리튬 유황전지용 폴리우레탄 고분자 전해질의 전기화학적 특성

김형주,신준호,김종화,김기원,안효준,안주현,Kim, Hyeong-Ju,Shin, Joon-Ho,Kim, Jong-Hwa,Kim, Ki-Won,Ann, Hyo-Jun,Ahn, Ju-Hyun 한국전기화학회 2002 한국전기화학회지 Vol.5 No.2

본 연구에서는 높은 인장강도와 탄성력을 가지는 다공성 폴리우레탄(polyurethane, PU)을 지지체(matrix)로 이용하고, 유기 전해액 ethylene carbonate(EC), propylene carbonate(PC), tetraethylene glycol dimethylether(TG)와 1M $LiCF_3SO_3$를 부피비 1:1 비율로 혼합하여 액체 전해액을 제조하였으며, 높은 이론용량을 가지는 Li/S전지에 적용하여 전기 화학적 특성을 조사하였다. 1M $LiCF_3SO_3$에 TG를 첨가할 경우 유기 전해액의 함침량이 약 $750\%$ 증가하였으며 방전용량$(1065mAh/g{\cdot}sulfur)$ 및 사이클 특성이 가장 우수하였다. 1M $LiCF_3SO_3$에 TG/EC(v/v,1:1) 및 PC/EC(v/v,1:1)를 첨가한 경우 이온 전도도는 각각 $3.15\times10^{-3}(S/cm)$ 와 $3.18\times10^{-3}(S/cm)$로 나타났다. Polyurethane was used as matrix for polymer electrolytes with liquid electrolyte consist of organic solvent as ethylene carbonate(EC), propylene carbonate(PC), and tetraethylene glycol dimethylether(TG) and 1M $LiCF_3SO_3$, which has high mechanical strength and porosity. Electrochemical properties fur polyurethane electrolytes with various liquid electrolytes were evaluated. The amount of immersed liquid electrolyte for TG with 1M $LiCF_3SO_3$ was increased to about $750\%$ by weight, and initial discharge capacity and cycle performance was better than others. Ionic conductivity for TG/EC(v/v,1:1) and PC/EC(v/v, 1:1) with 1M $LiCF_3SO_3$ was about $3.15\times10^{-3} S/cm, \;3.18\times10^{-3}S/cm$

특성도를 이용한 결측치 대체방법

김형주,김동재,Kim, Hyungju,Kim, Dongjae 한국통계학회 2017 응용통계연구 Vol.30 No.3

임상시험에서 어떻게 결측치를 다룰 것인가 하는 것은 큰 문제이다. 주로 주분석에서 사용하는 ITT원칙은 결측치가 어떠한 메커니즘을 따른다는 가정 하에 결측치를 대체 하지만 가정에 대한 타당성이 불확실한 문제가 있다. 즉, 올바른 결측치 대체방법은 매우 중요하다. 본 연구에서는 Kang과 Kim (1997)이 제안한 일치도와 유지도의 개념을 이용하여 새로운 결측치 대체방법을 제안하였다. 또한 실제자료를 이용하여 예제를 제시하고 Monte Carlo 모의실험을 통하여 기존방법과 대체 성능을 비교하였다. How to handle missing data is a main issue in clinical trials. We impute missing data based on missing data that follows a mechanism according to the intention-to-treat rule. However, using the right imputation method for missing data is very important because this supposition is unclear. We suggest a new imputation method for missing data using agreement and maintenance introduced by Kang and Kim (1997). We give an example and adapt a Monte Carlo simulation to compare the performance between the established method and the suggested method.

미생물을 이용한 대마의 리그닌과 펙틴 분해

김형주,권길광,서규원,김민철,김형섭,고준석,Kim, Hyung-Joo,Kwon, Kil-Koang,Seo, Kyu-Won,Kim, Min-Chul,Kim, Hyung-Sup,Koh, Joon-Seok 한국섬유공학회 2009 한국섬유공학회지 Vol.46 No.6

In this study, microbial degradation of lignin and pectin in raw hemp was investigated. Using lignin and pectin containing media, various microorganisms were isolated from soil and fecal samples of ruminant. The isolates were identified using the 16s rRNA method. The isolated strains were Klebsiella sp., E. coli, Aspergillus fumigatus, and Burkholderia sp. For the degradation of hemp, a pre-cultured isolate was inoculated (5% v/v) into the medium containing raw hemp (as a sole carbon source: 1% w/v) and nitrogen sources and the mixture was incubate aerobically for 168 hours in a shaking incubator (200 rev $min^{-1}$) at $30^{\circ}C$. The hemp biodegradation activity of the identified microorganism was measured by FT-IR. The FT-IR results showed that the Klebsiella sp. has the highest lignin and pectin degradation activity. These results show that the isolates and the reaction conditions could be applied to the conventional hemp fiber refinery processes.

