UPE1) 홍어껍질 콜라겐 펩타이드가 비만쥐의 산화스트레스 억제에 미치는 효과

김예진,최서희,구효근,우민지,노정숙,정갑섭 한국환경과학회 2018 한국환경과학회 학술발표회 발표논문집 Vol.2018 No.11

무조음악에 내재된 구조적 성부진행 연구 : ‘음향 간 성부진행’의 관점에서

김예진 한국서양음악학회 2021 서양음악학 Vol.24 No.2

The voice leading researches for the analysis of atonal music have been studied by focusing on measuring the degree of similarity through ‘connection of common tones’ and ‘maximally smooth voice leading progression’. However, in 2014, the Total Voice Leading theory proposed by Straus focuses on the ‘connection’ and ‘possibility’ of relationship between sonorities on the real music surface. In this paper, I first introduce Straus’s Total Voice Leading System, which provided a new perspective on the study of voice-leading progression in atonal music and I try to analyze the Webern’s song, ≪Three Songs≫, op. 25, no. 3. Through this analytical study, I could prove the structural total voice leading systems latent in Webern’s music by considering the possibility of acoustic voice leading. 지금까지 연구되어 온 무조음악 분석을 위한 성부진행 이론은 특정 음고류 집합에서 다른 음고류 집합으로의 진행 시, ‘공통음의 연결’과 ‘최대 근접 진행’을 통해 집합 사이 유사성의 정도를측정하기 위한 개념들을 제시하며 ‘자연스러운 성부진행’을 밝히는 데 주목하였다. 그러나 2014 년, 스트라우스가 제안한 총체적 성부진행(Total Voice Leading) 이론은 실제 음악 표면에 울리는 음들의 ‘연결’과 그 ‘가능성’에 대해 초점을 맞춘 실제적인 ‘들음의 경로’에 대한 탐구라 할 수있으며, 음향에 ‘내재된 기대’에 대한 가능성들의 ‘집합화’, 그리고 그 가능성들의 관계 조망을 통해 난해한 무조음악에 내재된 ‘성부진행 가능성’을 ‘총체적 성부진행’ 이론을 통해 가시화 한다. 이에 필자는 무조음악 성부진행 연구에 새로운 관점을 제공한 스트라우스의 총체적 성부진행이론을 소개하고, 베베른(Anton Webern, 1883∼1945)의 ≪3개의 가곡≫ op. 25, No. 3 작품을음향 간 성부진행의 관점에서 분석 시도한다. 음고류 사이 진행 가능성에 대한 고찰, 그리고 도출된 음향 간 총체적 성부진행들의 관계를 보다 심화된 층위에서 분석하여 무조음악 안에 내재된실제 울림의 구조적 성부진행을 밝히는 것이 본 논문의 목적이다.

COVID-19 연관 침습성 폐 아스페르길루스증 1례

김예진,최재필 대한내과학회 2021 대한내과학회 추계학술대회 Vol.2021 No.1

음악지각인지 연구 고찰을 통한 무조음악 교육을 위한 제언

김예진 한국음악교육공학회 2016 음악교육공학 Vol.- No.26

This paper begins by Leonard B. Meyer's statement, "music has meaning” in Emotion and Meaning in music. Music is used as form of communication of human-beings. For the study of the process of discovering meaning latent in music, I have reviewed cognitive researches on music perception. The problem of misleading musical meaning in atonal music is reasoned by the premise based on the tonal music perception. When we listen to diverse and complex music of twentieth-century, our perception's judgment comes from the cognitive progression of tonal music. For this reason, many student who don't have enough experience on atonal music have been a difficult situation when they listen to atonal music. In this respect, I try to suggest the proposal relating to our educational curriculum for atonal music in music colleges. 서양음악의 공통관습 어법의 ‘조성’(Tonality)은 현재 우리가 살고 있는 21세기 시대에도 여전히 음악청취의 보편적 원리로 적용되고 있다. 무조음악(Atonal music)이 실험된 후 100년 이상이 지난 지금까지도 ‘무조성’(Atonality) 음향에 대해 음악을 전공하는 학생들조차 여전히 거부반응을 보이고 있는 것이 현실이지만, 이에 대한 진지한 논의는 많이 부족했던 것이 사실이다. 이에 필자는 본 연구에서 음악의 청취과정에 대한 선 연구들을 살펴보며 무조음악 소통의 어려움의 원인을 유추해본다. 이를 극복하기 위해 한국의 주요 음악대학들의 교육 커리큘럼을 살펴보고, 음악대학의 교육 과정 고찰을 통해 여전히 무조음악 교육을 위한 체계적인 커리큘럼이 부재함을 확인하며, 20-21세기의 음악 교육에 대한 진지한 고민과 논의가 필요함을 피력한다. 무조음악의 ‘의미’있는 청취, ‘의미’있는 연주, ‘의미’있는 소통을 위해서 음악대학 교육 커리큘럼의 점검, 재고, 변화의 노력을 구하고자 한다.

