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태음조위탕(太陰調胃湯)의 항산화(抗酸化) 효능(效能)에 의한 간세포(肝細胞) 보호(保護) 효과(效果)에 관한 연구(硏究)
김만우,박성식,Kim, Man-woo,Park, Seong-sik 사상체질의학회 2001 사상체질의학회지 Vol.13 No.1
Effects of Taeumjowetang on Lipid Peroxidation by Free Radicals and Oxidative Damage of Hepatocytes by tert-Butyl Hydroperoxide. 1. Purpose The present study was carried out to evaluate the antioxidant effects of Taeumjowetang in vitro. 2. Methods In this study, antioxidant effects of TJT on lipid peroxidation were determined according to the method of TBA. (Abbreviation) TJT : Taeumjowetang, TBA : 2-thiobarbituric acid. 3. Results : 1) TJT inhibited markedly peroxidation of linoleic acid during the autoxidation. 2) TJT inhibited lipid peroxidation induced by hydroxyl radical derived from H2O2-Fe2+ in rat liver homogenate. 3) TJT showed 66% scavenging effect on DPPH radical. 4) TJT exhibited a 25% inhibitory effect on superoxide generation from xanthine-xan thine oxidase system. 5) To investigate the antioxidative effects of TJT on the hepatocytes, cultured normal rat liver cells(Ac2F) were prepared and incubated with or without TJT. After 16~18hr, cells placed in DMEM medium without serum, and then incubated with 1mM t-BHP for 2hr. Viable cells were detected by MTT assay. In this test, TJT protected the cell death induced by t-BHP and significantly increased cell viability in the normal rat liver cell. (Abbreviation) DPPH : ${\alpha},{\alpha}$-diphenyl-${\beta}$-picryl hydrazyl, DMEM : Dulbecco's Modified Eagle Medium, t-BHP : terr-butyl hydroperoxide, 4. Conclusion These results suggested that TJT might play a protective role in lipid peroxidation by free radicals.
위장관 ( 胃腸管 ) : 정상인에서 호기내 수소농도 측정법을 이용한 유당불내성률
김만우(Man Woo Kim),김평남(Pyoung Nam Kim),나한식(Han Sik Na),오재선(Jae Sun Oh),이승일(Seung Il Lee),박찬국(Chan Guk Park) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3
N/A In order to detect lactose intolerance in study groups, we have performed the lactose breath test, lactulose breath test, and oral lactose tolerance test. The 50 cases (28 men, 22 women) of this study were selected from healty adults without known disease and free from gastrointestinal symptoms. 1) In 50 subjects, there were 32 subjects who had the intolerant symptoms such as abdominal pain, flatulence and diarrhea. 2) All subjects with intolerant symptoms were more than 20 ppm in breath hydrogen. 3) In two subjects among 11 cases with less than 20 ppm in breath hydrogen by lactose breath test have not increased by lactulose breath test (<10ppm). 4) The prevalence of lactose intolerance in healthy adults was 82 percent. From the above results, it is concluded that lactose breath test offers an attractive, noninvasive way of diagnosing lactose intolerance.
김만우(Man Woo Kim),박찬국(Chan Gook Park) 대한내과학회 1994 대한내과학회지 Vol.46 No.6
N/A Objectives: It is well established that vestibular inputs are involved inproducing motion sickeness. Motion sick-eness is frequently accompanied by pallor and sweating, which are the result of vestibulo-autonomic nerve reflex. The purpose of this study is to investigate the relationships between the vestibular system and gastric contraction. Methods: Changes of intragastric pressure as well as activity of the vagus and sympathetic nerves induced by electrical stimulation of the vestibular nerve or vestibular nucleus were measured by means of electrophysiological recording system in Sprague-Dawley rats. The vestibular nerve was stimulated using silver-silver chloride ball electrodes implanted in the labyrinth, and the vestibular unclei were stimulated using needle electrodes in stereotaxic instruments. Results: The gastric contraction was increased by electrical stimulation of the vagus nerve, but the con- traction was inhibited by bilateral vagotomy or intravenous injection of atropine. Electrical stimulation of the major splanchnic nerve inhibited the gastric contraction, but bilateral splanchnicectomy was the just opposite. When electrical stimulation was applied to the vestibular nerve or vestibular nucleus, the gastric contraction was inhibited, however, systemic arterial pressure was elevated. In addition, the major splanchnic nerve showed excitatory response to electrical stimulation of the vestibular nerve or vestibular nucleus and the vagus nerve showed opposite responses. Conclusion: The vestibular system inhibits the gastric contraction through reflex pathways from the vagus and major splanchnic nerves.
위장관 ( 胃腸管 ) : 위궤양 환자에서 Omeprazole 반복 투여시 혈청 Gastrin과 Pepsinogen A치의 변화
김만우(Man Woo Kim),박찬국(Chan Gook Park),전용준(Yong Jun Jeon),신양수(Yang Su Shin),유병전(Byung Jeon Yuh),최성도(Sung Do Choi),서영환(Yong Hwan Suh),노상현(Sang Hyun Noh) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.4
N/A The fasting serum gasrin and pepsinogen A levels on oral Omeprazole treatment were observed in 17 patients of gastric ulcer diagnosed by gastrofiberscopy. The fasting serum gastrin and pepsinogen A levels 1 day prior to oral omeprazole treatment, during treatment (1st, 7th, 14th day) and fo]lowing 2 weeks treatment (1st, 7th, 15th day) were monitored respectively and compared each other. The results were as follows. 1) Serum gastrin and pepsinogen A levels during and following the treatment were significantly increased compared to basal gastrin and pepsinogen A levels before treatment each (p<0.01). 2) Serum gastrin levels following the 2 weeks treatment did not change significantly compared to that during treatment. 3) The relationship between the basal serum gastrin levels before treatment and the gasrin levels during the treatment showed positive correlation (r=0.414: p<0.01).
