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RKO 대장암 세포주와 MCF-7 유방암 세포주에서 Sodium Butyrate와 5-aza-2’-deoxycytidine에 의한 종양세포 성장억제 상승작용
조항주(Hang Joo Cho),박순철(Sun Cheol Park),김기환(Kee Whan Kim),강원경(Won Kyung Kang),조현민(Hyun Min Cho),김정수(Jeong Soo Kim),김영애(Young Ae Kim),안창혁(Chang Hyeok An) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.5
Purpose: It is known that DNA methylation is associated with histone acetylation status in regulation of gene expression. In this study, we investigate the effect of demethylating agents and histone deacetylase (HDAC) inhibitor on the tumor suppression and the combined effect of two agents according to methylation status in human colon and breast cancer cell lines. Methods: In this study, the RKO colorectal cancer cell line, MCF-7 breast cancer cell lines were considered. For each cell line, we used HDAC inhibitor sodium butyrate (SB), demethylating agent 5-aza-2’-deoxycytidine (5-aza-DC) and a combination of both agents. We estimated the percentage of cell survival using the XTT method and experimented with the augmentative effects of both agents. Results: In RKO cell line in which most of the genes are methylated, 74% of cell survival was shown for 5-aza-DC treatment and 83% of cell survival for SB treatment. In MCF-7 cell line that approximately half of the genes are methylated, 82% cell survival was shown for 5-aza-DC treatment and 63% cell survival for SB treatment. We observed that the survival fraction is lower after the combined treatment of 5-aza-DC and SB than that of 5?aza?DC or SB alone in both RKO (53%) and MCF-7 (49%) cell lines (P<0.001). Conclusion: For highly methylated genes, 5-aza-DC is more effective on the tumor suppression than SB. On the other hand, if the methylation of the promoter region is at low density, SB is noted to be more effective than 5-aza-DC. Furthermore, the combined treatment of 5-aza-DC and SB is more effective than using each agent alone.
4종의 Diamide계열 살충제에 대한 배추좀나방과 파밤나방의 지역계통별 감수성 평가
조선란,경예진,신소은,강원진,정대훈,이승주,박근호,김성일,조성우,김현경,구현나,김길하,Cho, Sun-Ran,Kyung, Yejin,Shin, Soeun,Kang, Won-Jin,Jung, Dae Hoon,Lee, Seung-Ju,Park, Geun-Ho,Kim, Sung Il,Cho, Sung Woo,Kim, Hyun Kyung,Koo, Hyun-Na,K 한국응용곤충학회 2018 한국응용곤충학회지 Vol.57 No.1
4종의 diamide계열 살충제를 이용한 배추좀나방과 파밤나방의 지역계통별 감수성을 조사하였다. 배추좀나방의 경우 성주와 거창지역 집단에서 4종의 약제 모두 추천농도에서 100%의 살충활성을 보인 반면, 평창지역 집단에서는 chlorantraniliprole에 대해 42.3%의 낮은 살충활성을 보였다. 감수성계통 배추좀나방과 저항성비를 비교한 결과 cyclaniliprole은 비교적 4지역에서 유사하거나 낮은 저항성비(0.1~6.3배)를 보인 반면, 평창지역 집단은 chlorantraniliprole (1,196.3배)와 cyantraniliprole (105.6배), flubendiamide (191.6배)은 매우 높은 저항성비를 보였다. 파밤나방의 경우 청주와 진도, 영광지역의 집단 모두 4종의 약제에 낮은 감수성을 나타났는데, 특히 청주와 진도지역의 집단은 flubendiamide에 대해 100,000배 이상의 저항성비를 보였다. 채집 연도(2014년과 2017년)에 따른 파밤나방에 대한 chlorantraniliprole의 감수성을 비교한 결과 2014년에 채집된 집단들은 모두 100%의 살충률을 보인 반면 2017년에 채집된 집단들은 살충활성이 매우 낮게 나타났다. 본 연구결과는 diamide계열 살충제가 빠르게 저항성이 발현되고 있으며 작용기작이 다른 약제와의 교호살포 등 종합적 방제전략을 수립하는데 기초자료가 될 수 있을 것이다. The present study evaluated the susceptibility of field populations of Plutella xylostella and Spodoptera exigua larvae to four diamide insecticides-chlorantraniliprole, cyantraniliprole, cyclaniliprole, and flubendiamide. All the four diamide insecticides induced 100% mortality in the populations from Seongju (SJ) and Geochang (GC) when treated at a concentration recommended for P. xylostella. However, a very low insecticidal activity was observed in the