Comparison of Mechanical Properties of Blended and Synthesized Biodegradable Polyesters

김예진,박오옥,강경돈,윤기철 한국고분자학회 2014 Macromolecular Research Vol.22 No.4

In this study, a new biodegradable co-polyester was prepared and characterized based on its crystallinityand thermal properties. The crystallinity decreased as the content of long chain monomers, such as adipic acid, inthe main chain of poly(butylene succinate) increased, whereas the flexibility increased. Compared with an immiscibleblended resin having the same monomer composition, the flexibility and elongation of the synthesized co-polyesterwas superior without compromise of biodegradability.

비만 청소년에서 동맥경화증을 조기에 예측하기 위한 경부 초음파를 이용한 경동맥 측정

김예진,심윤희,유정현,이근,홍영미 대한소아청소년과학회 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.7

Purpose : Adolescent obesity is known to be associated with complications such as hypertension, coronary artery disease and insulin resistance. We measured the common carotid artery by ultrasound as a predictor of atherosclerosis, and investigated the relationship between carotid artery parameters and serum cytokines in obese adolescents. Methods : Twenty-nine obese adolescents(16-17 years old, obesity index>130 percent) and twenty- seven normal controls were included. Obesity index and body mass index were calculated from their height and weight. Skin fold thickness was measured at the triceps, and fat mass and fat distribution by bioelectrical impedence analysis. Blood pressure was measured at resting state and serum lipid, insulin, and homocysteine levels after a 12-hour fasting period. Intimal wall thickness, systolic and diastolic diameters of the common carotid artery were measured by ultrasound, and compliance and distensibility calculated by equation. Results : Systolic and diastolic diameters of the carotid artery significantly correlated with arm circumference, body mass index, fat distribution and fat mass. The higher systolic blood pressure was, the larger systolic and diastolic diameter. The higher diastolic blood pressure was, the larger carotid intimal thickness. Insulin levels had positive correlations with systolic, diastolic diameters and serum homocysteine level with intimal thickness. Conclusion : The carotid artery diameter significantly increased with the degree of obesity and blood pressure. The carotid intimal wall thickness significantly correlated with diastolic blood pressure. Measurement of carotid artery thickness, insulin and homocysteine levels might be useful to predict the development of coronary artery disease. 목 적 : 소아 비만의 증가에 따라 소아기에 고혈압, 관상동맥질환, 당뇨병 등의 소아 성인병이 문제가 되고 있다. 중등도 이상의 비만 청소년에서 경부 초음파로 경동맥의 내피두께, 직경, 동맥의 유연도와 신전도를 측정함으로 조기에 동맥 경화증으로 진행을 예측할 수 있는지 알아보고, 동맥벽 두께와 혈청 사이토카인 등 여러 지표와의 관련성을 알아보고, 비만 청소년에서 관상동맥 질환으로 진행할 수 있는 위험 인자로 유용한지 알아보고자 하였다.방 법 : 16-17세의 29명의 중등도 이상의 비만 청소년을 대상군으로 하였고, 같은 연령의 정상 청소년을 대조군으로 하였다. 체질량 지수와 피부두께를 측정하였고, 생체전기저항 분석을 이용하여 체지방, 지방 분포를 측정하였다. 안정된 상태에서 수축기, 이완기 혈압을 측정하였다. 10시간 이상 금식 후 총 콜레스테롤, 중성 지방, HDL 콜레스테롤, LDL 콜레스테롤, 혈당, 호모시스틴, 인슐린, 인슐린 저항성을 측정하였다. 경부 초음파를 이용하여 경동맥의 내피 두께, 수축기와 이완기 동안의 내경, 동맥의 유연도와 신전도를 측정하였다. 결 과 : 경동맥의 수축기 내경, 이완기 내경은 상완둘레, 체질량 지수, 지방분포, 체지방이 증가함에 따라 유의하게 증가하였다. 수축기 혈압이 높을수록 수축기 및 이완기 내경이 유의하게 증가하였고, 이완기 혈압이 증가할수록 내피두께는 유의하게 증가하였다. 인슐린치가 증가할수록 수축기 및 이완기 내경이 유의하게 증가하였다. 호모시스틴치가 증가할수록 내피 두께가 유의하게 증가함을 알 수 있었다. 결 론:소아에서도 비만 정도가 심할수록, 혈압이 높을수록 경동맥의 내경이 증가하였고, 경동맥의 내피두께는 이완기 혈압과 유의한 상관성이 있었다. 혈압, 인슐린, 호모시스틴을 측정함으로 조기에 동맥경화증으로 진행을 예측하는데 유용하리라 생각되고 소아기 비만에서도 적극적인 체중 감량을 통해 소아 성인병으로 진행되는 것을 적극적으로 예방하여야 될 것으로 생각한다.

