농경지(農耕地)로부터의 오염물질(汚染物質) 유출부하특성(流出負荷特性) - 전(全)Kjeldahl 질소(窒素) 및 전인(燐)을 중심(中心)으로-

홍성구 ( Hong Sung Ku ),권순국 ( Kwun Soon Kuk ) 한국농공학회 1989 韓國農工學會誌 : 전원과 자원 Vol.31 No.3

With an objective to provide basic information for the management and the prediction of eutrophication in lentic water Systems, total amount of Kjeldahl nitrogen(T-N) and phosphorous(T-P) from irrigated water and drained water from flooded paddies were investigated during the rice growing period of 1988. A 29.3 ha paddies near Jungnam-myun, HwaSung-gun, Gyungi Province, Korea was instrumented for measuring runoff and sampling irrigated water and drained water from paddies. The following conclusions may be drawn from the result of this study. 1. During 115 days of investigation, T-N load for paddies was 362.6kg and T-P 63.44kg.These would be converted to 12.4kg T-N/ha and 2.17kg T-P/ha, respectively. 2. The T-N and T-P loadings in different periods showed a significant difference. The 25% of T-N loading was drained soon after fertilization period and 60% was drained during the rainy season from July 5 to July 24. 3. Annual loadings from paddies could be calculated to 30kg T-N/ha/year and 52kg T-P/ha/year considering non-measurement periods. 4. After the rainy season, the nutrient loads from drained water showed much less than those from irrigated water, and it may be suggested that the paddies would act as a stabilization pond. 5. The average concentrations of nutrients at 0.9km downstream from investigated paddies were 2.02(T-N) mg/1 and 0.52(T-P) mg/1, which were 1.82(T-N) mg/1 and 0.056(T-P) mg/1 lower than those of drained water from paddies.

제 50 차 대한내과학회 추계학술대회 초록집 : 만성 B 형 간염에서 Lamivudine 의 유지요법

홍성표,권창일,오재인,김경철,김배영,황성규,박필원,임규성 대한내과학회 1998 대한내과학회 추계학술대회 Vol.55 No.-

만성 활동성 B 형 간염에서 Lamivudine 의 간혈적 유지요법

홍성표,황성규,김경철,박필원,이준성,김세현,권창일,임규성 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.3

$quot;목적: 장기간 B형 간염 바이러스의 증식을 억제하면서 부작용과 비용을 절감하는 방법으로, lamivudine의 복용 간격을 점차 벌려서 간헐적으로 유지하는 방법을 매일 투여하는 대조군과 비교하여 그 효과를 연구하고자 하였다. 대상과 방법: 97년 6월부터 99년 4월까지 포천중문의대 분당차병원에서 간조직 생검을 실시하여 만성 활동성 B형 간염으로 진단된 환자들 중, interferon을 투여하여 비반응군으로 분류되었거나 재발되었던 환자 또는 부작용으로 치료를 중단한 환자를 연구 대상으로 하였다. 환자들을 lamivudine 투약 간격 조절군과 대조군으로 나누어서 투약 간격 조절군은 매일 복용으로 시작해서 1개월 간격으로 간기능 검사, HBeAg, anti-HBe 그리고 HBV DNA 등을 검사하여 HBV DNA가 음전되고 간기능 검사가 정상화되면 lamivudine 투여 간격을 매일 복용에서, 2일 간격, 3일 간격, 5일 간격, 7일 간격, 10일 간격으로 1단계씩 벌리면서 간기능 검사를 정상으로 유지하였고, 치료도중 HBV- DNA 또는 HBeAg이 다시 양전되거나 ALT치가 상승되면 투여기간을 단축하는 식으로 유지요법을 시행하였다. 대조군은 lamivudine을 매일 복용하게 하여 1개월 간격으로 치료반응 정도를 평가하였 될 odds가 대조군보다 각각 10.7배, 7배, 7.8배 높았다(p$lt;0.05). ALT 평균치는 치료 후 두 군 모두 큰 감소치를 나타내었는데 치료 후의 평균 수치는 두 군간에 통계학적인 차이는 없었다. 치료 중 ALT치가 계속 정상으로 유지되는 환자의 비율은 각각 14례(93.3%), 9례(81.8%)를 나타내었다. 임상적으로 breakthrough가 나타난 경우는 투약 간격 조절군에서 2예(13.3%), 대조군에서 3예(27.3%) 있었다. 결론: Lamivudine은 매일 투약하여 HBV-DNA가 음전되고 ALT치가 정상화되면 투약 간격을 늘려도 HBV-DNA의 증식을 억제하고 ALT를 정상으로 유지시킬 수 있으며, 계속 매일 투여하는 것과 비교하여도 오히려 효과적이므로 이러한 방법으로 소량의 약물로도 장기간의 유지요법이 가능할 것으로 생각된다. $quot;Background/Aims: This study was conducted to determine the effect of novel long-term maintenance treatment with lamivudine by gradual lengthening of the medication interval in patients with chronic active viral hepatitis B. Method: All patients were non-responder, relapsed or intolerable patients to previous interferon therapy. Patients were divided into a drug-interval changing study and a daily continual medication control group. Drug-interval changing protocol with gradual lengthening of the medication interval after conversion to undetectable HBV-DNA in serum and reduction of serum aminotransferase to normal level was monitored monthly. Results: Before treatment, 15 patients of the drug-interval change group and 11 patients of the daily medication group were similar in laboratory and pathologic findings. Mean follow-up periods were 12.8 moths and 11.4 months respectively. HBeAg seroconversion rate was higher in patients in the daily medication group (86.7% vs. 40.0%, p$lt;0.05). The odds of loss of HBeAg, development of anti-HBe, and suppression of HBV-DNA are about 11 times, 7 times, and 8 times higher in the drug-interval change group compared with the daily medication group, respectively (p$lt;0.05). Conclusion: Drug-interval lengthening method was effective in long-term suppression of viral replication with low cost.$quot;

