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Chitooligosaccharide가 생쥐의 간 기능에 미치는 영향
김세재,강소영,박승림,신태균,고영환,Kim, Se-Jae,Kang, So-Young,Park, Seung-Lim,Shin, Tae-Kyun,Ko, Young-Hwan 한국식품과학회 1998 한국식품과학회지 Vol.30 No.3
Chitin의 탈아세틸화로 얻어지는 화합물인 chitosan과 chitooligosaccharide는 다양한 생리활성 기능을 나타내므로 생물의학적인 응용에 많은 관심이 집중되고 있다. 본 연구는 수용성 chitooligosaccharide가 생쥐의 간 기능에 미치는 영향을 조사하기 위하여 수행되었다. 6주 동안 3% cholesterol를 식이한 생쥐에서는 혈장 cholesterol 함량이 증가하였으나, 1% chitooligosaccharide와 3% cholesterol을 함께 식이한 생쥐에서는 혈장 cholesterol 함량이 23% 정도 감소하였다. 그러나 혈장내 HDL-cholesterol과 간내 cholesterol 함량에는 유의한 차이가 없었다. 한편, 15% ethanol을 8주간 투여한 생쥐에서는 inflammation, necrosis, 지방구의 축적, GPT의 활성 증가 등 간 상해가 관찰되었다. 그와 반면에 0.5% chitooligosaccharide와 15% ethanol을 함께 투여한 생쥐에서는 ethanol에 의해 유발된 간 상해가 현저히 억제되어 지방구의 축적이 관찰되지 않았고, 혈장의 GPT 활성이 25%정도 감소하였다. 따라서, chitooligosaccharide가 생쥐에서 혈장 cholesterol 함량을 감소시키고, 알코올성 지방간을 예방하는 등 부분적인 기능이 있음을 보여주었다. Chitosan is the deacetylated product of chitin. Chitosan and its derivatives have many properties that make them attractive for a wide variety of health applications. This study was performed to investigate some effects of water soluble chitooligosaccharides on liver function in the mouse. The animals given the sterol diet containing 3% cholesterol for 6 weeks showed increase in plasma cholesterol level, which were lowered by 23% when they were fed on 1% chotooligosaccharide. While there was no significant change in liver cholesterol and plasma HDL-cholesterol levels. Continuous administration of 15% ethanol via drinking water to mice for 8 weeks elicited pathological alterations such as inflammation, necrosis, accumulation of lipid droplets in the liver and increase in GPT activity, while simultaneous administration of ethanol and chitooligosaccharide prevented remarkedly ethanol-induced liver injury; there was no observable lipid droplet and GPT activity was decreased by 25% in the liver. These results suggest that chitooligosaccharide play some roles in liver function, such as reducing the plasma cholesterol level and preventing alcoholic liver disease.
한국인 집단의 C5 isozyme 과 Gc subtypes
김세재,이정주,남궁용 한국유전학회 1986 Genes & Genomics Vol.8 No.3
The distributions of C_5 isozyme of the serum cholinesterase (E₂locus) and group-specific component (Gc) subtypes were studied in populations of Korea. The frequencies of C_5 were 0.091 in Seoul, 0.0836 in Kangreung, and 0.0318 in Cheju population. The gene frequencies of Gc were Gc¹F=0.4619, Gc¹S=0.2780, and Gc²=0.2601 in Seoul population. The observed numbers of phenotypes were in good agreements with the expected numbers on the basis of Hardy-Weinberg equilibrium in both systems. These findings were discussed in comparison with of other populations.
김세재,신혜선,강성일,박덕배 한국유전학회 2016 Genes & Genomics Vol.38 No.2
Obesity is associated with inflammatory status and linked with metabolic syndrome. Interaction between adipocytes and macrophages aggravates inflammation and leads to insulin resistance in adipocytes. Resveratrol improved reportedly obesity-related inflammatory responses, but the effects of resveratrol on the production of inflammatory mediators and glucose metabolism in inflamed adipose tissue is not completely known. In this study, we investigated the effects of resveratrol on inflammatory change and insulin resistance in the coculture of hypertrophied 3T3-L1 adipocytes and RAW 264.7 macrophages. Resveratrol decreased nitric oxide production and the expression of interleukin (IL)-6, IL-1b, tumor necrosis factor-a, inducible nitric oxide synthesis, and cyclooxygenase-2 in the coculture. Resveratrol increased glucose uptake by stimulating the phosphorylation of IRS-1 and AKT in the coculture. These results support that resveratrol have beneficial effect on inflammation and insulin resistance in inflamed adipose tissue.
