study is the simulation modeling of a material stock control system using DEVS models in order to get the most suitable stock amounts. The stock within an enterprise is built by the orders from outside world. The effect on the stock by the factors such as order, delivery, and production components has been analyzed based on simulation results.

Giving and Volunteering among Korean Americans - The Impact of Acculturation -

문성진 한국지방행정학회 2017 한국지방행정학보 (KLAR) Vol.14 No.2

Recently, many scholars suggested coproduction as an alternative to traditional public service delivery by public agencies. Citizens’ participation in the provision of public services through volunteering and donation would be particularly an important part of coproduction. This study empirically examines the philanthropic behavior of Korean Americans, one of the major Asian American ethnic groups. Based on a large-scale Korean American Philanthropic Survey, we examine how acculturation influences philanthropic behavior among Korean Americans. Our empirical results confirm the importance of acculturation in relation to participation in philanthropy, although a detail effect of individual measures that constitute acculturation is much more complex with the forms of philanthropy (non-religious versus religious versus informal) and philanthropic areas (giving versus volunteering)

목단피(牧丹皮)가 손상된 성상신경세포의 CD81 및 GFAP의 발현에 미치는 영향

문성진,성기문,임진영,송봉근,Moon, Sung-Jin,Seon, Ki-Moon,Lim, Jin-Young,Song, Bong-Keun 대한한방내과학회 2009 大韓韓方內科學會誌 Vol.30 No.1

Object : In conditions of brain infarction, irreversible axon damage occurs in the central nerve system (CNS), because gliosis makes physical and mechanical barriers. If gliosis formation could be suppressed, irreversible axon damage would be reduced. This could mean that an injured CNS could be regenerated. CD81 and GFAP have close relationships to gliosis. The increase in glial cells at CNS injury gives rise to the expression of CD81 and GFAP. CD81 was postulated to play a central role in the process of CNS scar formation. Method : In this study, the author investigated the effect of the water extract of the Moutan Radicis Cortex on regulation of CD81 and GFAP expression in injured CNS cells. MTT assay was used to examine cell viability, while RT-PCR and ELISA methods were carried out to measure the expression of CD81 and GFAP in the astrocyte. Results : We observed that water extract of the Moutan Radicis Cortex increased cell viability under hypoxia induced by $CoCl_2$ and suppressed the expression of CD81 and GFAP up-regulated by hypoxia. Conclusion : These results suggest that the Moutan Redicis Cortex could promote neural regeneration as a consequence of protecting CNS cells from hypoxia and suppressing the reactive gliosis following CNS injury.

자발적 환경행태와 사회자본: 자원동원이론을 기반으로

문성진,김민경 한국정책학회 2014 한국정책학회 동계학술발표논문집 Vol.2014 No.-

본 연구는 공유재 문제가 발생하는 대표적 분야인 환경문제를 대상으로 집단의 구성원들의 협력을 이끌어낼 수 있는 방법을 고안하는데 초점을 두고자 하였다. 이를 위하여 자발적 환경행태를 직접적 환경기여행태와 간접적 환경기여행태로 세분화하고, 자원동원이론을 바탕으로 자발적 환경행태 수행을 위한 토대자원으로서 개인유용자원과 사회자본의 역할을 검증하였다. 연구에 사용된 자료를 구축하기 위하여 2012년에 전국의 18세 이상 성인남녀를 대상으로 조사한 환경행태 설문조사를 수행하였으며, 이를 토대로 실증분석을 수행하였다. 분석결과 자발적 환경행태의 수행을 위해서는 개인유용자원이 동원되는 것으로 나타났다. 또한 신뢰의 조절효과를 분석한 결과, 신뢰는 개인유용자원을 대체하여 자발적 환경행태를 촉발하는 효과를 가지는 것으로 나타났다. 이러한 분석결과를 토대로 자발적 환경행태를 비롯한 집합행동의 촉발을 위해서 사회자본의 축적의 중요성을 제기하였다.