5-Fluorouracil, Mitomycin C 및 Acriflavine-Guanosine 복합제가 Ehrlich 암세포를 이식한 생쥐 위점막 점액상피세포의 미세구조에 미치는 영향

고은주,박경호,박대균,김덕수,고정식,Ko, Eun-Ju,Park, Kyung-Ho,Park, Dae-Kyoon,Kim, Duk-Soo,Ko, Jeong-Sik 한국현미경학회 2011 Applied microscopy Vol.41 No.1

이 실험은 Ehrlich 종양세포를 이식한 후 5-fluorouracil, mitomycin 및 acriflavine-guanosin 복합제(AG60)을 투여하였을 때, 위점막 점액상피세포의 미세구조적 변화를 연구하고자 시행하였다. 실험동물로는 ICR생쥐를 사용하였으며 정상대조군 이외의 종양대조군, 5-fluorouracil, mitomycin C 및 AG60 투여군의 동물들은 샅부위 피부밑조직에 각각 $1{\times}10^7$의 Ehrlich 종양세포를 이식하였다. 각각의 실험군은 종양세포를 이식한 다음날부터 5-fluorouracil (30 mg/kg), mitomycin C ($400{\mu}g/kg$) 및 AG60 (30 mg/kg)을 격일 간격으로 한번씩 피부밑조직에 주사하였다. 종양대조군은 종양세포이식 후에 0.2 mL의 생리식염수를 피부밑조직에 주사하였고 정상대조군은 종양세포를 이식하지 않은 동물을 사용하였다. 종양대조군을 비롯한 실험군은 생리식염수 또는 각각의 약제를 격일 간격으로 7회씩 투여한 다음날, 에테르(ether) 마취하에 앞배벽을 열어 위조직을 절취하였다. 절취한 조직은 2.5% 글루타르알데히드(glutaraldehyde)-1.5% 파라포름알데히드(paraformaldehyde) 혼합액에 고정한 후, 1% 오스뮴사산화물(osmium tetroxide)용액에 다시 고정한 후 탈수과정을 거쳐 애럴다이트(araldite) 혼합액에 포매하였다. 포매된 위점막 조직은 얇은 절편을 만들었으며, 각 절편은 우라닐아세테이트(uranyl acetate)용액과 구연산납(lead citrate)용액으로 대조염색한 후, 전자현미경으로 비교 관찰하였다. 5-fluorouracil 투여군은 종양대조군에 비해 점액상피세포에 수초구조(myelin figure)가 자주 관찰되고, 분비과립이 세포질을 포함한 막성구조에 싸여 속공간으로 함께 분비되는 부분분비현상이 보일 정도로 손상을 받았다. 그리고 mitomycin C 역시 수초구조가 자주 관찰되고 분비과립을 함유한 세포질이 속공간으로 돌출되는 등의 미세구조적 변화를 보였다. 그러나 AG60의 경우는 수초구조와 다소포체가 비교적 자주 관찰되는 외에는 별다른 미세구조적 변화를 관찰할 수 없었다. 이상의 결과를 종합해보면 mitomycin C, 5-fluorouracil 및 AG60을 반복 투여 하면 위점막 점액상피세포의 분비기능이 억제되었음을 시사하는 미세구조적 변화를 보였다. 그러나 세포의 손상 정도가 mitomycin C와 5-fluorouracil 투여군에 비해 AG60 투여군에서 매우 경미하였으므로 AG60은 위점막 점액상피세포의 분비기능에 큰 손상을 주지 않는 약제라고 생각된다. This experiment was performed to evaluate the morphological responses of the gastric epithelial cells of the mouse, inoculated with Ehrlich carcinoma cells in the inguinal area, following administration of 5-fluorouracil, mitomycin C or Acriflavine-Guanosine compound (AG60). In this study, each mouse was inoculated with $1{\times}10^7$ Ehrlich carcinoma cells subcutaneously in the inguinal area. From next day after inoculations, 0.2 mL of saline, 5-fluorouracil (30 mg/kg), mitomycin C ($400{\mu}g/kg$) or AG60 (30 mg/kg) were injected to the animals every other day, respectively. Each animals were sacrificed after 7th injection and tissue were taken from the gastric mucosa. Thereafter, the ultrathin sections were stained with uranyl acetate and lead citrate. In the 5-fluorouracil-, mitomycin C- or AG60-treated mice, myelin figures and multivesicular bodies within the gastric mucous epithelial cells were observed more frequently than those of the normal control. In the 5-fluorouracil-treated mice, membrane structures containing a few mucous granules in the luminal space were observed. Indeed, bulging cytoplasmic process containing mucous granules protruding into the gastric lumen were observed in the mitomycin Ctreated mice. Therefore, this study suggested that AG60 as compared with 5-fluorourail and mitomycin C may effective medicine without damage to the secretion ability of gastric mucous epithelial cells.

