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      • KCI등재

        정신분열병과 양극성장애에서 뇌파 동시성의 비교분석

        김용규,신재공,박종원,홍경수,이승연,오홍석,이용석,곽용태,장재승,이유상,Kim, Yong-Kyu,Shin, Jae-Kong,Park, Chong-Won,Hong, Kyung Sue,Lee, Seung-Yeoun,Oh, Hong-Seok,Lee, Yong-Suk,Kwak, Yong-Tae,Chang, Jae Seung,Lee, Yu-Sang 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2

        Objectives:EEG coherence could imply the connectivity between two different areas of the brain, which is known to be important in the pathophysiology of bipolar I disorder(BPD I) and schizophrenia. The authors investigated EEG coherence in patients with BPD I and schizophrenia to examine the connectivity of the neural circuit. Methods:EEGs were recorded in 15 schizophrenia and 14 bipolar disorder patients, and 14 age-matched normal control subjects from 16 electrodes with linked-ear reference. Spectral parameters and coherence were calculated for the alpha bandwidth(8-13Hz) by a multi-channel autoregressive model using 20 artifact-free 2-seconds epochs and the differences were compared among three groups by two different statistical methods;F-test and Kruskal-Wallis test. Furthermore, when there were significant differences among three groups, Scheffe's multiple comparison tests were provided and Jonckheere-Terpstra tests for the ordered alternative were given. Results:In the intra-hemispheric comparison, left frontal coherence was increased in order of control, BPD I and schizophrenia. In the inter-hemispheric comparison, 1) inter-prefrontal coherence in BPD I was signifi- cantly higher than in normal controls, and 2) inter-prefrontal coherence in schizophrenia was significantly lower than in controls. Conclusion:These results suggest that 1) both schizophrenia and BPD I are diseases having the abnormality of neural circuit connectivity in both frontal and prefrontal lobes, and 2) the abnormality is more severe in schizophrenia than in BPD I. Furthermore, the data support that a common pathogenetic process may reside in both schizophrenia and BPD I.

      • KCI등재

        수포각막병증에서 각막문신술과 양막이식술 동시 시행 7예

        김용규,한영근,위원량,이진학,권지원,Yong Kyu Kim,Young Keun Han,Won Ryang Wee,Jin Hak Lee,Ji Won Kwon 대한안과학회 2008 대한안과학회지 Vol.49 No.3

        `Purpose: We report on the clinical efficacy of the combined operation of corneal tattooing and amniotic membrane transplantation on the treatment of bullous keratopathy in patients with poor visual potentials. Case summary: We performed corneal tattooing and amniotic membrane transplantation in 7 eyes with bullous keratopathy. Postoperatively, we assessed the status of corneal reepithelialization, postoperative pain, and cosmetic effects. In all cases but one, corneal reepithelialization was successful without pain, and the corneal tattooing persisted throughout the follow-up period. In one case, a corneal epithelial defect developed, so we performed an additional amniotic membrane transplantation. After 2 weeks, the corneal epithelial defect healed and caused no further pain. Conclusions: The combined operation of corneal tattooing and amniotic membrane transplantation is a good choice for the treatment of bullous keratopathy with regard to cosmetic problems, pain, and poor visual potential.`

      • A comparative Study on the Activities of Glutamic Dehydrogenase and Glutamic Transaminase in Livers of the Crucian carp, Pigeon, and Rat

        김용규,남상열,Kim, Yong Kyu,Nam, Sang Yul The Korean Society for Integrative Biology 1969 동물학회지 Vol.12 No.2