population from Pyeongchang (PC) with 42.3% 3 d after treatment with chlorantraniliprole. The relative resistance ratio of P. xylostella to cyclaniliprole was similar or low (0.1-6.3 folds) in all the four areas. However, the population from PC exhibited a high resistance ratio to chlorantraniliprole (1,196.3 folds), cyantraniliprole (105.6 folds), and flubendiamide (191.6 folds) compared with that of the susceptible strain P. xylostella. Further, the populations of S. exigua from Cheongju (CJ), Jindo (JD), and Yeonggwang (YG) were not completely controlled by the 4 diamide insecticides. These populations also showed high relative resistance ratio when compared with that of the susceptible strain S. exigua. In particular, the populations from CJ and JD showed 100,000-fold higher resistance ratio to flubendiamide. A comparison of susceptibility of S. exigua larvae to chlorantraniliprole between 2014 and 2017 showed that chlorantraniliprole induced 100% mortality in all populations in 2014, whereas a very low insecticidal activity was observed among the populations in 2017. The results of the present study indicate that the insect pests rapidly develop resistance to diamide insecticides. Therefore, alternative insecticides with a different mechanism of action and comprehensive control strategy are needed. This study can serve as a basis to control pests effectively using diamide insecticides.
조현동,강원식,김두현,구자정,서권일 한국식품저장유통학회 2019 한국식품저장유통학회지 Vol.26 No.2
Stellaria aquatica, belong to the family Caryophyllaceae (commonly known as the carnation family), is a perennial plant found in subtropical and temperate regions. In addition, the seeds of S. aquatica are known to be polyphenol-rich; however, the biological activities of S. aquatica seeds have not yet been evaluated. To enhance the use of S. aquatica seeds as functional food and natural medicine, the total polyphenolic content, and anti-oxidant, anti-cancer, and immune-modulatory activities of S. aquatica seed extracts were investigated. The radical scavenging and reducing power activities of 1,000 μg/mL S. aquatica seed extracts were similar to those of BHT and α-tocopherol. In addition, total polyphenol and flavonoid contents of S. aquatica seed extracts were the highest in 70% EtOH extract (27.30 mg GAE/g and 23.22 mg QE/g, individually). In the case of HepG2, A549, MCF-7, and B16 cells, IC50 value of the 70% EtOH extract was lesser than that of other extracts, whereas the lowest IC50 activity of EtOH extracts was noted in HT-29 and PC-3 cells. Furthermore, EtOH, MeOH and 70% EtOH extract-induced cancer cell death was related to apoptosis. In RAW 264.7 macrophages, 70% EtOH extract significantly improved immune-modulatory activity by increasing nitric oxide (NO) production without inducing significant cytotoxicity. Taken together, our results provide important insights into the bioactive potential of S. aquatica seed extracts as functional food ingredient and natural medicine.
사례연구를 통한 Cross Site Script 공격 및 방어대책
손강원 ( Kang-won Son ),김지훈 ( Ji-hun Kim ),조두산 ( Doosan Cho ),윤종희 ( Jonghee Youn ) 한국정보처리학회 2015 한국정보처리학회 학술대회논문집 Vol.22 No.1
최근 인터넷 기술 발전에 따라 웹 시장이 커지고 웹 사이트 범죄가 급증하고 있다. 통계에 따르면 악성코드 주요 전파경로로 웹 사이트가 가장 높은 비율을 차지 할 정도로 조심해야 할 전파경로 중 하나이다. 그 중에서 이 논문은 웹 사이트 관련 공격 기술 중 하나인 크로스 사이트 스트립트(Cross Site Script, XSS)취약점을 알아본다. 먼저 XSS에 대해 알아보고, 실제 공격 예시를 살펴본다. 그리고 XSS를 막기 위한 방어대책으로 화이트 리스트와 필터링에 대해 알아본다.