원산지효과, 상표자산 및 상표충성 간의 관계에 관한 연구: 미국, 중국, 한국의 비교분석

고은주,김경훈,김숙현,이구봉,추붕,장호,Ko, Eun-Ju,Kim, Kyung-Hoon,Kim, Sook-Hyun,Li, Guo-Feng,Zou, Peng,Zhang, Hao 한국마케팅과학회 2009 마케팅과학연구 Vol.19 No.1

The marketing environment has become competitive to an extent that requires firms to target their products at markets that span national boundaries. However, competitive clout cannot be achieved in global consumer markets unless firms thoroughly understand and adequately respond to the core values and needs of those consumers. Brand equity is one of the most important assets to a company. Especially in sportswear markets, brand equity is the crucial value added to a product by its brand name. Factors such as country of origin also influence customer's attitude towards brand equity. Therefore, this paper discusses the relationship between country of origin effect and brand equity, and how they influence consumers' loyalty for respective brands. This paper focused on the sports shoes market, because it is an increasing area of opportunity for world manufacturers. The objectives of this study were the following. (1) Test the effect of country of origin on brand equity. (2) Test how brand equity influences consumers' brand loyalty. (3) Find whether there are differences in the effects of country of origin and brand equity among the three countries. (4) Find whether there are differences in the effects of country of origin and brand equity among the different lifestyles. Based on the review of literature results, the hypotheses are concluded as the following: H1-a: Country image has positive influence on country of origin. H1-b: Product perception has positive influence on country of origin. H2-a: Perceived quality has positive effect on brand equity. H2-b: Perceived price has positive effect on brand equity. H3: Country of origin has positive effect on brand equity. H4: Brand equity has a positive impact on brand loyalty. Research model was constructed (see Fig. 1). After data analysis, the following results were concluded: sports shoes purchase behavior showed significant differences among Korean, Chinese, and American consumers for favorite brand, purchased brand, purchased place, information usage, and favorite sports games. The results of this study also extend the research of the relationship among country of origin, brand equity and brand loyalty to the sports shoes market. Brand equity was proven to have a significant relationship with brand loyalty for all countries. The factors which can influence brand equity are different for different countries. The third finding of this paper is that we identified different three lifestyles, adventurer, follower, and laggard, for Korean, Chinese and American consumers. Without the nationality boundary, seeing the emergence of a new group of consumers who have similar preferences and buy similar brands is more important. All of the consumers consider brand equity to keep their brand loyalty. Perceived price is the only factor which can influence brand equity for adventurers; brand is more important for them. The laggards were not influenced by any factor. All of the factors expect perceived price are important for the followers. Marketing managers should consider brand equity when introducing their brand into a new market. Also localization is the basic strategy that all the sports shoes companies should understand. But as a global brand, understanding the same characteristics for each country is more important to build global strategy.

남성 유방암 폐전이 환자의 폐절제술 후 한의기반 통합암치료로 증상 호전에 대한 증례보고

고은주,하수정,박지혜,박소정,이연월,조종관,유화승,Ko, Eun ju,Ha, Su-jeong,Park, Ji-hye,Park, So-jung,Lee, Yeon-weol,Cho, Chong-kwan,Yoo, Hwa-seung 대한암한의학회 2020 大韓癌韓醫學會誌 Vol.25 No.1