        붕어, 비둘기, 흰쥐의 肝組織內의 蛋白質含量과 蛋白質代謝에 관하여는 GDH, GOT 및 GPT의 活性과 比較活性, 그리고 GDH 同位酵素를 測定하였다. 1. 蛋白質含量은 흰쥐, 비둘기가 各各 22.0$\pm$0.01mg/ml 및 22.0$\pm$0.16으로서 거의 같은 量의 蛋白質含量으로 組成되었으나 붕어의 肝臟組織內 蛋白質含量은 約 60%에 該當하는 13.0$\pm$0.09이었다(p < 0.01). 2. Glutamic transaminase는 흰쥐, 비둘기, 붕어의 순위로 그 活性度가 낮았다. 卽 GPT의 比較活性은 各各 3.77$\pm$0.18 unit/mg, 1.93$\pm$0.01 및 0.71$\pm$0.07 이었으며 GOT는 8.23$\pm$0.06 unit/mg, 3.95$\pm$0.09 및 0.92$\pm$0.01이었다(p < 0.01). 3. GOT/GDT 比는 흰쥐, 비둘기, 붕어에서 各各 0.20$\pm$0.004, 0.22$\pm$0.005 및 0.20$\pm$0.002로서 별 차이 없었다. 4. GDH 比較活性은 비둘기가 가장 높은 35.7$\pm$0.81 unit/mg이고 붕어는 9.6$\pm$0.16, 흰쥐는 20.5$\pm$0.81이었다. 5. Glutamic transaminase 와 GDH 比較活性이 動物의 種類에 따라 병행하였으며 特히 進化過程과 一致되는 것으로 思料된다. 6. GDH 同位酵素의 樣相은 種特異性이 뚜렷하였다. 흰쥐에서는 음극이 遲延性易動度區劃의 活性이 가장 높았으나, 비둘기에서는 兩極性區劃의 活性이 가장 높았다. 特히 魚類에서는 陰極性區劃이 全然 發見되지 않았으나 兩極性에 4個의 區劃을 볼수 있었다. The present investigation involves a comparative study of enzymatic activities in various animals. The levels of the liver protein of rat (22.0$\pm$0.01mg/ml and pigeon (22.0$\pm$ 0.16) are twice as high as that of crucian carp (13.0$\pm$ 0.09)(p < 0.01). Generally, the specific acitivity (3.77 $\pm$0.18 unit/mg) of rat glutamic pyruvic transaminase (GPT) is highest, pigeon intermediate (1.93 $\pm$0.01), and crucian carp lowest (0.71$\pm$0.07). On the other hand, the specific activity (8.23$\pm$0.09 unit/mg)of rat glutamic oxaloacetic transaminase (GOT) is highest, pigeon intermediate (3.95$\pm$0.09), and crucian carp lowest (0.92$\pm$0.01) (p < 0.01). Ratios of GOT activity to GPT activity appear no remarkable difference from the levels of various animals. Specific activity of glutamic dehydrogenase(GDH) in pigeon tissue exceeds those of rat and crucian carp. In liver, rat GOT specific activity is greater than crucian carp and pigeon. On the other hand, pigeon GDH specific activity is greater than those of rat and crucian carp. This wouls seem to be in accord with protein metabolic intensity. The patterns for GDH isozyme were remarkably appeared in various animals. Glutamic dehydrogenase isozymes gave different electrophoretic mobilities in various animals. It is interesting that crucian carp, pigeon, and rat would show this difference, which may be indicative of an evolutional pattern. The fact that livers in various animals show quite different enzyme activities would suggest the existence of such a general phylogenetic relationship.

      • SCOPUSKCI등재

        Kinetic and Equilibrium Studies on Complex Formation Between Ni(II) and D-Penicillamine in Aqueous Media

        김용규,최성락,Yong-Kyu Kim,Sung-Nak Choi Korean Chemical Society 1986 대한화학회지 Vol.30 No.5

        $Ni^{2+}$와 D-penicillamine사이의 착물형성반응에 대한 반응속도 및 평형에 관한 수용액중에서 실시하였다. 속도론적 실험은 압력-급변법을 사용하여 pH8~9범위에서 실시하였다. D-Penicillamine은 질소와 유황원자를 주게로 하여 pH>9.2조건에서 $Ni^{2+}$이온에 배위하나 pH값 8.25∼9.07범위에서 총괄 안정도 상수값이 급격히 감소하며 비해리된 mercapto기가 결합에 참여하지 않는 것으로 밝혀졌다. 또한 이 착물 형성반응에 있어 율속단계는 $Ni^{2+}$이온의 내부 배위권으로 부터 물분자가 유리되는 과정임이 밝혀졌다. Rates and equilibriurn of complex formation between $Ni^{2+}$ and D-penicillamine have been investigated in aqueous solutions. Kinetic study on the complex formation were performed in the pH range of 8∼9 by the use of pressure-jump technique. D-Penicillamine coordinates to the nickel(II) ion utilizing sulfur and nitrogen as donor atoms in the high pH condition (pH 9.2). However, in the pH range of 8.25∼9.07, the stepwise stability constant becomes drastically reduced and the undissociated mercapto group does not participate in bonding. The rate-determining step of the complexation reaction is found to be the release of a water molecule from the inner-coordination sphere of $Ni^{2+}$ ion.

