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김윤근,장윤석,정재원,이병재,김희연,손지웅,이상록,조상헌,박해심,이명현,민경업,김유영 ( Yoon Keon Kim,Yoon Suk Jang,Jae Won Jung,Byung Jae Lee,Hee Yeon Kim,Jee Wong Son,Sang Rok Lee,Sang Heon Cho,Hae Sim Park,Myung Hyun Lee,Kyung Up Min,Y 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backpwnd: Prevalence of bee venom allergy in Korea is unknown, Objective'. We performed a cross-sectional study to evaluate the prevalence of bee venom allergy and importance of risk factors, such as age, sex, and atopy, in the development of the allergic reaction in children and adults living in rural area of Cheju Island. Swbject and method: The prevalence was investigated in subjects with 1,054 children and 370 adults (701 male, 723 female), aged 7-87 years, living in rural area of Cheju Island. A history particularly focused on the systemic reactions after the bee stings was taken in all subjects. Skin prick test,s to common inhalant allergens, including house dust mites, fungi, tree, grass, mugwort and ragweed pollen, cockroach, animal epithelium, Japanese cedar pollen, and citrus red mite were performed. Result: The prevalence of bee venom allergy was 5.8% (mild systemic reactions 5.0%, severe systemic reactions 0.8% ). The prevalence was higher in adults than in children (10.2% vs. 5.0%, g = 12.0, p<0.01). Among t,he child!'en, the prevalerlce wB.S Signifcant,ly higher ill male than in female (8.6% vs. 1.3%, x=28.7, p<0.01), but no significant diffecence was noted between male and female in adults (10.0% vs. 10.3%, p>0.05). The prevalence of bee venom allergy was not significantly different between subjects with positive skin reaction and those with negative skin reaction to inhalant allergens (6.4% vs. 5.4% ), Conclasion'. The prevlence of bee venom allergy in inhabitants of rural area of Cheju Island is 5.8% (mild systemic,' 5.0%, severe systemic reaction. 0.8%), and bee venom allergy was more common in adults than in children, and in male children than in female children.
IgE - 수용체 매개성 호염기구히스타민유리능과 염색체 11q13 유전형 사이의 연관성
김윤근(Y K Kim),조상헌(S H Cho),고영률(Y Y Koh),손지웅(J W Son),민경업(K U Min),김유영(Y Y Kim) 대한내과학회 1999 대한내과학회지 Vol.56 No.3
N/A Objective : To evaluate that genetic factor(s) in chromosome 11q13 may control the expression of basophil histamine release (BaHR) after anti-IgE stimuli, linkage analysis between this phenotype and gene marker of chromosome 11q13 was performed. Material and methods : BaHR after anti-IgE stimuli and genotyping chromosome 11q13 using microsatellite marker (D11S97) was performed in 56 probands with asthma and 59 their sibs. The linkage between the phenotype and the genotype was evaluated by affected and quantitative trait locus (QTL) sib-pair analysis. Results : Maximal BaHR after anti-IgE were 43.3±3.5% in probands and 29.5±2.6% in sibs, respectively. Of 20 sib-pairs with the maximal BaHR more than 33%, 11 (55%) shared two D11S97 alleles, 9 (45%) shared one allele, neither sib-pair shared identical allele. The sharing rate of D11S97 alleles was 75.5%, which indicates linkage of the phenotype and the genotype (p= 0.026). Difference of the maximal BaHR between probands and their sibs was smaller in sib-pairs with two identical alleles than in those with one identical allele and with no identical allele (14.1±2.5% vs. 25.8±3.1% vs. 40.9±4.9%). Conclusion : Expression of basophil histamine release after anti-IgE stimuli was linked to gene marker of chromosome 11q13.