Objective: The purpose of this study is to report improvement of symptoms after lobectomy of male breast cancer lung metastasis treated with Korean Medicine based Integrative Cancer Treatment (ICT). Methods: A male left breast cancer patient diagnosed with metastasis on lung at July 2019. After Video assisted thoracic surgery (VATS) left lower lobe (LLL) lobectomy and En bloc wedge resection the patient visited the Daejeon korean medicine hospital of Daejeon university East West Cancer Center (EWCC) to treat operation-site (op-site) pain, dysphagia, anorexia with Korean Medicine Treatment. The patient was treated with Korean Medicine based ICT for an approximately 20 days. The clinical outcomes were measured by National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Numeral rating scale (NRS) and Eastern Cooperative Oncology Group (ECOG). The safety of treatment was verified by blood tests. Results: After treatment, op-site pain was improved from NRS 9 to 6, dysphagia and anorexia were relieved from NRS 9 to 2. And ECOG score of the patient was improved from grade 2 to 1. Conclusion: This case study suggests that Korean Medicine based ICT may help to improve post operative sequelae in metastatic lung cancer patient.

췌장암 간전이 환자의 통합 암 치료에 대한 증례보고

고은주,명지수,김종희,박지혜,박소정,이연월,유화승,Ko, Eun-ju,Myong, Ji-soo,Kim, Jong-hee,Park, Ji-hye,Park, So-jung,Lee, Yeon-weol,Yoo, Hwa-seung 대한암한의학회 2021 大韓癌韓醫學會誌 Vol.26 No.1

Objective: The purpose of this study is to report effects and potential of Integrative Cancer Treatment (ICT) on metastatic pancreatic cancer patient. Methods: A 79-year-old pancreatic cancer patient diagnosed with metastasis on liver visited the Daejeon Korean medicine hospital of Daejeon university East West Cancer Center (EWCC) on May 2021. The patient has been received chemotherapy (gemcitabine plus abraxane) and concurrently treated with ICT since May 2021. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA19-9) and numeric rating scales (NRS). Laboratory analysis and National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0 were used to evaluate the safety of ICT. Results: After treatment, constipation was relieved from NRS 5-6 to 2, both leg numbness was improved from NRS 9 to 2. Tumor size was generally decreased accompanying by reducing the levels of tumor markers. There were no severe adverse events induced by ICT based on NCI CTCAE version 5.0. Conclusion: This case study suggests that ICT in combination with chemotherapy may help in the treatment of patients with metastatic pancreatic cancer.

한부모 가구의 빈곤요인에 관한 연구

고은주 ( Eun Ju Ko ),김진욱 ( Jin Wook Kim ) 한국사회복지정책학회 2009 사회복지정책 Vol.36 No.2

의류브랜드 소비자의 고객관계관리 경험에 관한 탐색적 연구 - 남성복, 여성복, 캐주얼, 스포츠의류 소비자의 비교를 중심으로 -

고은주 ( Eun Ju Ko ),이주연 ( Joo Yun Lee ),윤혜림 ( Hye Lim Yun ) 대한가정학회 2006 Human Ecology Research(HER) Vol.44 No.5

의료기관인증평가 전후 인증기준 준수율의 변화

고은주(Eun-Ju Ko),이진용(Jin-Yong Lee),배석환(Seok-Hwan Bae),김현주(Hyun-Joo Kim) 대한방사선과학회(구 대한방사선기술학회) 2013 방사선기술과학 Vol.36 No.4

