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감염성 심내막염에 동반된 백색의 중심을 갖는 망막 출혈
정혜욱,문수정,권의용,이동욱,조남천.Hye Wook Jeong. M.D.. Su Joung Mun. M.D.. Eui Yong Kweon. M.D.. Dong Wook Lee. M.D. Nam Chun Cho. M.D. 대한안과학회 2007 대한안과학회지 Vol.48 No.11
Purpose: To report a case of white-centered retinal hemorrhage in infective endocarditis. Case summary: A 45-year-old patient complained of acute visual loss. The patient had a history of epidural anesthesia for the relief of back pain. On the day of admission the patient showed no light perception and had a white-centered retinal hemorrhage and cotton wool spot in the left eye upon fundus examination. Other ocular manifestations were not specific and there were no specific findings on a brain MRI and visual evoked potential. The patient was diagnosed with pyogenic spondylitis and was treated by abscess drainage and systemic antibiotics therapy. The patient’s near vision improved up to 0.4/0.5. He was diagnosed with infective endocarditis based on the echocardiogram with epidural and subarachnoid hemorrhage. Conclusions: Roth spot can occur in many diseases such as diabetes, leukemia, anemia, and trauma, but most commonly in sepsis due to infective endocarditis. Therefore, medical evaluation and an echocardiogram for patients with white-centered retinal hemorrhage should be considered.
눈물주머니조영술에서 정상을 보이는 눈물흘림 환자의 실리콘관 삽입술 결과
정혜욱,조남천,안민,Hye Wook Jeong,Nam Chun Cho,Min Ahn 대한안과학회 2008 대한안과학회지 Vol.49 No.5
Purpose: To Compare treatment results on silicone tube insertion according to the region and severity of resistance in lacrimal probing for functional nasolacrimal duct obstruction patients who complained of epiphora but are shown to be normal in lacrimal syringing and dacryocystography. Methods: A retrospective study was conducted with 40 subjects (42 eyes) who had silicone tube insertion because of functional nasolacrimal duct obstruction. A comparison was made of post-operational patient satisfaction by grading (0~3) according to the region and the severity of resistance and whether the resistance region was singular or multiple resistance regions were found on probing. Success was defined as a grade of more than one point. Results: Two eyes had no resistance regions, 28 eyes had one resistance region, and 12 eyes had more than two resistance regions on lacrimal probing. There was no statistical significance in the ranking of post-operative satisfaction among theses groups. There was also no difference among the groups for post-operative satisfaction according to obstruction site. Conclusions: Most functional nasolacrimal duct obstruction patients showed partial obstruction of the nasolacrimal duct on probing. Since functional nasolacrimal duct obstruction is not possible, we must treat patients for partial nasolacrimal duct obstruction, for wihch silicone tube insertion is thought to be effective.
