염색체 7번 장완의 부분적 역위 중복 1례

김현지,이소영,김미영,백청순,김원덕,이동석,김두권,최성민,Kim, Hyun Ji,Lee, So Young,Kim, Mi Young,Baek, Chung Sun,Kim, Won Duck,Lee, Dong Seok,Kim, Doo Kwun,Choi, Sung Min 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.5

Duplication of chromosome 7q has been reported as either partial or complete. Partial 7q duplication was first described by Carpentier in 1972. Pure partial duplication of the long arm of chromosome 7 is extremely rare and only 16 cases with a pure partial duplication of different 7q segment have been described in the literature. Pure partial duplication of the long arm of chromosome 7 is characterized by growth and developmental retardation, muscular hypotonia, distinct craniofacial dysmorphic features, a short neck and skeletal abnormalities. A 3 month-old male was referred to our department of Pediatrics because of dyspnea, hypotonia and delayed development. He shows growth and developmental delay, hypertelorism, a depressed nasal bridge, low set ears, a short neck and muscular hypotonia. Karyotype revealed 46, XY, dup(7)(q36q33) by GTC-banding. We report a case of a partial inverted duplication of chromosome 7q. 저자들은 호흡곤란, 근력저하, 발달지체로 병원에 온 3 개윌된 남아의 염색체 핵형분석에서 46, XY, dup(7)(q36q33)으로 진단된 1례를 경험하였기에 보고하는 바이다.

한우의 FABP4 유전자 선별에서 사육환경 보정 효과

김현지,이제영,Kim, Hyun-Ji,Lee, Jea-Young 한국통계학회 2015 응용통계연구 Vol.28 No.5

가축의 경제적인 특성은 환경적인 요인과 유전적인 요인의 영향을 복합적으로 받는다. 우리는 한우의 경제적 특성에 영향을 미치는 유전적인 요인에 관심이 있으며, 우리의 목적은 경제형질에서 환경적인 요인을 보정하여 유전효과를 더욱 정확하게 검증하는 것이다. 본 연구에서는 환경적인 요인과 유전적인 요인으로 구성된 통계모형을 구축하고, 이 모형에서 환경적인 요인인 사육농가의 효과와 도축일령의 효과를 제거하여 보정된 경제형질값을 구한다. 그리고 보정 전 후 경제형질값을 다중인자차원축소 방법에 적용하여 각각의 우수 유전자와 유전자조합을 선별하고, 정확도를 비교한다. 그 결과, 우리는 환경요인을 보정한 경제형질값을 활용하여 우수 유전자 선별의 정확도를 높였고, 한우의 등급과 지방산과 깊은 연관이 있는 우수한 FABP4 유전자를 선별하였다. Economic-traits of livestock are affected by environmental and genetic factors. We are interested in genetic factors that influence the economic-traits of Korean cattle. It is necessary to adjust environmental factors in order to enhance the accuracy of the genetic effect analysis. In this paper, we propose a statistical model of Korean cattle that exclude environmental breeding farm and age factors. We formulated an adjusted economic-trait value, and applied multifactor dimensionality reduction (MDR) method to data of before-and-after adjustment to identify major FABP4 genes. We were able to increase the accuracy of the analysis after adjustment and identify superior FABP4 genes that influence grade and fatty acid.

허약아(虛弱兒) 증상 연구를 통한 인터넷 중독의 한의학적 접근

김현지,박은정,Kim, Hyun-Ji,Park, Eun-Jung 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : The purpose of this study is to research the internet addiction and the Weak children. Methods : Total 400 of 5th and 6th grade JeonJu Elementary student children consisted with 203 men, 197 women were chosen for this study. They answered questionnaires of the internet addiction and the Weak children on June 12th, 2008. Results : 75% were general internet user, latent danger user group was 14.7%, high danger user group was 10.3%. The mean of the general weak children was the highest and then the group of children who had Heart, the Lung, the Liver, the Spleen, the Kidney problems were followed. These showed the relationships with living styles, especially eating patterns and parents' concerns about children's internet use. The more serious internet addiction was, the more the weaker children symptoms were answered significantly. The heart weak children symptoms were found in latent-high danger internet user group. Conclusions : In conclusion, the physical and psychological symptoms of the internet addiction children were resulted by the disturbance of Qi and the pathological change of internal organs.

