성경의 명료성이 상담 실천에 갖는 함의에 대한 고찰

김규보 總神大學校 2021 總神大論叢 Vol.41 No.-

인간은 하나님의 형상으로 창조되었기에 상담은 본질적으로 창조주 하나님의 말씀에 기초해야 한다. 이에 본고는 성경의 명료성이 상담 실천에 주는 함의를 살펴본다. 첫째, 성경의 명료성은 하나님의 주권적인 선택을 포함하기에 기독교 상담의 주권은 오직 하나님께 있음을 선언한다. 둘째, 성경의 명료성은 성령 안에서 누구나 하나님의 말씀을 소유할 자유가 있기에 성경적 상담사들은 실천 현장에서 하나님의 말씀을 활용할 자유가 있음을 강조한다. 셋째, 성경의 명료성은 하나님의 말씀이 모든 지식과 가치, 삶의 원리와 방식을 결정하는 최종 기준임을 강조하기에 성경적 상담은 하나님의 말씀을 기초로 인간의 병리를 이해하는 체계를 마련할 필요가 있음을 제시한다. 넷째, 성경의 명료성은 하나님의 다스림에 순종할 인간의 책임과 의무를 분명하게 제시하기에 성경적 상담은 내담자 중심이라기보다 하나님 중심의 상담이다. 다섯째, 성경의 명료성은 말씀 안에 임재하시는 하나님을 증거하기에 그리스도를 인격적으로 만나는 것이 성경적 상담 실천의 본질적인 요소임을 가르친다. 궁극적으로 이 연구는 성경의 명료성은 인생을 향한 하나님의 주권과 다스림, 임재를 드러냄으로써 하나님의 형상으로 창조된 인간을 위한 상담은 하나님의 말씀에 기초해야 한다는 실천적 가치를 뒷받침하는 신학적 초석임을 논한다.

Breast Conservation Therapy versus Mastectomy in Patients with T1-2N1 Triple-Negative Breast Cancer: Pooled Analysis of KROG 14-18 and 14-23

김규보,박혜진,신경환,김진호,최두호,박원,안승도,김수산,김대용,김태현,김진희,김지영 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4

Purpose The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) versus mastectomy for patients with pT1-2N1 triple-negative breast cancer (TNBC). Materials and Methods Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) received whole breast RT with or without regional nodal RT, while none who underwent mastectomy (n=108) received it. All patients received taxane-based adjuvant chemotherapy. The median follow-up periods were 65 months in the BCS+RT group, and 74 months in the mastectomy group. Results The median age of all patients was 48 years (range, 24 to 70 years). Mastectomy group had more patients with multiple tumors (p < 0.001), no lymphovascular invasion (p=0.001), higher number of involved lymph node (p=0.028), and higher nodal ratio  0.2 (p=0.037). Other characteristics were not significantly different between the two groups. The 5-year locoregional recurrence-free, disease-free, and overall survival rates of BCS+RT group versus mastectomy group were 94.6% versus 87.7%, 89.5% versus 80.4%, and 95.0% versus 87.8%, respectively, and the differences were statistically significant after adjusting for covariates (p=0.010, p=0.006, and p=0.005, respectively). Conclusion In pT1-2N1 TNBC, breast conservation therapy achieved better locoregional recurrencefree, disease-free, and overall survival rates compared with mastectomy.

Preparation of Hollow Titania Microcapsules Containing Titania Nanoparticles via Layer-by-Layer (LbL) Self-Assembly Method

김규보,이종민,권용구 한국고분자학회 2008 한국고분자학회 학술대회 연구논문 초록집 Vol.33 No.1

IDI 디젤기관의 개선된 단일영역 열발생량 계산

김규보,전충환,장영준,이석영,Kim Gyu-Bo,Jeon Choung-Hwan,Chang Young-Jun,Lee Suk-Young 한국마린엔지니어링학회 2004 한국마린엔지니어링학회지 Vol.28 No.7