분변 DNA 메타-바코딩을 이용한 반달가슴곰의 먹이원 분석을 위한 사전 연구
한상현(Sang-Hyun Han),김태욱(Tae-wook Kim),김정진(Jeong-jin Kim),김낙원(Rak-Won Kim),김종백(Jong-baek Kim),김만우(Man-woo Kim),최주열(Ju-yeol Choi),박석호(Seok-ho Park),정동혁(Dong-hyuk Jeong),이사현(Sa-Hyun Lee),장정재(Jeong-Jae Jan 국립공원연구원 2021 국립공원연구지 Vol.12 No.1
지리산국립공원과 인근 지역의 야생에서 활동 중인 반달가슴곰의 먹이원 정보를 수집하기 위하여 분변 DNA를 메타-바코딩 기법으로 분석하였다. 동물 먹이원 분석은 미토콘드리아 DNA의 COI 유전자 서열, 식물 DNA 분석은 엽록체 DNA의 tRNA e-f 영역과 핵 DNA의 ITS 영역을 분석하였다. 분석결과 검출된 동물성 먹이원은 무척동물 5개 OTU와 무당개구리, 노루, 고라니, 너구리, 오소리 등 5개의 척추동물 등 총 10개 OTU가 검출되었다. 식물성 먹이원은 212종의 OTU들이 검출되었다. 연도별로 검출된 최상위 10 OTU들은 분변이 수집된 시기에 따라 서로 상이한 양상을 보였다. 봄철 분변 DNA에서는 초본류, 양치식물들이 많았고, 가을철 분변 DNA에서는 다래류, 뽕나무류, 참나무류가 많이 검출되었다. 연구결과, 반달가슴곰은 야생에서 매우 다양한 동물, 식물 먹이원을 이용하며, 이 중에서는 사람의 활동과 연관된 먹이원도 이용하는 것으로 확인되었다. 이번 연구를 통해 확보된 먹이원 정보는 지리산국립공원과 인근 지역에서 야생 반달가슴곰의 섭식활동과 서식지 이용에 대한 생태적 특성을 이해하고, 개체군 보호와 서식지 관리를 위한 보전 전략을 수립하는 데 있어 유용한 기초 정보가 될 것으로 기대된다. This study analyzed preliminarily to identify the dietary resources using fecal DNA meta-barcoding in the Asiatic black bears inhabiting the Jirisan National Park and its surrounding areas. We used mtDNA COI gene sequences for detecting animals, and chloroplast DNA tRNA e-f and nuclear DNA ITS for plants. The results showed that there were 10 OTUs including 5 invertebrate OTUs and 5 vertebrate OTUs. A total of 212 plant OTUs were found, among those 81 OTUs in 2018, 57 OTUs in 2019, and 155 OTUs in 2020. The top 10 plant OTUs varied considerably in collection seasons. Grasses and ferns were abundantly found in spring, but wild kiwi fruits, mulberry, and acorns were mainly found in summer and autumn. These results indicated that the Asiatic black bears used various animals and plants for their food resources and some were related to human activities. Our findings suggested that it may be valuable basic information for better understanding of ecological features of dietary behavior and habitat use as well as for making up a conservation strategy for protecting this restoring population and planning habitat management at the Jirisan National Park and its surrounding areas, South Korea.
간경변증과 원발성 간암 환자의 혈중 동과 아연에 관한 연구
안기완(Gi Wan An),김만우(Man Woo Kim),조건국(Kun Kook Cho),조승렬(Seung Ryul Cho),김만중(Man Jung Kim),김원학(Won Hak Kim) 대한내과학회 1987 대한내과학회지 Vol.33 No.3
N/A The copper and zinc concentrations were measured in sera of 28 cases of liver cirrhosis, 10 cases of liver cirrhosis with hepatocellular carcinoma, 17 cases of hepatocellular carcinoma and 48 normal control cases by atomic absorption spectrometer in Chosun University Hospital from July 1985 to July 1986. The result were as follows; 1) The mean concentrations of copper in serum of normal control and liver cirrhosis group were 96.03±5. 02, 86.61±7.98 ㎍/dl respectively, but in serum of hepatocellular carcinom a with and without liver cirrhosis the concentrations were each 123.74±13.04 and 127.93± 24.24 ㎍/dl, which were significantly higher than that of normal control group (p<0.001). 2) The mean concentration of zinc in serum of normal control group was 104.81±3.40 ㎍/dl, but in serum of liver cirrhosis, hepatocellular carcinoma with and without liver cirrhosis the concentrations were each 69.03±10.55, 76.01±11.12 and 58.72±12.65 ㎍/dl, which were significantly lower than the former (p<0.001). 3) The ratio of copper to zinc level in serum of normal control group was 0.940.06, but in serum of liver cirrhosis, hepatocellular carcinoma with and without liver cirrhosis the concentration-ratios were each 1.36±0.05, 1.65±0.03 and 2.34±0.59, which were higher than the former. But in serum of hepatocellular carcinoma with and without liver cirrhosis, the ratios of copper to zinc level were significantly higher than that of liver cirrhosis (p < 0,001). Consequently, in hepatocellular carcinoma with and without liver cirrhosis group, the serum copper levels were significantly higher in comparison with that of normal control group. In hepatocellular carcinoma with and without liver cirrhosis group, the serum zinc levels were significantly lower in comparison with that of normal control group. In hepatocellular carcinoma with and without liver cirrhosis, the ratios of copper to zinc level were significantly highter than that of normal control group, These findings demonstrate the usefulness of these parameters as the diagnostic aid in patients with hepatocellular carcinoma.