도로포장체의 동결에 영향을 미치는 통계적 요인

김현지,이제영,김병두,조규태,Kim, Hyun-Ji,Lee, Jea-Young,Kim, Byung-Doo,Cho, Gyu-Tae 한국데이터정보과학회 2016 한국데이터정보과학회지 Vol.27 No.1

우리나라의 기후적 특성으로 토지가 동절기에는 동결작용을 받고 해빙기에는 융해작용을 받는다. 이러한 동결융해작용의 피해를 최소화하기 위하여 도로 포장 분야에서는 도로 포장 두께에 관한 많은 연구들이 진행 중에 있다. 본 연구는 도로포장 현장계측 온도데이터를 이용하여, 도로 포장 두께를 위해 사용되는 변수들의 적절성을 확인하기 위해 엔트로피 지수를 이용한 의사결정나무 분석을 시행한다. 각 층 온도를 이용하여 생성한 최저동결층 (순서형 변수)을 목표변수로 분석하며, 분석에 사용된 독립변수는 동결지수에 따라 $350{\sim}450^{\circ}C{\cdot}$일, $450{\sim}550^{\circ}C{\cdot}$일, $550{\sim}650^{\circ}C{\cdot}$일로 구분된 지역 변수, 절토부, 절성경계부, 2m 이하 성토부 구간으로 이루어진 단면 변수 그리고 동상방지층 설치 유무이다. 또한, 월과 대기온도도 독립변수에 포함시킨다. 그 결과, 월, 동상방지층 유무, 대기온도, 지역 순으로 최저동결층에 영향을 주는 것으로 나타났다. Due to the character of the climate of Korea, the pavement of a road is Influenced by freezing in winter season and thawing in thawing season. In the last few years, several articles have been devoted to the study to minimize the damage of freezing and thawing action. The purpose of this paper is to identify appropriacy of factors that influence road pavement thickness. We conduct the decision tree analysis on the field data of road pavement. The target variable is 'Frost penetration'. This value was calculated from the temperature data. The input variables are 'Region', 'Type of road pavement', 'Anti-frost layer', 'Month' and 'Air temperature'. The region was divided into 9 regions by freezing index $350{\sim}450^{\circ}C{\cdot}day$, $450{\sim}550^{\circ}C{\cdot}day$, $550{\sim}650^{\circ}C{\cdot}day$. The type of road pavement has three-section such as area of cutting, boundary area of cutting and bankin, lower area of banking. As the result, the variables that influence 'Frost penetration' are Month, followed by anti-frost layer, air temperature and region.

적록 색각 이상자를 위한 HSV색공간을 이용한 색변환 기법

김현지,조재영,고성제,Kim, Hyun-Ji,Cho, Jae-Young,Ko, Sung-Jea 대한전자공학회 2013 전자공학회논문지 Vol.49 No.11

본 논문에서는 적록색각 이상자를 위한 색 변환 알고리즘을 제안한다. 적록색각 이상자는 원추세포의 이상으로 인해 색상과 명도를 일반인과 다르게 인지하기 때문에 적색과 녹색의 구분에 어려움을 겪는다. HSV 색공간은 이러한 특성을 파악할 수 있는 인간의 색지각과 유사한 색 공간으로, 제안하는 방법에서는 HSV 색 공간에서 색상과 명도를 보정하여 색을 변환 한다. 이때 색상과 명도 보정정도는 개개인의 색각이상 심각도에 따라 다르게 결정된다. 색각 이상자 개개인에 따라 다른 보정정도를 적용함으로서 기존 이미지의 자연스러움은 유지 하고 구분하기 힘들었던 색상들도 구분 가능하게 변환된다. 제안하는 방법을 색각 이상자에게 적용하여 시뮬레이션으로 확인한 결과, 색각 이상자가 구분하기 힘든 색상들이 색상의 자연스러움을 유지하면도 색차를 인지할 수 있는 색으로 변환되는 것을 확인할 수 있었다. This paper proposes a new re-coloring method for the people with the red-green color vision deficiency (CVD). These people have difficulty in discriminating the red and green colors since they abnormally perceive the hue and luminance value of the colors. We introduce a color transformation that adjusts the hue and luminance value in HSV color space. The color transformation is determined according to the severity of CVD. Our aim is to maintain the color differences in original image while maintaining the recolored image to be natural to the people with normal color vision. Experimental results show that the proposed method can yield more comprehensible images for the people with red-green CVD while maintaining the naturalness of the recolored images.