Performance of disposable endoscopic forceps according to the manufacturing techniques

권창일,김광일,문종필,윤호,고원진,조주영,홍성표 대한내과학회 2019 The Korean Journal of Internal Medicine Vol.34 No.3

Background/Aims: Recently, to lower the production costs and risk of infection, new disposable biopsy forceps made using simple manufacturing techniques have been introduced. However, the effects of the manufacturing techniques are unclear. The aim of this study was to evaluate which types of biopsy forceps could obtain good-quality specimens according to the manufacturing techniques. Methods: By using an in vitro nitrile glove popping model, we compared the popping ability among eight different disposable biopsy forceps (one pair of biopsy forceps with cups made by a cutting method [cutting forceps], four pairs of biopsy forceps with cups made by a pressing method [pressing forceps], and three pairs of biopsy forceps with cups made using a injection molding method [molding forceps]). Using an in vivo swine model, we compared the penetration depth and quality of specimen among the biopsy forceps. Results: In the in vitro model, the molding forceps provided a significantly higher popping rate than the other forceps (cutting forceps, 25.0%; pressing forceps, 17.5%; and molding forceps, 41.7%; p = 0.006). In the in vivo model, the cutting and pressing forceps did not provide larger specimens, deeper biopsy specimen, and higher specimen adequacy than those obtained using the molding forceps (p = 0.2631, p = 0.5875, and p = 0.2147, respectively). However, the molding forceps showed significantly more common crush artifact than the others (cutting forceps, 0%; pressing forceps, 5.0%; and molding forceps, 43.3%; p = 0.0007). Conclusions: The molding forceps provided lower performance than the cutting and pressing forceps in terms of crush artifact.

흰쥐 간세포의 동결 및 해동 조건

홍성표,김경철,정은미,황성규,박필원,오성욱,임규성,권창일 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.3

Background/Aims: During cryopreservation of hepatocytes, a dramatic loss in cell number, viability and differentiated cell function is usually inevitable because hepatocytes are very sensitive to stress during freezing and thawing. We tried to investigate the optimal cryopreservation conditions of hepatocytes including the constituents of the freezing medium and freezing rate. Mcthods: Isolated hepatocytes were cryopreserved in media containing 10% glycerol or dimethyl sulfoxide (DMSO) of variable concentration. Different freezing procedures (stepwise, rapid, and programmed with or without shock cooling) were used and they were stored in a liquid nitrogen tank. After rapid thawing at 39°C, followed by dilution and removal of the cryopreservative, the ability of the hepatocytes to exclude trypan blue dye (TB) was evaluated. Hepatocytes were fractionated through a Nycodenz density gradient centrifugation (DGC) to eliminate dead cells. Cells were plated on dishes coated with type I collagen. Results: Cell viabiity of hepatocytes recovered from cryopreservation was maintained better using 10, 15, and 20% DMSO as a cryopreservative and programmed cell freezer with shock cooling. After Nycodenz DGC a hepatocyte fraction highly enriched in viable cells could be taken between 11% and 30%. In culture, cryopreserved hepatocytes exhibited a morphology with epithelial characteristics. Conclusions- These results suggest that rate-adjusted progrananed freezing with shock cooling and 10, 15 and 20% DMSO increased the viability of cryopreserved hepatocytes. The hepatocyte fraction highly enriched in viable cells could be taken using Nycodenz DGC. In order to establish a bank of hepatocytes for hepatocyte transplantations and artificial livers a more improved method is nevertheless necessary to increase the viability of hepatocytes after cryopreservation. (Korean J Hepatol 2001;7:308-314)

농촌유역특성과 하천수질과의 관계

홍성구 ( Hong Seong Gu ),권순국 ( Kwun Soon Kuk ) 한국농공학회 2001 韓國農工學會誌 : 전원과 자원 Vol.43 No.3

In interpreting stream water quality data, scientific or statistical mehtods should be employed. Classical parametric statistical methods may not be adopted in analyzing water quality data, due to the violation of normality. In this study, nonparametric statistical methods, such as Kruskal-Wallis test and Mann-Whitney test, were used in comparing water quality data from several monitoring stations. Water quality data used are those collected Bokha watershed, located in Ichon-city, Kyonggi province. Based on the test results, domestic sewage is the major pollution source. A couple of sub-watersheds with a large number of livestock do not show significant differences in water quality parameters. It should be noted that comparison of mean values of water quality parameters is difficult to relate water quality with watershed characteristics. The results also indicate that livestock farming does not significantly affect the water quality.