노랑초파리의 ultraspiracle 유전자 산물은 발생과정에서 광범위하게 발현되는 전사조정인자이다
김세재 濟州大學校 基礎科學硏究所 1995 基礎科學硏究 Vol.8 No.1
노랑초파리의 ultraspiracle 유전자 산물(Usp)은 ecdysone receptor(EcR)와 이합체를 형성함으로서 호르몬의 작용을 매개하는 전사인자로써 스테로이드 호르몬 수용체군에 속한다. 유전적인 분석과 분자생물학적 분석에 의하면 Usp는 초파리 배발생, 눈의 형태형성, 암컷의 생식과정에 관여한다. 본 연구에서는 발생과정중에 각 조직에서 usp유전자의 발현양상을 immunocytochemistry와 insitu Hybridization 방법으로 조사하였다. Usp의 발현은 발생의 전과정을 통해 조사된 모든 조직의 핵에서 검출되었다. 본 연구결과는 Usp는 발생과정에서 호르몬의 작용을 매개할 뿐 아니라 암컷과 수컷의 생식과정에도 관여한다고 사료된다. ultraspiracle(usp) gene produt(Usp) is a member of the superfamily of steroid hormone receptors in Drosophila melanogasler which mediate the hormone action by heteromerization with ecdysone receptor(EcR). Based on the genetic and molecular characterization of usp, it has been proposed that Usp funtions in at least three significant developmental pathway: embryogenesis, eye morphogenesis, and female reproduction. The expression patterns of Usp were investigated in individual tissues from different developmental stages of Drosophila. Usp is localized in the nucleus with ubiquitous distribution throughout development. This result suggests that Usp is not a transcriptional regulatory factor modulating the various process involving hormone response, but also associated with female and male reproduction in development of Drosophila.
노랑초파리 흔적날개 돌연변이체의 발생에 미치는 온도의 영향 : 발생단계에 따른 글리세롤 - 3 인산 탈수소 효소와 락트산 탈수소 효소의 변화
김세재,이정주,백상기 한국유전학회 1987 Genes & Genomics Vol.9 No.3
Temperature affects the rate of development of an organism. To investigate the effects of the extreme temperature on the developmental profiles in Drosophila melanogaster vestigial mutant, the early first-instar larvae were incubated at temperature extreme (31℃) for 2 days and transferred thereafter to moderate temperature (24℃), and the enzyme activities and the changes in the electrophoretic patterns of glycerol-3- phosphate dehydrogenase and lactate dehydrogenase were studied throughout the developmental stages. The thermophene that has relatively normal wing was induced by temperature treatment from vestigial phenotype, but the life span of adult thermophene flies was shortened. The enzyme activities of glycerol-3-phosphate dehydrogenase and lactate dehydrogenase during development were markedly influenced by temperature treatment in vestigial mutant comparing with the normal wild type files; however, the electrophoretic patterns of both enzymes were not changed.
Interactions between Drosophila USP and ECR - A was Identified in Yeast Two - Hybrid System
김세재,이정주,고인숙,정기화,박지권 한국유전학회 1996 Genes & Genomics Vol.18 No.3
ultraspiracle gene product (USP) is one of several orphan receptors in Drosophila, sharing significant homology with the mammalian retinoid X receptor. In Drosophila the response to the hormone is mediate in part by USP and ecdysone receptors (ECR), which are members of the nuclear receptor superfamily. Heterodimers of these proteins bind to ecdysone response elements (EcRE) and ecdysone to modulate transcription. We used the yeast two-hybrid assay for detection of protein-protein interactions in vivo to screen for novel partners of USP. The GAL4 DNA-binding domain fused to USP was used as bait to screen a Drosophila embryonic cDNA library in which the cDNA was fused to the GAL4 activation domain. Several cDNA clones encoding proteins that interact with USP were isolated, one of which corresponded to the ecdysone receptor A isoform (ECRA). Domain analysis on USP revealed that the ligand binding domain is required for heterodimerization with ECR-A. Given the ability of USP to dimerize preferentially with ECR-A, this strategy should be useful for cloning novel partners for USP from a variety of cell types.