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정훈(Hoon Jeong),이승룡(Seung Yong Lee),김수웅(Su Ung Kim),한만덕(Man Deuck Han),이은방(Eun Bang Lee),천선아(Seon Ah Cheon),김상미(Sang Mee Kim),김경란(Kyung Ran Kim),이승목(Seung Mok Lee),현익상(Ik Sang Hyun),이준우(June Woo Lee) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4
A polysaccharide, G009, isolated from Ganoderma lucidum IY 009, was subjected to investigating on general pharmacology. This material at the large oral doses of 1000 and 2000 ㎎/㎏ in mice did not exhibit any abnormal behaviors and another effects on central nervous system. It also had no influences on hexobarbital-induced sleeping time, rotarod test and spontaneous activity test at each oral dose of 1000 ㎎/㎏ in mice. No effects on the body temperature and on acetic acid induced writhing syndrome in mice were observed with its oral administration at 1000 ㎎/㎏, and the convulsions induced by strychnine and pentetrazole were not inhibited at its oral doses of 1000 ㎎/㎏ in mice. The solution of G009 as given intravenously at the doses of 30 and 60 ㎎/㎏ in rabbit had no influences on blood pressure and respiration rates and depth. In isolated organs of rat uterus and fundus muscles and guinea pig ileum and trachea, it did not show any contraction or relaxation at the concentrations of 2 X 10^(-3) g/㎖, and the contractive actions produced by oxytocin, acetylcholine, serotonin and histamine were not inhibited at the same doses. This material showed no effect on intestinal propulsion test in mice and gastric secretion in rats at the oral doses of 1000 ㎎/㎏. However, it is interesting that the material exhibited potent inhibition of acidified aspirin induced gastric damage at the doses of 500 and 1000 ㎎/㎏ in rats.
영지의 단백다당체 G009 의 마우스와 기니픽에 있어서의 항원성에 관한 연구
박종일(Jong Il Park),정태천(Tae Cheon Jeong),차신우(Shin Woo Cha),신호철(Ho Chul Shin),정훈(Hoon Jeong),김수웅(Su Ung Kim),한상섭(Sang Seop Han) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.1
In the present study, the antigenic potential of G009, a polysaccharide isolated from Ganoderma lucidum IY009, was determined in BALB/c mice and Hartley guinea pigs. Antigenicity tests, including passive cutaneous anaphylaxis (PCA), active systemic anaphylaxis (ASA) and indirect hemagglutination test (IHA) were performed according to the established guidelines of National Institute of Safety Research. The results were as follows: 1. Mice showed no production of antibodies against G009 sensitized with an adjuvant, aluminum hydroxide gel (alum), when judged by the heterologous PCA test in rats. Meanwhile, antibodies against ovalbumin (OVA) sensitized with alum were clearly detected. 2. In the studies with guinea pigs, both the sensitization of G009 alone and of G009 with complete Freund`s adjuvant (CFA) did not produce positive reactions in homologous PCA. In the case of ASA, however, G009 alone and G009 with CFA produced positive reactions. 3. No G009 specific reaction was observed in an IHA assay using sera isolated from G009 sensitized mice. These findings suggest that G009 have no antigenicity potential in mice but may have weak antigenicity in guinea pigs.
G009 가 Peroxidizers 에 의해 유발된 지질 과산화에 미치는 영향
이준우(June Woo Lee),정훈(Hoon Jeong),이승목(Seung Mok Lee),김기남(Ki Nam Kim),한만덕(Man Deuck Han),이승룡(Seung Yong Lee),김수웅(Su Ung Kim),강상모(Sang Mo Kang) 한국응용약물학회 1996 Biomolecules & Therapeutics(구 응용약물학회지) Vol.4 No.3
In this study, the anti-lipidperoxidative effects of G009, a polysaccharide extracted from Ganoderma lucidum IY009, was determined in ascorbic acid-Fe^(2+)-adenosine 5-diphosphate-intoxicated rat. In a model of ascorbic acid-Fe^(2+)-adenosine 5-diphosphate-induced hepatotoxicity in rat, G009 exhibited anti-lipidperoxidative effect in rat liver homogenate, and that malondialdehyde values of the liver homogenate inhibited from 48.1 % to 74.8% in comparison to controls (p<0.05). The malondialdehyde formation in serum inhibited 66.5% at 100 mg/kg of G009. Also, serum levels of glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in peroxidizer-induced rats treated with G009 was decreased compared with control. Especially, the formation of lipid peroxides in serum was related to glutamic pyruvic transaminase levels. These results suggest that G009 has a protective effect on ascorbic acid-Fe^(2+)-adenosine 5-diphosphate-induced hepatic injury through an inhibition of lipid peroxidation in liver.
박만기(Man Ki Park),박정일(Jeong Hill Park),이미영(Mi Young Lee),박인정(In Jeong Park),김수웅(Su Ung Kim),이승룡(Seung Yong Lee),정훈(Hoon Jeong),이준우(Junn Woo Lee),한만덕(Man Deuck Han) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.3
G009, isolated from the mycelia of Ganoderma lucidum, has been reported as a potent liver-protecting compound. To characterize this compound, its physicochemical properties were studied. The average molecular weight of the most abundant constituent of G009 was 9.4 kD. The contents of carbohydrate and protein in G009 were 70% and 12.4%, respectively. The main carbohydrate constituents were glucose, xylose, mannose and galactose. Seventeen kinds of amino acid were detected. The contents of carbon, hydrogen, and nitrogen were 40, 5.7, and 1.8%, respectively. Ca, Mg, Zn were also determined.