Siewert 분류에 의한 협의의 분문부 위암(type II)과 분문하 위암(type III)의 검토

김형주,권성준,Kim Hyoung-Ju,Kwon Sung Joon 대한위암학회 2004 대한위암학회지 Vol.4 No.3

Purpose: To determine the clinical value of the Siewert classification for gastic-cancer patients in Korea, we evaluated and compared the clinicopathologic factors of type II and type III cancer. Materials and Methods: The medical records of 89 consecutive patients who had undergone surgery for an adenocarcinoma of the gastroesophageal junction (GEJ) at the Department of Surgery, Hanyang University Hospital, between Jun. 1992 and Dec. 2003 were reviewed retrospectively. Results: There were one patient with type I, 12 pateints with type II and 77 patients with type III. During the same period, 1,341 patients underwent surgery for a gastric carcinoma, so proportion of GEJ cancer being $6.6\%$. The median followup duration was 31 months (range: $2\∼135$ months), and the follow-up rate was $100\%$. Between type II and type III cancers, there were no significant differences in the clinicopathologic variables including age, sex, gross appearance, histologic type, depth of invasion, and pathologic stage. The longest diameter of the tumor was larger in type III ($6.1\pm2.1$ cm) than in type II ($3.9\pm1.1$ cm)(P=0.001). A total gastrectomy with Roux-en-Y esophagojejunostomy was done most frequently, while jejunal interposition was done in 3 cases of type II and 2 cases of type III. More than a D2 lymphadenectomy was done all cases. The numbers of dissected lymph nodes and metastatic lymph nodes in type II were 43.8 and 5.8 respectively, while they were 49.8 and 8.1 in type III, but the difference between the two groups were not statistically significant. The mean length of the proximal resection margin was $15\pm5$ mm in type II and $21\pm13$ mm in type III, but this difference was not statistically significanct. The time to recurrence after operation was 19.3 months in type II and 16.9 months in type III. The five-year survival rates of type II and III were $68.8\%\;and\;52.7\%$ respectively, but difference was not significant. Conclusion: There were no significant differences in the clinicopathologic variables, including survival rate, between type II and type III cancers in Korean patients According to these findings, it appears to be reasonable to classify type III cancer as a cardia cancer in a broad sense.

갑상선 결절의 수술적 치료에 있어서 세침흡인세포검사의 진단적 유용도

김형주,정파종,Hyoung-Ju Kim,M,D,and Pa Jong Jung,M,D 대한갑상선-내분비외과학회 2001 The Koreran journal of Endocrine Surgery Vol.1 No.1

Purpose: Fine-needle aspiration cytology (FNA) and Frozen section biopsy (FS) have been used to distinguish benign lesions from malignancies and for deciding the extent of operative procedures to be used in the management of thyroid nodules. We performed this study in order to determine the diagnostic value of FNA, the need for FS in intraoperative procedures, and their value in deciding the extent of surgery. Methods: The medical records of 365 consecutive patients who had undergone surgery for thyroid nodules at the Department of Surgery, Hanyang University Hospital, between Jan. 1996 and Dec. 1998 were reviewed retrospectively. Both FNA and FS were performed on all patients who underwent thyroid surgery during this period. Among these, 35 patients who were diagnosed as insufficient for diagnosis by FNA were excluded. Results: Definitive histopathological diagnosis revealed benign lesions in 232 patients and malignancies in 98. A borderline group consisted of patients whose specimens were interpreted as follicular neoplasms by FNA and FS. The overall results for FNA and FS were as follows: sensitivity, 98 versus 100; specificity 97 versus 99; and diagnostic accuracy, 97 versus 99%. Five patients who were diagnosed with benign lesions by FNA were rediagnosed by FS as having malignant lesions. The final diagnosis was papillary carcinoma. Of the 45 patients who were interpreted borderline by FNA, 7 patients had benign lesions and 38 were borderline by FS. Finally, 34 patients were diagnosed as having benign lesions and 11 as having malignancies. Conclusion: FNA has a high diagnostic accuracy for the differential diagnosis of thyroid nodules. FS may be unnecessary for patients whose FNA results indicate malignancy, particularly in cases of papillary carcinoma, therefore the routine use of FS for patients who have been diagnosed as having a papillary carcinoma by FNA may be omitted. If FNA results are borderline, FS may be helpful in confirming a follicular neoplasm. If FNA indicates a benign status, FS seems to be necessary to decide the extent of surgery. (Korean J Endocrine Surg 2001;1:73-77)

