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人蔘Saponin이 實驗的 動脈硬化症 誘發에 미치는 影響
具滋賢 한양대학교 의과대학 1983 한양의대 학술지 Vol.3 No.2
It has been noted that ginseng saponins, one of the major components of Korean ginseng(C.A. Meyer) roots, are surface active and effective solubilizer of non-polar lipids such as cholesterol and triglycerides in aqueous media. It was also reported that moderate amounts of the saponin stimulated various enzymes nonspecifically, lipid transport, phospholipid biosynthesis and chylomicron hydrolysis. In connection with above experimental results, this study was attempted to observe the preventive effect of the saponin against hypercholesterolemia and aortic atheroma formation of prolonged cholesterol fed rabbits and some biochemical approaches to understand the above effect were made. The results obtained in this study are as follows; 1. Examination of the blood serum lipid variation of cholesterol fed rabbits with and/or without saponin on time course showed that the saponin has some preventive effect on the induction of hypercholesterolemia. 2. No occurrence of atheroma in aorta, coronary and renal arteries was observed microscopically in the rabbits fed cholesterol and saponin until four weeks feeding, while in the rabbits fed cholesterol without the saponin, atheroma in ascending aorta appeared after 2 weeks' feeding. This suggested that the saponin has some preventive effect on formation of atheroma in aorta tissue. 3. Specific radioactivity ratio of cholesterol in aorta tissue to blood serum cholesterol of the rabbits fed with high cholesterol diet containing[4.¹⁴C] cholesterol with and/or without the saponin for 4 weeks showed that the elevation of cholesterol influx rate from blood to aorta tissue by prolonged high cholesterol diet was significantly diminished by simultaneous feeding of ginseng saponin. From the above results and previous study, it may be presented, as conclusions, that ginseng saponin might stimulate the lipid transport by enhancing the cholesterol metabolism, phospholipid biosynthesis and chylomicron hydrolysis, resulting in the prevention of hypercholesterolemia, and that might diminish the increasing cholesterol influx rate from blood to aorta tissue caused by prolonged cholesterol feeding, resulting in the prevention of aortic atheroma formation.
구자현 이화여자대학교 음악연구소 2007 이화음악논집 Vol.11 No.2
19세기를 거치면서 음향학은 실험과 수학을 바탕으로 물리학의 한 분야로 정립되고 있었다. 이러한 과정에서 음악과 음향학은 긴밀한 교감을 갖고 발전했다. 다양한 악기가 음향학에서 우선적으로 사용하는 실험용 음원이 되었고 악기 제작자들도 악기의 개량과 개발을 위해 악음에 대한 과학적 탐구활동을 전개하였다. 정률과 절대 음높이에 대한 음악계의 요구가 컸던 시기에 음향학자들은 이것들을 위한 이론적 및 정량적 기초를 제공하는 중요한 역할을 담당했다. 두 분야의 긴밀한 교감 속에서 '음악 과학은 음악도들에게 필수적인 과목으로 간주되었던 것이다. During the nineteenth century, acoustics was established as a subfield of physics on the basis of experiment and mathematics. In this course, music and acoustics developed in close interaction between each other. Various musical instruments became primary sound sources in acoustical experiments and musical-instrument makers undertook scientific investigations for improving and creating instruments. Responding to the needs of the music world for reasonable temperaments and absolute pitches, acousticians played an important role of providing them with the theoretical and quantitative foundations. It was through sympathy between the two fields that 'musical science' was regarded as an imperative subject for musical students.
젊은 남성에서 성정체성에 대한 고환의 영향 : 지역 기반 조사 Community-Based Survey
구자현,김민의,이남규,박영호 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2
We investigated the influence of testis on the gender identity in late adolescent Korean males dwelling in a community. Of 27,202 men aged 20 years dwelling in the community, 2,700 men were randomly selected at a 10.0% sampling fraction. A total of 2,080 men who agreed to participate in the study and all volunteers underwent a standard evaluation. For the evaluation of influences of testis on the gender identity, we used the Bem Sex Role Inventory in the subjects who had testis torsion, testis injury of cryptorchidism as well as with no testicular disease. They were categorized as group 1; normal testis size, group 2; testis atrophy, and group 3; no testis in the scrotum. The median masculinity scores of group 1, 2 and 3 were not significantly different (group 1; 4.3 [3.65.0], group 2; 3.9 [3.1-4.5] and group 3; 4.6 [4.0-5.1], p=0.065). Regarding the femininity score, there were no differences among groups (group 1; 4.6 [4.0-5.1] versus group 2; 4.5 [3.9-4.8] and group 3; 4.6 [4.2-4.9], p=0.609). In group 3, the masculinity and femininity scores were not also different between of men underwent orchiectomy and did not undergo correction of cryptorchidism. We did not find the impact of testis on gender identity in our cohort. Additional research is needed to clarify the underlying psychopathology involved.
전방 경추 추간판 제거술 및 유합술 후 연부조직 부종에 의한 기도폐쇄-증례 보고-
구자현,박은수,임영수 대한중환자의학회 2010 Acute and Critical Care Vol.25 No.2
Acute airway obstruction after anterior cervical surgery is rare, but does occur. Airway obstruction due to prevertebral soft tissue swelling is unpredictable, but potentially lethal. We managed a 67-year-old male who developed acute airway obstruction caused by marked prevertebral soft tissue swelling on the first day after anterior cervical discectomy and fusion at the C4-C5 level.