An one-zone heat release analysis was applied to a 4 cylinder indirect injection diesel engine. The objective of the study is to calculate heat release accurately considering the effect of specific heat ratio. heat transfer and crevice model and to find out combustion characteristics of an indirect diesel engine considering the effect of the pressures in main and swirl chambers. Especially specific heat ratio indicating combustion characteristics is adapted. instead of that indicating matter properties, which has been used in former studies Moreover by adaption of blowby model, cylinder gas mass became accurately calculated. Therefore, with ideal gas equation, calculating cylinder gas temperature, it was found to affect heat transfer loss and heat release. Determining heat transfer constants $C_1$. $C_2$ as 0.6 respectively. the integrated gross heat release values were predicted well for the measured value at various engine speed, full load operating conditions. The curve of heat release rate was similar to SI engine rather than DI engine. That is originated from that swirl chamber reduce an instant combustion which occurs in DI engine due to ignition delay on early stage of combustion.

구원드라마의 인간 이해와 성경적 상담을 위한 함의: 창조를 중심으로

김규보 개혁신학회 2024 개혁논총 Vol.67 No.-

First, the creation drama reveals that every person is created in the image of God, possessing divine value and dignity. This truth underscores that biblical counseling is a practice characterized by respect and love, irrespective of the client’s condition or circumstances. Second, the creation drama emphasizes that all existence, by God, created from nothingness. This teaches us that biblical counseling is grounded in the Word of God, forming a triological therapeutic relationship between a counselee and a counselor before God. Third, the creation drama highlights that everyone’s identity is in nature derived from God. This suggests that biblical counseling is oriented towards re-establishing the creation order in a holistic way in relationships with God. Fourth, the creation drama presents God’s purpose for each person here and now. This instructs us that counseling goals should be formulated in alignment with re-creating the order on God’s purpose.

Prognostic Value of p53 and bcl-2 Expression in Patients Treated with Breast Conservative Therapy

김규보,지의규,한원식,노동영,박인애,오도연,임석아,김태유,방영주,하성환 대한의학회 2010 Journal of Korean medical science Vol.25 No.2

Prognostic value of p53 and bcl-2 expression on treatment outcome in breast cancer patients has been extensively evaluated, but the results were inconclusive. We evaluated the prognostic significance of these molecular markers in patients treated with breast conserving surgery and radiotherapy. One hundred patients whose immunostaining of p53 and bcl-2 expression was available among 125 patients who underwent radiotherapy after breast conserving surgery and axillary lymph node dissection were enrolled into this study. Eighty-seven patients also received adjuvant chemotherapy and/or hormonal therapy. Conventional clinicopathologic variables and treatment-related factors were also considered. The 5-yr loco-regional relapse-free and distant metastasis-free survival rates were 91.7% and 90.9%, respectively. On univariate analysis, age, T stage and the absence of bcl-2 & estrogen receptor (ER) expression were associated with loco-regional relapse-free survival. When incorporating these variables into Cox proportional hazard model, only bcl-2(-)/ER(-) phenotype was an adverse prognostic factor (P=0.018). As for the distant metastasis-free survival, age, T stage, and p53 expression were significant on univariate analysis. However, p53 expression was the only prognosticator on multivariate analysis (P=0.009). A bcl-2(-)/ER(-) phenotype and p53 expression are useful molecular markers predicting loco-regional relapse-free and distant metastasis-free survival, respectively, in patients treated with breast conserving surgery and radiotherapy.

