Room Temperature Phosphorescence from Inclusion Complex of ${\beta}$-Cyclodextrin and 1-Bromonaphthalene in the Presence of Phenol and 1-Butanol

김상진,Kim, Sang Jin 대한화학회 2001 Bulletin of the Korean Chemical Society Vol.22 No.12

미국.일본의 심해생명공학 연구동향

김상진,Kim, Sang-Jin 한국미생물학회 2003 微生物과 産業 Vol.29 No.2

3${\beta}$-Hydroxy-12-oleanen-28-oic Acid 유도체들의 PTP-1B저해활성에 대한 CoMSIA분석

김상진,정영호,김세곤,성낙도,Kim, Sang-Jin,Chung, Young-Ho,Kim, Se-Gon,Sung, Nack-Do 한국응용생명화학회 2008 Applied Biological Chemistry (Appl Biol Chem) Vol.51 No.3

기질 화합물로써 3${\beta}$-Hydroxy-12-oleanen-28-oic acid 유도체(1-30)들과 그들의 protein tyrosine phosphatase(PTP)-1B 저해활성에 관한 비교분자 유사성 지수분석(CoMSIA)보델을 유도하였다. QSAR 모델의 통계 값은 CoMFA>CoMSIA${\geq}$HQSAR>2D-QSAR 모델의 순서로 양호하였다. 최적화된 CoMSIA F1 모델은 grid 3.0${\AA}$과 field fit 정렬조건에서 가장 족은 예측성과 상관성($r^2_{cf}$=0.754 및 $r^2_{ncv}$=0.976)을 나타내었다. 저해 활성에 관한 CoMSIA상의 기여비율(%)은 수소결합 받게장(48.9%), 입체장(25.8%) 및 소수성장(25.4%)의 순서이었다. 그러므로 기질 화합물의 PTP-1B에 대한 저해활성은 $R_4$-치환기의 수소결합 받게 장(A)에 의존적이었다. 등고도 분석 결과로부터 $R_1$-치환기는 수소결합 받게장이 작고 $R_3$-치환기는 입체장이 작으며 그리고 $R_4$-치환기는 수소결합 받게장, 소수성 및 입체장이 큰 치환기가 저해활성을 증가시킬 것으로 예측되었다. The comparative molecular similarity indices analysis (CoMSIA) models between 3${\beta}$-Hydroxy-12-oleanen-28-oic acid (1-30) analogues as substrate molecule and their inhibitory activities ($pI_{50}$) against protein tyrosine phosphatase (PTP)-1B were derived and discussed quantitatively. Listing in order, the CoMFA>CoMSIA${\geq}$HQSAR>2D-QSAR model, these QSAR models had the better statistical values. The optimized CoMSIA F1 model at grid 3.0${\AA}$ had the best predictability and fitness ($q^2$=0.754 and $r^2$=0.976) by field fit alignment. The order of contribution ratio (%) of CoMSIA fields concerning the inhibitory activities was a H-bond acceptor (48.9%), steric field (25.8%) and hydrophobic field (25.4%), respectively. Therefore, the inhibitory activities of substrate molecules against PTP-1B were dependent upon H-bond acceptor field (A) of $R_4$-group. From the analytical results of CoMSIA contour maps, oleanolic acid derivatives will have better inhibition activities if $R_1$ group has H-bond acceptor disfavor, $R_3$group has steric disfavor and $R_4$ group has steric, hydrophobic, H-bond favor.

동기 및 비동기 겸용모드의 멀티미디어 원격교육 시스템 개발에 관한 연구

김상진,김석수,박길철,황대준,Kim, Sang-Jin,Kim, Seok-Soo,Park, Gil-Cheol,Hwang, Dae-Joon 한국정보처리학회 1997 정보처리논문지 Vol.4 No.12

본 논문에서 제안하는 원격교육 시스템은 정보 통신 기술과 멀티미디어 기술을 이용해서 사이버 스페이스상에서 열린 교육을 위한 교육자와 피교육자간의 상호 참여를 통한 동기 및 비동기의 학습이 모두 가능하도록 개발된 원격 교육 시스템이다. 특히 기존의 원격 교육 시스템이 갖는 생소함과 불편함을 가능한 느끼지 않도록 개발하였고, 면대면 효과를 최대로 지원하는 멀티미디어 기술상의 상호작용이 가능한 실시간 동기모드의 학습모드와 사용자 위주의 비동기 모드의 자율학습을 진행하다가 필요한 자료의 지원을 받아 원하는 선생님의 학습자료를 다운로딩 할 수 있고, 선생님과의 동기 학습 모드 변환이 가능한 시스템이다. 본 시스템은 응용 공유기술, 화이트보드, 다양한 비디오 윈도우 표시, 비디오, 사용자 인터페이스를 지원하고 있으며, 또한 세션관리, 통신제어, 각 미디어 제어의 제어 기술이 지원되고 있다. In this paper, we proposed the "synchronous & asynchronous distance education system" which is able to interact among teachers and students for open education in cyberspace, and it is based telecommunication technology and multimedia technology. Specially, This system gets rid of the nufamiliarity and inconvenient feeling during the distance education. Also it supports the mediation of floor mode, for a group lecture and supports the synchronous mode for face-to-face effective and asynchronous mode for self-learning. The asynchronous mode has the down load function and the consultant mode (between teacher and student). The element technologies of this system consists of application sharing technique, whiteboard, various video window display, audio support, user interface, environment setup, session management, access control, network control and media control for collaborative distance education.