과학ㆍ기술ㆍ사회 - 21세기의 과학기술, 경제논리 경계해야

김형주,Kim, Hyeong-Ju 한국과학기술단체총연합회 1999 과학과 기술 Vol.32 No.12

21세기는 과학혁명이 일어날 것이라고 과학자들은 말하고 있다. 고도로 발달된 과학기술과 그 기술에 의해 빚어진 새로운 생활모습이 나타날 것이다. 그런데 과학기술은 양날의 칼과 같아서 적절히 사용하면 우리 삶을 윤택하게 해주지만 이기적인 욕망에 칼자루를 맡기면 오히려 인류 멸망의 불씨를 제공할 수도 있다. 과학기술이 인류를 위해 쓰여지도록 하기 위해선 그 기술의 경제적 이익과 사회적 비용을 적정하게 가름할 수 있는 윤리의식 확보가 선행되어야 할 것이다.

보리 잎과 옥수수 수염의 혼합과 유산균 발효를 이용한 γ-aminobutyric acid 생산 증진

김형주,윤영걸,Kim, Hyung-Joo,Yoon, Young-Geol 한국유기농업학회 2017 韓國有機農業學會誌 Vol.25 No.1

GABA는 glutamic acid decarboxylase에 의해서 L-glutamic acid가 탈탄산화되어 생합성된 비단백질 아미노산이다. GABA는 식물에서 스트레스에 대항한 대응반응으로 생성된다. 사람의 중추신경계에서는 주요 억제성 신경전달물질 중 하나로 항고혈압, 항당뇨 효능이 있다고 알려져 있다. 본 연구에서 우리는 보리 잎과 옥수수 수염을 유산균과 함께 발효함으로써 GABA 생성을 증진시키고자 하였다. 보리 잎과 옥수수 수염을 다양한 무게 비율로 조합하여 혼합하였고, $30^{\circ}C$에서 48시간 동안 배양기 안에서 L. plantarium과 함께 발효시켰다. 발효된 혼합물을 열수 추출한 후, thin layer chromatography와 GABase assay를 이용하여 GABA의 생산을 분석하였다. 우리는 9:1 혼합발효추출물이 다른 비율의 추출물 보다 GABA 함량이 높은 것을 확인하였는데 이것은 혼합과 발효기술이 보리 잎과 옥수수 수염 내 GABA 양 증진에 효과가 있음을 의미한다. 또한 몇 가지 생리활성을 분석한 결과 혼합발효추출물의 항산화 효능이 비발효 추출물에 비하여 증진되었고 세포독성은 나타나지 않음을 확인하였다. 이러한 결과는 보리 잎과 옥수수 수염의 조합과 이것을 유산균과 함께 발효시키는 방법이 고함량의 GABA와 증진된 생리 활성을 지닌 기능성 식품으로서의 개발 가능성이 있음을 의미한다. ${\gamma}$-aminobutyric acid (GABA) is a non-proteinogenic amino acid biosynthesized through decarboxylation of L-glutamic acid by glutamic acid decarboxylase. GABA is believed to play a role in defense against stress in plants. In humans, it is known as one of the major inhibitory neurotransmitters in the central nervous system, exerting anti-hypertensive and anti-diabetic effects. In this report, we wanted to enhance the GABA production from the barley leaf and corn silk by culturing them with lactic acid bacteria (LAB). The barley leaf and corn silk were mixed with various weight combinations and were fermented with Lactobacillus plantarum in an incubator at $30^{\circ}C$ for 48 h. After extracting the fermented mixture with hot water, we evaluated the GABA production by thin layer chromatography and GABase assay. We found that the fermented mixture of the barley leaf and corn silk in a nine to one ratio contained a higher level of GABA than other ratios, meaning that the intermixture and fermentation technique was effective in increasing the GABA content. We also tested several biological activities of the fermented extracts and found that the extracts of the fermented mixture showed improved antioxidant activities than the non-fermented extracts and no indication of cytotoxicity. These results suggest that our approach on combining the barley leaf and corn silk and its fermentation with LAB could lead to the possibility of the development of functional foods with high levels of GABA content and improved biological activities.

