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김제훈,김동순,송진우 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background: In 2016, a new conceptual framework for acute respiratory deterioration (ARD) and a revised definition of acute exacerbation (AE) in idiopathic pulmonary fibrosis (IPF) were proposed. The aim of this study was to investigate the incidence, risk factors and outcome of AE in IPF by a revised definition and compare with the results of past definition. Methods: Patients with IPF (n=445) were included and clinical data were retrospectively reviewed. Results: The median follow-up period was 30.6 months. ARD requiring hospitalization occurred in 28.9% and AE in 17.3 %. The 1- and 3-year incidences of AE were 7.6 and 20.9%, respectively. AE group was older and had lower FVC, DLco and the lowest, resting oxygen saturation and distance during of 6-minute walk test (6MWT) and more decline in FVC (for 6 months), compared to non-ARD group. Age, DLco and decline in FVC were significant predictors for AE. The in-hospital mortality rate after AE was 29.4%, and PaO2/FiO2 ratio and procalcitonin levels were significant prognostic factors. Compared to results of the past definition (1- year incidence, 5.2%; in-hospital mortality rate, 41.3%), the revised definition increased the incidence by 46%, and decreased in-hospital mortality rate by 28.8%. Conclusion: The revised definition significantly changed the incidence and outcome of AE. Old age, low DLco and more decline in FVC were risk factors for AE.
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약품(액상소석회) 저장조 준설 작업자의 유해인자 특성 평가 사례
김제훈,김기연 한국산업보건학회 2024 한국산업보건학회지 Vol.34 No.1
Objectives: The study was performed to investigate characteristics of hazardous factors regarding chemical(liquid lime) tank dredging workers by case survey. Methods: Field data such as working condition, MSDS and respirators applied to chemical tank dredging work were analyzed and the work environmental factors of noise and indoor air quality were measured to compare existing data with actual work situations. Results: No health hazards to workers due to working conditions were confirmed during dredging work inside the chemical storage tank. All air quality measurement data during dredging work satisfied the management standards, and there were no by-products. During dredging work, there was a significant change in noise depending on the type of work, but considering the noise reduction rate(NRR) of the earplugs worn by workers, there was no actual health hazard due to noise exposure. Conclusions: A fit test for respirator and the expiration date of the safety helmet should be observed to ensure an appropriate level of safety and health for dredging workers in the chemical storage tank.
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원발성 위장관 림프종의 수술 후 복합 화학요법과 화학요법 단독과의 비교: 단일 기관 연구
김제훈,이호섭,이준섭,이진영,김수영,김철수,양정욱,유가인 고신대학교(의대) 고신대학교 의과대학 학술지 2015 고신대학교 의과대학 학술지 Vol.30 No.1
Objectives: There is still no consensus on the optimal treatment for primary gastrointestinal lymphoma (PGIL). The aim of this study was to compare surgery combined with chemotherapy and chemotherapy alone in PGIL. Methods: We retrospectively reviewed and analyzed the treatment outcomes of 107 patients with primary gastrointestinal lymphoma diagnosed between March 1999 and December 2009 at Kosin University Gospel Hospital. Patients were divided into two groups: 35 patients who underwent surgery combined with chemotherapy (group A) and 72 patients who were treated with chemotherapy alone (group B). And we analyzed prognostic factors associated with short survival. Results: The 5-year progression free survival rates (PFS) of group A and B were 86.7% and 66.1%, respectively (P = 0.037), while the 5-year overall survival rates (OS) were 86.8% and 68.4%, respectively (P = 0.129). In multivariate analysis, Both PFS and OS were not changed by treatment strategies (surgery combined with chemotherapy or chemotherapy only). The international prognostic index (IPI) was the only independent predictive factor for PFS. Conclusions: In our study, surgery combined with chemotherapy and chemotherapy only make no difference of survival rate. And further randomized prospective studies are needed to confirm a treatment strategies at improving survival outcomes in PGIL patients.
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Tracheal pleomorphic adenoma with coexisting pulmonary tuberculoma
김제훈,옥철호,장태원,정만홍 영남대학교 의과대학 2018 Yeungnam University Journal of Medicine Vol.35 No.1
Tracheal tumors are rare and difficult to diagnose. Moreover, delays in diagnosis are very common because the symptoms are nonspecific. As a result, tracheal tumors are commonly mistreated as chronic obstructive pulmonary disease or bronchial asthma. We report a case of a 49-year-old male who presented with a 3- month history of dyspnea and cough. Chest computed tomography scan showed a 1.5×1.3 cm homogenous tumor originating from the right lateral wall of the tracheobronchial angle into the tracheal lumen as well as a 0.5×0.4 cm round nodular lesion at the right upper lobe with multiple mediastinal lymph nodes enlargement. Bronchoscopic findings revealed a broad-based, polypoid lesion nearly obstructing the airway of the right main bronchus. The patient was diagnosed with pleomorphic adenoma which is the most common benign tumor of the salivary glands, but rarely appears in the trachea. Upon surgery, tracheal pleomorphic adenoma and co-existing active pulmonary tuberculoma that had been mistreated as bronchial asthma over 3 months was revealed. Following surgery, the patient underwent anti-tuberculosis treatment. No recurrence has been detected in the 3 years since treatment and the patient is now asymptomatic.
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김제훈 한국생약학회 1982 생약학회지 Vol.13 No.4
회첨(Siegesbeckia pubescens Makino)은 漢方에서 單味로 血壓 및 半身不隨 등에 用藥되어 왔다. 이 生藥의 作用物質을 究明하기 위하여 成分 硏究를 着手하여 Campound A: C<sub>20</sub>H<sub>32</sub>O₃, mp 192∼3˚, B: C<sub>20</sub>H<sub>32</sub>O₄, mp 260∼2˚, C: C<sub>26</sub>H<sub>44</sub> O₃·H₂O, mp 225∼6˚, D: C<sub>20</sub>H<sub>32</sub>O₃, mp 207.5˚, E: C<sub>20</sub>H<sub>32</sub>O₄, mp 239∼42˚, F: C<sub>20</sub>H_(30)O₄, mp 258∼60˚ 및 steroids로서 campesterol, stigmasterol, β-sitosterol, α-spinasterol, stigmast-7-enol 등의 成分을 究明하였고 이들 物質의 生理作用에 對하여 檢討하였다.
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김제훈 대한약학회 1964 약학회지 Vol.8 No.2
A new alkaloid, named tenuidine was isolated from Polygala tenuifolia Willdenow. Its molecular formula corresponded to $C_{21}$ $H_{31}$ $O_{5}$ $N_{3}$ and its constants were m.p.256, [.alpha.]$_{D}$$^{18.5}$=1200.deg.(ethanol). Its infrared absorption spectra exhibited bands at 3.300, 1600, 1580, 1500 $cm^{-1}$ / confirming indole ring and at 2800-2700 $cm^{-1}$ / indicating quinoline ring. Bands at 1610, 1530 $cm^{-1}$ / indicated the presences of benzene ring and 1642$cm^{-1}$ / carbochelate.e.e.
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