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운동실조와 현훈을 주소로 한 소뇌경색 환자의 척담탕 치험 1례
최인영,김미경,김보람,최동준,한창호,정승현,신길조,이원철,Choi, In-Young,Kim, Mi-Kyung,Kim, Bo-Ram,Choi, Dong-Jun,Han, Chang-Ho,Jung, Seung-Hyun,Shin, Gil-Jo,Lee, Won-Chul 대한중풍순환신경학회 2008 대한중풍.순환신경학회지 Vol.9 No.1
Ataxia and vertigo are frequent clinical findings in cerebellar infarction patients. In severe cases, they cannot achieve normal activity in daily life. A 65-year-old man was admitted with ataxia and vertigo diagnosed as acute cerebellar infarction. We prescribed for Chukdam-tang to treat the phlegm disease. After this treatment, ataxia and vertigo improved. We suggest Chukdam-tang is significantly effective on the treatment of cerebellar infarction.
흰쥐 대뇌세포의 저산소증 모델에서 석창포(石菖蒲 Acori graminei rhizoma. AGR)에 의한 유전자 표현 변화의 microarray 분석
신길조,박동준,정승현,문일수,이원철 한국생명과학회 2007 생명과학회지 Vol.17 No.2
Acori graminei Rhizoma (AGR) is a perennial herb which has been used clinically as a traditional oriental medicine against stroke, Alzheimer’s disease, and vascular dementia. We investigated the effect of AGR on the modulation of gene expression profile in a hypoxic model of cultured rat cortical cells. Rat cerebrocortical cells were grown in Neurobasal medium. On DIV12, cells were treated with AGR (10 ug/㎖), given a hypoxic shock (2% O2, 3 hr) on DIV14, and total RNAs were prepared one day after shock. Microarray analyses indicated that the expression levels of most genes were altered within the global M values +0.5 and -0.5, i.e., 40% increase or decrease. There were 750 genes which were upregulated by < global M +0.2, while 700 genes were downregulated by > global M -0.2. The overall profile of gene expression suggests that AGR suppresses apoptosis (upregulation of anti-apopotic genes such as TEGT, TIEG, Dad, p53, and downregulation of pro-apopotic genes such as DAPK, caspase 2, pdcd8), ROS (upregulation of RARα, AhR), and that AGR has neurotrophic effects (upregulation of Akt1, Akt2). These results provide a platform for investigation of the molecular mechanism of the effect of AGR in neuroprotection.
흰쥐의 중대뇌동맥 결찰로 유발된 뇌허혈에서 양격산화탕(凉膈散火湯)이 신경세포에 미치는 효과
신길조,오경환,정승현,이원철,Shin, Gil-cho,Oh, Kyung-hwan,Jeong, Sung-hyun,Lee, Won-chul 대한중풍순환신경학회 2006 대한중풍.순환신경학회지 Vol.7 No.1
Objectives : Yanggyuksanhwa-tang is a prescription used for cerebral infarction clinically. Methods : According to previous research data, the effect of Yanggyuksanhwa-tang on cerebral infarction, we induced cerebral infarction by middle cerebral artery occlusion(MCAO) in rats, and the rats were administered Yanggyuksanhwa-tang. Results: Infarct area, infarct volume were measured, and the level of elements such as c-Fos, Bax and caspase-3 in penumbra of infarct were expressed by immunohistochemical staining. Conclusion : Yanggyuksanhwa-tang showed neuroprotective effect through preventing neuronal cell apoptosis.
신길조,Shin, Gil Cho 대한중풍순환신경학회 2017 대한중풍.순환신경학회지 Vol.18 No.1
It is difficult to combine oriental and western medicine. Each medicine has a different academic background, perspective on the world, and studying methodology. The claim that two paradigms can not be combined is not obtained from an actual verification, but this means it is so hard to combine two medicines having different backgrounds. The amalgamation of oriental and western medicine should be phased in on the basis of the continuous reciprocal understanding and commitment. First, the strength and weakness of each medicine over the treatment and research are required to be identified. Then, a few complementary areas can be chosen enabling a trial of fusion on a small scale. A cycle of problem solving and a new research can be set by analyzing research results obtained through the implementation over a period of time. In other words, the researchers of oriental and western medicine should repeat a continuous and gradual complementary research process by identifying issues to be improved and complemented through a consensus. Once the methodology obtained through the process of problem solving and proficient implementation is established in a stable condition, a method to widen the fusion area by expanding the operating area and implementation method can be chosen. However, the integral system of oriental medicine shouldn't be substituted by mechanical idea or reductionism. What should be done primarily for oriental medicine is to objectify things through quantification. In particular, the oriental treatment should accept the microscopic diagnosis to determine the structure and observe the biochemical change.