재발된 간헐외사시로 재수술한 환자의 임상분석

김상진,최동규,Sang Jin Kim,Dong Gyu Choi 대한안과학회 2007 대한안과학회지 Vol.48 No.2

Purpose: To analyze the clinical course and relationships between the factors and surgical outcomes after reoperation for recurrent intermittent exotropia. Methods: Surgical results were retrospectively investigated in 38 patients who had undergone reoperation at least 3 months after surgical correction. Recurrence was defined as an exodeviation of more than 10 prism diopters at the primary position. We investigated the recurrence rate according to the follow-up duration with survival analysis, and analyzed the relationships between the factors and surgical outcome. Results: The mean survival period was 22.7±20.2 months (range, 3 to 72 months). As the follow-up duration increased, the recurrence rate progressively increased. The hazard ratio for recurrence of a unilateral medial rectus resection as a reoperation was significantly higher than that for a unilateral lateral rectus recession and medial rectus resection (recession and resection)(p=0.021). After using unilateral recession and resection as the primary surgery, the hazard ratio for recurrence of unilateral recession and resection as a reoperation was not significantly different from that for unilateral lateral rectus recession (p=0.480). After a bilateral lateral rectus recession, the hazard ratio for recurrence of unilateral medial rectus resection was not significantly different from that for bilateral medial rectus resection (p=0.076). Conclusions: The surgical options for recurrent intermittent exotropia are contralateral recession and resection or contralateral lateral rectus recession. The procedure chosen depends on the operator`s preference after performing unilateral recession and resection as the primary surgery. After a bilateral lateral rectus recession, the hazard ratio for recurrence of unilateral medial rectus resection was not significantly higher than that for a bilateral medial rectus resection, but even so, a bilateral medial rectus resection may be more effective than unilateral medial rectus resection for recurrent intermittent exotropia.

유류에 오염된 아비류 (Loons)의 체내 조직 중 필수원소 농도

김상진,이종남,이두표,Kim Sang-Jin,Lee Jong-Nam,Lee Doo-Pyo 환경독성보건학회 2006 환경독성보건학회지 Vol.21 No.3

Concentrations of four essential metals (Fe, Cu, Mn and Zn) were determined in apparently oil-polluted dead or near-dead three loon species collected in the Busan coast, Korea. Fe, Cu, Mn and Zn concentrations were generally high in liver, and also, Mn and Zn were high in bone. There were significant differences in some tissue concentrations of Fe, Cu, Mn and Zn among three species, but did not show any consistent evidence of species-specific accumulation. Mean concentration of Fe was 11,635$\pm$4010 $\mu$g/g, Cu 64.3$\pm$30.7 $\mu$g/g, Mn 13.1$\pm$2.32 $\mu$g/g, and Zn 121$\pm$24.8 $\mu$g/g in liver of all three species examined. Mn and Zn levels in this study were similar to those of normal loons and other seabirds reported from different countries. However, Fe and Cu liver levels were extraordinarily higher than those of reported. This result suggests that unusual accumulations of essential metals such as Fe and Cu may partially arise from long-term starvation due to oil pollution.

Effect of Mesoporous TiO₂ in Facilitated Olefin Transport Membranes Containing Ag Nanoparticles

김상진,정정표,김동준,김종학,Kim, Sang Jin,Jung, Jung Pyu,Kim, Dong Jun,Kim, Jong Hak The Membrane Society of Korea 2015 멤브레인 Vol.25 No.5