Endoscopic Submucosal Dissection Using a Novel Versatile Knife: An Animal Feasibility Study (with Video)

권창일,김광일,정일권,김원희,고광현,홍성표,정석,이돈행 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.6

Background/Aims: In order to reduce the procedure time and the number of accessory changes during endoscopic submucosal dissection (ESD), we developed a novel versatile knife, which has the combined advantages of several conventional knives. The aim of this study was to compare the efficacy, safety, and histological quality of ESD performed using this novel versatile knife and a combination of several conventional knives. Methods: This was an in vivo animal study comparing two different modalities of ESD in mini-pigs. Completion time of each resection was documented, and the resected specimens were retrieved and evaluated for completeness. To assess the quality control of the procedures and adverse events, detailed histopathological examinations were performed. Results: A total of 18 specimens were dissected by ESD safely and easily (nine specimens using the new versatile knife; nine specimens by mixing conventional knives). All resections were completed as en bloc resections. There was no significant difference in procedure time between the 2 modalities (456 seconds vs. 355 seconds, p=0.258) and cutting speed (1.983 mm2/sec vs. 1.57 mm2/sec, p=1.000). The rate of adverse events and histological quality did not statistically differ between the modalities. Conclusions: ESD with a versatile knife appeared to be an easy, safe, and technically efficient method.

아버지의 성 상동형(sex-role stereotype)과 아동의 성 상동형과의 관계연구

권은정,김연신,노명희,박영미,원경록,이경열,이계숙,이진용,임희진,최여정,최혜영,홍성애 연세대학교 생활과학대학 1987 婦學 Vol.20 No.-

The purpose of this study was to explore the relationship between the sex-role stereotype of the father and the child. We investigated the following: ⑴ Is there a relationship between the sex-role stereotype of the father and the child? ⑵ Is the age of the child a variable in the relationship between the sex-role stereotype of the father and the child? ⑶ Is the sex of the child a variable in the relationship between the sex-role stereotype of the father and the child? The subjects were 193 13-year-old students attending a middle school in Seoul and their fathers and 70 5-year-olds attending a kindergarten in Kwachon and their fathers. The test for the 193 middle school students and their fathers was the Likert Scale of the Bem Sex-Role Inventory which was utilized by the experimenters after a pretest. The instrument for the 5-year-olds was the 22 story-picture card Williams and Bunnett test(1975) modified by Lee, Sook(1982). The kindergarten fathers were tested with the same instrument as the middle school fathers. The data from these 2 tests were then compared using χ^2 test and percent(%). The result of this study were: ⑴ A relationship between the sex-role stereotype of the father and the child was found only between the sex-role stereotype of the middle school students and their fathers. ⑵ Age of the child was found to be a variable in the relationship between the sex-role stereotype of the father and the child. That is, a significant relationship was found between the sex-role stereotype of the middle school students and their fathers, but not between the sex-role stereotype of the preschool children and their fathers. ⑶ Sex of the child was found to be a variable in the relationship between the sex-role stereotype of the father and the child. That is, a significant relationship was found between the sex-role stereotype of the middle school boys and their fathers, but not between the sex-role stereotype of the middle school girls and their fathers.

Immediate Endoscopic Management of an Intramural Hematoma Developed during Colonoscopy

권창일,김덕환,홍성표 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.5

Brief report

PUS와 지하 바닥구조 접합부 전단 성능평가

홍성진(Hong Seong-Jin),천성철(Chun Sung-Chul),김승훈(Kim Seung-Hun),노삼영(Noh Sam-Young),김갑수(Kim Kap-Soo),권대홍(Kwon Dae-Hong) 대한건축학회 2011 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.31 No.2(구조계)

Recently the Permanent Uni-wall System (PUS) has been developed which improved the disadvantage of the CIP and could be used as permanent retaining wall. From analyses of the characteristics of design and construction of PUS, shear friction reinforcements with couplers were adopted for shear design of the joints. Twelve types of joints were developed which were classified according to the types of floor structures, wale, and piles of PUS. Two typical joints were tested and the joints showed satisfactory behaviors on the points of shear strength, stiffness, and serviceability. Especially the shear strengths were much higher than the design strengths due to the shear keys which were by-products in splicing shear reinforcements.