군집 별 표준곡선 매개변수를 이용한 치밀오일 생산성 예측 순환신경망 모델

한동권(Dong-kwon Han),김민수(Min-soo Kim),권순일(Sun-il Kwon) 한국정보통신학회 2021 한국정보통신학회 종합학술대회 논문집 Vol.25 No.2

치밀오일 미래 생산성 예측은 잔류오일 회수량 및 저류층 거동 분석을 위해 중요한 작업이다. 일반적으로 석유공학적 관점에서 감퇴곡선법을 이용하여 생산성 예측이 이루어지는데, 최근에는 데이터기반의 머신러닝 기법을 이용한 연구도 수행되고 있다. 본 연구에서는 딥러닝 기반 순환신경망과 LSTM, GRU 알고리즘을 이용하여 미래 생산량 예측을 위한 효과적인 모델을 제안하고자 한다. 입력변수로는 치밀오일 생산 시 산출되는 오일, 가스, 물과 이와 더불어 다양한 군집분석을 통해 산출된 표준곡선이 주요 매개변수이고, 출력변수는 월별 오일 생산량이다. 기존의 경험적 모델인 감퇴곡선법과 순환신경망 모델들을 비교하였으며, 모델의 예측성능을 향상시키기 위해 하이퍼파라미터 튜닝을 통해 최적 모델을 도출하였다. Predicting future productivity of tight oil is an important task for analyzing residual oil recovery and reservoir behavior. In general, productivity prediction is made using the decline curve analysis(DCA). In this study, we intend to propose an effective model for predicting future production using deep learning-based recurrent neural networks(RNN). LSTM, and GRU algorithms. As input variables, the main parameters are oil, gas, water, which are calculated during the production of tight oil, and the type curve calculated through various cluster analyzes. the output variable is the monthly oil production. Existing empirical models, the DCA and RNN models, were compared, and an optimal model was derived through hyperparameter tuning to improve the predictive performance of the model.

새로운 유전체 편집용 유전자 가위, 크리스퍼 (CRISPR/Cas9 system) - 분자생물학의 새 기원을 연다? -

권순일 ( Sun-il Kwon ) 한국고등직업교육학회 2015 한국고등직업교육학회논문집 Vol.16 No.1

The emergence of a new genome-editing tool called CRISPR/Cas9 system which makes accurate and targeted modification to the genome of living organisms has drawn keen interest from world biomedical researchers. The CRISPR/Cas9 system is based on a prokaryotic immune system which gives acquired immunity to invading exogenous genetic elements by recognizing the memorized DNA sequences. The previous versions of genome-editing tools, zinc finger nucleases and TALENs, are costly and time-consuming to prepare, because they rely on protein engineering to target specific sites in the genome. However, the CRISPR/Cas9 system can recognize target sites on the basis of nucleotide base pairing with a short sequence of guide RNA. thus make it easier and flexible to implement. The CRISPR/Cas9 system could be used for editing/modifying the endogenous genome, disrupting the gene of interest, activating or repressing gene expression and labeling a regions of genomic DNA for imaging in a wide variety of biomedically important cell types and organisms. Due to these abilities, CRISPR/Cas9 system will transform genomic research and will spur the opening of a new era of molecular biomedicine and agricultural breeding. In this article, the latest research trend and applications of CRISPR/Cas9 system were studied. The ethical concern of CRISPR/Cas9 on human therapeutic use were also discussed.

종양표지자 발굴의 동향과 기대

권순일 ( Sun-il Kwon ) 한국고등직업교육학회 2013 한국고등직업교육학회논문집 Vol.14 No.2

Tumor markers are the biological substances produced by cancer cells or by other types of cells of the body due to cancer with high specificity. Tumor markers can be detected with the blood, tumor tissue, stool, urine or other bodily fluids of cancer patients. The usage of tumor markers may be diagnosis of cancer, prediction of a patient’s therapeutic response to certain drugs, determination of cancer recurrence, and so on. Discovery and development of new tumor marker is of much concern because of its great potential in cancer management as well as its application in target therapy. The candidates for tumor markers could be obtained from DNA, RNA, hormones, glycoproteins, metabolites, tumor-associated antigens, enzymes, or oncogene products. To discover new tumor markers, a holistic and systematic high-throughput process called omics technology is commonly adopted. Among the omics like genomics, transcriptomics, proteomics, and metabolomics, the proteomic approach is most widely used due to the diversity and dynamism of proteins in relation to cancer biology. In this short review, the latest research trend and prospective in the discovery and development of new tumor markers was discussed.

맞춤의학으로 향해 가는 걸음 -개인 유전체 분석 서비스-

권순일 ( Sun-il Kwon ) 한국고등직업교육학회 2013 한국고등직업교육학회논문집 Vol.14 No.2

It is the small but not ignorable differences in the nucleotide sequence of our genome that influence our individual looks, physiology, disease susceptibility, response to drugs and other numerous characteristics. Thanks to the rapid development of next generation sequencer (NGS), the cost to determine whole human genome nucleotide sequence has been dropped tremendously and now is approaching to US$ 1,000 per person. As a consequence the interest in personal genomics is sharply increasing which will use the knowledge of individual genetic variations to personal diagnosis and treatment in medicine. The personal genome analysis providers like 23 and Me^® and de CODE me^® offers the information on the disease susceptibilities, drug responses, ancestry and other genetic traits. We are still the early stage of personalized medicine. However, the rapidly expanding personal genome analysis is building an important infrastructure to realized it. In this review, the progress and latest trend in personal genome analysis was studied. Various issues were handled like advent of new NGS, target therapeutic development for personalized medicine, and intellectual properties of human genome. The pending issues and future perspectives of personal genome analysis were also discussed.