      • KCI등재

        트레킹운동 중 활력과 정서 변화의 관계

        김용규(Yong Kyu Kim) 한국사회체육학회 2014 한국사회체육학회지 Vol.0 No.57

        The purpose of this study was to investigate the correlation between vitality and emotion during trekking. Research problems are following; For the first time, to inspect changes of heart rate,perceived difficulty, vitality and emotion during trekking. Secondly to analyze the correlations between heart rate and perceived difficulty. Finally to analyze the correlations between vitality and emotion. For the subjects of this study were33 students(male: 27, female: 6) of D university. They were selected by convenience sampling and walked along the trekking course for 5 hours. The collected data were analyzed by descriptive statistics, reliability analysis, correlation analysis and content analysis. The following conclusionswere drawn: First, the change tendency of heart rate and perception of difficulty was similar. And there were positive relationships between both. Second, the change tendency of vitality and positive emotion was similar and vitality and negative emotion was opposite tendency.

      • KCI등재

        12주간의 복합운동이 비만여성의 Retinol-binding Protein 4, 체지방률 및 동맥경직도에 미치는 영향

        김용규(Yong-Kyu Kim),이정윤(Jeoung-Yun Lee),이서형(Seo-Hyung Lee) 한국생활환경학회 2017 한국생활환경학회지 Vol.24 No.2

        The purpose of this study was to evaluate the effects of combined exercise on Retinol-binding protein 4(RBP-4), arterial stiffness and %body fat in obese middle-aged women. In this study, 24 subjects were divided into 2 groups, exercise(n=12) and control group(n=12), participated in this study for 12 weeks. The untrained obese women in I city voluteered to participate in this study. RBP-4, arterial stiffness and %body fat were analyzed before and after 12-weeks exercise intervention.. All data were expressed as mean±SD by using SPSS package program(win 23.0). The results of this study were as follows : RBP-4(P<.01), %body fat(P<.01) were significantly decreased in the exercise group. Arterial stiffness of right hand, left hand, right foot and left foot(P<.01) were significantly increased in the exercise group. It was concluded that combined exercise program favorably affects the RBP-4, %body fat and arterial stiffness. Therefore, 12weeks combinded exercise may be beneficial to prevent and improve obesity and cardiovascular disease in obese subjects.

      • KCI등재

        유무선 통신서비스 수요의 실증분석

        김용규 ( Yong Kyu Kim ),유진수 ( Jin Soo Yoo ),전성훈 ( Seong Hoon Jeon ),황윤재 ( Yoon Jae Whang ) 정보통신정책학회 2012 정보통신정책연구 Vol.19 No.4

        본 연구는 유무선 서비스의 통화량과 요금에 관한 월간 시계열 자료를 사용하여 다양한 유무선 통화수요의 자기가격탄력성, 교차가격탄력성 및 소득탄력성을 추정하였다. 이를 위해 유선의 시내, 시외, LM(Land to Mobile) 그리고 이동의 음성, SMS(Short Message Service) 등으로 통화수요를 구분하고 각 통화에 대한 지출비중방정식 체계를 추정하였다. 추정 모형으로는 AIDS(Almost Ideal Demand System)을 이용하였고 추정 과정에서 변수들간의 공적분 관계를 고려하여 삼각오차수정모형 (Triangular Error Correction Model)을 이용하였다. 추정결과에 따르면 유선 시내의 가격탄력성은 -1.06으로 나타났으며 이동전화의 가격탄력성은 -0.85로 나타났다. 이러한 탄력성의 크기는 기존의 연구 결과와 대체로 유사한 것으로 나타났다. In this paper, we estimate the own- and cross- price elasticities and income elasticity of various fixed and mobile telephone services using monthly time series data. We estimate expenditure share of various telecommunications services such as local, toll, LM(Land to Mobile), Mobile voice and Short Message Services. We employ AIDS (Almost Ideal Demand System) as the estimation model and employ Triangular Error Correction Model in the estimation to consider the cointegrated relationship between variables. We show that the own-price elasticity of the demand for local call is -1.06 and the ownprice elasticity of the demand for mobile is -0.85. This result is consistent with those of previous studies.

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