Selective Radiation Therapy for Ductal Carcinoma In Situ Following BreastConserving Surgery According to Age and Margin Width: Korean Radiation Oncology Group 11-04 and 16-02 Studies

김규보,김진희,김용배,서창옥,신경환,김진호,김태현,정소연,최두호,박원,안승도,김수산,예지원,강민규,김동원,김이준 한국유방암학회 2017 Journal of breast cancer Vol.20 No.4

Purpose: The optimal indications for omitting adjuvant radiation therapy (RT) after breast-conserving surgery are still controversial in ductal carcinoma in situ (DCIS) of the breast. The purpose of this study was to validate the role of postoperative RT in DCIS patients aged ≤50 years and with tumor margin widths of <1 cm, both of which have been proven to be high-risk features for recurrence in cohorts not receiving RT. Methods: Using two multicenter retrospective studies on DCIS, a pooled analysis was performed among patients aged ≤50 years and with margin widths <1 cm. All patients underwent breast-conserving surgery. Two hundred thirty-two patients received postoperative RT, while 54 did not. The median follow-up period was 77 months (range, 2–190 months) and 70 months (range, 5–166 months) in the patients who received RT and those who did not, respectively. Results: The patients who received RT had larger tumors (p<0.001), higher nuclear grade (p<0.001), closer margin width (p<0.001), and negative estrogen receptor expression (p=0.010) compared with those who did not receive RT. During the follow-up period, there were 17 ipsilateral breast tumor recurrences (IBTRs) as follows: invasive carcinoma in 10 patients and DCIS in seven. In the univariate analysis, the treatment with RT and human epidermal growth factor receptor 2 (HER2) status were significant risk factors for IBTR. The 7-year IBTR rates with and without postoperative RT were 3.6% and 13.1%, respectively (p=0.008). HER2positive tumors had a higher IBTR rate than the HER2-negative tumors (7-year rate, 13.6% vs. 3.9%; p=0.003). Conclusion: Postoperative RT following breast-conserving surgery significantly reduced the 7-year IBTR rate in the DCIS patients aged ≤50 years and with margin widths <1 cm. HER2 positivity was associated with increased IBTR in these patients.

Central Nervous System Failure in Korean Breast Cancer Patients with HER2-Enriched Subtype: Korean Radiation Oncology Group 16-15 Multicenter Retrospective Study

김규보,신경환,김진호,최두호,박원,김용배,김현주,김진희,Hyeli Park,이선영,김지영,오도훈,김인아 한국유방암학회 2019 Journal of breast cancer Vol.22 No.1

Purpose: The purpose of this study was to evaluate the risk of central nervous system (CNS) failure in Korean patients with human epidermal growth factor receptor 2 (HER2)-enriched breast cancer treated with surgery followed by postoperative radiotherapy (RT). Methods: A total of 749 patients from eight institutions were enrolled in this study. All of them underwent surgery followed by postoperative RT from 2003 to 2011; 246 (32.8%) received neoadjuvant chemotherapy and 649 (81.7%) received adjuvant chemotherapy. Adjuvant trastuzumab was administered to 386 patients (48.6%). Results: The median follow-up duration was 84 (range, 8–171) months. The 7-year disease-free and overall survival rates were 79.0% and 84.2%, respectively. On multivariate analysis, mastectomy, nodal involvement, and presence of lymphatic invasion were correlated with poor overall survival (p = 0.004, 0.022, and 0.011, respectively), whereas T stage and lymphatic invasion were associated with disease-free survival (p = 0.018 and 0.005, respectively). Regarding CNS failures, 30 brain metastases, 2 leptomeningeal metastases, and 8 brain and leptomeningeal metastases were noted. The 7-year CNS relapse-free survival rates in patients receiving and not receiving trastuzumab were 91.2% and 96.9%, respectively (p = 0.005). On multivariate analysis, the administration of adjuvant trastuzumab was the only prognostic factor in predicting a higher CNS failure rate (hazard ratio, 2.260; 95% confidence interval, 1.076–4.746; p = 0.031). Conclusion: Adjuvant trastuzumab was associated with higher CNS failure rate in Korean patients with HER2-enriched breast cancer. Close monitoring and reasonable approaches such as CNS penetrating HER2 blockades combined with the current standard therapy could contribute to improving intracranial tumor control and quality of life in patients with CNS metastasis from HER2-enriched breast cancer.