원인불명의 호흡곤란을 호소한 증례 보고 1례

김현지,이해자,박은정,Kim, Hyun-Ji,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2007 대한한방소아과학회지 Vol.21 No.3

Objectives The purpose of this study is to report a case showed significant consult in treating Idiopathic chronic hyperventilation patient with oriental medicine. Methods The patient had suffered from dysypnea for 7 months, so we treated her with herbal medicine, acupuncture, laser, CEP nebulizer and cupping. Results and Conclusions This study shows that oriental medicine works for treating Idiopathic chronic hyperventilation. For more accurate studies, further studies are needed with more clinical cases.

대학생들의 탄산수 효능에 대한 인식과 지식이 섭취 행태 및 만족도에 미치는 효과

김현지,장재선,홍명선,서화정,Kim, Hyun Ji,Jang, Jae Seon,Hong, Myung Sun,Seo, Hwa Jeong 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.4

The purpose of this study was to determine the effects of awareness and knowledge of the efficacy of carbonated water on consumption patterns and satisfaction for college students, who are the principal consumers of carbonated water. A survey was conducted with 502 college students in the Metropolitan area from May 13 to 18, 2015 and 455 questionnaires were analyzed. As for the differences in awareness and knowledge of the efficacy of carbonated water according to gender, females (14.60 and 0.76) had better awareness and knowledge than males (13.40 and 0.58) (p=0.000 and p=0.036). The more positive the awareness of carbonated water, the greater the knowledge (p=0.000); the greater the knowledge of carbonated water, the higher level of consumption satisfaction (p=0.006). The odds ratio of awareness for carbonated water was 11.98; that is, positive awareness led to higher levels of satisfaction than negative awareness (p=0.003). Since awareness of the efficacy of carbonated water was found to affect carbonated water drinking and satisfaction, it is necessary to provide correct information about the efficacy of carbonated water.

해수침투와 농업활동에 의한 사천-하동 해안지역 지하수의 오염 특성

김현지,함세영,김남훈,정재열,이정환,장성,Kim, Hyun-Ji,Hamm, Se-Yeong,Kim, Nam-Hoon,Cheong, Jae-Yeol,Lee, Jeong-Hwan,Jang, Sung 대한자원환경지질학회 2009 자원환경지질 Vol.42 No.6

연구지역인 사천-하동지역은 농업지역으로서 오랫동안 농업용 지하수를 사용하여 왔으며, 또한 남해에 인접해 있다. 본 연구에서는 해수침투와 농업활동에 의한 오염을 고찰하기 위해 연구지역의 지하수 화학성분을 분석하였다. 대부분의 지하수 시료들은 해안으로 갈수록 전기전도도($227{\sim}7,910\;{\mu}S/cm$)가 증가하는 경향을 보이며 해수(0.55)와 비슷한 Na/Cl 농도를 보였다. 또한, Cl과 $HCO_3$ 농도 확률누적곡선의 통계학적 해석에 의하면, 연구지역 지하수의 30.1%가 해수의 영향을 많이 받은 영역에 속하는 것으로 나타났다. 지하수 유형은 Ca-Cl과 Na-Cl 형을 나타냈으며, 이는 해수의 영향과 이에 수반된 양이온교환을 지시한다. 수소 산소동위원소 분석 결과, 사천-하동 지역 지하수의 산소 수소 동위원소비는 $\delta^{18}O$가 -8.53~-6.13‰, ${\delta}D$가 -58.7~-43.7‰로서 우리나라 전체 평균 산소 수소 동위원소비에 비해서 약간 더 무거운 경향을 보인다. 질소동위원소 분석 결과, $\delta^{15}N-NO_3$값이 -0.5~19.1‰의 범위로 나타나 질산염 오염의 기원은 주로 토양의 유기질소와 분뇨 기원 그리고 이들의 혼합기원으로 나타났다. 그러나, 부분적으로는 탈질효과도 있는 것으로 보인다. 요인분석 결과 4개의 요인이 도출되었으며, 전체 분산을 가장 많이 설명하는 요인 1 (고유치 6.21)은 해수침투의 영향을 지시한다. 군집분석 결과, 연구지역의 지하수는 담수, 담수-해수의 혼합지하수로 분류된다. Groundwater has been extracted for irrigation in Sacheon-Hadong area, which is close to the South Sea. We analyzed chemical components of groundwater to examine the effects of seawater intrusion and agricultural activities in the study area. Most groundwater samples displayed the Na/Cl concentration ratios similar to that of seawater (0.55) with an increasing tendency of electrical conductivity ($227-7,910\;{\mu}S/cm$) towards the coast. In addition, statistical interpretation of the cumulative frequency curves of Cl and $HCO_3$ showed that 30.1% of the groundwater samples were highly affected by seawater intrusion. Groundwaters in the study area mostly belonged to the Ca-Cl and Na-Cl type, demonstrating that they were highly influenced by seawater intrusion and cation exchange. The result of oxygen-hydrogen isotope analysis demonstrated slightly higher $\delta^{18}O$ ((-8.53)-(-6.13)‰) and ${\delta}D$ ((-58.7)-(-43.7)‰) comparing to mean oxygen-hydrogen isotope ratios in Korea. As a result of nitrogen isotope analysis, the $\delta^{15}N-NO_3$ values ((-0.5)-(19.1)‰) indicate two major sources of nitrate pollution (organic nitrogen in soil and animal and human wastes) and mixed source of the two. However, denitrification may partly contribute as a source of nitrogen. According to factor analysis, four factors were identified among which factor 1 with an eigenvalue of 6.21 reflected the influence of seawater intrusion. Cluster analysis indicated the classification of groundwater into fresh, saline, and mixed ones.

