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$CCl_4$속에서 Thioacetamide의 N-C(S) 부자유회전에 미치는 몇가지 Amide의 영향
노성구,최영상,윤창주,Seong-Gu Ro,Young-Sang Choi,Chang-Ju Yoon 대한화학회 1987 대한화학회지 Vol.31 No.6
$CCl_4$속에서 티오아세트산아미드(TA)와 몇가지 아미드(N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMA) and N,N-dimethylpropionamide (DMP)) 사이의 수소결합이 TA의 N-C(S) 결합 주위의 부자유 회전에 미치는 영향을 nmr 분광학적인 방법으로 연구하였다. $CCl_4$분율이 증가할 때 TA의 $NH_2$기의 양성자 nmr 스펙트럼은 이중선으로 뚜렷하게 분리되었으며, 그 정도는 DMF < DMA < DMP순으로 증가하였다. 이런 현상을 TA와 아미드사이의 분자간 수소결합으로 설명하였다. The effect of the hydrogen-bonding between thioacetamide (TA) and amides (N,N-dimethylformamide (DMF), N,N-dimethylacetamide (DMA) and N,N-dimethylpropionamide (DMP)) on the hindered rotation of N-C(S) bond of TA was investigated by the nmr spectroscopy. The $^1H$-nmr spectrum of $NH_2$ group in TA was distinctly separated into two peaks with increasing the amount of $CCl_4$ and the effect of amides on the peak separation was in the order of DMF < DMA < DMP. Those phenomena were interpreted in terms of hydrogen-bonding between TA and amide.
노성구 대한감염학회 2003 감염과 화학요법 Vol.35 No.1S
미생물 유전체학(Bacterial Genomics) 기술의 발달로 현재 수십 개의 박테리아에 대한 염기 서열 분석이 마무리되고 약 200여개의 바테리아에 대한 염기서열 분석이 진행되고 있다. 그리고 이런 연구들을 통하여 새로운 유전자들이 많이 발굴 되고 있다. 새로운 유전자들의 기능을 분석하기 위하여 생물 정보학에서는 유전자들의 염기서열이 비슷하면 그 기능도 비슷하다는 전체에서 출발한다. 그러나 실제로 염기서열이 비슷하다 하더라도 그 산물인 단백질의 기능과 구조가 다른 경우가 많이 있다. 그리고 박테리아 유전자의 25-40%는 지금까지 발견되지 않은 새로운 것들이기 때문에 이 경우에는 서열의 비교를 통해서 기능을 규명하기가 어렵다. 이런 문제들을 극복하기 위해서 박테리아 단백질들의 3차원 구조가 필요하다. 지금까지 그 구조가 밝혀져서 PDB(Protien Data Bank)에 등록된 단백질들을 보면 단백질의 기능은 아미노산 서열보다는 3차원 구조와 더 밀접한 관계를 가지고 있다는 것을 알 수 있다. 즉 구조적으로 비슷한 단백질들은 분명히 비슷한 기능을 가진다는 것이다. 따라서 유전자들의 기능을 파악하는데 있어서 단백질의 3차원 구조는 매우 중요한 역할을 한다.
천선,노성구,김양미,윤창주,이지영,Ki-Woong Jeong 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.3
Antagonists of the d -opioid receptor are effective in overcoming resistance against analgesic drugs such as morphine. To identify novel antagonists of the d -opioid receptor that display high potency and low resistance, we performed 3D-QSAR analysis using chemical feature-based pharmacophore models. Chemical features for d -opioid receptor antagonists were generated using quantitative (Catalyst/HypoGen) and qualitative (Catalyst/HipHop) approaches. For HypoGen analysis, we collected 16 peptide and 16 non-peptide antagonists as the training set. The best-fit pharmacophore hypotheses of the two antagonist models comprised identical features, including a hydrophobic aromatic (HAR), a hydrophobic (HY), and a positive ionizable (PI) function. The training set of the HipHop model was constructed with three launched opioid drugs. The best hypothesis from HipHop included four features: an HAR, an HY, a hydrogen bond donor (HBD), and a PI function. Based on these results, we confirm that HY, HAR and PI features are essential for effective antagonism of the d -opioid receptor, and determine the appropriate pharmacophore to design such antagonists.
