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가교키토산 매트릭스를 통한 Silver Sulfadiazine의 투과
나재운,Nah, Jae Woon 대한화학회 1996 대한화학회지 Vol.40 No.9
Chitin을 epichlorohydrin과 반응시켜 가교 chitin을 합성하고, $C_2$ 위치의 아세트아미드기를 탈아세틸화하여 가교 chitosan을 얻었다. 가교 chitosan을 증류수에 팽윤시킨 다음 글리세린과 silver sulfadiazine을 가하여 고분자 matrix를 제조하였다. 이렇게 제조된 matrix로부터 in vitro에서의 약물 방출 pattern을 고찰하기 위해 pH7.4 인산염 완충용액 중에서 약물의 함유량, 글리세린의 농도 변화 및 matrix 두께변화에 미치는 인자들에 관하여 연구 검토 하였다. 고분자 matrix내의 약물의 함유량과 matrix의 두께가 증가할수록 약물 방출 지속 시간은 지연되었다. 그러나 글리세린의 함유량이 증가함에 따라 약물 방출 지속 시간은 오히려 감소 하였다. 또한 약물의 함유량과 글리세린의 함유량이 증가할수록 겉보기 방출속도상수 (K)값도 증가하였으나, matrix 두께가 증가함에 따라서는 겉보기 방출속도상수(K)값이 일정하였다. 이상과 같이 가교 chitosan은 약품의 방출 조절형 제제로서 사용 가능성을 나타냈으며, 약물로 사용된 silver sulfadiazine의 방출거동은 Higuchi model에 따른 확산으로 생각되었다. Crosslinked chitosan was prepared from chitin after reaction with epichlorohydrin followed by deacetylation at C2-position. Epidermal releasing polymeric matrix was prepared after swelling crosslinked chitosan with distilled water and adding silver sulfadiazine and glycerine as a plasticiser. The release behavior of silver sulfadiazine from polymeric matrix was studied in pH 7.4 phosphate buffer solution by varing the drug content, glycerine concentration, and the thickness of the matrix. The drug release time was delayed by increasing the content of silver sulfadiazine and the thickness of the matrix, whereas decreased as glycerine concentration increased. The apparent constant(K) of release rate was independent upon the matrix thickness, but was proportional to the content of drug or glycerine of crosslinked chitosan matrix. These results indicated that chitosan matrix showed some potential as a drug delivery system for transdermal therapeutic application.
나재운,정영일,이동병,조종수,김성호,김성현 한국키틴키토산학회 1999 한국키틴키토산학회지 Vol.4 No.1
The polymeric matrices coated with poly(DL-lactide) were prepared using chitosan derivatives such as chitosan, chitosan hydrochloride, and sulfonated chitosan for application of drug deliver systems. The drug release study using prednisolone as a model drug was performed in the phosphate buffered solutions at PH 7.4. The release rate of drug was decreased according to the increased content of matrices. The release rate or predrusolone according to the kinds of polymeric matrices coated were decreased in the order of chitosan, sulfonated chitosan, and chitosan hydrochloride. Drug release rate of polymeric matrices coated with poly(DL-lactide) was not only two times slower than noncoated one, but also the burst effect of initial period of drug release was decreased In comparison with noncoated one. From these results it was expected that these formulations based on the chitosan derivative matrices coated with poly(DL-lactide) were acceptable drug delivery devices for a sustained-release dosage form of drug.
나재운,조종수,정영일,김성호,장미경,김성현 한국키틴키토산학회 1998 한국키틴키토산학회지 Vol.3 No.4
The study of drug delivery system has been advanced for effective and safe therapy of drug. Added to chitosan deacetylated from chitin silver sulfadiazine (AgSD) and glycerine, transdermal device chitosan matrix which sustained and controlled was produced. The amount of drug release and release time were controlled by varying the drug content, of drug of glycerine of chitosan matrix. The apparent constant (K) of release ratewas poportirmal to the content of drug or glycerine of chitosan matrix. The release behavior of drug using was consistent with the Higuchi's diffusion model. These results indicated that chitosan matrix showed some potential as a drug delivery system for transdermal therapeutic application.