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인삼의 연근별 가공방법에 따른 Ginsenoside 함량 특성
오동주,이충렬,곽창훈,이관영,하재현,이수지,정진욱,황광보,조항식 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04
인삼은 보통 4-6년간 재배한 수삼을 그대로 소비하거나 또는 가공하여 다양한 제품으로 생산하여 시중에 유통하고 있다. 인삼의 주된 약리적 효능을 나타내는 ginsenoside는 가공방법에 따라 성분함량 차이가 크게 달라지는 양상을 보이고 있다. 따라서, 본 연구에서는 동일한 조건에서 재배한 수삼을 연근별로 홍삼, 태극삼, 피부직삼으로 가공하여 ginsenoside의 변화를 조사하였다. 사포닌분석은 식약청의 ginsenoside 분석법에 준하 여 분석하였고, HPLC는 Perkin Elmer Series200을 이용하였으면, Column은 ODS Column(C18)을 사용하였다. 검출기는 UV Detector를 203nm에서 분석하고 이동상 용매는 Water, ACN(B&J, USA)을 사용하였다. 가공인삼 에 따른 ginsenoside 12종을 분석 결과, 총사포닌은 5년근의 피부직삼이 가장 높았고 홍삼, 태극삼 순이었다. Rb1은 5년근 피부직삼에서, Rg1은 5년근 홍삼에서 높은 경향이었고, Rg3와 Rh2는 6년근 홍삼에서 가장 높았 다. 또한, Re는 큰 차이를 보이지 않았고 Extract contents는 4년근 태극삼에서 높은 경향을 보였고, Crued saponin contents는 5년근 피부직삼에서 높은 경향이 있었다.
오동주,O, Dong-Ju 사단법인 한국당뇨협회 2006 당뇨 Vol.194 No.-
관상 동맥성 심장 질환의위험 요인들은 거의 모두가 평소의 생활습관과 관련이 있다. 따라서 관상 동맥성 심장질환을 예방하기 위해서는 이런 바람직하지 못한 생활습관을 조절하는 것이 가장 중요하고 또 효과적인 대책이라고 할수 있다.
오동주,김소연,최인학,한혜민,변형권,정광윤,백승국 대한이비인후과학회 2018 대한이비인후과학회지 두경부외과학 Vol.61 No.12
Background and Objectives Previous studies have suggested the usefulness and importanceof postoperative voice therapy, for which there are indirect and direct methods. The aimof this study was to evaluate the efficacy of treatment according to different voice therapymethods. Subjects and Method Patients with vocal polyp were divided into three groups. Group 1 receiveddirect voice therapy after phonomicrosurgery and Group 2 indirect voice therapy afterphonomicrosurgery. Group 3 did not receive any voice therapy. Results Perceptual, acoustic, aerodynamic voice outcome parameters differed significantlybetween pre and post-operative treatments. In almost all of the voice analysis, Group 1, whounderwent direct voice therapy, improved more significantly compared with Group 2 and 3. Conclusion Postoperative voice therapy following phonomicrosurgery may be an effectiveadjuvant treatment in patients with vocal polyps. In particular, direct voice therapy can be effectivefor improving postoperative voice outcome.
Atenolol 전처치 개흉견에서 심근재관류가 좌심실 수축 및 확장기능과 좌심실 크기에 미치는 영향에 관한 연구
오동주,노영무 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.1
Although early reperfusion limits or even prevents myocardial necrosis, this beneficial effect dose not lead to immediate functional improvement, and the return of contractile function in the myocardium salvaged by reperfusion is delayed for hours or even days (stunning phenomenone or postischemic myocardial dysfunction), and functional expansion in both ischemic and non-ischemic myocardium caused by coronary occlusion does not return immedialely by reperfusion. To investigate the effect of early reperfusion on the left ventricular function and the functional expansion of the left ventricle, left anterior descending coronary artery was occluded by silk snare distal to the first diagonal branch for 30 minutes and was followed by reperfusion for 60 minutes in 9 atenolol pretreated open-chest dogs. Atenolol caused fall in arterial pressure (from 114 to 95 mmHg in systole, 88 to 65 mmHg in diastole, mean), reduced heart rate (from 161/min to 113/min, mean) and cardiac output (from 2.2 L/min, to 1.5L/min, mean) before occlusion, but arterial pressure and heart rate did not change. Both ischemic and non-ischemic areas at end-systole and at end-diastole were increased in 30 seconds after occlusion. After reperfusion rerovery of expansion of ischemic area to pre-occlusion level was achieved in 40 minutes and non-ischemlc area in 20 minutes Decreased cardiac output and percent change in area(% △ A) during occlusion were recovered in 15 minutes and 20 minutes, respectively. The ratio of early peak filling wave to late peak filling wave (E/A velocity) measured by Doppler echocardiography were reversed by occlusion and recovered in 5 minutes after reperfusion. These findings suggest that decreased diastolic function caused by coronary occlusion is recovered earlier than the systolic function, and recovery of systolic function is accompanied by a recovery of non-ischemic area expansion after reperfusion, which may indicate that the change in non-ischemic area during occlusion and after reperfusion is due to the change in systolic function.
서방형verapamil의 과량 복용으로 인한 약물 중독1예
김응주,강창돈,이은미,박창규,권영주,표희정,김상욱,서흥석,오동주 대한응급의학회 1998 대한응급의학회지 Vol.9 No.1
Verapamil overdose results in cardiac arrhythmia including the complete A-V block, and hypotension due to decreased peripheral resistance and decreased myocardial contractility. However, sustained-release verapamil overdose frequently has atypical presentations, such as delayed and prolonged course of toxic signs and symptoms. Although several cases of sustained-release verapamil overdose have been reported worldwidely, the specific treatment modalities and prognostic indicators for verapamil overdose have not been well-defined. Recently, we experienced a case of sustained-release verapamil overdose in 30-year-old female. 10 hours after verapamil ingestion she presented in severe bradycardia and hypotensive shock state. Initial EKG showed the complete AV block and her systolic blood pressure was below 60 mmHg. Temporary cardiac pacemaker was performed and she was treated with activated charcoal, glucagon, amrinone, and several sympathomimetics, and 48 hours after admission, she was fully recovered.