배양한 흰쥐 대뇌세포의 저산소증 모델에서 황금(黃芩)이 유전자 표현에 미치는 영향
정승현,신길조,이원철,김성배,Chung, Sung-Hyun,Shin, Gil-Cho,Lee, Won-Chul,Kim, Sung-Bae 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4
Objectives : The purpose of this investigation is to evaluate the effects of Scutellaria baicalensis GEORGI on alteration in gene expression in a hypoxia model using cultured rat cortical cells. Methods : E18 rat cortical cells were grown in a Neurobasal medium containing B27 supplement. On 12 DIV, Scutellaria baicalensis GEORGI(20 ug/ml) was added to the culture media and left for 24 hrs. On 11 DIV, cells were given a hypoxic insult $(2%\;O_2/5%\;CO_2,\;37^{\circ}C,\;3\;hrs)$, returned to normoxia and cultured for another 24 hrs. Total RNA was prepared from Scutellaria baicalensis GEORGI-untreated (control) and -treated cultures and alteration in gene expression was analysed by microarray using rat 5K-TwinChips. Results : For most of the genes altered in expression, the Global M values were between -0.5 to +0.5. Among these, 1143 genes increased in their expression by more than Global M +0.1, while 1161 genes decreased by more than Global M -0.1. Effects on some of the genes whose functions are implicated in neural viability are as follows: 1) The expression of apoptosis-related genes such as Bad (Global M = 0.39), programmed cell death-2(Pdcd2) (Global M = 0.20) increased, while Purinergic receptor P2X(P2rxl) Global M = -0.22), Bc12-like1(Bc1211)(Global M = -0.19) decreased. 2) The expression of 'response to stress-related genes such as antioxidation-related AMP-activated protein kinase subunit gamma 1 gene (Prkag1) (Global M = 0.14), catalase gene (Global M = 0.14) and Heme Oxygenase(Hmoxl) increased. 3) The expression of Fos like antigen 2 (Fos12) expressed in neurons that survive ischemic insult increased (Global M = 0.97). Conclusions : these data suggest that Scutellaria baicalensis GEORGI increases the expression of antiapoptosis- and antioxidation- related genes in a way that can not yet be explained.
청심온담탕(淸心溫膽湯)의 효능(效能)에 관(關)한 문헌적(文獻的) 고찰(考察)
김인섭,신길조,조기호,김영석,배형섭,Kim, In-Sup,Sin, Gil-Jo,Jo, Gi-Ho,Kim, Yeong-Seok,Bae, Hyeong-Seop 대한한방내과학회 1992 大韓韓方內科學會誌 Vol.13 No.1
In order to study oriental medical literature and clinical effects of Chungsimondamtang, the experiments of analgesic action, sedative action, anticonvulsive action, action on the isolated ileum, action on the circulatory system and hyperlipidaemia were observed. The results were as follows: 1. The analgesic effects were significantly noted. 2. The prolongaton of hypnotic time was noted. 3. The inhibitory effects on the convulsion induced by strychnine, picrotoxin and caffeine were significantly recognized. 4. The spontaneous momentum of isolated ileum was evidently inhibited, and recognized anti Ach. and anti Ba. effects. 5. The effects of descending blood pressure in normal rats and anesthetized rabbits were strongly recognized. 6. The effects of inhibition on the increase of TG. and TC. levels in hyperlipidaemia rats induced by Triton WR-1339 was significantly recognized. 7. The effects of inhibition on the increase of TG. and TC. levels in hyperlipidaemia rats induced by 75% fructose was significantly recognized. With the genelalization of the above-mentioned experimental results, literatual and clinical effects of Chungsimondamtang were approximate to actual experimental results.
치매(痴呆)에 관(關)한 동서의학적(東西醫學的) 비교(比較) 고찰(考察)
이동원,신길조,이원철,Lee, Dong-Weon,Shin, Gil-Jo,Lee, Won-Chul 대한한방내과학회 1995 大韓韓方內科學會誌 Vol.16 No.1
This study was done in order to investigate the etiology and pathology of dementia in the variety literature. Dementia in elderly persons(above the age of 60) mainly classfied Alzheimer disease and Cerebral vascular dementia. The results were as follows: 1. Dementia patients have abnormal mental function, who have no mental weakness but defects of memory, verbal disturbance, behavior disturbance and loss of intellectual function. 2. Dementia regard as 'me-beng(?病)', 'jeon-gwang(癲狂)', and 'heo-ro(虛勞)' in oriental medicine and the symptom is a silence with no response, mixing, a crying or a laugh, a stranger behavior and a amnesia; disturbances of speech, emotion, behavior. 3. Dementia caused by Alzheimer disease, Multi infarct dementia, Parkinson's disease, sequelae of acute CO poisoning, head injury and alcoholism(occidental medically) and the 'Dam(痰) and Damhwa(痰火), weakness of heart and spleen(心脾虛) caused by pent up anger of seven emotions(七情鬱結), the weakness of liver and kidney(肝腎不足)(oriental medically). 4. The causes of Alzheimer disease are various; a heredity factor, a morphological factor of brain tissues, a psychological factor and a biochemical factor (occidental medically) ; the 'Dam(痰) and Damhwa(痰火) caused by weakness of the internal organs and disturbance of the emotions(oriental medically). 5. Cerebral vascular dementia caused by loss of the certain cerebral neurons and oriental medically caused by obstruction of 'dam(痰)' or 'eo heul(瘀血)'. It is recommended that further study of many sided investigations, specially against a weakness of spiritual functions and a certain neurotoxin in the future.