Recent progress in dendrimer-based nanomedicine development

김예진,박은지,나동희 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.6

Dendrimers offer well-defined nanoarchitectureswith spherical shape, high degree of molecular uniformity,and multiple surface functionalities. Such unique structuralproperties of dendrimers have created many applicationsfor drug and gene delivery, nanomedicine, diagnostics, andbiomedical engineering. Dendrimers are not only capableof delivering drugs or diagnostic agents to desired sites byencapsulating or conjugating them to the periphery, butalso have therapeutic efficacy in their own. When comparedto traditional polymers for drug delivery, dendrimershave distinct advantages, such as high drug-loadingcapacity at the surface terminal for conjugation or interiorspace for encapsulation, size control with well-definednumbers of peripheries, and multivalency for conjugationto drugs, targeting moieties, molecular sensors, andbiopolymers. This review focuses on recent applications ofdendrimers for the development of dendrimer-basednanomedicines for cancer, inflammation, and viral infection. Although dendrimer-based nanomedicines still facesome challenges including scale-up production and wellcharacterization,several dendrimer-based drug candidatesare expected to enter clinical development phase in thenear future.

Co-Crystallization Behavior of Biodegradable Poly(butylene succinateco- adipate-co-terephthalate) Copolyesters

김예진,박오옥,강경돈,윤기철,황윤일 한국고분자학회 2015 Macromolecular Research Vol.23 No.10

Simultaneous Determination of Cysteamine and Cystamine in Cosmetics by Ion-Pairing Reversed-Phase High-Performance Liquid Chromatography

김예진,나동희 한국독성학회 2019 Toxicological Research Vol.35 No.2

Cysteamine has been used in cosmetics as an antioxidant, a hair straightening agent, and a hair waving agent. However, recent studies indicate that cysteamine can act as an allergen to hairdressers. The objective of this study was to develop and validate a simple and effective reversed-phase high-performance liquid chromatography (RPHPLC) method for the measurement of cysteamine and its dimer, cystamine. Sodium 1-heptanesulfonate (NaHpSO) was used as an ion-pairing agent to improve chromatographic performance. Separation was performed on a Gemini C18 column (250 mm × 4.6 mm, 5 μm particle size) using a mobile phase composed of 85:15 (v/v) 4 mM NaHpSO in 0.1% phosphoric acid:acetonitrile. UV absorbance was monitored at 215 nm. The RP-HPLC method developed in this study was validated for specificity, linearity, limit of detection, limit of quantitation, precision, accuracy, and recovery. Cysteamine and cystamine were chromatographically resolved from other reducing agents such as thioglycolic acid and cysteine. Extraction using water and chloroform resulted in the recovery for cysteamine and cystamine ranging from 100.2-102.7% and 90.6-98.7%, respectively. This validated RP-HPLC method would be useful for quality control and monitoring of cysteamine and cystamine in cosmetics.

Clinical Manifestations of Norovirus Infection in Korean Pediatric Cancer Patients

김예진,최현신,최영배,황지영,천두성,정혜숙,최연호,유건희,성기웅,구홍회 대한소아감염학회 2011 Pediatric Infection and Vaccine Vol.18 No.1

Purpose:Norovirus infection, a common cause of community-acquired gastroenteritis, can also lead to severe illness in immunocompromised patients. We investigated clinical manifestations of norovirus infection in pediatric cancer patients. Methods:Stool specimens were collected from pediatric patients with gastrointestinal symptoms between November 2008 and September 2009 at Samsung Medical Center, Seoul, Korea. Norovirus infection was identified by reverse-transcription polymerase chain reaction (RT-PCR). A retrospective chart review was performed in pediatric cancer patients who were diagnosed with norovirus infection. Results:Ten patients were diagnosed with norovirus infection by RT-PCR in stool samples. The median age was 0.83 years (range 0.25-5.5 years) and the male to female ratio was 1.5:1 (6 males and 4 females). Underlying diseases were hematologic malignancies (4/10, 40%), neuroblastoma (4/10, 40%), and brain tumors (2/10, 20%). Three patients were infected before hematopoietic cell transplantation (HCT) and four patients after HCT. All patients had diarrhea (10/10, 100%), with a median frequency of diarrhea of 8.5 times/day (range 4-22 times/day). Median virus shedding duration was 72.5 days (range 19-299 days). Four patients with pneumatosis intestinalis were conservatively treated with bowel rest and total parenteral nutrition. One patient with severe diarrhea and bloody stool had concomitant chronic gut graft-versus-host disease (GVHD). Norovirus infection-related mortality was not observed. Conclusion:Norovirus infection can cause significant clinical manifestations with prolonged viral shedding in immunocompromised patients. Norovirus should be considered in pediatric cancer patients with severe gastrointestinal symptoms.