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CDX1 and CDX2 Expression in Intestinal Metaplasia, Dysplasia and Gastric Cancer
강정묵,이병환,김나영,이혜승,이희은,박지현,김주성,정현채,송인성 대한의학회 2011 Journal of Korean medical science Vol.26 No.5
Intestinal metaplasia (IM) has been regarded as a premalignant condition. However, the pathogenesis of IM is not fully understood. The aim of this study was to evaluate the role of CDX1 and CDX2 in the formation of IM and the progression to dysplasia and gastric cancer (GC). A total of 270 subjects included 90 with GC, dysplasia and age- and sexmatched controls. Real-time PCR (RT-PCR) was performed with body specimens for CDX1and CDX2. The expression of CDX2 was significantly higher in H. pylori positive group than H. pylori negative group (P = 0.045). CDX1 and CDX2 expression increased proportional to the IM grade of the body (P < 0.001). CDX2 expression was significantly higher in incomplete type of IM than in complete type (P = 0.045). The expression of CDX1 in dysplasia group was significantly higher than in the control group (P = 0.001); in addition,CDX1 and CDX2 in cancer group was significantly higher than control group (P < 0.001,and P < 0.001, respectively). Aberrant expression of CDX1 and CDX2 correlated with H. pylori infection and grade of IM in the body. Furthermore, the results suggest that CDX1and CDX2 play a role in the progression to GC and dysplasia.
Enhancement of Gastric Ulcer Healing and Angiogenesis by Cochinchina Momordica Seed Extract in Rats
강정묵,김나영,김봉철,김주현,이봉용,박지현,이미경,이혜승,김주성,정현채,송인성 대한의학회 2010 Journal of Korean medical science Vol.25 No.6
Cochinchina momordica seed is the dried ripe seed of Momordica cochinchinensis,a perennial vine. The antiulcer effect of an extract from cochinchina momordica seeds (SK-MS10) was evaluated in a rat model of acetic acid-induced gastric ulcers. Gastric ulcers were produced by subserosal injection of acetic acid. SK-MS10 (200mg/kg) or vehicle was administered orally once per day for 14 days after the acetic acid injection. The stomach was removed and the ulcer size measured at day 7 and 14 of the treatment. Expression of vascular endothelial growth factor (VEGF) was assessed by real-time RT-PCR and Western blot analysis. In addition, the microvasculature density (MVD) adjacent to the ulcer margin was examined by immunohistochemistry. The treatment with SK-MS10 for 7 and 14 days significantly accelerated ulcer healing and increased the expression of mRNA (at day 7) as well as VEGF protein (at day 14) compared to the vehicle-treated rats. The MVD for factor VIII was also higher in the SK-MS10 treatment group compared to the vehicle-treated rats; however, these differences were not statistically significant. These results suggest that SK-MS10 treatment accelerates the healing of gastric ulcers via upregulation of VEGF and angiogenesis in an acetic acid rat model.
일개 대학병원에 내원한 뇌경색 환자와 정상인에서 대사증후군 유병률 비교
강정묵 대한뇌졸중학회 2005 Journal of stroke Vol.7 No.1
Department of Internal Medicine and Neurology*, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine; Department of Internal Medicine, Catholic University School of Medicine**, Seoul, KoreaBackground: Ischemic stroke is the important cause of mortality after coronary heart disease and cancer, and the leading cause of disability. Metabolic syndrome confers an increased risk for cardiovascular morbidity and mortality. But, the study on the relationship between cerebral infarction and metabolic syndrome has been scarcely reported. The aim of this study is to elucidate the incidence of metabolic syndrome in patients with ischemic stroke and the differences between the two groups divided by the presence or absence of metabolic syndrome. Methods: 127 patients with ischemic stroke documented with brain MRI and 130 age, sex-matched control subjects without any medical history were studied. Blood pressure, body mass index (BMI), fasting blood glucose, triglyceride, high-density lipoprotein (HDL) cholesterol, total cholesterol and low-density lipoprotein (LDL) cholesterol were checked. NCEP-ATP III criteria for metabolic syndrome was used and BMI was used instead of abdominal circumference. Statin users are classified as positive for triglyceride or HDL-cholesterol component. The subjects with ischemic stroke were subclassified into 5 groups according to Trials of Org 10172 in Acute Stroke treatment (TOAST) criteria. Results: Prevalence of metabolic syndrome reached up to 41.7% in patients with documented ischemic stroke, compared with 29.2% in normal controls. Among the individual components of metabolic syndrome, only the prevalence of fasting hyperglycemia was significantly higher in ischemic stroke group than normal controls. Mean blood pressure and the number of involved components of metabolic syndromewere higher in ischemic stroke group than normal controls and significantly more subjects with ischemic stroke had smoking history. The odds ratio for ischemic stroke by the presence of metabolic syndrome was 1.734(95% CI, 1.034 to 2.908) and if analyzed separately, the presence of fasting hyperglycemia showed significantly increased odds ratio for ischemic stroke among the components (OR=4.049; 95% CI, 2.373 to 6.908). According to TOAST criteria, small vessel occlusions were the most prevalent(35.5%) and large artery thrombosis were the next(30.6%). Although statistically insignificant, small vessel occlusion and larg eartery thrombosis groups showed relatively higher prevalence of metabolic syndrome(46.4 and 40.5%).Conclusions: Patients with ischemic stroke had higher prevalence of metabolic syndrome compared with normal controls and the presence of metabolic syndrome increased the risk for ischemic stroke Among the metabolic components, fasting hyperglycemia significantly increased the risk for ischemic stroke. This result emphasizes the importance of managing the metabolic syndrome in ischemic stroke patients. Key Words: Metabolic syndrome, Ischemic stroke, Fasting hyperglycemia