2차 Seed Grain을 사용한 ZnO 바리스터의 제조

김형주,마재평,백수현,Kim, Hyung-Joo,Mah, Jae-Pyung,Paek, Su-Hyon 대한전자공학회 1990 전자공학회논문지 Vol.27 No.3

1차와 2차 Seed grain을 제조하였다. 보다 큰 grain size를 갖는 1차 seed의 제조 조건은 2.0mol.%의 $BaCO_3$ 첨가와 10시간의 소경이었다. 가장 큰 2차 seed를 얻을 수 있는 1차 seed의 첨가량이 3wt.%로 나타나서, 전통적 방식으로 제조된 바 있는 저전압용 바리스터계에 이를 첨가하여 저전압 ZnO 바리스터를 제조하였다. 이와 같은 조건하에서 제조된 바리스터는 대개 10V/mm의 항복전압과 15~22의 비선형지수를 나타냈다. We fabricated primary and secondary seed grains. Primary seed grains having larger grain size were obtained under the conditions that were 2.0mol.% $BaCO_3$ and 10 hours sintering. The amount of primary seed grain that yield the largest secondary seed grain was chosen as 3wt.% and we fabricated the low voltage varistors which were jointed the low voltage-oriented ZnO varistor system made by conventional method with the secondary seed grains. As a result, the ZnO varistors under those conditions showed approximately 10V/mm of nonlinear resistance and 15-22 of nonlinear exponent.

DSRC 자료를 이용한 고속도로 단기 통행시간 예측

김형주,장기태,Kim, Hyungjoo,Jang, Kitae 대한토목학회 2013 대한토목학회논문집 Vol.33 No.6

현재까지 통행시간 예측과 관련된 다양한 연구들이 수행되었지만, 한국고속도로 특성에 맞는 예측방법론에 대한 실증연구는 부족한 실정이다. 이에 본 연구에서는 실제 통행시간을 기반으로한 DSRC 자료를 바탕으로 한국고속도로에 적절한 예측방법론을 도출한다. 경부고속도로 안성 JC~오산IC 구간의 24시간 DSRC 자료를 이용하며 단주기 통행시간 예측 및 비선형 관계에서 높은 정확도를 보이는 인공신경망 기법을 적용한다. 이어서 랜덤난수를 이용한 통행시간 예측결과의 정확도 검증을 실시한다. 통행시간 예측결과 오차율이 약 4%로 우수한 예측력을 보였으며, 이는 패턴기반 인공신경망 예측시 이력자료의 전처리 과정과 최적의 입력층 및 은닉층의 선정으로 인한 결과로 판단된다. 통행시간 예측결과의 검증을 위해서 랜덤난수를 이용하였으며, 랜덤난수가 이력자료 패턴에 포함되지 않은 경우 실측치와의 오차율이 18.98%로 높게 도출되었다. 이는 인공신경망을 이용한 통행시간 예측시 패턴DB가 예측의 정확도에 주요하게 작용한 결과로 판단된다. 본 연구의 결과를 통해서 한국고속도로 특성에 맞는 통행시간 예측 및 정보제공이 가능할 것으로 판단된다. This paper develops a travel time prediction algorithm that can be used for real-time application. The algorithm searches for the most similar pattern in historical travel time database as soon as a series of real-time data become available. Artificial neural network approach is then taken to forecast travel time in the near future. To examine the performance of this algorithm, travel time data from Gyungbu Highway were obtained and the algorithm is applied. The evaluation shows that the algorithm could predict travel time within 4% error range if comparable patterns are available in the historical travel time database. This paper documents the detailed algorithm and validation procedure, thereby furnishing a key to generating future travel time information.