이 연구는 의료기관인증 획득 당시와 인증획득 이후 인증기준 준수율이 얼마나 향상 또는 감소되었는지를 확인하고자 의료기관인증을 획득한 대전지역의 4개 대학병원에 종사하며 의료기관 인증평가를 경험한 방사선사를 대상으로 하였다. 연구방법으로는 의료기관인증평가 기준 틀을 재분류하여 환자안전, 직원 및 환경안전영역에 대해 평가하였다. 환자안전(patient safety) 8문항, 직원안전(staff Safety) 5문항, 환경안전(environmental safety) 3문항으로 총 16문항으로 구성하였고 인증기준 준수율은 10점 척도로 인증평가 당시와 현재의 인증기준 준수율을 측정하였다. 연구결과 인증기준 준수율은 인증평가 당시에 비해 2012년 12월 현재 평균적으로 환자안전, 직원 및 환경안전 영역 모두가 떨어졌다. 세부문항 16개 중에서 가장 많이 떨어진 문항은 환자안전 영역의 손위생이었다. 손위생은 개인의 노력 및 필요성에 대한 인식도 중요하지만 지속적인 교육과 관리·감독이 역시 중요하다. 따라서 의료기관들은 인증기준 준수의 필요성에 대해 지속적인 교육 시행과 적극적인 관리·감독이 필요하다. This study aimed to assess whether the changes in compliance rates of evaluation criteria after healthcare accreditation among radiologic technologists working at four university hospitals which had acquired healthcare accreditation in Daejeon metropolitan area. In this study, the evaluation criteria of healthcare accreditation were reclassified and reevaluated to three areas which include patient safety, staff safety, and environmental safety. Each area has eight, three, and five questions, respectively. Each compliance rate was quantitatively measured on a scale of 0 to 10 before and after in this study. The result shows that the overall compliance rates were decreased on all areas compared to the time healthcare accreditation was obtained. The compliance rate of hand hygiene was drastically reduced. To maintain the compliance rates, not only individuals but healthcare organizations should simultaneously endeavor. In particular, healthcare organizations should make an effort to provide continuous education opportunity to their workers and supervise the compliance regularly.

청소년의 우울이 사이버불링 가해행동에 미치는 영향: 부모-자녀 간 폐쇄적 의사소통의 조절효과를 중심으로

고은주(Eun Ju Ko),김계숙(Gye Sook Kim),김진욱(Jin Wook Kim) 서강대학교 생명문화연구소 2019 생명연구 Vol.52 No.-

본 연구는 청소년의 우울이 사이버블링 가해행동에 미치는 영향과 이 관계에 대한 부모-자녀 간 폐쇄적 의사소통의 조절효과를 검증하는 것을 목적으로 하였다. 조절변수인 부모-자녀 간의 폐쇄적 의사소통을 부-자녀, 모-자녀, 부모-자녀의 세 가지로 구분하여 연구모형을 설계하였다. 분석결과 세 가지 부모-자녀 간의 폐쇄적인 의사소통 모두에서 사이버블링 가해행동에 대한 조절효과를 확인하였다. 부모-자녀 간의 폐쇄적 의사소통 수준이 낮을 경우, 우울이 사이버블링 가해행동에 미치는 정적 영향을 완충시키는 역할을 하였다. 이러한 조절효과는 청소년의 우울 수준이 높을 경우에 더 큰 영향을 미치는 것으로 나타났다. 연구결과를 바탕으로 청소년의 사이블링 가해행동 완화를 위해 청소년복지 차원의 실천적 개입 방안을 제언하였다. This study examined the moderating effects of closed communication between parents and children on the relationship between children’s depression and cyberbullying behaviors. The research model was designed to classify the controlled variable, parent-child communication, as father-child, mother-child, and parents-child. As a result of the analysis, we confirmed the moderating effects of all three parent-child communication on cyberbullying behavior. In case, the degree of closed communication between parents and children is low, it buffers the positive effect of depression on cyberbullying behavior. These moderating effects were found to have a greater impact on adolescent depression. Based on the findings, this study suggests several practical ways of intervention to mitigate cyberbullying behaviors of adolescents.

초음파에서 고위험 병변과 DCIS

고은주(Eun Ju Ko) 대한초음파의료영상학회 2023 대한초음파의료영상학회 학술대회 초록집 Vol.7 No.1

정보제공매체(情報提供媒體)의 구성방식(構成方式)에 따른 패션상품(商品) 정보검색(情報檢索)의 편의성(便宜性)에 관(關)한 연구(硏究)

고은주 ( Eun Ju Ko ) 한국패션비즈니스학회 2000 패션 비즈니스 Vol.4 No.4

The purpose of this study was to examine the usage of internet advertisement, to define the convenient dimensions of information navigation medium, and to examine the difference of convenient information navigation among advertisement types and information design methods. Thirty-four subjects were selected for the survey study and descriptive anlysis, factor analysis and ANOVA were used for the data analysis. The results of this study were: 1. the most perceived channel about the web site information was the search engine, the most preferred type of information design was the mixed type with text and image, and the most preferred medium for fashion information is the magazine. 2. the convenient dimensions of information navigation medium were information understanding, design composition, easy navigation, timely navigation, and convenient navigation. 3. the information design method is the significant factor influencing on the convenient information navigation.