랩온어칩 중 PCR칩의 최신 개발동향과 미래 전망

권순일 (Sun-Il Kwon),도성탁 (Seong-Tak Do) 대구보건대학 2008 대구보건대학 論文集 Vol.28 No.-

A chip format for the analysis and diagnosis, so called lab on a chip (LOC), is of great interest with its huge potential in a variety of bioassays. Together with technological advances in microelectromechanical system (MEMS) and micro total analysis system (μTAS), the polymerase chain reaction (PCR) chips are studied extensively last few years among LOCs. A great progress was made with PCR chips like chip architecture, micromachining, surface chemistry, control of heat, integration with other analytical functional units. In this review, latest trends and achievements in PCR chip research were summarized. The primary concern was placed on chip substrate, surface treatment, reaction volume, reaction speed, heat insulation, prevention of evaporation and air bubble, and on-chip detection of PCR products. Practical obstacles such as processing cost and detection technology which should be overcome so as to realize PCR chips in actual research and diagnostic area were surveyed. The advances in MEMS and μ TAS technology may provide with the solutions for the current issues in PCR chips. PCR chips will be developed as rapid, specific and customized bioassay methods in the future.

맞춤의학시대를 열어갈 질환관련 SNP 연구의 최근 동향

권순일 ( Sun-il Kwon ) 한국고등직업교육학회 2009 한국고등직업교육학회논문집 Vol.10 No.1

A single-nucleotide polymorphism (SNP) is a single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population. Genome-wide association studies are to identify genes involved in human disease by searching SNPs that occur more frequently in people with a particular disease than in people without the disease. In this way we can pinpoint genes that may contribute to a person’s risk of developing a certain disease. SNP may also be associated with absorbance, response and clearance of therapeutic agents. In the future, the most appropriate drug for an individual could be determined in advance of treatment by analyzing a patient’s SNP profile with strategic personalized medicine. In this short review, we discussed historical background of disease-associated SNP detection, advance in SNP-related technologies, latest accomplishment and its clinical significance in SNP research in association with common diseases, and prospect in the future research.

바이오의약품 연구개발의 최근 동향 - 바이오시밀러가 열어주는 기회와 가능성 -

권순일 ( Sun-il Kwon ) 한국고등직업교육학회 2015 한국고등직업교육학회논문집 Vol.16 No.1

The biologics(biologic medical products) is the term used by the regulatory agencies to mention for a group of therapeutic macromolecular products engineered by biological processes including recombinant DNA technology like human insulin and monoclonal antibody-based medicines. These biologics are getting more important as they could be targeted to treat a variety of difficult medical conditions for which no other treatments are available such as autoimmune diseases and cancers. In addition the biologics showed improved efficacy with less side effects in comparison to chemically synthesized small molecule drugs. The biologics have changed the paradigm of pharmaceutical development last 20 years. The biologics have rapidly outridden the chemically synthesized drugs, and occupy 7 out of world top 10 pharmaceuticals in 2014. As the patents for the various major blockbuster biologics are being expired to 2019, the biosimilar products, namely follow-on biologics, have drawn significant interest. This situation provides a great opportunity for Korean biopharmaceutical entites to play a key role in the world biopharmaceutical arena. Last several years many of domestic biopharmaceutical industry put their resources heavily to develop promising biosimilars, and have obtained tangible results with the governmental approvals from various countries like the EU, the US and Japan. They are expected to grow as a world leaders in biologic area in the near future.

면진장치용 강재댐퍼의 형상 최적화

권순일 ( Kwon Sun-il ),이상호 ( Lee Sang-ho ),오상훈 ( Oh Sang-hoon ),유홍식 ( Ryu Hong-sik ),박진삼 ( Park Jin-sam ) 한국구조물진단유지관리공학회 2008 한국구조물진단유지관리공학회 학술발표회 논문집 Vol.12 No.1

As an energy absorption device in the base isolation system for dissipating the earthquake input energy, dampers also need a high degree of deformation capacity. As such, U-shaped steel damper has been developed using SN490B which has better deformation capacity than mild steel such as SS400. In order to achieve the goals, this research is conducted in two different stages. First, demonstrate the excellent deformation capacity of high toughness steel through comparative study with SS400. Second, suggest four types for U-shaped dampers based on the stress distribution that obtained from analytical study using computer program ANSYS 9.0.

에너지/환경 : 생산유전의 CO2 공법 적용성 평가를 위한 평가차트 개발 및 응용

권순일 ( Sun Il Kwon ),조현진 ( Hyun Jin Cho ),하세훈 ( Se Hun Ha ),이원규 ( Won Kyu Lee ),양성오 ( Sung Oh Yang ),성원모 ( Won Mo Sung ) 한국화학공학회 2007 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.45 No.6

사과 교배 실생의 유년성 단축을 위한 생장조절제 살포 등 몇 가지 처리의 효과

권순일(Sun-Il Kwon),김목종(Mok-Jong Kim),강인규(In-Kyu Kang) 한국원예학회HST 2002 원예과학기술지 Vol.20 No.별호1