북한이탈주민의 사회적 트라우마와 긍휼의 실천

김규보 한국복음주의실천신학회 2020 복음과 실천신학 Vol.57 No.-

이 연구의 목적은 북한이탈주민이 경험하는 트라우마의 양상을 이해 하고, 기독교 가치를 통한 회복의 가능성을 제안하는 것이다. 북한이탈 주민은 북한사회에서도 남한사회에서도 타자화 된 집단이다. 타자화는 경쟁적이고 불안정한 사회 속에서 선과 악에 대한 이분법적 사고와 부 정적 투사를 통해 특정 집단에 대한 차별적 사회를 형성하는 심리구조 이다. 북한이탈주민은 고난의 행군으로 대표되는 북한 사회의 경제적 위기 속에서 지배층으로부터 타자화 되어 기아와 박해, 학대 가운데 생 존 트라우마를 경험했다. 생존을 위한 투쟁으로서 탈북한 그들은 남한 사회에서도 사회적 소수자를 향한 낙인 아래 여전히 트라우마를 경험 한다. 이에 그리스도께서 십자가에서 보이신 긍휼의 실천은 회복과 변 화의 가능성을 소망하게 한다. 긍휼의 실천은 상호 공감적 경청과 타인 을 향한 자발적 돌봄으로 구체화 된다. 공감적 경청의 실천을 통해 남 한주민과 북한이탈주민은 서로의 생존에 대한 불안을 이해하고 위로하 게 됨으로써 배타적인 태도는 줄여가는 반면, 신뢰와 배려는 확장해 갈 수 있다. 또한 타인을 위한 자발적인 돌봄은 트라우마로 상실했던 연대 감을 회복하는 동시에 하나님 나라의 직분에 참여함으로써 잃었던 인 간으로서의 존엄성과 가치, 삶의 초월적 의미와 목적을 회복할 수 있게 한다. 결과적으로 남한주민과 북한이탈주민이 함께하는 긍휼의 실천은 서로의 집단에 대한 긍정적 경험을 축적시키고, 그 관계는 표면적인 환 대와 조건적 수용을 넘어 진정한 공감과 화해, 협력의 국면으로 접어들 게 한다. 궁극적으로 이 논문은 긍휼의 실천이 북한이탈주민의 사회적 트라우마를 치유하는 방편이 되며 남북의 상호 신뢰와 협력 관계 형성 에 기여함을 논한다. This paper argues that cultivating compassion in Christianity contributes to heal social trauma of North Korean defectors, and thereby builds mutual trust and cooperative attitudes in relationship with South Korean citizens. North Korean defectors have experienced diverse traumatic events by “othering” both in the North and the South. Othering is a psychological structure that forms a discriminative culture against a certain group by dichotomous thinking and negative projection in a competitive and unstable society. In the North, many are dehumanized by hunger, persecution, and abuse in asymmetric power and authority, so that they had to escape from their society for survival. In the South, they still suffer from social trauma, identified by concealed prejudice and discrimination against social minorities. In this reality, Christ’s compassionated work for the humankind encourages both North Korean defectors and South Korean citizens to practice compassion. The practice of compassion is embodied in mutual empathy and voluntary caring for others. Through the practice of mutual empathy, both parties can understand each other’s anxiety for survival, while reducing their exclusive attitudes and expanding mutual trust and respect. Through the practice of voluntary caring for others, they rebuilds the sense of solidarity, while restoring the dignity, value, meaning and purpose of life. As a result, South Koreans and North Korean defectors in practicing compassion can accumulate positive experiences for each other, and then, their relationships enter into a phase of genuine empathy and reconciliation.

Synthesis of Magnetite Core/Titania Shell Nanoparticles via Layer-by-Layer Self-Assembly Method

김규보,차경진,전진아,권용구 한국고분자학회 2009 한국고분자학회 학술대회 연구논문 초록집 Vol.2009 No.4