성대 부전 마비의 진단에서 후두 근전도 검사의 유용성

김현지,박혜상,김한수,박기덕,정성민,Kim, Hyun-Ji,Park, Hae-Sang,Kim, Han-Su,Park, Kee-Duk,Chung, Sung-Min 대한후두음성언어의학회 2011 대한후두음성언어의학회지 Vol.22 No.2

Background and Objectives : Vocal fold paresis is a clinical condition and considered as a continuum of neurologic dysfunction encompassing partial denervation and variable degrees and patterns of reinnervation. Its incidence, clinical presentation, significance are incompletely understood and still debated. This study describes the clinical, electromyographic findings in patients who presented with complaints of dysphonia and whose laryngoscopic finding revealed vocal fold paresis. Materials and Method : 47 patients (male : 25, female : 22) who referred to Ewha Womans University Medical Center Voice clinic for evaluation of vocal complaints were enrolled in this study. All patients had undergone a through history and physical examination including strobovideoscopic and laryngoscopic examination. Patients with in the history and/or laryngoscopic examination suggestive of vocal fold paresis were evaluated by laryngeal electromyography (LEMG). Results : Of these patients, 23 (48.9%) were found to have evidence of neuropathy on LEMG. There was no significant difference in voice symptoms and laryngoscopic findings between two groups of patients with evidence of neuropathy and who show normal findings on LEMG. Conclusion : LEMG can clinically help to guide the evaluation and management of vocal fold paresis. Due to some limitations of LEMG, laryngoscopic findings and clinical correlations should also be considered when diagnosing the vocal fold paresis.

계획행동이론을 적용한 하동지역 농업유산관광객의 행동의도 - 농업유산에 대한 지각된 가치와 사전적 지식의 역할을 중심으로 -

김현지,황길식,Kim, Hyun-Ji,Hwang, Kil-Sik 한국농촌계획학회 2018 농촌계획 Vol.24 No.2

The study aims to predict the behavior of tourists in Hadong County, which is registered as KIAHS. Based on the theory of planning behavior, we intend to verify the theory of planned behaviour, which adds descriptive parameters of the perceived value and prior knowledge of an agricultural heritage. In detail, first, the perceived value and prior knowledge of tourists about an agricultural heritage understand the influence of tourists' Attitude. Second, we could see the role of the behavioral factors in the causal relationship of the planned behavioral theory. We have identified the planned behavioral theory that attitudes, subjective norms, and perceptual behavior controls affect the intention of the revisit. Hadong should remember that by sending and providing various information about Hadong Green Tea and World Agricultural Heritage sites, it is possible to elicit changes in visitor attitudes and revisit visits.