Array-비교유전체보합법을 이용한 망막아세포종 세포주(Y-79, WERI-Rb-1)의 유전체이상 분석
정혜욱(Hye-Wook Jeong),김미진(Mi-Jin Kim),한후재(Hoo Jae Hann),박수연(Soo-Yeun Park) 대한해부학회 2008 Anatomy & Cell Biology Vol.41 No.2
Retinoblastoma is the most common intraocular malignancy in young children, arising in approximately 1 per 20,000 live births. Although it is established that the functional loss of both alleles of the RB1 gene is a prerequisite for the development of retinoblastoma, little is known about the genetic events that are required for tumor progression. To screen the genomic aberrations, two retinoblastoma cell lines, Y-79 and WERI-Rb-1, were analysed by using array-CGH. As a result, gains of AHRR, EXOC3, CEP72, TRIP13, TERT, SEMA5A, TAS2R1, MARCH6, CTNND2, CDH12, NHLRC1, TPMT, AOF1, FANCC, NCBP1, XPA, TGFBR1, BAAT, MRPL50, ZNF189, ALDOB, ABCA1, FCMD, TAL2, ZNF462, COL27A1, ORM1, ORM2, AKNA, ASTN2, TRIM32, GSN, STOM, LHX2, PBX3, ABL1, FIBCD1, WNK4, CCDC56, CNT1, BECN1, PSME3, AOC2, LOXHD1, ST8SIA5, SMAD2, KIAA0427, COL18A1, COL6A2, FTCD and LSS were found in both cell lines. Lost clones detected in both cell lines were RB1, ZDHHC3, EXOSC7, CLEC3B, CACNA2D3, DEFB106A, FAM90A6P, FAM90A7, ZMYND11, LARP5, GTPBP4, IDI2, IDI1, KLF6, AKR1CL2, FBXO18, IL15RA, IL2RA, TAF3, GATA3, CUGBP2, DHTKD1, SEC61A2, NUDT5, ITGA8, PTER, C1QL3, RSU1, DNMT2, PTPLA, PLXDC2, NEBL, MLLT10, DNAJC1, PIP5K2A, PRTFDC1, NRP1, PARD3, MGMT, RFP2OS, RFP2, KCNRG, IGHV, CDH19, TXNDC10 and RTTN. Through this study, it is confirmed that many genomic aberrations are involved in the development and progression of retinoblastoma. Genomic profiling of retinoblastoma cell lines by array-CGH revealed numerous imbalanced regions and novel candidate genes. These data provide a basis for more detailed molecular characterization and testing their pathologic roles of these candidates. 망막아세포종(retinoblastoma)은 소아안구에 발생하는 암으로 RB1 유전자의 결함이 발병에 선행한다고 알려져 있으나, 종양의 진행과 관련된 유전적 지표는 거의 알려진 바가 없다. 이에 본 연구에서는 망막아세포종의 발병 및 진행과 관련된 유전자이상을 규명하고자 array-비교유전체보합법을 이용하여 망막아세포종 세포주 (Y-79와 WERI-Rb-1)의 유전체를 분석하였다. 두 세포주 모두에서 RR, EXOC3, CEP72, TRIP13, TERT, SEMA5A, TAS2R1, MARCH6, CTNND2, CDH12, NHLRC1, TPMT, AOF1, FANCC, NCBP1, XPA, TGFBR1, BAAT, MRPL50, ZNF189, ALDOB, ABCA1, FCMD, TAL2, ZNF462, COL27A1, ORM1, ORM2, AKNA, ASTN2, TRIM32, GSN, STOM, LHX2, PBX3, ABL1, FIBCD1, WNK4, CCDC56, CNT1, BECN1, PSME3, AOC2, LOXHD1, ST8SIA5, SMAD2, KIAA0427, COL18A1, COL6A2, FTCD, LSS의 51개 유전자가 공통적으로 증가하였고, RB1을 비롯하여 ZDHHC3, EXOSC7, CLEC3B, CACNA2D3, DEFB106A, FAM90A6P, FAM90A7, ZMYND11, LARP5, GTPBP4, IDI2, IDI1, KLF6, AKR1CL2, FBXO18, IL15RA, IL2RA, TAF3, GATA3, CUGBP2, DHTKD1, SEC61A2, NUDT5, ITGA8, PTER, C1QL3, RSU1, DNMT2, PTPLA, PLXDC2, NEBL, MLLT10, DNAJC1, PIP5K2A, PRTFDC1, NRP1, PARD3, MGMT, RFP2OS, RFP2, KCNRG, IGHV, CDH19, TXNDC10, RTTN의 46개 유전자가 공통적으로 감소했다. 본 연구에서는 array-비교유전체보합법을 이용하여 망막아세포종 세포주에 대한 유전자변화를 최초로 확인하였고, 이를 통해 기존에 알려지지 않은 많은 이상부위와 새로운 후보유전자를 발견하였다. 즉, 이상의 유전자들은 망막아세포종의 발생 또는 진행과 관련된 유전자들일 것으로 판단되며 향후 이에 대한 기능적 연구가 요구된다.