An MG53-IRS1-interaction disruptor ameliorates insulin resistance
박준섭,이현,최보운,노성구,이도영,나정은,홍정호,이재선,김봉우,고영규 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Mitsugumin 53 (MG53) is an E3 ligase that induces insulin receptor substrate-1 (IRS-1) ubiquitination and degradation in skeletal muscle. We previously demonstrated that the pharmaceutical disruption of the MG53-IRS-1 interaction improves insulin sensitivity by abrogating IRS-1 ubiquitination and increasing IRS-1 levels in C2C12 myotubes. Here, we developed a novel MG53-IRS-1 interaction disruptor (MID-00935) that ameliorates insulin resistance in diet-induced obese (DIO) mice. MID-00935 disrupted the molecular interaction of MG53 and IRS-1, abrogated MG53-induced IRS-1 ubiquitination and degradation and improved insulin signaling in C2C12 myotubes. Oral administration of MID-00935 increased insulin-induced IRS-1, Akt, and Erk phosphorylation via increasing IRS-1 levels in the skeletal muscle of DIO mice. In DIO mice, MID-00935 treatment lowered fasting blood glucose levels and improved glucose disposal in glucose and insulin tolerance tests. These results suggest that MID-00935 may be a potential muscle-targeting drug candidate for treating insulin resistance.
김귀남(Gwinam Kim),황성구(Sunggu Hwang),노정필(jungpil Noh),허선철(Sunchul Huh) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
The Carbon nanotubes has good mechanical, electronic, thermal properties, however it is difficult to add in metal matrix because of van der waals force. In this study, we study dispersion method using the electroless plating. Therefore, the particles size and created quantity of Nickel for 15min, 30min and 60min were measured with the plating solution, which is constantly mixed with nickel culfate and sodium hypophosphite. the plated powders were observed on surface and analyzed at component by FESEM and TEM
이은조,송민지,이해암,강설희,김미나,양은경,이도영,노성구,조중명,김인겸 대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.5
CG200745 is a novel inhibitor of histone deacetylases (HDACs), initially developed for treatment of various hematological and solid cancers. Because it is water-soluble, it can be administered orally. We hypothesized that the HDAC inhibitor, CG200745, attenuates cardiac hypertrophy and fibrosis in deoxycorticosterone acetate (DOCA)-induced hypertensive rats. For establishment of hypertension, 40 mg/kg of DOCA was subcutaneously injected four times weekly into Sprague-Dawley rats. All the rats used in this study including those in the sham group had been unilaterally nephrectomized and allowed free access to drinking water containing 1% NaCl. Systolic blood pressure was measured by the tail-cuff method. Blood chemistry including sodium, potassium, glucose, triglyceride, and cholesterol levels was analyzed. Sections of the heart were visualized after trichrome and hematoxylin and eosin stain. The expression of hypertrophic genes such as atrial natriuretic peptide A (Nppa) and atrial natriuretic peptide B (Nppb) in addition to fibrotic genes such as Collagen-1, Collagen-3, connective tissue growth factor (Ctgf ), and Fibronectin were measured by quantitative real-time PCR (qRT-PCR). Injection of DOCA increased systolic blood pressure, heart weight, and cardiac fibrosis, which was attenuated by CG200745. Neither DOCA nor CG200745 affected body weight, vascular contraction and relaxation responses, and blood chemistry. Injection of DOCA increased expression of both hypertrophic and fibrotic genes, which was abrogated by CG200745. These results indicate that CG200745 attenuates cardiac hypertrophy and fibrosis in DOCA-induced hypertensive rats.