십이지지(十二地支)의 음양(陰陽) 오행(五行) 육기(六氣) 장부(臟腑)의 배합(配合) 및 상충(相沖) 상합(相合)에 관한(關) 연구(硏究)

김형주,전윤주,윤창열,Kim, hung Joo,Jeon, yun ju,Yun, Chang-Yeol 대전대학교 한의학연구소 2018 혜화의학회지 Vol.27 No.1

Objectives : Ten heavenly stems(10天干) and Twelve earthly branches(12地支) are symbols exposing change order in heaven and earth, and are a very important sign in studying oriental philosophy and oriental medicine. Especially, 10 heavenly stems(10天干) and 12 earthly branches(12地支) are indispensable for the study of Five Circuits And Six Qi(오운육기), and a deep study is needed. Methods : I have examined Yin Yang combination(음양배합), Five elements combination(오행배합), Six Qi 3Yin 3Yang combination(육기삼음삼양배합), viscera combination(장부배합), Mutual collision(상충), Six combination(육합), Three combination(삼합), etc. of 12 earthly branches(12지지) by referring to books such as "Yellow Emperor Internal Classic" ("黃帝內經") and "Principle of universe change" ("우주변화의 원리"). Results & Conclusions : Zi Yin Chen Wu Shen Xu(子 寅 辰 午 申 戌) become Yang(陽), Chou Mao Si Wei You Hai(丑 卯 巳 未 酉 亥) become Yin(陰), Zi Si Yin Mao Chen Si(子 丑 寅 卯 辰 巳) become Yang, and Wu Wei Shen You Xu Hai(午 未 申 酉 戌 亥) become Yin. Twelve earthly branches can be divided into five movements by its original meaning, where YinMao(인묘) is tree, SiWu(사오) is a fire, ShenYou(신유) is a gold, HaiZi(해자) is water, and ChenXuChouWei(진술축미) mediate in the middle of four movements So they become soil(土). SiHai(巳亥) is JueYin Wind Tree(궐음 풍목), ZiWu(子午) is ShaoYin Monarch Fire(소음 군화), ChouWei(丑未) is TaiYin Humid Soil(태음 습토), YinShen(寅申) is ShaoYang Ministerial Fire(소양 상화), MaoYou(卯酉) is YangMing Dry Gold(양명 조금), and ChenXu(辰戌) is TaiYang Cold Water(태양 한수). Viscera combination(장부배합) combines Zi(子) and Bile(膽), Chou(丑) and Liver(肝), Yin(寅) and Lung(肺), Mao(卯) and Large intestine(大腸), Chen(辰) and Stomach(胃), Si(巳) and Spleen(脾), Wu(午) and Heart(心), Wei(未) and Small intestine(小腸), Shen(申) and Bladder(膀胱), You(酉) and Kidney(腎), Xu(戌) and Pericardium(心包), Hai(亥) and Tri-energizer(三焦), Which means that the function of the viscera and channels is the most active at that time. Twelve earthly branches mutual collisions collide with Zi(子) and Wu(午), Chou(丑) and Wei(未), Yin(寅) and Shen(申), Mao(卯) and You(酉), Chen(辰) and Xu(戌), and Si(巳) and Hai(亥). The two colliding earthly branches are on opposite sides, facing each other and restricting each other by the relation of Yin-Yin and Yang-Yang it rejects each other so a collision occurs. Six Correspondences(六合) coincide with Zi(子) and Chou(丑), Yin(寅) and Hai (亥), Mao(卯) and Xu(戌), Chen(辰) and You(酉) and Si(巳) and Shen(申) Wu(午) and Wei(未). Three combination(三合) is composed of ShenZiChen(申子辰), SiYouChou(巳酉丑), YinWuXu(寅午戌), and HaiMaoWei(亥卯未). Three combination(三合) is composed of ShenZiChen(申子辰), SiYouChou(巳酉丑), YinWuXu(寅午戌), and HaiMaoWei(亥卯未). This is because the time Six Qi(六氣) shifts in these three years are the same.