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권태균,Heeseung Choi 대한스트레스학회 2019 스트레스硏究 Vol.27 No.1
This study is a systematic review of literature to analyze the characteristics and effects of suicide prevention programs for the elderly. We systematically reviewed literature published from 2007 to 2018 in 8 domestic and foreign databases (KISS, NDSL, Koreamed, RISS, Pubmed, CINAHL, EMBASE, CENTRAL). The main search terms were 'elderly', 'suicide', 'intervention program', and included 8 articles matching the selection criteria in the final analysis. The program was divided into activities, counseling, and community support programs. Most of the programs effectively reduced suicidal ideation and depression by reducing suicide risk factors and improving protective factors. As a result of the analysis, it was found that it is necessary to develop a specialized program for the prevention of suicide in the elderly considering social, environmental, personal and community characteristics. 본 연구는 노인 자살 예방 프로그램의 특성과 효과를 분석하기 위한 체계적 문헌고찰 연구이다. 국내외 8개의 데이터 베이스(KISS, NDSL, Koreamed, RISS, Pubmed, CINAHL, EMBASE, CENTRAL) 에 2007부터 2018년까지 발표된 문헌을 체계적으로 고찰하였다. 주요검색어는 ‘노인’, ‘자살’, ‘중재 프로그램’ 등 이었으며, 선정기준에 맞는 8개의 문헌을 최종 분석에 포함하였다. 프로그램은 활동, 상담, 지역사회 지지체계를 활용한 프로그램으로 나뉘었으며, 대부분 자살 위험 요인 감소와 보호 요인 향상을 통해 자살생각이나 우울을 효과적으로 낮추었다. 분석 결과, 사회환경적, 개인적, 지역사회의 특성을 고려한 특화된 노인 자살예방 프로그램의 개발이 필요함을 알 수 있었다.
방광이행세포암종에서 종양억제유전자 부위의 Microsatellite Instability와 p53 유전자의 돌연변이 분석
권태균,정성광,김법완,김진아,김정완 경북대학교 병원 2001 경북대학교병원의학연구소논문집 Vol.5 No.1
Purprose: The objectives of this study is to eveluate the role of microsatellite instability(MI) and p53 gene inactivation in transitional cell carcinoma(TCC) of the bladder. Meterials and Methods: TOtal 31 cases of TCC patients, not treated with radiation or anticancer chemotherapy, were included in this study.Fifteen out of 31 patients were superficial and 16 were invasive TCC according to pathologic stage, while 16 were low grade and 15 were high grade TCC according to Ash grading system.The presence of MI was investigated in 3 loci of 9p site(D9S162, IFNA,D9S1747), and 6 loci of 17p site(D17S261, D17S513, D17S654, D17S695,D17S796, TP53) using a method based on the polymerase chain reaction(PCR).And the p53 point mutations were detected using polymerase chain reaction-single stranded conformation polymorphism(PCR-SSCP)analysis.The p53 protein overexpression was determined by immunohistochemical stain using DO-7 parimary antibody on formalin fixed, paraffin embedded tissue sections. Results: On MI anaylsis, altered band pattern were detected in 16 of 31 case (51.6%) in 9p region and 15 of 31 cases(48.4%) in 17p region.MI of the 9p region showed no association with tumor grade or stage.MI of the 17p site also showed no difference between superficial and invasive tumor group,but were higher in high grade(73.3%) than low grade tumor group(25.0%).On PCR-sscp analysis, total 8 mutations were found in 6 cases(19.4%) and 4 of 8 mutations (50%) were at exon 8.On immunohchemical staining, p53 nuclear overexpressions were found in 18 cases(58.1%)and more common in high grade and invasive tumor group(p<0.05). Fifteen out of 18 cases(83.3%) showed MI of the 9p or 17p regions. Conclusions: These results suggest that the p16 alterations may associated with high grade/invasive tumor.And DNA mismatch repair system may play an important role in tumorigenesis of bladder tumor.MI analysis can be a useful method to detect early genetic alterations in transitional cell carainoma of the bladder.(Korean J Urol 1999;40:1449~58)