용액-확산 메커니즘에 의해 결정되는 기존의 고분자에서와는 달리, 촉진수송은 투과도와 선택도를 동시에 향상시킬 수 있는 기술이다. 본 연구에서는 은 나노입자, 폴리비닐피롤리돈, 7,7,8,8-테트라시야노퀴노디메탄으로 구성된 촉진수송 올레핀 분리막에 있어서, 메조기공 티타늄산화물($m-TiO_2$)에 대한 영향을 연구하였다. 특히 메조기공 티타늄산화물은 폴리비닐클로라이드-g-폴리옥시에틸렌 메타크릴레이트 가지형 공중합체를 템플레이트로 하여 쉽고 대량 생산이 가능한 방법으로 제조하였다. 엑스레이 회절분석에 따르면, 제조된 메조기공 티타늄산화물은 아나타제와 루타일 상의 혼합으로 구성되어 있으며, 결정의 크기가 약 16 nm 정도 되었다. 메조기공 티타늄산화물을 첨가하였을 때, 분리막의 확산도가 증가하여 혼합기체 투과도가 1.6에서 16 GPU로 증가하였고 선택도는 45에서 37로 약간 감소하였다. 메조기공 티타늄산화물이 첨가되지 않은 분리막은 장시간 성능이 유지되었으나, 메조기공 티타늄산화물이 첨가된 분리막의 경우 시간이 지남에 따라 투과도와 선택도가 감소하였다. 이는 티타늄산화물과 은 사이의 화학적 상호작용으로 은 나노입자의 올레핀 운반체로써의 활성을 감소시키기 때문으로 사료된다. Facilitated transport is considered to be a possible solution to simultaneously improve permeability and selectivity, which is challenging in normal polymeric membranes based on solution-diffusion transport only. We investigated the effect of adding mesoporous $TiO_2$ ($m-TiO_2$) upon the separation performance of facilitated olefin transport membranes comprising poly(vinyl pyrrolidone), Ag nanoparticles, and 7,7,8,8-tetracyanoquinodimethane as the polymer matrix, olefin carrier, and electron acceptor, respectively. In particular, $m-TiO_2$ was prepared by means of a facile, mass-producible method using poly(vinyl chloride)-g-poly(oxyethylene methacrylate) graft copolymer as the template. The crystal phase of $m-TiO_2$ consisted of an anatase/rutile mixture, of crystallite size approximately 16 nm as determined by X-ray diffraction. The introduction of $m-TiO_2$ increased the membrane diffusivity, thereby increasing the mixed-gas permeance from 1.6 to 16.0 GPU ($1GPU=10^{-6}cm^3$(STP)/($s{\times}cm^2{\times}cmHg$), and slightly decreased the propylene/propane selectivity from 45 to 37. However, both the mixed-gas permeance and selectivity of the membrane containing $m-TiO_2$ rapidly decreased over time, whereas the membrane without $m-TiO_2$ had more stable long-term performance. This difference might be attributed to specific chemical interactions between $TiO_2$ and Ag nanoparticles, causing Ag to lose activity as an olefin carrier.

모바일산업 지속가능 시스템 평가모델 설계를 위한 인간시스템통합 (HSI) 방법론 연구

김상진,차우창,Kim, Sang Jin,Cha, Woo Chang 한국시스템엔지니어링학회 2021 시스템엔지니어링학술지 Vol.17 No.1

The aim of this study is to propose the design suitable for sustainability evaluation model of the mobile industry considering system process (SEP). Although a quantitative evaluation was conducted on the link between the national sustainability report and the mobile industry, it was confirmed that it was difficult to identify stakeholders. So it is necessary to develop the design process suitable for the more operator-specific interfaces. The Human System Integration (HSI) methodology was proposed through linkage with work domain analysis. Agile methodology and Resilience engineering methodology were added for sustainable model design. The proposed sustainability system evaluation model is applied so that it can be easily used in all industries.

시스템엔지니어링 기술 프로세스를 적용한 지속 가능 평가모델 설계 연구 : 모바일 산업 중심으로

김상진,차우창,Kim, Sang Jin,Cha, Woo Chang 한국시스템엔지니어링학회 2021 시스템엔지니어링학술지 Vol.17 No.2

A study on the sustainability evaluation of the requirements of the mobile industry closely related to the human factor was needed. We conducted the sustainability evaluation of the mobile industry using a quantitative evaluation method with the AHP tool and a qualitative evaluation method reflecting the technological age flow of the philosophical thoughts to improve the reliability of the evaluation results of the model verification. And this evaluation is to evaluate the consistency of the connection between the national sustainability and the mobile industry. In order to draw the conclusion of the relevance, the team member Delphi 5-point scale was used. As a result, the priority was confirmed in the national sustainable development indicator and mobile industry indicator. Quantitative and qualitative evaluation was applied to the discontinued model of mobile to derive insufficient indicators, and it was confirmed that if the indicators were improved and reflected, it would be sustainable. And in order to secure reliability and accuracy, we made a proposal to apply the systems engineering process to the development of the model evaluation field. The systems engineering technology process meets the needs and requirements of stakeholders throughout the lifecycle and it is suitable for the development model of the industry's sustainability assessment.

코퍼스 기반 음성합성기를 위한 합성단위 경계 스펙트럼 평탄화 알고리즘

김상진,장경애,한민수,Kim Sang-Jin,Jang Kyung Ae,Hahn Minsoo 대한음성학회 2005 말소리 Vol.56 No.-

Speech unit concatenation with a large database is presently the most popular method for speech synthesis. In this approach, the mismatches at the unit boundaries are unavoidable and become one of the reasons for quality degradation. This paper proposes an algorithm to reduce undesired discontinuities between the subsequent units. Optimal matching points are calculated in two steps. Firstly, the fullback-Leibler distance measurement is utilized for the spectral matching, then the unit sliding and the overlap windowing are used for the waveform matching. The proposed algorithm is implemented for the corpus-based unit concatenating Korean text-to-speech system that has an automatically labeled database. Experimental results show that our algorithm is fairly better than the raw concatenation or the overlap smoothing method.